Dr Jacinta Kalisch-Smith
@jkalism.bsky.social
330 followers 600 following 7 posts
BHF Intermediate Fellow, Group Leader Investigating placental and cardiac vascular development in pregnancy pathologies - miscarriage, congenital heart defects, fetal growth restriction. kalischsmithlab.org IDRM, University of Oxford 🇬🇧 PhD UQ 🇦🇺
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Reposted by Dr Jacinta Kalisch-Smith
bertiegottgens.bsky.social
Collaborative science is just so much fun! From our brilliant collaboration with Liz Robertson from @dunnschool.bsky.social; embryology, single cell omics and computational biology deliver new insights into the intricacies of blood and endothelial development. www.sciencedirect.com/science/arti...
Reposted by Dr Jacinta Kalisch-Smith
simoesfilipa.bsky.social
🧪 Job alert 🔊 we are hiring a Research Assistant - join the Simões Group at DPAG-IDRM @ox.ac.uk supporting #cardiovascular development and regeneration research, working with #zebrafish and #human stem cell systems: my.corehr.com/pls/uoxrecru... @oxforddpag.bsky.social @idrm.ox.ac.uk (1/4)
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my.corehr.com
Reposted by Dr Jacinta Kalisch-Smith
idrm.ox.ac.uk
Exciting news! Dr Jacinta Kalisch-Smith, @jkalism.bsky.social, has been awarded a BHF fellowship to explore how placental blood vessels support fetal growth and development.

Her research could change how we detect and prevent complications during pregnancy.

🔗 Read more: shorturl.at/OVzqq
Reposted by Dr Jacinta Kalisch-Smith
dev-journal.bsky.social
Feto-placental blood vessel development

In this Review, Jacinta Kalisch-Smith @jkalism.bsky.social gives an overview of placental vascular development and pathologies in mice and humans and highlights key remaining questions in the field:
doi.org/10.1242/dev....
Figure 3: Human villous feto–placental blood vessel development.
Reposted by Dr Jacinta Kalisch-Smith
hellmutaugustin.bsky.social
Epigenetic regulation of placental vascularization - now published in Developmental Cell (www.sciencedirect.com/science/arti...). Congratulations & thanks to Stephanie Gehrs for fantastic work and paving the way of the www.augustinlab.de into the world of vascular epigenetics. There’s more to come!
jkalism.bsky.social
This Review discusses placental vascular progenitors and derivatives (with their molecular markers), genetic knockouts, trophoblast-endothelial signalling, co-occurrence with embryonic heart defects, genetic tools and pathologies that are impacted by placental vascular defects.
jkalism.bsky.social
I hope it will be a good reference for the community and will help inspire other vascular and placental biologists to investigate the placental vasculature.

@socdevbio.bsky.social @bsdb.bsky.social @navbo.bsky.social @oxforddpag.bsky.social @ox.ac.uk @biologists.bsky.social
jkalism.bsky.social
I had a some great news this week, being awarded an independent @thebhf.bsky.social fellowship. Thanks to the support from @idrm.ox.ac.uk @oxforddpag.bsky.social @ox.ac.uk colleagues past and present. Looking forward to the next few years investigating placental vascular development.
idrm.ox.ac.uk
🎉 Congratulations to Jacinta Kalisch-Smith who has just been awarded a 5 year Intermediate Fellowship from the British Heart Foundation.

Her fellowship will study how placental blood vessels develop to understand the cause of neonatal heart conditions from early pregnancy @oxforddpag.bsky.social
Reposted by Dr Jacinta Kalisch-Smith
degrainger.bsky.social
✨Excited to share our work revisiting the developmental origins of mammalian lymphatic endothelial cells.✨

A summary of our key findings using scRNA-seq, snMultiome-seq and imaging to show the direct specification of mesenchymal progenitors to LECs🧵 #blutorial #blabstract

tinyurl.com/LECspec
Direct specification of lymphatic endothelium from mesenchymal progenitors - Nature Cardiovascular Research
Lupu, Grainger, Kirschnick et al. show that, contrary to prevailing belief, the initial specification of mammalian lymphatic endothelial cells primarily occurs from previously unidentified mesenchymal...
tinyurl.com
Reposted by Dr Jacinta Kalisch-Smith
oliverastone.bsky.social
Very happy to share our work on lymphatic endothelial cell specification, which was published in Nature Cardiovascular Research this week.
Reposted by Dr Jacinta Kalisch-Smith
katherine-brown.bsky.social
Here in the UK, the HFEA is recommending changing the 14-day rule on human embryo research to allow culture up to 28 days. This will open up new avenues of research into previously inaccessible stages of development, and potentially provide new understanding of the causes of early pregnancy failure.
Limit on human embryo research should be extended to 28 days, says UK regulator
Experts say increasing law from 14 days could lead to breakthroughs in understand of miscarriages
www.theguardian.com
jkalism.bsky.social
Sorry to hear this Tom, hope someone can help you get some feedback. I certainly wouldn't have progressed without it.
thomasnicol.bsky.social
...So when the @royalsociety.org says "due to the high number of applications we are unable to provide feedback", it sits badly. What little down time we have sunk into an application and the funder cant even say if it was on the right track, feels like a kick in the teeth to young researchers. 3/3