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Dave Grainger

@degrainger.bsky.social

1.5K followers 660 following 35 posts

Developmental biologist studying endothelial cell differentiation and heterogeneity Postdoc in the Stone Lab - Institute of Developmental and Regenerative Medicine, Oxford, UK

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Dave Grainger @degrainger.bsky.social · Jan 13

A huge thank you to all my co-authors, particularly Irina Lupu, Nils Kirschnick, @oliverastone.bsky.social and Friedemann Kiefer

I am grateful to have been part of a project that opens so many exciting questions for the field

For more details, please read our paper:
doi.org/10.1038/s441...

Direct specification of lymphatic endothelium from mesenchymal progenitors - Nature Cardiovascular Research

Lupu, Grainger, Kirschnick et al. show that, contrary to prevailing belief, the initial specification of mammalian lymphatic endothelial cells primarily occurs from previously unidentified mesenchymal...

doi.org

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Reposted by Dave Grainger

kostaslekkos.bsky.social @klekkos.bsky.social · 7d

Do zebrafish regenerate their hearts equally? In our new paper at the @tillymommersteeg.bsky.social lab we uncovered variations in the regenerative response of 7 wt zebrafish strains leading us to identify a critical role of oxidative phosphorylation in long-term heart regeneration.
rdcu.be/eI1v5

Oxidative phosphorylation is required for cardiomyocyte re-differentiation and long-term fish heart regeneration

Nature Cardiovascular Research - Lekkos et al. show that a metabolic switch toward oxidative phosphorylation is required for cardiomyocyte re-differentiation and heart regeneration after injury in...

rdcu.be

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Reposted by Dave Grainger

Kate Cavanaugh @katecavanaugh.bsky.social · 7d

See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...

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Dave Grainger @degrainger.bsky.social · 14d

Whether you're into photography or not there's something here for everyone. Some amazing shots

www.britishphotographyawards.org/2025-shortli...

British Photography Awards

The British Photography Awards is a charity oriented photography prize open to all UK residents and British photographers the world over

www.britishphotographyawards.org

Dave Grainger @degrainger.bsky.social · 28d

Whew the most amazing I've ever seen the sea. Off the coast of Kerry, Ireland

Picture from the edge of a cliff looking along the coast with dark grey rocks sticking out of a turbulent aqua marine sea with lots of foam

Reposted by Dave Grainger

FocalPlane @focalplane.bsky.social · Sep 4

ICYMI – Our featured image was this beautiful colour-coded depth projection of the blood endothelial cells of the mouse embryonic thymus & surrounding structures.
The image was acquired by David Grainger. Find out about David’s research⤵️
focalplane.biologists.com/2025/08/29/f...
#SciArt

Featured image with David Grainger - FocalPlane

Featured image with David Grainger - News

focalplane.biologists.com

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Dave Grainger @degrainger.bsky.social · Sep 5

Have a look at my featured image with FocalPlane. It's a thymus, I swear 🦋

FocalPlane @focalplane.bsky.social · Sep 4

Featured image with David Grainger - FocalPlane

Featured image with David Grainger - News

focalplane.biologists.com

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Reposted by Dave Grainger

Private Eye Magazine @privateeyenews.bsky.social · Sep 3

“I’m not sure I want to give way to the right”

From the new Private Eye, in shops now.

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Reposted by Dave Grainger

Thiago Carvalho @cyrilpedia.bsky.social · Aug 25

Wow
'Here, we present a high-speed blockface volumetric imaging system with an optimized workflow of whole-body clearing, capable of imaging the entire adult mouse at micrometer resolution within 40 h.'

www.cell.com/cell/fulltex...

High-speed mapping of whole-mouse peripheral nerves at subcellular resolution

A high-speed pipeline enables whole-mouse imaging and mesoscopic analysis of peripheral nerves using transgenic, immunostaining, and viral labeling, providing an effective means to map body-wide struc...

www.cell.com

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Dave Grainger @degrainger.bsky.social · Aug 16

Giant fiancée took me out for my nearly-birthday

A woman and a man standing next to eachother in a black and white room. An optical illusion makes the woman appear twice the height of the man

Reposted by Dave Grainger

Beth Psaila @bethpsaila.bsky.social · Aug 15

Thrilled that our paper is in print @science.org!!
*Platelets sequester cell free DNA, including free fetal and tumour-derived DNA*
Tweetorial from @l-cmurphy.bsky.social below. Check out the news feature science.org/content/arti... and terrific editorial from Dennis Lo #platelets_in_the_limelight

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Dave Grainger @degrainger.bsky.social · Jul 23

Looking forward to the Spa GP this weekend. Ferrari sharing some cool artwork this week

Comic book style drawing of a red formula 1 car driving on a race track with green mountains in the background and orange flowers in the foreground. Written on the floor next to the F1 car is written Spa Francorchamps

Reposted by Dave Grainger

Daniyal Jafree @daniyaljafree.bsky.social · Jul 22

Excited to share our new collaborative preprint between @uclnews.bsky.social and @sickkidsto.bsky.social 🥳

We found that kidney lymphatic vessels, an emerging target in kidney diseases, partly arises from the same group of cells that give rise to the kidney

www.biorxiv.org/content/10.1...

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Genetic lineage tracing identifies intermediate mesoderm as a novel contributor to mammalian kidney lymphatics

The lymphatic vasculature is essential for fluid homeostasis, immune regulation and possesses diverse organ-specific functions. During development, lymphatic endothelial cells (LEC) arise from multipl...

www.biorxiv.org

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Dave Grainger @degrainger.bsky.social · Jul 20

I've seen a massive influx of bot-looking accounts following me on here. Almost all only posting about US politics. Hope it doesn't drown out why I joined this platform like it did on twitter

Reposted by Dave Grainger

Development @dev-journal.bsky.social · May 28

Register now to attend our #DevPres webinar next week, featuring the winners of the @bsdb.bsky.social poster prize, @shifaant.bsky.social and @giuliapaci.bsky.social, and chaired by Abigail Tucker.

4 June at 15:00 BST

us02web.zoom.us/webinar/regi...

Development presents...
Wednesday 4 June 15:00 BST
BSDB poster prize winners. CHair: Abigail Tucker
Giulia Paci University College London - ‘3D cell topology regulates signalling range to promote precise patterning of wing sensory organs’
Shifaan Thowfeequ University of Oxford - ‘Visualising calcium dynamics in the developing embryo: from fertilisation to the first heartbeat’

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Reposted by Dave Grainger

Institute of Developmental & Regenerative Medicine @idrm.ox.ac.uk · May 28

🎓 The MRC/BHF Centre of Research Excellence in Advanced Cardiac Therapies (REACT) is inviting applications for a fully funded DPhil studentship, based at the IDRM.

Learn more and apply: lnkd.in/gb-mEX8K

@oxforddpag.bsky.social

Dave Grainger @degrainger.bsky.social · May 20

My entry SMILE made it into the top ten 😁

Alongside many great entries. My favourite is Minnie's Bow!

Young Embryologist Network @yen-network.bsky.social · May 20

See the winners of the YEN Image Competition 2025. Thanks for everyone who sent us their amazing embryology images!

#yen2025

thenode.biologists.com/yen-image-co...

YEN Image Competition 2025 - the Node

The winners of the Young Embryologist Network (YEN) 2025 Image Competition announcement.

thenode.biologists.com

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Dave Grainger @degrainger.bsky.social · May 19

Great evening of talks at #pint25 in Oxford Tech Me Out theme. Very interesting talks from Alex and Jorge from @alpinef1.bsky.social followed by Muhammed Waqas from JLB.

Alpine even brought a front wing from their 2024 F1 car!
@pintofscience.uk

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Dave Grainger @degrainger.bsky.social · May 18

Great weekend celebrating @emmarose64.bsky.social's graduation with friends and family. Very proud! 😊

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Reposted by Dave Grainger

Young Embryologist Network @yen-network.bsky.social · May 2

We indeed got many entries!

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Reposted by Dave Grainger

Pint of Science UK @pintofscience.uk · Apr 14

✨Tickets for #pint25 are now on sale!✨
🎟Book here 👉 pintofscience.co.uk 👈
🐝🧪👩‍🔬📚🔬👓🧠🐟🫀💫🥼👨‍🔬🔭🧫🦴

🗓19th-21rd May 2025
📍45+ locations across the UK
🗣400 event

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Reposted by Dave Grainger

Young Embryologist Network @yen-network.bsky.social · Apr 7

YEN Image Competition Update!

We already have some amazing contributions from early career researchers from the UK, Switzerland and US. We would love to see contributions from other countries as well! If you can't travel to the conference remember you can always participate online.

World map with YEN Image Competition contributors.

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Reposted by Dave Grainger

Molecular Instruments, Inc. @hcrimaging.bsky.social · Mar 28

#onlywithHCR: @degrainger.bsky.social, @oliverastone.bsky.social, and their team reveal that lymphatic endothelial cells arise from specialized progenitors. #HCRimaging helped them to visualize endothelial progenitors in whole-mount mouse embryos.

Learn more: www.nature.com/articles/s44...

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Reposted by Dave Grainger

Biomedical Picture of the Day BPoD @bpodaily.bsky.social · Mar 20

Lymphatic vessels traced to their origins from a specialised pool of cells called angioblasts

📷: Irina Lupu @degrainger.bsky.social Nils Kirschnick et al @oliverastone.bsky.social Friedemann Kiefer
@ox.ac.uk @uni-muenster.de @naturecvr.bsky.social

➡️: bpod.org.uk/archive/2025...

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Reposted by Dave Grainger

Hans schoofs @hansschoofs.bsky.social · Mar 20

• Happy to announce that our paper in @nature.com is finally out! Thanks to the perseverance of @taijamakinenlab.bsky.social and our many collaborators we finally pulled it off! A small 🧵

www.nature.com/articles/s41...
Laymen video:
www.nature.com/articles/d41...

Dynamic cytoskeletal regulation of cell shape supports resilience of lymphatic endothelium - Nature

Dynamic cytoskeletal regulation of lymphatic endothelial cell shape, induced by isotropic stretch and crucial for dermal lymphatic capillary function, is identified and found to result from continuous...

www.nature.com

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Reposted by Dave Grainger

the Node @the-node.bsky.social · Mar 11

Together with @focalplane.bsky.social, we're having an image competition to accompany the #Biologists100 conference.

Thank you everyone who submitted their images. Shortlisting only 15 was tough!

Browse through the gallery and vote for your favourite image:
thenode.biologists.com/vote-for-you...

Vote for your favourite image in the Node–FocalPlane image competition - the Node

Browse through the gallery of the 15 shortlisted images and vote for your favourite image by Wednesday 26 March.

thenode.biologists.com

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