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preLights @prelights.bsky.social · 4h

Insightful #postLight just uploaded by @vibhasingh.bsky.social 👀

She revisits work from Jonathan Kuhn & team #DevreotesLab, originally posted as a preprint and now published in @natcomms.nature.com

postLight: prelights.biologists.com/highlights/c...

Complementary Cytoskeletal Feedback Loops Control Signal Transduction Excitability and Cell Polarity - preLights

The cytoskeleton talks back and has a bi-directional influence on cell polarity.

prelights.biologists.com

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The Company of Biologists @biologists.bsky.social · 5h

Our first extraordinary biologist featured this week is Katherine Brown, @biologists.bsky.social Publishing Director and former @dev-journal.bsky.social Executive Editor, who has been closely involved with @prelights.bsky.social since its inception. #100biologists

@katherine-brown.bsky.social

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preLights @prelights.bsky.social · 5h

Hsp70 phosphorylation stalls cell cycle, buying time for DNA repair

Ana Sanchez-Molina: “This #preprint provides detailed mechanistic, biochemical, and genetic evidence of a conserved mechanism of cell cycle regulation in response to DNA damage.” #preLight ⬇️
prelights.biologists.com/highlights/a...

A conserved Hsp70 phosphorylation regulates cell cycle progression after DNA damage - preLights

Hsp70 phosphorylation stalls cell cycle, buying time for DNA repair.

prelights.biologists.com

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preLights @prelights.bsky.social · 1d

Being active when everyone else is asleep 💤

Stefan F. Wirth highlights work from Jona Lopez Pedersen & team (Toxopeus Lab #stfxuniversity) exploring why & how the stonefly Allocapnia pygmaea survives sub-zero temperatures. #preprint

#preLight #Ecology ⬇️👀
prelights.biologists.com/highlights/t...

The cold tolerance of an adult winter-active stonefly: How Allocapnia pygmaea (Plecoptera: Capniidae) avoids freezing in Nova Scotian winters - preLights

Being active when everyone else is asleep: why the stonefly Allocapnia pygmaea survives subzero temperatures

prelights.biologists.com

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Nadja M. Hümpfer @nadjahuempf.bsky.social · 1d

Thank you, fellow preLighter @sristi.bsky.social for mentioning our #Atlas 🗺️ on #Cytokinesis ⌛ in the September in #preprints list @prelights.bsky.social 😊

prelights.biologists.com/prelists/sep...

September in preprints – Cell biology edition - preLights

prelights.biologists.com

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preLights @prelights.bsky.social · 1d

Lot of new preLights this week! 🙌

Ruoheng Li discusses a #preprint from the #ExtavourLab @harvard.edu studying an extraordinary case of epithelial morphogenesis.

How shrimp embryos set up an epithelial checkerboard: down and across.
#preLight #DevBio ⬇️👀 prelights.biologists.com/highlights/l...

Lineage domains and cytoskeletal cables organize a cellular square grid in a crustacean - preLights

How shrimp embryos set up an epithelial checkerboard: down and across

prelights.biologists.com

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preLights @prelights.bsky.social · 2d

Excellent #postLight uploaded by @fadelvalle.bsky.social!

He revisits work from Werner van der Meer & colleagues originally posted as a preprint and now published in @cp-cellreports.bsky.social

postLight: prelights.biologists.com/highlights/l...

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preLights @prelights.bsky.social · 2d

Stopping norovirus at the gate. 🚧

In her first preLight, Leonie Brüne explores work from Maryna Chaika & team (@uniluebeck.bsky.social) highlighting polyamines as a possible new lead for therapeutics against norovirus. #preprint

#preLight #Immunology ⬇️👀
prelights.biologists.com/highlights/p...

Polyamine depletion inhibits norovirus infection by blocking virus-induced apoptosis - preLights

Stopping norovirus at the gate: Polyamines as a possible new lead for therapeutics against norovirus

prelights.biologists.com

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Dan Portik @dportik.bsky.social · 7d

New pre-print from the Banfield lab, highlighting an interesting case of 1.5Mb megaplasmids found in human gut.

Plasmid genomes were resolved using #PacBio HiFi sequencing with hifiasm-meta for #metagenome assembly. Host association was detected using epigenetic signals.

doi.org/10.1101/2025...

Megaplasmids associate with Escherichia coli and other Enterobacteriaceae

Humans and animals are ubiquitously colonized by Enterobacteriaceae , a bacterial family that contains both commensals and clinically significant pathogens. Here, we report Enterobacteriaceae megaplas...

doi.org

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preLights @prelights.bsky.social · 7d

Happy October 1st!

A good time to share another #CellBio #preprint reading list put together by a team of preLighters: @sristi.bsky.social, Matthew Davies, @vibhasingh.bsky.social, @fadelvalle.bsky.social & Barbora Knotkova.

Check out their picks ⬇️👀
prelights.biologists.com/prelists/sep...

September in preprints – Cell biology edition - preLights

prelights.biologists.com

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preLights @prelights.bsky.social · 8d

Our latest ‘call for preLighters’ closes tonight!

Interested, but didn’t find the time to write an application? Expressions of interest are also welcome – just email us at [email protected]

Why join? See what other preLighters have to say…⬇️👀

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preLights @prelights.bsky.social · 8d

Turning back the clock on stem cells. 🕒

Did you see the preLight @vibhasingh.bsky.social posted last week highlighting the #preprint of Eva Mejía-Ramírez & team?

#preLight: prelights.biologists.com/highlights/t...

This work was also discussed in a recent webinar ⬇️👀

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Ethan (Chee Kiang) Ewe @ethanewe.bsky.social · Aug 11

🔥my latest paper from @odedrechavi.bsky.social lab🔥
we found small RNAs act across tissues to regulate fertlity in C. elegans 🪱. Surprisingly, we also found that O2-sensing neurons inhibit germline maintenance. Follow along our journey👇https://www.biorxiv.org/content/10.1101/2025.08.07.669182v1

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Nadja M. Hümpfer @nadjahuempf.bsky.social · 10d

Now out on bioRxiv. 🥳My research on #cytokinesis, averaging thousands of #ExM images🔬, creating a dynamic atlas of cytokinesis 🦠⏳. Here's an animated sneak peek of what we found. Better resolution on bioRxiv😄 #PSFoftheGIF

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Denis Wirtz @deniswirtz.bsky.social · 10d

Multimodal SRS imaging reveals metabolic remodeling in ovarian precancerous lesions.

In collaboration with Prof. Lingyan Shi (UCSD), we integrated spatial metabolomics into a new 3D tissue mapping workflow at single-cell resolution

More here: www.biorxiv.org/content/10.1...

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The Company of Biologists @biologists.bsky.social · 10d

Calling early-career developmental biologists!

Apply for a funded place at our #Workshop, Novelty, Co-option and Divergence During Gene Network Evolution.

Application deadline: 5 December

www.biologists.com/workshops/ju...

#DevBio #BiologistsWorkshops #Collaboration #Networking

Workshop: Novelty, Co-option and Divergence During Gene Network Evolution. Organisers: James Hombría and Antónia Monteiro. 14-17 June 2026, Buxted Park, East Sussex, UK. Early-career researchers apply for funded places.

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FocalPlane @focalplane.bsky.social · 12d

ICYMI – the recording from FocalPlane features… @prelights.bsky.social LIVE is up!
preLighters @fadelvalle.bsky.social & @vibhasingh.bsky.social present their live preLights & share research talks from @probablycarmen.bsky.social & Eva Mejía-Ramírez.
#preprints #cellbio #microscopy

FocalPlane features... preLights recording - FocalPlane

FocalPlane features... preLights recording - News

focalplane.biologists.com

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preLights @prelights.bsky.social · 13d

Shape-shifting RNAs 🪄

Structural cues drive partitioning and active remodelling in stress granules for rapid cellular recovery - #preprint from the lab of Yue Wan (@astar-gis.bsky.social), highlighted by Mohammed Jalloh (@uarizona.bsky.social).

#preLight ⬇️👀
prelights.biologists.com/highlights/r...

RNA Structure Directs RNA Partitioning and is Actively Disrupted inside Stress Granules to Enable Cellular Recovery - preLights

Shape-Shifting RNAs: Structural Cues Drive Partitioning and Active Remodeling in Stress Granules for Rapid Cellular Recovery

prelights.biologists.com

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Pascal Mamassian @mamassian.bsky.social · 14d

A nice shift in perceived colour between central and peripheral vision. The fixated disc looks purple while the others look blue.

The effect presumably comes from the absence of S-cones in the fovea.

From Hinnerk Schulz-Hildebrandt:
arxiv.org/pdf/2509.115...

An array of 9 purple discs on a blue background. Figure from Hinnerk Schulz-Hildebrandt.

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Ulrich Hohmann @hohmannulrich.bsky.social · 15d

How are RNAs sorted for export vs. degradation in the nucleus? In collaboration with @heick.bsky.social’s lab we (@clemensplaschka.bsky.social and @juliusbrennecke.bsky.social labs) discovered a direct mechanistic link between the export and decay machineries: www.biorxiv.org/content/10.1... (1/x)

Molecular basis of polyadenylated RNA fate determination in the nucleus

Eukaryotic genomes generate a plethora of polyadenylated (pA+) RNAs[1][1],[2][2], that are packaged into ribonucleoprotein particles (RNPs). To ensure faithful gene expression, functional pA+ RNPs, in...

www.biorxiv.org

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preLights @prelights.bsky.social · 15d

preLights is a #preprint highlighting service—supported by @biologists.bsky.social—encouraging #ECRs to highlight and discuss preprints that spark interest or debate within the biological #community. #SciComm

Interested in joining? Our 'call for preLighters' is open for another week! ⬇️👀

preLights @prelights.bsky.social · Sep 1

🚨 New call for preLighters!🚨

Help us highlight the most exciting biological #preprints. Share your insights, build your profile, and be part of a supportive community! 🌍

Interested? Apply today & help shape the future of science publishing! 📢

More info: prelights.biologists.com/news/join-th...

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The Company of Biologists @biologists.bsky.social · 20d

Our next extraordinary biologist is Tshepiso Majelantle, early-career researcher and postdoc at Witwatersrand University, South Africa, who attended @biologists.bsky.social's first Global South Workshop in 2024. #100biologists #NPAW2025

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FocalPlane @focalplane.bsky.social · 20d

📢 Join us next week for our mini-symposium with the membrane trafficking webinar series
Featuring talks from @nickader.bsky.social, @maiblab.bsky.social and Mónica Quiñones-Frías, and a keynote lecture from Gillian Griffiths @griffithslab.bsky.social.

FocalPlane features... membrane trafficking - FocalPlane

FocalPlane features... membrane trafficking - News

focalplane.biologists.com

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Thomas Arnesen @natmachinery.bsky.social · 20d

Anatomy and habitat shape the oxygen sensing machinery of flowering plants | new preprint from Licausi lab @syno2xis.bsky.social #hypoxia #N-degron @ispt-proteinterm.bsky.social www.biorxiv.org/content/10.1...

Anatomy and habitat shape the oxygen sensing machinery of angiosperms

Hypoxia sensing via the Cys/Arg branch of the N-degron pathway (Cys-NDP) is central for flooding responses in plants, yet how evolutionary and ecological factors have shaped the core oxygen sensing me...

www.biorxiv.org

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preLights @prelights.bsky.social · 20d

Another preprint highlight was posted by Kanishka Parashar!

Read how paclitaxel can target cancer cells by destabilising nuclear integrity in interphase - #preprint from @matteoall.bsky.social & team #preprint

#preLight ⬇️👀
prelights.biologists.com/highlights/p...

Paclitaxel compromises nuclear integrity in interphase through SUN2-mediated cytoskeletal coupling - preLights

Paclitaxel destabilizes nuclear integrity in interphase by driving microtubule–vimentin aggregates towards the nucleus, leading to SUN2 dependent loss of Lamin A/C loss and enhanced cancer cell vulner...

prelights.biologists.com

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