Lightnews — Scholar-powered news

Reposted by Ethan (Chee Kiang) Ewe

EMBO Reports @emboreports.org · 23h

Yun Zhang and Andrew Samuelson @urochester.bsky.social show that #aging impairs #viral #defense in Caenorhabditis elegans due to loss of DRH-1/RIG-I deSUMOylation by ULP-4/SENP7.

-> www.embopress.org/doi/full/10....

1 4

Ethan (Chee Kiang) Ewe @ethanewe.bsky.social · 1d

Exciting story! Congrats!

Reposted by Ethan (Chee Kiang) Ewe

David Katz @katzlab.bsky.social · 1d

Very excited to share our very exciting story on how misinherited chromatin affects individual cells to cause a behavior defect in C. elegans (a thread👇) www.pnas.org/doi/10.1073/...

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

www.pnas.org

5 12 46

Reposted by Ethan (Chee Kiang) Ewe

bioRxiv Developmental Biology @biorxiv-devbio.bsky.social · 2d

Reciprocal E-cadherin signaling aligns apical surfaces between neighboring epithelial tissues to complete the C. elegans digestive tract https://www.biorxiv.org/content/10.1101/2025.10.06.680605v1

1 1

Reposted by Ethan (Chee Kiang) Ewe

Genetics Society of America @genetics-gsa.bsky.social · 2d

📅 Oct 29, 1 p.m. EDT
Postdoc Opportunities Abroad
Hear from early career researchers building successful careers outside the U.S.—and get tips for planning your own path. @ethanewe.bsky.social

You’ll need to create a GSA account, but both events are free—register now: buff.ly/DUzRI4Y

2/2🧵

2 4

Reposted by Ethan (Chee Kiang) Ewe

Nature @nature.com · 2d

BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance"

Stay tuned for more.
#NobelPrize

1 98 230

Reposted by Ethan (Chee Kiang) Ewe

bioRxivpreprint @biorxivpreprint.bsky.social · 4d

RiboTRAP-seq identifies spatially distinct functions for the anterior and posterior intestine in immune and metabolic regulation in C. elegans https://www.biorxiv.org/content/10.1101/2025.10.03.680215v1

1 2

Reposted by Ethan (Chee Kiang) Ewe

Needhi Bhalla 💅🏽 @needhibhalla.bsky.social · 4d

“The question facing every scientist and every builder is whether you’ll be among those shaping what comes next. The experimenters are out there, creating the future one preprint, one dataset, one radically transparent step at a time.

They’re not waiting for permission. Neither should you.”

Prachee Avasthi @pracheeac.bsky.social · 4d

New Blog Post:
Scholarly Communication Is a Research Problem. This Means You.

pracheeac.substack.com/p/scholarly-...

Scholarly Communication Is a Research Problem. This Means You.

Scholarly Communication Is a Research Problem.

pracheeac.substack.com

1 3 7

Reposted by Ethan (Chee Kiang) Ewe

Needhi Bhalla 💅🏽 @needhibhalla.bsky.social · 4d

There’s some things I disagree with here but this is absolutely on point: “Science moves faster when we write for each other rather than for gatekeepers...The transformation of scientific communication requires scientists willing to experiment and builders ready to support them.”

Prachee Avasthi @pracheeac.bsky.social · 4d

New Blog Post:
Scholarly Communication Is a Research Problem. This Means You.

pracheeac.substack.com/p/scholarly-...

Scholarly Communication Is a Research Problem. This Means You.

Scholarly Communication Is a Research Problem.

pracheeac.substack.com

2 4 11

Reposted by Ethan (Chee Kiang) Ewe

Priti Agarwal @pritiagarwal.bsky.social · 6d

🚨 New preprint!
We profile the transcriptome of the C. elegans distal tip cell: a persistent leader cell that invades basement membrane to shape the gonad.

Our dataset defines the molecular signature of invasive leader cells & uncovers new regulators of collective cell invasion.

Stage-specific transcriptomics of a leader cell reveals cell machineries driving collective invasion

Collective cell invasion underlies organ development, epithelial repair, and cancer metastasis. Leader cells remodel extracellular matrix, sense guidance cues, reorganize their cytoskeleton, and coord...

www.biorxiv.org

1 6 11

Ethan (Chee Kiang) Ewe @ethanewe.bsky.social · 4d

Congratulations!!🍾🎉🎊

1 1

Reposted by Ethan (Chee Kiang) Ewe

bioRxiv Genomics @biorxiv-genomic.bsky.social · 5d

The RNA-binding protein NOVA-1 regulates circRNA expression, alternative splicing, and aging in C. elegans https://www.biorxiv.org/content/10.1101/2025.10.02.679314v1

2 2

Reposted by Ethan (Chee Kiang) Ewe

bioRxivpreprint @biorxivpreprint.bsky.social · 7d

Specialization of ubiquitin ligases to distinct nucleic acid sensors https://www.biorxiv.org/content/10.1101/2025.10.01.678329v1

1 2

Reposted by Ethan (Chee Kiang) Ewe

Jordan Ward @gotworms.bsky.social · 8d

Great opportunity and submissions are a little down so nominate your outstanding recent graduate, worm peeps!

Maureen Barr @barrlab.bsky.social · 8d

Worm peeps: nominate a newly minted PhD for the Sydney Brenner Thesis Award! #celegans

Genetics Society of America @genetics-gsa.bsky.social · 8d

📢 Deadline extended! Apply by Oct 3 for the 2025 Sydney Brenner Thesis Award—honoring outstanding theses in nematode biology (defended Oct 1, 2024–Sept 30, 2025).
Send in your nomination today! 🔗:

7 5

Reposted by Ethan (Chee Kiang) Ewe

bioRxiv Developmental Biology @biorxiv-devbio.bsky.social · 7d

Microbes suppress genetic disorders of hyper-activated Ras by inhibiting iron-mediated growth factor modulation in C. elegans https://www.biorxiv.org/content/10.1101/2025.09.30.679430v1

2 2

Reposted by Ethan (Chee Kiang) Ewe

Celja Uebel @celjauebel.bsky.social · 7d

Hi fellow C. elegans scientists, I've made a few videos that may be of use for new trainees working in worm labs. Hoping to add more in the future, but figured I'd share this resource as is in case it's helpful :)
www.youtube.com/@Workingwith...

Working with C. elegans

This channel provides clear demonstrations of core C. elegans lab skills, including: recognizing life stages and common phenotypes, picking and manipulating worms, and maintaining healthy cultures. De...

www.youtube.com

1 13 32

Reposted by Ethan (Chee Kiang) Ewe

Spang Lab @spanglab.bsky.social · 7d

A little stress is good for you in #health #ageing ! #Diet is important! Take a look at our article with Emmanouil Kyriakakis as 1st author!
@unibas.ch
@natcomms.nature.com
@snsf.ch
#Longevity #healthspan
rdcu.be/eI1vZ

Bacterial RNA promotes proteostasis through inter-tissue communication in C. elegans

Nature Communications - Kyriakakis et al. show that bacterial RNA can improve C. elegans healthspan and reduce toxic protein aggregation in muscles. This depends on inter-tissue communication and...

rdcu.be

2 4

Reposted by Ethan (Chee Kiang) Ewe

PLOS Biology @plosbiology.org · 7d

How do #neurons maintain adequate lysosomal function during adulthood? This study shows that basal HLH-30 activity is essential for maintaining neuronal #lysosomal function & structural integrity in #Celegans, protecting against aging-related dendritic defects @plosbiology.org 🧪 plos.io/4nU79QF

The C. elegans PVD neuron morphology in wild-type (upper) versus TFEB/hlh-30 loss-of-function mutant (lower) animals in mid-adulthood. In the TFEB/hlh-30 mutant, but not in wild-type, dendrite degeneration and disorganized outgrowths are visible.

2 6

Reposted by Ethan (Chee Kiang) Ewe

Maureen Barr @barrlab.bsky.social · 8d

Worm peeps: nominate a newly minted PhD for the Sydney Brenner Thesis Award! #celegans

Genetics Society of America @genetics-gsa.bsky.social · 8d

📢 Deadline extended! Apply by Oct 3 for the 2025 Sydney Brenner Thesis Award—honoring outstanding theses in nematode biology (defended Oct 1, 2024–Sept 30, 2025).
Send in your nomination today! 🔗:

2025 Brenner Award Nomination

This nomination form is for the 2025 Brenner Award Nomination. Due: September 30th, 2025. Please do not include any information besides what is asked as a formal nominee form and recommendation…

buff.ly

1 11 17

Reposted by Ethan (Chee Kiang) Ewe

Abby Dernburg @adernburg.bsky.social · 8d

This is an embarrassing way to cover a paper that is basically negative results (spoiler alert: this did not go as the investigators might have hoped).
bbc.com/news/article...

Human skin DNA fertilised to make embryo for first time

US scientists testing the technique say it could help people overcome infertility and potentially allow same-sex couples to have a genetically related child.

bbc.com

1 9 23

Ethan (Chee Kiang) Ewe @ethanewe.bsky.social · 8d

Agree. Love eggs in all forms!

a cartoon fried egg with a face and the words he 's a good egg below it

ALT: a cartoon fried egg with a face and the words he 's a good egg below it

media.tenor.com

1

Ethan (Chee Kiang) Ewe @ethanewe.bsky.social · 8d

So glad to be among these good eggs, as @mads100tist.bsky.social once called us!

MwahahahahahadScientist @mads100tist.bsky.social · 8d

It's online! In this series of perspectives @dev-journal.bsky.social, yours truly talks about the exciting open questions and many things to do in the field of dev bio and neuroscience #DevBio🧪 #PIsOfTomorrow journals.biologists.com/dev/article/...

Pathway to Independence: a forecast for the future of developmental biology

ABSTRACT. In 2022, Development launched its Pathway to Independence (PI) programme, aimed at supporting postdocs as they transition to their first independent position. In 2025, we welcome our third c...

journals.biologists.com

1 1 7

Reposted by Ethan (Chee Kiang) Ewe

MwahahahahahadScientist @mads100tist.bsky.social · 8d

It's online! In this series of perspectives @dev-journal.bsky.social, yours truly talks about the exciting open questions and many things to do in the field of dev bio and neuroscience #DevBio🧪 #PIsOfTomorrow journals.biologists.com/dev/article/...

Pathway to Independence: a forecast for the future of developmental biology

ABSTRACT. In 2022, Development launched its Pathway to Independence (PI) programme, aimed at supporting postdocs as they transition to their first independent position. In 2025, we welcome our third c...

journals.biologists.com

2 22 78

Reposted by Ethan (Chee Kiang) Ewe

MwahahahahahadScientist @mads100tist.bsky.social · 8d

With perspectives from my esteemed colleagues @ethanewe.bsky.social @maxfarnworth.bsky.social @anzymiller.bsky.social @marliesoomen.bsky.social @giuliapaci.bsky.social @sonyawiden.bsky.social and Toshimichi Yamada 🧪RNAs of all kinds, junk, jumping, and fluctuating genes, cells&tissues with opinions!

MwahahahahahadScientist @mads100tist.bsky.social · 8d

It's online! In this series of perspectives @dev-journal.bsky.social, yours truly talks about the exciting open questions and many things to do in the field of dev bio and neuroscience #DevBio🧪 #PIsOfTomorrow journals.biologists.com/dev/article/...

Pathway to Independence: a forecast for the future of developmental biology

ABSTRACT. In 2022, Development launched its Pathway to Independence (PI) programme, aimed at supporting postdocs as they transition to their first independent position. In 2025, we welcome our third c...

journals.biologists.com

1 10 23

Reposted by Ethan (Chee Kiang) Ewe

Alexei Maklakov @alexeimaklakov.bsky.social · 13d

www.science.org/doi/10.1126/...

Lysosomes signal through the epigenome to regulate longevity across generations

The epigenome is sensitive to metabolic inputs and is crucial for aging. Lysosomes act as a signaling hub to sense metabolic cues and regulate longevity. We found that lysosomal metabolic pathways sig...

www.science.org

4 7