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alexeimaklakov.bsky.social
Alexei Maklakov
@alexeimaklakov.bsky.social
870 followers 480 following 38 posts
Biology of Ageing and Life History Evolution, University of East Anglia, Norwich, UK
Posts Media Videos Starter Packs
Reposted by Alexei Maklakov
jonathanslaght.com
Jonathan C Slaght @jonathanslaght.com · 5d
super cool study found human artifacts in Bearded vulture nests, incl. "weaponry like a crossbow bolt and wooden lance, decorated sheep leather, and parts of a slingshot....a shoe made from twigs and grass is ~675-years-old." link to paper: doi.org/10.1002/ecy..... www.popsci.com/environment/... 🧪🌍🦉
Multi-generational vulture nests hold 700 years of human artifacts
Crossbow bolts, sandals, slingshots, and more.
www.popsci.com
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Reposted by Alexei Maklakov
evoldir.bsky.social
EvolDir @evoldir.bsky.social · 6d
The University of East Anglia seeks a Senior Research Associate in evolutionary ecology of animal behaviour and gut microbiome, with a salary of £38,784 to £46,049. Apply by 31 Oct 2025. Details: https://www.uea.ac.uk. #job
Find your place at UEA
The University of East Anglia is a home for everyone, a champion of interdisciplinarity that stands for equal opportunity in higher education. Join us at an Open Day.
www.uea.ac.uk
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Reposted by Alexei Maklakov
jay.bsky.team
Jay 🦋 @jay.bsky.team · 6d
“It actually doesn’t take much to be considered a difficult woman. That’s why there are so many of us.”
― Jane Goodall

💙 RIP to a real one. My childhood hero
Jane Goodall with monarch butterfly scarf
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Reposted by Alexei Maklakov
biouea.bsky.social
UEA Biological Sciences @biouea.bsky.social · 6d
"Everything is connected. Everyone can make a difference."
Rest in peace, Jane Goodall.
We are proud to have known you.
#UEAScience
Jane Goodall stands at a plinth, mid-speech, with a UEA logo behind her, when she opened the New Science Building in 2019.
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Reposted by Alexei Maklakov
nature.com
Nature @nature.com · 6d
“Without them, it’s hard to imagine research continuing at anything near the pace and quality we’ve seen in the past.”

Beyond the crucial data they contain, model organism databases have provided an important space for researchers to exchange ideas and resources
go.nature.com/4nVQ7lb
Model organism databases face budget cuts and closures
Beyond the crucial data they contain, these digital archives have provided an important space for academic communities to exchange ideas and resources.
go.nature.com
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Reposted by Alexei Maklakov
eivimeycook.bsky.social
Ed Ivimey-Cook @eivimeycook.bsky.social · 6d
A fantastic few days of ageing talks, great people, and excellent food!

Massive thanks to (Hanna!) @kokkonut.bsky.social, Margaux Bieuville, Victor Ronget, and the fantastic people at The Gutenberg Workshops in the Life Sciences
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Reposted by Alexei Maklakov
alicegodden.bsky.social
Alice Godden @alicegodden.bsky.social · 6d
🧬 Our latest paper out in Scientific Reports!
We explored how Gum Arabic (a dietary fibre) affects the microbiota–gut–brain axis and whole-organism fitness in zebrafish.

🔗 www.nature.com/articles/s41...
@immler.bsky.social @biouea.bsky.social

What we found ⬇️
Gum Arabic modulates the microbiota-gut-brain axis and affects general fitness in zebrafish - Scientific Reports
Scientific Reports - Gum Arabic modulates the microbiota-gut-brain axis and affects general fitness in zebrafish
www.nature.com
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Reposted by Alexei Maklakov
eivimeycook.bsky.social
Ed Ivimey-Cook @eivimeycook.bsky.social · 9d
Back in Ingelheim for another Evolution of Ageing workshop (massive thanks to The Gutenberg Workshops in the Life Sciences for hosting). It’s set to be a great three days of talks and presentations!
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Reposted by Alexei Maklakov
alperakay.bsky.social
Alper Akay @alperakay.bsky.social · 10d
Super frustrating story on how NHS missed lyme disease and how ME/CFS has become an umbrella diagnosis for doctors. www.theguardian.com/world/2025/s...
As my daughter got sicker and sicker, our quest for answers dragged on. How did we all miss the bacteria taking over her body?
I write about nature, but when Milly got sick with a mystery illness, it never occurred to me that a long-forgotten tick bite could be the cause
www.theguardian.com
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alexeimaklakov.bsky.social
Alexei Maklakov @alexeimaklakov.bsky.social · 13d
www.science.org/doi/10.1126/...
Lysosomes signal through the epigenome to regulate longevity across generations
The epigenome is sensitive to metabolic inputs and is crucial for aging. Lysosomes act as a signaling hub to sense metabolic cues and regulate longevity. We found that lysosomal metabolic pathways sig...
www.science.org
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Reposted by Alexei Maklakov
erictopol.bsky.social
Eric Topol @erictopol.bsky.social · 18d
Which one is it going to be?
www.economist.com/leaders/2025...
www.nytimes.com/2025/09/14/m...
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alexeimaklakov.bsky.social
Alexei Maklakov @alexeimaklakov.bsky.social · 20d
We argue that selection shadow - gradual decline in the force of selection after the onset of reproduction - is sufficient/parsimonious to explain why damage accumulates with age. 'Aging clocks' measure damage accumulation, they neither require nor support any kind of 'program'-based explanation.
meyerdh.bsky.social
David Meyer @meyerdh.bsky.social · 20d
🕰️ Is aging driven by a programmed/programmatic mechanism, or by the unavoidable burden of imperfect maintenance? Our perspective argues that aging reflects finite maintenance and reduced evolutionary pressure🧵🧪 www.nature.com/articles/s43... @bjornschumacher.bsky.social @alexeimaklakov.bsky.social
Aging by the clock and yet without a program - Nature Aging
Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair processes resultin...
www.nature.com
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Reposted by Alexei Maklakov
erictopol.bsky.social
Eric Topol @erictopol.bsky.social · 21d
Low dose aspirin (160mg/d) reduced recurrence in people with colon cancer and PI3K mutations. Emblematic of precision, individualized medicine since the data for aspirin across all colon cancer has been mixed.
www.nejm.org/doi/full/10....
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Reposted by Alexei Maklakov
advancehe.bsky.social
Advance HE @advancehe.bsky.social · 22d
Well done @kellyedmunds.bsky.social @uniofeastanglia.bsky.social on your #NTFS2025 award! Kelly is a leading educator at UEA, renowned for transforming science education through inclusive, student-centred pedagogy.
NTFS 2025 - Kelly Edmunds
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Reposted by Alexei Maklakov
alicegodden.bsky.social
Alice Godden @alicegodden.bsky.social · 22d
Our new paper is out in Dev Biol! 🎉 🐸🧬
We show #miR-196a directs #neural crest fate in #Xenopus by repressing immature neural #ectoderm — evidence #miRNAs can potentially drive, not just fine-tune, early patterning
👉 Read more here: doi.org/10.1016/j.yd...
@devbiol.bsky.social @biouea.bsky.social
Schematic overview of our project. Dissection of Xenopus neural crest following morpholino knockdown of miRNA, then extraction of RNA for RNA-seq
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Reposted by Alexei Maklakov
mkarag.bsky.social
Marianna Karageorgi @mkarag.bsky.social · 23d
How do populations maintain an evolutionary memory? I am happy to share that our work with Dmitri Petrov @petrovadmitri.bsky.social, Paul Schmidt, and colleagues on dominance reversal and stabilization of insecticide resistance in changing environments over time is now published at Nature EE.
Beneficial reversal of dominance maintains a large-effect resistance polymorphism under fluctuating insecticide selection - Nature Ecology & Evolution
Measuring selection and dominance in fitness of the insecticide-resistant Ace alleles in Drosophila melanogaster, the authors show evidence for beneficial reversal of dominance, a mechanism that can s...
www.nature.com
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Reposted by Alexei Maklakov
arvidagren.bsky.social
Arvid Ågren @arvidagren.bsky.social · 24d
Take a sneak peak at The Paradox of the Organism at Google books books.google.com/books?hl=sv&...

Don’t forget to pre-order!
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Reposted by Alexei Maklakov
erictopol.bsky.social
Eric Topol @erictopol.bsky.social · 23d
Two new randomized trials testing higher dose semaglutide (Ozempic) for obesity, obesity + diabetes: some further weight loss, similar safety profile
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
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Reposted by Alexei Maklakov
danielbolnick.bsky.social
Daniel Bolnick @danielbolnick.bsky.social · 25d
Cover of the new issue of Evolution Letters @evolletters.bsky.social featuring our stickleback-tapeworm paper. academic.oup.com/evlett
What happens to immunity and infection prevalence in the 50 years after a host invades a new location
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Reposted by Alexei Maklakov
nature.com
Nature @nature.com · 24d
Having older siblings affects a child’s chance of survival – but the precise effect depends on the older siblings’ sex and age

go.nature.com/46oaaCU
Will a child survive? Older siblings have a powerful influence
Swiss birth data from 1750 to 1870 reveal that girls who had lots of older brothers close to their own age were less likely to survive than were those who did not.
go.nature.com
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Reposted by Alexei Maklakov
ecoevorxiv.bsky.social
EcoEvoRxiv @ecoevorxiv.bsky.social · 24d
squidSim: a flexible R package for structured and reproducible simulations in Ecology and Evolutionary Biology
DOI: doi.org/10.32942/X20...
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Reposted by Alexei Maklakov
jennyperry.bsky.social
Jen Perry @jennyperry.bsky.social · 25d
MSc position in my lab. Come study the evolutionary & behavioural ecology of insects!
@stfx-university.bsky.social
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Reposted by Alexei Maklakov
agingbiology.bsky.social
Aging Science News @agingbiology.bsky.social · 25d
Male Reproductive Senescence in Mammals Is Pervasive and Aligned With the Slow-Fast Continuum
onlinelibrary.wiley.com/doi/abs/10.1...
Male Reproductive Senescence in Mammals Is Pervasive and Aligned With the Slow‐Fast Continuum
We found evidence of male reproductive senescence in 59.6% of the mammalian studied species, with a detection probability increasing with larger sample sizes and a longer age range relative to lifesp....
onlinelibrary.wiley.com
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Reposted by Alexei Maklakov
biotay.bsky.social
Tay (Antonio J. Osuna Mascaró) @biotay.bsky.social · 27d
1/3 Rooks that understand us when we speak!

Leo, a 21-year-old rook, began following verbal instructions spontaneously during comparative cognition experiments. He has been tested for this ability, and did great.

(paper) link.springer.com/article/10.1...
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Reposted by Alexei Maklakov
rmcelreath.bsky.social
Richard McElreath 🐈‍⬛ @rmcelreath.bsky.social · 28d
“Overall, the message from this survey is positive; evolutionary biologists are readily employable outside of academia, generally well-prepared for those jobs, and report high levels of satisfaction” www.biorxiv.org/content/10.1...
Leaving Academia: Insights from Evolutionary Biologists on Their Career Transitions and Job Satisfaction
Many who have obtained PhDs in evolutionary biology will ultimately pursue careers that fall outside a narrow definition of an academic career. At the same time, PhD students and supervisors of PhD st...
www.biorxiv.org
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