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Reposted by David Meyer

yifanzhao.bsky.social @yifanzhao.bsky.social · 3d

Super grateful that our scETM work (from my summer internship with Dr. Yue Li, in collab. with Huiyu Cai and @tangjian.bsky.social) was recognized with an honourable mention at SIB PhD Paper Award competition. Many thanks to the jury and congrats to @meyerdh.bsky.social and Can Chen! #bc2basel

SIB Swiss Institute of Bioinformatics @sib.swiss · 29d

The PhD Paper Award jury gives honourable mentions to:

Can Chen for “Structure-Aware Protein Self-Supervised Learning” doi.org/10.1093/bioi...

Yifan Zhao for “Learning interpretable cellular and gene signature embeddings from single-cell transcriptomic data” doi.org/10.1038/s414...

#bc2basel

Structure-aware protein self-supervised learning

AbstractMotivation. Protein representation learning methods have shown great potential to many downstream tasks in biological applications. A few recent st

doi.org

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Reposted by David Meyer

Ed Ivimey-Cook @eivimeycook.bsky.social · 6d

A fantastic few days of ageing talks, great people, and excellent food!

Massive thanks to (Hanna!) @kokkonut.bsky.social, Margaux Bieuville, Victor Ronget, and the fantastic people at The Gutenberg Workshops in the Life Sciences

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Reposted by David Meyer

Christian Frezza @frezzalab.bsky.social · 14d

Ribonucleotide incorporation into mitochondrial DNA drives inflammation

www.nature.com/articles/s41...

Congratulations to the Langer lab @mpiage.bsky.social, Amir, and the rest of the team!

Ribonucleotide incorporation into mitochondrial DNA drives inflammation - Nature

Imbalanced nucleotide metabolism leads to age- and mtDNA-dependent inflammatory responses and senescence-associated secretory phenotype in senescence.

www.nature.com

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Reposted by David Meyer

Andreas Beyer Group @beyerlab.bsky.social · 16d

This review of our @crc1678.bsky.social member @bjornschumacher.bsky.social and @meyerdh.bsky.social is greatly summarizing fundamentals of the molecular biology of aging. What causes aging? Read the answer!

Björn Schumacher @bjornschumacher.bsky.social · 18d

🔥🔥🔥Out now: our Perspectives article in @nataging.nature.com outlining how aging is driven by molecular damage leading to increasing molecular noise whose quantification could track aging with the precision of a clock @meyerdh.bsky.social @alexeimaklakov.bsky.social
www.nature.com/articles/s43...

Aging by the clock and yet without a program - Nature Aging

Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair processes resultin...

www.nature.com

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Reposted by David Meyer

Björn Schumacher @bjornschumacher.bsky.social · 18d

🔥🔥🔥Out now: our Perspectives article in @nataging.nature.com outlining how aging is driven by molecular damage leading to increasing molecular noise whose quantification could track aging with the precision of a clock @meyerdh.bsky.social @alexeimaklakov.bsky.social
www.nature.com/articles/s43...

Aging by the clock and yet without a program - Nature Aging

Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair processes resultin...

www.nature.com

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Reposted by David Meyer

Alexei Maklakov @alexeimaklakov.bsky.social · 20d

We argue that selection shadow - gradual decline in the force of selection after the onset of reproduction - is sufficient/parsimonious to explain why damage accumulates with age. 'Aging clocks' measure damage accumulation, they neither require nor support any kind of 'program'-based explanation.

David Meyer @meyerdh.bsky.social · 20d

🕰️ Is aging driven by a programmed/programmatic mechanism, or by the unavoidable burden of imperfect maintenance? Our perspective argues that aging reflects finite maintenance and reduced evolutionary pressure🧵🧪 www.nature.com/articles/s43... @bjornschumacher.bsky.social @alexeimaklakov.bsky.social

Aging by the clock and yet without a program - Nature Aging

Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair processes resultin...

www.nature.com

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Reposted by David Meyer

CRC1678 @crc1678.bsky.social · 20d

👵🏻⏰👴🏻 Is aging a programmed process? Check out this perspective article in Nature Aging by our two #CRC1678 members @meyerdh.bsky.social and @bjornschumacher.bsky.social. Congratulations! 🥳

David Meyer @meyerdh.bsky.social · 20d

🕰️ Is aging driven by a programmed/programmatic mechanism, or by the unavoidable burden of imperfect maintenance? Our perspective argues that aging reflects finite maintenance and reduced evolutionary pressure🧵🧪 www.nature.com/articles/s43... @bjornschumacher.bsky.social @alexeimaklakov.bsky.social

Aging by the clock and yet without a program - Nature Aging

Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair processes resultin...

www.nature.com

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David Meyer @meyerdh.bsky.social · 20d

You can also read it here
rdcu.be/eG1N7
👇

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David Meyer @meyerdh.bsky.social · 20d

I am grateful to the reviewers Alan Cohen, Vera Gorbunova, and Steven Cummings for insightful comments that made this piece much clearer. 🙏

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David Meyer @meyerdh.bsky.social · 20d

Aging is the default state of biological systems.
Changing markers picked up by aging clocks won’t roll back time, they only mark it.
The way forward is strengthening repair & maintenance and embracing biology’s messy and stochastic reality.
➡️ www.nature.com/articles/s43... 6/

Aging by the clock and yet without a program - Nature Aging

Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair processes resultin...

www.nature.com

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David Meyer @meyerdh.bsky.social · 20d

We previously showed that stochastic variation alone can create aging clocks predicting age across species & interventions. Because repair & maintenance can never be perfect, small errors inevitably build up, giving rise to aging. www.nature.com/articles/s43...
#Entropy #DNARepair 5/

Aging clocks based on accumulating stochastic variation - Nature Aging

Meyer and Schumacher use simulations to show that accumulation of stochastic variation is sufficient to build clocks that can measure both chronological and biological age, sensitive to changes induce...

www.nature.com

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David Meyer @meyerdh.bsky.social · 20d

The accuracy of DNA methylation & other aging clocks has revived programmed and programmatic aging theories. But clocks don’t prove an intrinsic timer. They reflect the accumulation of molecular errors as repair systems are never perfect. #Longevity #Biology 4/

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David Meyer @meyerdh.bsky.social · 20d

The force of natural selection is strongest during development and wanes after reproduction. Maintenance & repair only need to be good enough for fitness, not perfect, therefore leaving room for gradual decline. #Evolution #DNArepair 3/

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David Meyer @meyerdh.bsky.social · 20d

Aging started with the very first replicators on earth facing a harsh entropic environment. Life could persist only by evolving repair and maintenance systems to counter damage. Aging and death is therefore the default state, happening because maintenance can never be perfect 2/

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David Meyer @meyerdh.bsky.social · 20d

🕰️ Is aging driven by a programmed/programmatic mechanism, or by the unavoidable burden of imperfect maintenance? Our perspective argues that aging reflects finite maintenance and reduced evolutionary pressure🧵🧪 www.nature.com/articles/s43... @bjornschumacher.bsky.social @alexeimaklakov.bsky.social

Aging by the clock and yet without a program - Nature Aging

Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair processes resultin...

www.nature.com

2 9 25

David Meyer @meyerdh.bsky.social · 23d

Thank you 🙏

Reposted by David Meyer

CRC1678 @crc1678.bsky.social · 23d

💪🎉Congratulations to our #CRC1678 member @meyerdh.bsky.social for winning the SIB Bioinformatics PhD Paper Award 2025 for his work on Ageing Clocks ⏰ 👵🏻👴🏻

David Meyer @meyerdh.bsky.social · 27d

✨ I’m honored and grateful to have received the SIB Bioinformatics PhD Paper Award 2025 for part of my PhD work.

Thank you for your guidance and inspiration @bjornschumacher.bsky.social

#SIBAwards #bc2basel #Bioinformatics

SIB Swiss Institute of Bioinformatics @sib.swiss · 29d

💫 The PhD Paper Award goes to @meyerdh.bsky.social from Uni-Köln 💫

“David Meyer’s paper ‘Aging clocks based on accumulating stochastic variation’ presents a completely novel concept and a fresh way to address the problem”.

#Bioinformatics #SIBawards #bc2basel

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David Meyer @meyerdh.bsky.social · 27d

✨ I’m honored and grateful to have received the SIB Bioinformatics PhD Paper Award 2025 for part of my PhD work.

Thank you for your guidance and inspiration @bjornschumacher.bsky.social

#SIBAwards #bc2basel #Bioinformatics

SIB Swiss Institute of Bioinformatics @sib.swiss · 29d

💫 The PhD Paper Award goes to @meyerdh.bsky.social from Uni-Köln 💫

“David Meyer’s paper ‘Aging clocks based on accumulating stochastic variation’ presents a completely novel concept and a fresh way to address the problem”.

#Bioinformatics #SIBawards #bc2basel

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Reposted by David Meyer

SIB Swiss Institute of Bioinformatics @sib.swiss · 29d

Read David’s award winning article ‘Aging clocks based on accumulating stochastic variation’. www.nature.com/articles/s43... #bc2basel

Aging clocks based on accumulating stochastic variation - Nature Aging

Meyer and Schumacher use simulations to show that accumulation of stochastic variation is sufficient to build clocks that can measure both chronological and biological age, sensitive to changes induce...

www.nature.com

1 1 2

Reposted by David Meyer

SIB Swiss Institute of Bioinformatics @sib.swiss · 29d

💫 The PhD Paper Award goes to @meyerdh.bsky.social from Uni-Köln 💫

“David Meyer’s paper ‘Aging clocks based on accumulating stochastic variation’ presents a completely novel concept and a fresh way to address the problem”.

#Bioinformatics #SIBawards #bc2basel

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David Meyer @meyerdh.bsky.social · 29d

Thank you for the shout-out!

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Reposted by David Meyer

Marc Robinson-Rechavi @marcrr.ecoevo.social.ap.brid.gy · 29d

#bc2basel @SIB PhD Paper Award 👏 David Meyer: Aging clocks based on accumulating variation
https://doi.org/10.1038/s43587-024-00619-x

Aging clocks based on accumulating stochastic variation - Nature Aging

Meyer and Schumacher use simulations to show that accumulation of stochastic variation is sufficient to build clocks that can measure both chronological and biological age, sensitive to changes induced by smoking, calorie restriction, parabiosis and reprogramming.

www.nature.com

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Reposted by David Meyer

David Vilchez @thevilchezlab.bsky.social · Sep 3

🚨 New from our lab: Here we explored how aging contributes to harmful protein aggregation in diseases like Huntington’s & ALS.
The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch
🧵
www.nature.com/articles/s43...

The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivation - Nature Aging

Aging is a risk factor for neurodegenerative diseases associated with protein aggregation. Here the authors identify age-related hyperactivation of EPS8/RAC signaling in C. elegans as a driver of path...

www.nature.com

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Reposted by David Meyer

David Vilchez @thevilchezlab.bsky.social · Sep 2

New work from the lab! C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules - Bilican - FEBS Letters - Wiley Online Library febs.onlinelibrary.wiley.com/doi/10.1002/...

FEBS Press

Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient-derived neurons and C. elegans models, w...

febs.onlinelibrary.wiley.com

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David Meyer @meyerdh.bsky.social · Aug 21

Can't wait to be at the #ARDD2025 next week! agingpharma.org

I'm presenting
"Aging by the clock and yet without a program" on Tuesday in the GeroPhysics session.

If you're at the conference, let's grab a coffee and chat!
🧪

#AgingResearch #Longevity #Science

ARDD 2025

In this symposium, leaders in the aging and longevity field will describe the latest progress in the molecular, cellular and organismal basis of aging and our search for interventions. A panel of thou...

agingpharma.org

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