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Reposted by David Vilchez

Harmit Singh Malik @harmitmalik.bsky.social · 21d

www.cell.com/cell/abstrac...

A host organelle (in sea slugs) integrates stolen chloroplasts for animal photosynthesis

A host organelle integrates stolen chloroplasts for animal photosynthesis

Sea slugs steal foreign chloroplasts and store them in specialized organelles that facilitate photosynthesis and eventual digestion to mediate starvation resistance.

www.cell.com

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Reposted by David Vilchez

Universität zu Köln @unicologne.bsky.social · Sep 3

🧓Wie das Altern neurodegenerative Krankheiten treibt 🧠

@thevilchezlab.bsky.social @cecad.bsky.social hat einen direkten molekularen Zusammenhang zwischen Altern und neurodegenerativen Krankheiten identifiziert.

Fluoreszenzfärbung von Neuronen unter einem Mikroskop mit grünen und blauen Markierungen auf dunklem Hintergrund.

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Reposted by David Vilchez

Universität zu Köln @unicologne.bsky.social · Sep 3

🧓How aging drives neurodegenerative diseases🧠
@thevilchezlab.bsky.social @cecad.bsky.social has identified a direct molecular link between aging and neurodegeneration by investigating how age-related changes in cell signalling contribute to toxic protein aggregation.

flourescent picture of motor neurons dyed green and blue (nucleus).

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David Vilchez @thevilchezlab.bsky.social · Sep 3

A titanic effort from Seda and the lab in collaboration with Nuria Flames’ lab ‪@sedakoyuncu.bsky.social‬ @unicologne.bsky.social‬ @cecad.bsky.social‬ ‪@ibv-csic.bsky.social‬ ‪@nataging.nature.com‬‬‬‬‬‬

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David Vilchez @thevilchezlab.bsky.social · Sep 3

We also discovered that the deubiquitinase USP4 leads to EPS8 accumulation during aging.
Reducing USP4 prevented EPS8 accumulation, extended lifespan, and lessened disease effects.
👉 Targeting EPS8/USP4 could open new therapeutic strategies for neurodegeneration.

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David Vilchez @thevilchezlab.bsky.social · Sep 3

In C. elegans & human cells, we found that age-related EPS8/RAC signaling hyperactivation promotes pathological aggregation of fifferent proteins (polyQ, FUS, TDP-43).
Decreasing EPS8 (or tuning RAC signaling) prevents aggregation & and neurodegeneration.

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David Vilchez @thevilchezlab.bsky.social · Sep 3

🚨 New from our lab: Here we explored how aging contributes to harmful protein aggregation in diseases like Huntington’s & ALS.
The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch
🧵
www.nature.com/articles/s43...

The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivation - Nature Aging

Aging is a risk factor for neurodegenerative diseases associated with protein aggregation. Here the authors identify age-related hyperactivation of EPS8/RAC signaling in C. elegans as a driver of path...

www.nature.com

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David Vilchez @thevilchezlab.bsky.social · Sep 2

New work from the lab! C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules - Bilican - FEBS Letters - Wiley Online Library febs.onlinelibrary.wiley.com/doi/10.1002/...

FEBS Press

Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient-derived neurons and C. elegans models, w...

febs.onlinelibrary.wiley.com

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David Vilchez @thevilchezlab.bsky.social · Aug 30

Shuttle and stabilize: H1.2-FUS complex in amyotrophic lateral sclerosis pathogenesis
journals.lww.com/nrronline/ci...

Shuttle and stabilize: H1.2-FUS complex in amyotrophic... : Neural Regeneration Research

An abstract is unavailable. This article is available as a PDF only.

journals.lww.com

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David Vilchez @thevilchezlab.bsky.social · Aug 23

I was just wondering the same thing, given the number of recent papers along these lines

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Reposted by David Vilchez

Nature Cell Biology @natcellbio.nature.com · Aug 22

💫NEW: @annaleder.bsky.social et al. show that the chaperones PDIA6, Hsp70 BiP, ERdj3, PDIA1 and Hsp90 form co-condensates within the endoplasmic reticulum, enhancing folding and preventing misfolding of client proteins. @masgu.bsky.social @hillerlab.bsky.social
bit.ly/47b3Mjk

A multichaperone condensate enhances protein folding in the endoplasmic reticulum - Nature Cell Biology

Leder et al. show that the chaperones PDIA6, Hsp70 BiP, ERdj3, PDIA1 and Hsp90 form co-condensates within the endoplasmic reticulum, enhancing folding and preventing misfolding of client proteins.

bit.ly

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David Vilchez @thevilchezlab.bsky.social · Jul 30

Franziska Hommen did an excellent job in her thesis defense — we have a new PhD in the building! @cecad.bsky.social @cga-age.bsky.social

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David Vilchez @thevilchezlab.bsky.social · Jul 29

Hi Dani, I would really appreciate it if you can add me to the Science feed:
www.davidvilchezlab.com
scholar.google.com/citations?us...

Vilchez Lab

Curious to see what we do? Check out our research summary video: https://youtu.be/kalsrf1ZbQ0

www.davidvilchezlab.com

David Vilchez @thevilchezlab.bsky.social · May 17

Learning a lot and having fun at the #OpenDay #Science @cecad.bsky.social @mpiage.bsky.social

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David Vilchez @thevilchezlab.bsky.social · May 15

The project will be carried out at the CECAD Research Center (University of Cologne): @unicologne.bsky.social @uniklinikkoeln.bsky.social @cecad.bsky.social

David Vilchez @thevilchezlab.bsky.social · May 15

We have a 4-year postdoc position open in our Research Unit on proteostasis!
The project explores inter-tissue regulation using advanced proteomics approaches.
Collaborative & interdisciplinary environment. More details & application here:
jobs-uk-koeln.onlyfy.jobs/job/pktg6ivj...

Postdoc Position (f/m/x)

We are looking to support our rapidly growing team as soon as possible:

jobs-uk-koeln.onlyfy.jobs

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David Vilchez @thevilchezlab.bsky.social · Apr 29

🤪🤪🤪🤪🤪🤪🤪🤪🤪

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David Vilchez @thevilchezlab.bsky.social · Apr 25

Felicidades!

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Reposted by David Vilchez

Coleen Murphy @ctmurphy1.bsky.social · Apr 23

🧪#Celegans - I am very excited to announce the publication of our latest finding in transgenerational epigenetic inheritance (TEI) of learned pathogen avoidance - • C. elegans transgenerational avoidance of P. fluorescens is mediated by the Pfs1 sRNA and vab-1 www.science.org/doi/10.1126/...

C. elegans transgenerational avoidance of P. fluorescens is mediated by the Pfs1 sRNA and vab-1

C. elegans’ TEI of learned pathogen avoidance is induced by a third bacterial small RNA, Pfs1, from P. fluorescens 15.

www.science.org

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David Vilchez @thevilchezlab.bsky.social · Apr 23

Thanks Barak😉

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David Vilchez @thevilchezlab.bsky.social · Apr 23

The study is part of the CRC1678 consortium;) @crc1678.bsky.social

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Reposted by David Vilchez

Trends in Biochemical Sciences @cp-trendsbiochem.bsky.social · Apr 18

Online now - a tribute to the memory of Prof. Joan J. Guinovart from Jordi Duran and Matthew Gentry.

Prof. Guinovart was a renowned biochemist in the field of glycogen metabolism and known for his leadership in science.

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David Vilchez @thevilchezlab.bsky.social · Apr 18

New work from our lab;)

bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · Apr 17

C9orf72 ALS-causing mutations lead to nucleoporin Nup107 aggregation and subsequent pathological changes https://www.biorxiv.org/content/10.1101/2025.04.16.649118v1

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David Vilchez @thevilchezlab.bsky.social · Apr 4

Thank you Oded!

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David Vilchez @thevilchezlab.bsky.social · Apr 4

Happy to have you aboard, Bjoern!

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