Lightnews — Scholar-powered news

Reposted by Björn Schumacher

Cologne Graduate School of Ageing Research @cga-age.bsky.social · Aug 12

Apply now for a fully funded #PhD position at the Cologne Graduate School of Ageing Research and become part of our vibrant #AgingResearch commmuny.
🗓️ Deadline: November 3, 2025.
ℹ️ More info: www.ageing-grad-school.de
📣 Spread the news!

22 16

Björn Schumacher @bjornschumacher.bsky.social · 4d

What Jane Goodall Taught Us About Living a Long Life
The scientist, who died at 91 on Wednesday, was a model for healthy aging.
www.nytimes.com/2025/10/02/w...

What Jane Goodall Taught Us About Living a Long Life

www.nytimes.com

4

Björn Schumacher @bjornschumacher.bsky.social · 8d

mproving the stability of the genome thus reducing mutation accumulation and enhancing the maintenance of functional genomes. Great collaboration with Arturo Bujarrabal,
@garinis.bsky.social, , Jan Vijg @cecad.bsky.social @uniklinikkoeln.bsky.social @unicologne.bsky.social

2

Björn Schumacher @bjornschumacher.bsky.social · 8d

Now out in print: Targeting DNA damage in ageing: towards supercharging DNA repair. New perspectives how we could tackle cancer and aging at their mechanistic root cause: I
www.nature.com/articles/s41...

Targeting DNA damage in ageing: towards supercharging DNA repair - Nature Reviews Drug Discovery

DNA damage to the somatic genome has been identified as a major cause of ageing. This Perspective provides an overview of current understanding of the role of genome instability in the ageing process and assesses therapeutic strategies targeting the cellular response to DNA damage to delay ageing and prevent associated diseases.

www.nature.com

1 1 7

Björn Schumacher @bjornschumacher.bsky.social · 8d

Amazing retreat of the @dfg.de Research Unit FOR5504 on the Physiological Causes and Consequences of Genome Instability and the Institute for Genome Stability in Aging and Disease with keynotes by @apoetsch.bsky.social and @garinis.bsky.social

1 5

Björn Schumacher @bjornschumacher.bsky.social · 9d

It was great fun speaking with Debbie Toiber and @barakrotblat.bsky.social on my path to science and why studying aging is so important to me. open.spotify.com/episode/2brg...

4 13

Reposted by Björn Schumacher

Andreas Beyer Group @beyerlab.bsky.social · 16d

This review of our @crc1678.bsky.social member @bjornschumacher.bsky.social and @meyerdh.bsky.social is greatly summarizing fundamentals of the molecular biology of aging. What causes aging? Read the answer!

Björn Schumacher @bjornschumacher.bsky.social · 19d

🔥🔥🔥Out now: our Perspectives article in @nataging.nature.com outlining how aging is driven by molecular damage leading to increasing molecular noise whose quantification could track aging with the precision of a clock @meyerdh.bsky.social @alexeimaklakov.bsky.social
www.nature.com/articles/s43...

Aging by the clock and yet without a program - Nature Aging

Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair processes resultin...

www.nature.com

1 5 10

Reposted by Björn Schumacher

Teif lab @teiflab.bsky.social · 19d

Aging by the clock and yet without a program [perspective by David Meyer, Alexei Maklakov & Björn Schumacher] www.nature.com/articles/s43...

1 5

Björn Schumacher @bjornschumacher.bsky.social · 19d

The first master regulator of DNA repair capacities that could be therapeutically targeted is the DREAM complex as we show here: www.nature.com/articles/s41...

The DREAM complex functions as conserved master regulator of somatic DNA-repair capacities - Nature Structural & Molecular Biology

In this work, the authors show that the DREAM complex suppresses the expression of numerous DNA-repair proteins in somatic cells. Suppression of the DREAM complex, either by altering individual compon...

www.nature.com

2

Björn Schumacher @bjornschumacher.bsky.social · 19d

For more on the central role of DNA damage in the aging process read here our review article in Nature @natureportfolio.nature.com www.nature.com/articles/s41...

The central role of DNA damage in the ageing process - Nature

This Review examines the evidence showing that DNA damage is associated with ageing phenotypes, suggesting that it may have a central role as the cause of ageing.

www.nature.com

1

Björn Schumacher @bjornschumacher.bsky.social · 19d

For more on how the onslaught of DNA damage that drives the aging process could be therapeutically mitigated read our article on boosting DNA repair capacities here: www.nature.com/articles/s41...

Targeting DNA damage in ageing: towards supercharging DNA repair - Nature Reviews Drug Discovery

DNA damage to the somatic genome has been identified as a major cause of ageing. This Perspective provides an overview of current understanding of the role of genome instability in the ageing process ...

www.nature.com

2 2

Björn Schumacher @bjornschumacher.bsky.social · 19d

For more on how molecular noise can measure biological age read our stochastic clock paper here: www.nature.com/articles/s43...

Aging clocks based on accumulating stochastic variation - Nature Aging

Meyer and Schumacher use simulations to show that accumulation of stochastic variation is sufficient to build clocks that can measure both chronological and biological age, sensitive to changes induce...

www.nature.com

1 1

Björn Schumacher @bjornschumacher.bsky.social · 19d

🔥🔥🔥Out now: our Perspectives article in @nataging.nature.com outlining how aging is driven by molecular damage leading to increasing molecular noise whose quantification could track aging with the precision of a clock @meyerdh.bsky.social @alexeimaklakov.bsky.social
www.nature.com/articles/s43...

Aging by the clock and yet without a program - Nature Aging

Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair processes resultin...

www.nature.com

1 17 41

Reposted by Björn Schumacher

CRC1678 @crc1678.bsky.social · 20d

👵🏻⏰👴🏻 Is aging a programmed process? Check out this perspective article in Nature Aging by our two #CRC1678 members @meyerdh.bsky.social and @bjornschumacher.bsky.social. Congratulations! 🥳

David Meyer @meyerdh.bsky.social · 20d

🕰️ Is aging driven by a programmed/programmatic mechanism, or by the unavoidable burden of imperfect maintenance? Our perspective argues that aging reflects finite maintenance and reduced evolutionary pressure🧵🧪 www.nature.com/articles/s43... @bjornschumacher.bsky.social @alexeimaklakov.bsky.social

Aging by the clock and yet without a program - Nature Aging

Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair processes resultin...

www.nature.com

3 7

Reposted by Björn Schumacher

David Meyer @meyerdh.bsky.social · 20d

🕰️ Is aging driven by a programmed/programmatic mechanism, or by the unavoidable burden of imperfect maintenance? Our perspective argues that aging reflects finite maintenance and reduced evolutionary pressure🧵🧪 www.nature.com/articles/s43... @bjornschumacher.bsky.social @alexeimaklakov.bsky.social

Aging by the clock and yet without a program - Nature Aging

Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair processes resultin...

www.nature.com

2 9 25

Björn Schumacher @bjornschumacher.bsky.social · Aug 14

Registration open now! Join us for the most exciting Gordon Research Conferences on Systems Aging in 2026. Super exciting program with outstanding speakers from across the entire field. Ample opportunity to discuss your science with leaders in the Systems Aging Feld. www.grc.org/systems-agin...

2026 Systems Aging Conference GRC

The 2026 Gordon Research Conference on Systems Aging will be held in Newry, Maine. Apply today to reserve your spot.

www.grc.org

1 2

Björn Schumacher @bjornschumacher.bsky.social · Jul 18

🔥🔥🔥 Read now our latest article: The Somatic Impact on Inheritance and the Germline Control of the Soma | Annual Reviews - www.annualreviews.org/content/jour...

The Somatic Impact on Inheritance and the Germline Control of the Soma | Annual Reviews

The faithful transmission of genomic DNA over succeeding generations is an essential prerequisite for species maintenance. The germplasm theory by August Weismann has been foundational for the current...

www.annualreviews.org

3 7

Reposted by Björn Schumacher

Barak Rotblat @barakrotblat.bsky.social · Jun 24

mtor and DNA damage in kidney health 👇

Björn Schumacher @bjornschumacher.bsky.social · Jun 24

🔥🔥🔥Check out our latest paper on the kidney, wonderful collaboration with Fabian Braun & Christine Kurschat @cecad.bsky.social. Read now: JCI Insight - Loss of genome maintenance is linked to mTOR complex 1 signaling and accelerates podocyte damage insight.jci.org/articles/vie...

2 5

Björn Schumacher @bjornschumacher.bsky.social · Jun 24

Thanks Or

1

Björn Schumacher @bjornschumacher.bsky.social · Jun 24

Thanks Christian

1

Björn Schumacher @bjornschumacher.bsky.social · Jun 24

Thanks Barak!

1

Björn Schumacher @bjornschumacher.bsky.social · Jun 24

🔥🔥🔥Check out our latest paper on the kidney, wonderful collaboration with Fabian Braun & Christine Kurschat @cecad.bsky.social. Read now: JCI Insight - Loss of genome maintenance is linked to mTOR complex 1 signaling and accelerates podocyte damage insight.jci.org/articles/vie...

4 8 17

Björn Schumacher @bjornschumacher.bsky.social · Jun 19

Register now for the 7th German-French DNA Repair Meeting, which will take place at the Campus Pierre et Marie Curie of Sorbonne University in Paris, France, from 5–7 November 2025. premc.org/dnarepair202...

11 16

Björn Schumacher @bjornschumacher.bsky.social · Jun 17

Paradigmenwechsel in der Medizin, um gesunde Lebenszeit verlängern www.nd-aktuell.de/artikel/1191...

Gesunde Lebenszeit verlängern

Viele Menschen wissen durchaus, was ein gesunder Lebensstil wäre. Umsetzbar sind diese Ansprüche trotzdem nicht für jeden. Ein Paradigmenwechsel in der Medizin könnte helfen.

www.nd-aktuell.de

1 2

Björn Schumacher @bjornschumacher.bsky.social · Jun 17

Gesundes Altern ermöglichen: Leopoldina-Diskussionspapier empfiehlt Umdenken in Forschung und Medizin nachrichten.idw-online.de/pressrelease...

Gesundes Altern ermöglichen: Leopoldina-Diskussionspapier empfiehlt Umdenken in Forschung und Medizin

nachrichten.idw-online.de

2