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Thomas Arnesen

@natmachinery.bsky.social

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Thomas Arnesen @natmachinery.bsky.social · Apr 3

Protein N-terminal modifications - Feature Review and cover in the recent issue of @cp-trendsbiochem.bsky.social Thanks to all authors, Editor @sanniejculbertson.bsky.social and reviewers for great work and support! @ispt-proteinterm.bsky.social www.cell.com/trends/bioch...

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Thomas Arnesen @natmachinery.bsky.social · 1d

Uptake of anti-cancer drugs depends on N-terminally acetylated anion channels | @ispt-proteinterm.bsky.social www.nature.com/articles/s42...

NAA60 facilitates LRRC8A- and LRRC8D-mediated platinum drug uptake - Communications Biology

Genome-wide CRISPR/Cas9 screening identifies the N-terminal acetyltransferase NAA60 to facilitate cis- and carboplatin drug sensitivity, most likely by neutralizing Nt acetylation of the LRRC8A/D VRAC subunits regulating substrate permeability.

www.nature.com

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Reposted by Thomas Arnesen

Trends in Biochemical Sciences @cp-trendsbiochem.bsky.social · 2d

📢 Our October issue is now online. Access the full issue 👉 www.cell.com/trends/bioch....

🎨 The cover highlights a Review from @chiosislabmskcc.bsky.social‬ and co on how PTMs reprogram chaperones into epichaperomes.

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Reposted by Thomas Arnesen

dave dougan @douganlab.bsky.social · 2d

And now for something completely different in co-translational targeting: Molecular Cell www.cell.com/molecular-ce...

And now for something completely different in co-translational targeting

In two recent papers in Cell, Zhu et al. and Luo et al. use selective ribosome profiling to identify the substrates and timing of co-translational protein targeting to mitochondria. The results sugges...

www.cell.com

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Thomas Arnesen @natmachinery.bsky.social · 3d

A Cell-Potent Bisubstrate Inhibitor to Probe NatD Acetyltransferase Activity | The inhibitor effectively reduced cellular Nα-acetylation on histone H4, leading to reduced migration in lung cancer cells | @acs.org ACS Chemical Biology @ispt-proteinterm.bsky.social pubs.acs.org/doi/10.1021/...

A Cell-Potent Bisubstrate Inhibitor to Probe NatD Acetyltransferase Activity

N-terminal acetyltransferase D (NatD) is a highly selective enzyme that acetylates the α-N-terminal amine of histones H4 and H2A, which share the SGRGK motif. Elevated NatD expression has been observe...

pubs.acs.org

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Reposted by Thomas Arnesen

International Society for Protein Termini (ISPT) @ispt-proteinterm.bsky.social · 13d

Protein N-terminal acetylation regulates the growth of rice plants | #NAA30 #NatC #rice #acetylation www.sciencedirect.com/science/arti...

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Thomas Arnesen @natmachinery.bsky.social · 13d

Two new volumes of Methods in Enzymology with 29 chapters/papers on Protein termini methods and reviews are now out! Thx to all authors!🙌 @ispt-proteinterm.bsky.social #N-degron #prenylation #myristoylation #formylation #arginylation #oxidation #acetylation www.sciencedirect.com/bookseries/m...

Methods in Enzymology | Volume 719: Protein Termini - Part B | ScienceDirect.com by Elsevier

Read the latest chapters of Methods in Enzymology at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature

www.sciencedirect.com

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Reposted by Thomas Arnesen

Lisa Heinke @lisaheinke.bsky.social · 15d

Are you excited?? Because I am!

25 years ago I was 10 and had just started secondary school yet our journal was already covering groundbreaking science, long before I'd even heard of molecular cell biology 🧐
Safe to say I'm fairly familiar with it now 🤭

Enjoy our issue!!!!!!!!!!!

Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 15d

Hello Bluesky! We're celebrating ✨25th years of NRMCB✨ with our October Issue - out now!

It offers a glimpse into our journal's scope - cell death, enhancers, cell cycle, migration, transposable elements, membrane contact sites & AI!

go.nature.com/4nJUz6w

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Thomas Arnesen @natmachinery.bsky.social · 15d

Developing leaves form a spatiotemporal oxygen gradient that is sensed through the oxygen sensing machinery and directs morphogenesis | New preprint from @daanweits.bsky.social and @syno2xis.bsky.social labs #N-degron #Cysteine #hypoxia @ispt-proteinterm.bsky.social www.biorxiv.org/content/10.1...

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Thomas Arnesen @natmachinery.bsky.social · 20d

Anatomy and habitat shape the oxygen sensing machinery of flowering plants | new preprint from Licausi lab @syno2xis.bsky.social #hypoxia #N-degron @ispt-proteinterm.bsky.social www.biorxiv.org/content/10.1...

Anatomy and habitat shape the oxygen sensing machinery of angiosperms

Hypoxia sensing via the Cys/Arg branch of the N-degron pathway (Cys-NDP) is central for flooding responses in plants, yet how evolutionary and ecological factors have shaped the core oxygen sensing me...

www.biorxiv.org

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Reposted by Thomas Arnesen

International Society for Protein Termini (ISPT) @ispt-proteinterm.bsky.social · 21d

New review on the generation and consequences of N-terminal proteoform diversity from Evan Morrison and Olivia Rissland | #N-degron #RNA @cp-cellreports.bsky.social www.sciencedirect.com/science/arti...

The generation and consequences of N-terminal proteoform diversity

N-terminal proteoforms are protein variants with altered N termini that arise from RNA-driven processes, such as alternative promoter usage, splicing,…

www.sciencedirect.com

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Reposted by Thomas Arnesen

Sannie Culbertson @sanniejculbertson.bsky.social · 22d

🎉 As we prep for #TIBSCelebrates50, I'd love for participation from YOU! Share your creativity and have your artwork featured on the cover of @cp-trendsbiochem.bsky.social!

📆 Deadline is Sept 30!!

Trends in Biochemical Sciences @cp-trendsbiochem.bsky.social · 22d

🚨 The #TIBSCelebrates50 call for cover art is open thru Sept 30 - share your ideas now!

🎨 Have your original artwork featured on the cover of the January issue! One design will be selected to celebrate this milestone with us.

More info here 👉 www.cell.com/trends/bioch...

#TIBS50 #CoverArt

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Reposted by Thomas Arnesen

International Society for Protein Termini (ISPT) @ispt-proteinterm.bsky.social · Sep 8

Targeted degradation of pathogenic TDP-43 proteins in amyotrophic lateral sclerosis using the AUTOTAC platform | Yong Tae Kwon lab | #N-degron www.biorxiv.org/content/10.1...

Targeted degradation of pathogenic TDP-43 proteins in amyotrophic lateral sclerosis using the AUTOTAC platform

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons and the cytoplasmic aggregation of misfolded proteins in the spinal cord...

www.biorxiv.org

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Reposted by Thomas Arnesen

International Society for Protein Termini (ISPT) @ispt-proteinterm.bsky.social · Sep 8

A synthetic ERFVII-dependent circuit in yeast sheds light on the regulation of early hypoxic responses of plants | Preprint from @mikellavi.bsky.social @beagiuntoli.bsky.social @syno2xis.bsky.social #N-degron #hypoxia www.biorxiv.org/content/10.1...

A synthetic ERFVII-dependent circuit in yeast sheds light on the regulation of early hypoxic responses of plants

Plants face hypoxic conditions either chronically, as particular tissues are characterized by fluctuating or stable low oxygen levels, or acutely, when flooded. In vascular plants, transcriptional ada...

www.biorxiv.org

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Reposted by Thomas Arnesen

Dan Grabarczyk @dangrabarczyk.bsky.social · Aug 28

Glad to share the final version of our story about the UBR4 complex, an E4 ligase protein quality control hub @science.org. Now with more cryo-EM structures and a deeper dive into substrate recognition, especially escaped mitochondrial proteins @clausenlab.bsky.social www.science.org/doi/10.1126/...

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Reposted by Thomas Arnesen

Liam Faller @liamfaller.bsky.social · Aug 28

Very cool stuff on the co-translational folding of dimers by Sander Tans and his team @amolf-nl.bsky.social:

www.nature.com/articles/s41...

Co-translational ribosome pairing enables native assembly of misfolding-prone subunits - Nature Communications

Protein complexes are essential for cell function. Here, authors show that paired ribosomes can help each other’s nascent chains fold correctly, enabling proper dimer assembly and preventing misfoldin...

www.nature.com

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Reposted by Thomas Arnesen

Ahmad Jomaa @jomaalab.bsky.social · Aug 26

Want to know how lipidation of some nascent chains takes place by NMT2-- Check our latest work on how NAC couples Protein Synthesis with Nascent Polypeptide Myristoylation on the Ribosome out today @embojournal.org‬: www.embopress.org/doi/full/10....

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Reposted by Thomas Arnesen

Vinay Shukla @vinayshukla.bsky.social · Aug 23

Structural basis for the recognition and ubiquitylation of type-2 N-degron substrate by PRT1 plant N-recognin
nature.com/articles/s41...
#plantscience

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Reposted by Thomas Arnesen

Alexey Amunts @amunts.bsky.social · Aug 22

Emmanuel Levy @elevylab.bsky.social has joined BlueSky 🌟 with a fantastic Cell paper with Shu-ou Shan, showing the interactome of the TOM complex and how cotranslational mito import prioritizes large globular domains. Beautiful science!
Give him a warm welcome 🎉
link: www.cell.com/cell/fulltex...

Principles of cotranslational mitochondrial protein import

Selective ribosome profiling reveals that nearly 20% of mitochondrial proteins in human cells are imported during translation on cytosolic ribosomes. Cotranslational import requires an N-terminal pres...

www.cell.com

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Thomas Arnesen @natmachinery.bsky.social · Aug 20

Nitric oxide promotes cysteine N-degron proteolysis through control of oxygen availability | Important finding by Kim, Tian, Ratcliffe and Keeley @ox.ac.uk @ispt-proteinterm.bsky.social #N-degron www.pnas.org/doi/10.1073/...

Nitric oxide promotes cysteine N-degron proteolysis through control of oxygen availability | PNAS

Selected proteins containing an N-terminal cysteine (Nt-Cys) are subjected to rapid, O2-dependent proteolysis via the Cys/Arg-branch of the N-degro...

www.pnas.org

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Thomas Arnesen @natmachinery.bsky.social · Aug 19

Disease resistance in rice steered by a long non-coding RNA via protein N-terminal acetylation | @ispt-proteinterm.bsky.social advanced.onlinelibrary.wiley.com/doi/10.1002/...

Gene Editing of a Susceptibility LncRNA Enhances Broad‐Spectrum Disease Resistance in Rice without Developmental Trade‐Offs

Editing susceptibility lncRNAs offers a strategy to enhance disease resistance without yield loss. RESIS, a domestication-acquired, pathogen-induced lncRNA, promotes protein N-terminal acetylation th...

advanced.onlinelibrary.wiley.com

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Reposted by Thomas Arnesen

International Society for Protein Termini (ISPT) @ispt-proteinterm.bsky.social · Aug 19

Melon wrinkles linked to protein N-terminal acetylation. link.springer.com/article/10.1...

Fine mapping and prediction of a candidate gene for wrinkled rind in melon (Cucumis melo L.) - Theoretical and Applied Genetics

Key message The Cmwr locus was fine mapped to chromosome 2 in wrinkled-rind melon, and MELO3C010304.2 (CmNaa35, encoding an N-α-acetyltransferase) was identified as the most likely candidate gene for ...

link.springer.com

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Thomas Arnesen @natmachinery.bsky.social · Aug 18

Global profiling of N-terminal cysteine–dependent degradation mechanisms | PNAS | @ispt-proteinterm.bsky.social www.pnas.org/doi/10.1073/...

Global profiling of N-terminal cysteine–dependent degradation mechanisms | PNAS

Hypoxia, a condition characterized by insufficient oxygen supply, challenges cellular homeostasis and energy production, triggering adaptive respon...

www.pnas.org

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Reposted by Thomas Arnesen

Lars-Anders Carlson @lacarlson.bsky.social · Aug 13

Repost appreciated:
Open #PhDposition in structural virology in my group! Join us in Umeå, Sweden to uncover how arboviruses remodel infected cells. In situ #cryoET and #cryoEM combined with #virology, #cellbiology, and #biophysics.
Deadline 7 September. More info: www.carlsonlab.se/join/

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Reposted by Thomas Arnesen

Norwegian Centre for Molecular Biosciences and Medicine (NCMBM) @ncmbm.bsky.social · Aug 12

💡Interested in our recently advertised @embl.org-style group leader positions but still not sure about it? Maybe this clip will convince you to join us👇!

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Reposted by Thomas Arnesen

Dan Gibbs 🌱🧬 @djgibbs.bsky.social · Aug 7

Our 'Spotlight' discussing an excellent recent paper by @lauradc.bsky.social @n-end-rules.bsky.social & @syno2xis.bsky.social et al on the evolution of oxygen signalling in land plants is now online at Molecular Plant.

Spotlight: tinyurl.com/7ydn6p4a

Original paper: tinyurl.com/yw5yd4f8

The evolutionary rise of oxygen sensing in land plants

Land plants evolved from aquatic green algal ancestors to dominate terrestrial ecosystems approximately 480 million years ago during the Ordovician period (Hammarlund et al., 2020). This major event i...

www.cell.com

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