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Reposted by Lars-Anders Carlson

Kenneth Ehses @denkenny.bsky.social · 14h

✨Excited that the main project of my PhD is now available as a pre-print on #bioRxiv

Here, we used #CryoET to visualise mitochondrial proteostatic stress and together with SPA #CryoEM shed light into the functional cycle of the Hsp60:10 chaperone system. #TeamTomo

🔗 www.biorxiv.org/content/10.1...

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Juan S. Bonifacino @juanbonifacino.bsky.social · 15h

Excited to share our latest manuscript by @saikat2025.bsky.social and an international team, reporting variants in the EARP- and GARP-interacting protein EIPR1 associated with a neurodevelopmental disorder. Will send you the PDF if you can’t access the article: academic.oup.com/brain/articl...

EIPR1 variants cause a neurodevelopmental disorder with endolysosomal and dense core vesicle defects

Abstract. EIPR1 (EARP-interacting protein 1, formerly known as TSSC1) is a WD40-domain protein that interacts with the EARP (endosome-associated recycling

academic.oup.com

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Roni Odai @rodai.bsky.social · 6d

Viral AlphaFold Database (VAD) is live in Science Advances

~27,000 predicted viral protein monomers & homodimers

Conserved folds across bacteria, archaea & eukaryotic viruses

New toxin–antitoxin system KreTA uncovered

Vast “functional darkness” remains uncharted

www.science.org/doi/10.1126/...

The Viral AlphaFold Database of monomers and homodimers reveals conserved protein folds in viruses of bacteria, archaea, and eukaryotes

VAD is a Viral AlphaFold Database of protein monomers and homodimers from viruses infecting hosts across the tree of life.

www.science.org

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Derek Lowe @dereklowe.bsky.social · 18h

I don’t think I’ve ever had more fun in the lab than when I was making MOFs myself (and trying to use them for small-molecule X-ray structure determination). So let me celebrate by posting a few of the MOF crystals I prepared:

Bright green transparent metal-organic framework crystals prepared with copper and a “multipronged” carboxylic acid ligand. The crystals formed blocky roughly rectangular pieces with some very large emerald-like chunks.

Pink/red transparent metal-organic framework crystals prepared with cobalt and a “multipronged” carboxylic acid ligand. The crystals formed as a mixture of long rectangular types and aggregated chunks.

Purple transparent metal-organic framework crystals prepared with cobalt and a “multipronged” carboxylic acid ligand. The crystals formed long slightly blocky needles.

Clear transparent metal-organic framework crystals prepared with zirconium and a “multipronged” carboxylic acid ligand. The crystals formed chunky hexagons.

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Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 1d

A good day to remember John Gurdon’s school report from his biology master at Eton

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Briggs Group @briggsgroup.bsky.social · 2d

The mechanistic basis of cargo selection during Golgi maturation. From Rebecca Taylor, @katciazynska.bsky.social, @jggkaufman.bsky.social & @grigorytagiltsev.bsky.social at @mpibiochem.bsky.social with David Owen and Sean Munro's group @cellbiol-mrclmb.bsky.social | www.science.org/doi/10.1126/...

The mechanistic basis of cargo selection during Golgi maturation

Resident proteins of the Golgi recycle in vesicles and the protein GOLPH3 enables the COPI vesicle coat to accomplish this.

www.science.org

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Lars-Anders Carlson @lacarlson.bsky.social · 1d

Cool conference!

CryoCloud @cryocloudio.bsky.social · 1d

CryoCloud is heading to Women in Electron Microscopy #WeM2025 this week!

We’re proud to sponsor this inaugural event supporting women in electron microscopy.

Our own @ievadr.bsky.social will speak on cloud-native automation to enable high-throughput #cryoEM for drug discovery.

See you there!

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RCSB Protein Data Bank @rcsbpdb.bsky.social · 1d

The genome of ebola virus contains instructions for building seven proteins, which assemble with the genomic RNA to form one of the deadliest viruses.

PDB101: Molecule of the Month: Ebola Virus Proteins

Structures of ebola virus proteins are giving new hope for fighting this deadly virus

pdb101.rcsb.org

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Thelonevirologist @thelonevirologist.bsky.social · 1d

Immunogenicity of a trivalent haemorrhagic fever vaccine candidate against Sudan virus, Marburg virus and Lassa virus in an mpox vaccine

www.microbiologyresearch.org/content/jour...

Immunogenicity of a trivalent haemorrhagic fever vaccine candidate against Sudan virus, Marburg virus and Lassa virus in an mpox vaccine

A multivalent vaccine targeting high-consequence infectious diseases in Sub-Saharan Africa (SSA), which are linked to high mortality, morbidity and overlapping clinical manifestations, would significa...

www.microbiologyresearch.org

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Victor de Lorenzo (CNB, Madrid) @vdlorenzo.bsky.social · 1d

Université Grenoble Alpes opens a full professorship in microbiology in 2026. The selected candidate will develop their research program on quantitative approaches in microbiology in the Laboratoire Interdisciplinaire de Physique. More info: liphy.univ-grenoble-alpes.fr/en/join-us/r...

Professorship (tenure) in 'Quantitative approaches in microbiology' (CNU Sections 64/65) | LIPhy - Université Grenoble Alpes

liphy.univ-grenoble-alpes.fr

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Chris H. Hill @chillzaa.bsky.social · 1d

Enteroviruses cause over a billion infections each year, but the details of how their genomes capture host ribosomes have remained elusive. I'm pleased to share a new preprint from Miguel in our group, providing some new insights into this problem:
www.biorxiv.org/content/10.1...

Structural and mechanistic insights into translation initiation on the enterovirus Type 1 IRES

Enteroviruses are a widespread and diverse set of pathogens responsible for over ~1 billion human infections annually. Upon cell entry, translation of the virus genome is mediated by an internal ribos...

www.biorxiv.org

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BK. Titanji @boghuma.bsky.social · 2d

A new Nature Medicine study analyzing health records from >100 million people in the US offers compelling evidence that reactivation of varicella-zoster virus (VZV) ,the same virus that causes chickenpox and shingles may contribute to dementia risk.
www.nature.com/articles/s41...

Varicella-zoster virus reactivation and the risk of dementia - Nature Medicine

Large-scale longitudinal health records reveal consistent association of varicella-zoster virus reactivation with dementia.

www.nature.com

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The Daum Lab @daumlab.bsky.social · 2d

Out in Science Advances: Our #cryoEM structure of HFTV1, a virus infecting the halophile #archaea. *First full atomic structure (containing all structural proteins) of any tailed virus!* Congrats and thanks to all co-authors and our fantastic collaborators! www.science.org/doi/10.1126/...

Cryo-EM resolves the structure of the archaeal dsDNA virus HFTV1 from head to tail

This structure of an archaeal tailed virus (arTV) provides detailed insights into arTV assembly and infection mechanisms.

www.science.org

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Sjors Scheres @sjorsscheres.bsky.social · 3d

If you are interesting in developing new algorithms for #cryoEM as a #PhD student or as a #postdoc, then do email or DM me. We have exciting opportunities coming up.

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Lars-Anders Carlson @lacarlson.bsky.social · 3d

These stoic thoughts are hard to digest for us today. Yet they can be traced back to Socrates, and are perhaps still worth considering?

Daily Stoic @daily-stoic.bsky.social · 4d

"It can ruin your life only if it ruins your character. Otherwise it cannot harm you" Marcus Aurelius

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Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 5d

Next week is #Nobelprize week !!!

perhaps the future winners are here on bluesky 👀 and will join @jenniferdoudna.bsky.social @carolynbertozzi.bskyverified.social @joachim123.bsky.social @francesarnold.bsky.social @ardemp.bskyverified.social @m-bmoser.bsky.social @e-charpentier.bsky.social

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Jan-Hannes Schaefer @jhschaef.bsky.social · 4d

Helical Reconstruction of Amyloids in cryoSPARC?
We present guidelines, limitations & future perspectives for processing amyloids in cryoSPARC @structurabio.bsky.social.
Great collaboration of the Kelly Lab and @landerlab.bsky.social #cryoEM #amyloid www.biorxiv.org/content/10.1...

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Ruth Ann Crystal @drruth.bsky.social · 4d

The HPV vaccine is doing what had been promised.
17 years after it became available, HPV infections decreased significantly in vaccinated people and unvaccinated people because of herd immunity. buff.ly/WvjQ1BS

h/t @boghuma.bsky.social

#medsky #pedsky 🛟🧪

Light blue background. Young woman with dark hair makes a sign of strength with her arm and she has a vaccine bandaid on her upper arm. It says "The HPV Vaccine Works!"

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Sjors Scheres @sjorsscheres.bsky.social · 3d

Below (by @landerlab.bsky.social) is the 2nd #cryosparc recipe on @biorxivpreprint.bsky.social in a month. I remain worried about closed-source software affecting progress in #cryoEM. We should develop new algorithms instead!

#OpenSoftwareAcceleratesScience

www.biorxiv.org/content/10.1...

www.biorxiv.org

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Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 5d

AI-generated papers
AI-generated peer-review reports
AI-generated images
AI-grant writing
Algorithms to spot promising science

I'm very worried, we should all be very worried

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UK Health Security Agency @ukhsa.bsky.social · 5d

Although we have discovered eggs of Aedes mosquitoes recently, there is no evidence of established populations in the UK and we are unlikely to see them for the moment.

Read more about how we monitor mosquitoes:
ukhsa.blog.gov.uk/2024/12/03/h...

Map showing distribution of Aedes invasive mosquitoes, June 2025

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Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 5d

Giant DNA viruses encode a hallmark translation initiation complex of eukaryotic life

www.biorxiv.org/content/10.1...

Giant DNA viruses encode a hallmark translation initiation complex of eukaryotic life

In contrast to living organisms, viruses were long thought to lack protein synthesis machinery and instead depend on host factors to translate viral transcripts. Here, we discover that giant DNA virus...

www.biorxiv.org

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Lars-Anders Carlson @lacarlson.bsky.social · 5d

Thanks to all speakers, participants and organisers of cryoNET 2025 in Umeå! It was a great meeting! See you all in Copenhagen from cryoNET 2026.

www.umu.se/en/chemical-...

cryoNET Symposium, 1-2 October 2025

Registration is closed

www.umu.se

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Oded Rechavi @odedrechavi.bsky.social · 5d

Friday Papers Club! 🍿In light of Pubmed going down, the collapse of social media, and my recent success at getting recommendations for interesting papers from those still around, I am starting a new tradition! - Recommend a good scientific manuscript! 👇

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Thelonevirologist @thelonevirologist.bsky.social · 6d

LRP8 is a receptor for tick-borne encephalitis virus

www.nature.com/articles/s41...

LRP8 is a receptor for tick-borne encephalitis virus - Nature

LRP8, an apolipoprotein E and reelin receptor with high expression in the brain, is a receptor for tick-borne encephalitis virus.

www.nature.com

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