Lightnews — Scholar-powered news

Kenneth Ehses @denkenny.bsky.social · 5h

✨Excited that the main project of my PhD is now available as a pre-print on #bioRxiv

Here, we used #CryoET to visualise mitochondrial proteostatic stress and together with SPA #CryoEM shed light into the functional cycle of the Hsp60:10 chaperone system. #TeamTomo

🔗 www.biorxiv.org/content/10.1...

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Reposted by Kenneth Ehses

Razvan Borza @rborza.bsky.social · Jul 9

🚀 My first Cryo-EM structures are OUT on the PDB!

🎉Super excited about this milestone as PhD, it’s been a journey, and I’m grateful to finally have these as my first Cryo-EM structures! 🙌

🔁Thank you for sharing!❤️

Read @daaninthelab.bsky.social et. al.: www.science.org/doi/10.1126/...

⬇️ 2nd video

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Reposted by Kenneth Ehses

Biozentrum, University of Basel @biozentrum.unibas.ch · 9d

Assistant/Associate Professor in Structural Biology, Biophysics or Biological Imaging

www.biozentrum.unibas.ch/open-positio...

#biozentrum #University #Basel #Professor #Structural #Biology #Biophysics #Biological #Imaging

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Reposted by Kenneth Ehses

Jakob Meier-Credo @meiercredo.bsky.social · 19d

Check out our new preprint on an integrated pipeline combining in situ #cryo-ET with MALDI #MSImaging for single-cell identification and classification from previously analysed EM-grids.
Link: www.biorxiv.org/content/10.1...

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Reposted by Kenneth Ehses

Ben Engel @cellarchlab.com · 18d

A molecular-resolution look into the near-native architecture of the spinach chloroplast🌱. This one was a long time in the oven, but we're happy to finally share our "version of record". What long-standing debates did we settle? Check back for a short thread🧵 on Monday. #TeamTomo #PlantScience 🧪🧶🧬🔬🌾

eLife @elife.bsky.social · 18d

🌱 Using ‘compelling’ methods, including #CryoET, researchers mapped spinach thylakoid membranes at single-molecule precision, revealing how photosynthetic complexes are organised and settling long-standing debates on chloroplast architecture.
buff.ly/j3TSIkn

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Reposted by Kenneth Ehses

Jenny Sachweh @jennysachweh.bsky.social · Aug 18

My PhD paper is in press @cellpress.bsky.social and now online: www.sciencedirect.com/science/arti...!

Contents: weird #NPCs in yeast and flies, #CLEM, in situ #cryoET and more!

Made possible by the amazing @becklab.bsky.social team at @mpibp.bsky.social and collaborators! #TeamTomo

The small GTPase Ran defines nuclear pore complex asymmetry

Nuclear pore complexes (NPCs) bridge across the nuclear envelope and mediate nucleocytoplasmic exchange. They consist of hundreds of nucleoporin build…

www.sciencedirect.com

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Reposted by Kenneth Ehses

Chi-Min Ho @cmholab.bsky.social · Aug 18

Our #CryoET story on how a top antimalarial drug candidate perturbs the native malarial translation machinery is out @natsmb.nature.com🥳 rdcu.be/eBbrH

A massive team effort led by @leonieanton.bsky.social Meseret Haile & Wenjing Cheng in collaboration with Jerzy Dziekan & the Alan Cowman! #TeamTomo

Integrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug

Nature Structural & Molecular Biology - Integrated structural biology approach leveraging in situ cryo-electron tomography reveals molecular details of the native malarial translation...

rdcu.be

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Reposted by Kenneth Ehses

Lars-Anders Carlson @lacarlson.bsky.social · Aug 13

Repost appreciated:
Open #PhDposition in structural virology in my group! Join us in Umeå, Sweden to uncover how arboviruses remodel infected cells. In situ #cryoET and #cryoEM combined with #virology, #cellbiology, and #biophysics.
Deadline 7 September. More info: www.carlsonlab.se/join/

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Reposted by Kenneth Ehses

Pilhofer Lab 🦠❄️🔬 @pilhoferlab.bsky.social · Aug 12

Check out 🧐 our new preprint 📜:
www.biorxiv.org/content/10.1...
Congrats🎉 to @vasilgaisin.bsky.social and Corina Hadjicharalambous, who studied contractile injection systems directly in hot spring♨️ bacterial mats🦠
#microsky #teamtomo #Chloroflexota

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Reposted by Kenneth Ehses

A. Reza Mehdipour @rezamehdipour.bsky.social · Aug 5

We are excited to announce the first in-cell structure of a LINC complex within a native nuclear envelope at subnanometer resolution!! #In-cell cryo-ET + #atomistic MD simulations! @tomdendooven.bsky.social et al!!
www.biorxiv.org/content/10.1...

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Reposted by Kenneth Ehses

Jim Hurley @jimhurley.bsky.social · Jul 31

Congratulations @kev-in-situ-et.bsky.social and the whole team on in situ cryo-ET images of OA-induced mitochondria damage and Parkin-dependent mitophagy out now tinyurl.com/25b82cp4. We couldn't have done it without in situ guru @wilflinglab.bsky.social and mito guru @samlewis.bsky.social .‬

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Reposted by Kenneth Ehses

Katie Downes @dr-downes.bsky.social · Jul 30

Very excited to announce that my first, first author paper, is now on BioRxiv! In this paper we unambiguously show #COPII coated vesicles in unperturbed human cells for the very first time!!

Make my day and check it out!
www.biorxiv.org/content/10.1...

#Cryo-ET #TeamTomo #Cryo-CLEM ❄️🔬❄️🔬❄️🔬❄️🔬

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Reposted by Kenneth Ehses

Marcel Dickmanns | 🌿❄️🔬 @madic.bsky.social · Jul 26

New preprint: In situ Architecture of #Plasmodesmata.

Using #cryoET, #AlphaFold & proteomics, we uncover the native organization of plant intercellular nanopores.

🔗 doi.org/10.1101/2025...

🧪🧵1/n
#teamtomo #PlantScience #Physcomitrium #Arabidopsis #cryoEM

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Reposted by Kenneth Ehses

Michael Grange @michaelgrange.bsky.social · Jun 17

Proud to share our latest paper. doi.org/10.1016/j.cr...

Through the dedication of @glynnca.bsky.social and @cryingem.bsky.social we report a thorough method to image molecular organisation within hippocampus tissue.

Structural biology in tissue is well and truly here!

@rosfrankinst.bsky.social

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Reposted by Kenneth Ehses

Frank Noe @franknoe.bsky.social · Jul 10

BioEmu now published in @science.org !!

What is BioEmu? Check out this video:
youtu.be/LStKhWcL0VE?...

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Reposted by Kenneth Ehses

Juha Huiskonen @juhahuiskonen.bsky.social · Jul 8

In our latest preprint on bioRxiv, we present the in situ structure of
the human gap junction at 14 Å resolution using cryo-ET.

The structure provides a blueprint for investigating how connexin
regulation shapes intercellular communication in health and disease.

CryoET tomogram with the gap junction (green), ribosomes (cyan) and microtubules (pink)

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Reposted by Kenneth Ehses

Albert and Mary Lasker Foundation @laskerfdn.bsky.social · Jun 18

The Fang Lab and @korostelevlab.bsky.social‬
present cryo-EM structures of two natural RNA nanocages found in bacterial and phage genomes. These findings could inform design of engineered RNA nanocages as delivery vehicles for research and therapeutic applications.

Cryo-EM structure of a natural RNA nanocage - Nature

Nature - Cryo-EM structure of a natural RNA nanocage

www.nature.com

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Reposted by Kenneth Ehses

Daniel Hurdiss @danielhurdiss.bsky.social · Jun 18

Latest preprint from the lab, many years in the making!

By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase.

This could have big implications for our understanding of viral replication & assembly (🧵)

www.biorxiv.org/content/10.1...

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Reposted by Kenneth Ehses

Svetlana Dodonova @dodonova-sveta.bsky.social · May 26

We’ve uncovered Asgard chromatin structures formed by a Hodarchaeal histone : closed hypernucleosome conserved in archaea and an open form resembling the H3-H4 eukaryotic octasome. Fantastic work by @harshranawat.bsky.social!
www.biorxiv.org/content/10.1...
#Chromatin #Asgard #Archaea #cryoEM

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Reposted by Kenneth Ehses

Rasmus Jensen @rasmusjensen.bsky.social · May 23

Very nice and generous summary of our recent preprint by @ewanbirney.bsky.social #cryoem #cryoet #proteinfolding #translocation

Ewan Birney @ewanbirney.bsky.social · May 22

This is just an excellent preprint by Rasmus Jensen and colleagues from Julia Mahamid's lab @embl.org - a tour de force of Cryogenic electron tomography to do in cell structural biology in which they discover a new complex and solve its structure and function! www.biorxiv.org/content/10.1...

In-cell discovery and characterization of a non-canonical bacterial protein translocation-folding complex

Cryo-electron tomography has emerged as powerful technology for in-cell structural biology, and in combination with breakthroughs in protein structure prediction, offers a unique opportunity for illum...

www.biorxiv.org

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Reposted by Kenneth Ehses

Yi-Wei Chang @yiweichang.bsky.social · May 15

Excited to share our new @science.org paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals.
www.science.org/doi/10.1126/...

Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis

Influenza viruses replicate and transcribe their genome in the context of a conserved ribonucleoprotein (RNP) complex. By integrating cryo–electron microscopy single-particle analysis and cryo–electro...

www.science.org

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Reposted by Kenneth Ehses

Harry M. Williams @harrywilliams.bsky.social · May 9

A new paper from my new colleagues in Lausanne! Microsecond time-resolved cryo-EM rumbles closer day by day. Very cool work!

cryoEM papers @cryoempapers.bsky.social · May 8

Ultrathin Liquid Cells for Microsecond Time-Resolved Cryo-EM www.biorxiv.org/content/10.1101/2025.05.05.652279v1 #cryoem

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Reposted by Kenneth Ehses

Florent Waltz @florentwaltz.bsky.social · May 6

You want to start tomography? Solve structures inside cells? Reach Nyquist 😳 ? @phaips.vd.st and I have a website for you! tomoguide.github.io
You'll find a tutorial on how to reconstruct tomograms, pick particles and do subtomogram averaging, using different software!
Hope it will be useful !

3.8 angstrom resolution ribosome from 33 tomograms

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Reposted by Kenneth Ehses

Lorenz Lamm @lorenzlamm.bsky.social · Apr 25

🦠🧠 MemBrain update! 🧠🦠
We’ve updated our preprint! It now covers the full MemBrain v2 pipeline for end-to-end membrane analysis in #CryoET: segmentation, particle picking, and spatial statistics.
🔗 Preprint: doi.org/10.1101/2024...
🔗 Code: github.com/CellArchLab/...
🧵(1/6) #TeamTomo

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Reposted by Kenneth Ehses

Ricardo D. Righetto @lifeonthewedge.bsky.social · Apr 23

We have updated our #MemBrain v2 preprint with a lot more details about the MemBrain-pick and MemBrain-stats modules, as well as some application examples!

Stay tuned for the upcoming thread by lead author @lorenzlamm.bsky.social! 🧠🧵

#CryoET #TeamTomo
www.biorxiv.org/content/10.1...

Figure 4. MemBrain v2 end-to-end workflow detects periodic phycobilisome organization. A: Raw tomogram slice of EMD-31244. B: Out-of-the-box MemBrain-seg segmentation (light blue). C: A single membrane instance can be visualized in Surforama and manually annotated with GT phycobilisome positions (magenta). D: MemBrain-pick localizes particles (trained with data from C) on all membranes in the tomogram. E: MemBrain-stats computes Ripley’s O statistic using the positions from D with a bin size of 5nm. The distance between peaks (35 nm) was measured to estimate chain unit spacings.

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