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Florent Waltz

@florentwaltz.bsky.social

2.2K followers 1.1K following 160 posts

SNSF Ambizione Project Leader Looking at tiny frozen mitochondria with big microscopes 🔬 cryoEM/cryoET Green organisms 🌿 & evolution 🦠 Biozentrum, hosted in the Engel Lab, CH 🇫🇷 -> 🇩🇪 -> 🇨🇭 Website: https://www.waltzresearch.com/

www.waltzresearch.com

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Florent Waltz @florentwaltz.bsky.social · Mar 20

The final version of our work on the in-cell architecture of the mitochondrial respiratory chain is now online in @science.org 🎉
You can find the full story here www.science.org/doi/10.1126/...
@verenaresch.bsky.social did a wonderful job on the cover and animation, she really brought it to life 👩‍🎨

Science Magazine @science.org · Mar 20

In a new Science study, cryo–electron tomography captures the in-cell architecture of the mitochondrial respiratory chain, illuminating how the coordinated action of molecular machines drives life’s fundamental energy conversion.

Learn more in this week's issue: scim.ag/3FA3Ygq

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Florent Waltz @florentwaltz.bsky.social · 13d

Check this out! The mysterious widespread CAGE protein complex found by my colleague @computingcaitie.bsky.social ! Cool stuff there 🥨
Shows you how much we still can and have to discover !

Caitie McCafferty @computingcaitie.bsky.social · 15d

I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate www.biorxiv.org/content/10.1... #cilia #protistsonsky 🧬🧪

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Florent Waltz @florentwaltz.bsky.social · 16d

I had a wonderful time in Japan 🗼! Huge thanks to @ken-wakaba.bsky.social for inviting me to Sangyo University in Kyoto. Thanks to Takashi Yamano (and Ken-ichi) for organizing the Beyond the Green 🍀 session at the Japanese Botanical Society meeting!
Great science and discussions!

Speakers of the beyond the green session

Florent Waltz @florentwaltz.bsky.social · Aug 28

Mitochondria finally made the headlines, yay!

Oh wait, ... oh no ....

jen sometimes aph 🌻 @bunnibytz.bsky.social · Aug 27

via @acyn.bsky.social

RFK JR: I’m looking at kids as I walk through the airports today...and I see these kids that are just overburdened with mitochondrial challenges, inflammation—you can tell from their faces, movements, and lack of social connection

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Reposted by Florent Waltz

Chi-Min Ho @cmholab.bsky.social · Aug 18

Our #CryoET story on how a top antimalarial drug candidate perturbs the native malarial translation machinery is out @natsmb.nature.com🥳 rdcu.be/eBbrH

A massive team effort led by @leonieanton.bsky.social Meseret Haile & Wenjing Cheng in collaboration with Jerzy Dziekan & the Alan Cowman! #TeamTomo

Integrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug

Nature Structural & Molecular Biology - Integrated structural biology approach leveraging in situ cryo-electron tomography reveals molecular details of the native malarial translation...

rdcu.be

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Florent Waltz @florentwaltz.bsky.social · Aug 11

Then I definitely need to pass by when I'll be there in September!

Florent Waltz @florentwaltz.bsky.social · Aug 8

Do they give out Hello Kitty Chlamy stickers 👀?

Florent Waltz @florentwaltz.bsky.social · Aug 4

I hope the hat stays on 🎩!

Florent Waltz @florentwaltz.bsky.social · Aug 2

Very cool! How do cytosolic ribosomes discriminate between ER and mitochondria targeted proteins?
NAC recognizes mitochondrial targeting sequences! Very important since over 95% of the mitochondrial proteome is translated in the cytosol and then imported to mitochondria.
Congrats!

Ahmad Jomaa @jomaalab.bsky.social · Aug 1

Check out our new preprint on the discovery of a molecular switch in NAC that mediates nascent chain sorting on the ribosome and prevents mitochondrial protein mistargeting by SRP. A great collaboration with the Shan Lab @Caltech and the Qi Lab @UVA: www.biorxiv.org/content/10.1...

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Florent Waltz @florentwaltz.bsky.social · Aug 2

Very cool Ahmad, congrats!

Florent Waltz @florentwaltz.bsky.social · Jul 31

A step towards easier control over mitochondrial gene expression:

Silencing mitochondrial gene expression in living cells | Science www.science.org/doi/10.1126/...

Silencing mitochondrial gene expression in living cells

Mitochondria fulfill central functions in metabolism and energy supply. They express their own genome, which encodes key subunits of the oxidative phosphorylation system. However, the central mechanis...

www.science.org

Florent Waltz @florentwaltz.bsky.social · Jul 29

How can the alignment pin break in the first place 😱😱😱😱

Florent Waltz @florentwaltz.bsky.social · Jul 27

Cell-to-cell connections in plants 🌿!

Using cryo-ET 🔬 to have a look at plasmodesmata.

Congrats Marcel, Matthias and co!
You managed to push it far beyond what I thought was possible !

Marcel Dickmanns | 🌿❄️🔬 @madic.bsky.social · Jul 26

New preprint: In situ Architecture of #Plasmodesmata.

Using #cryoET, #AlphaFold & proteomics, we uncover the native organization of plant intercellular nanopores.

🔗 doi.org/10.1101/2025...

🧪🧵1/n
#teamtomo #PlantScience #Physcomitrium #Arabidopsis #cryoEM

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Reposted by Florent Waltz

Marcel Dickmanns | 🌿❄️🔬 @madic.bsky.social · Jul 26

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Florent Waltz @florentwaltz.bsky.social · Jun 17

Cool paper from cool people 😎
Expand all the things!

Flora Vincent @floravincent.bsky.social · Jun 17

Excited to share the lab's 1rst preprint! Rapid high-res immunofluorescence is now possible in cultured & environmental diatoms thanks to 4-fold expansion microscopy. A step-change for comparative cell biology in one of the most important phytoplankton groups on the planet 🥳
tinyurl.com/m9s5su7s 1/2

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Florent Waltz @florentwaltz.bsky.social · Jun 4

Curious about dinoflagellates? Tiny water bugs with super cool cellular architecture?
Check out this cool initiative from my colleague @manondemulder.bsky.social and her friends!

Their 1st online seminar is next month, don't miss it!

Manon Demulder @manondemulder.bsky.social · Jun 4

We’re kicking off the DinoSphere Online Seminar Series! Join us for our first session with Karel Mockaer (Heidelberg) & Yong Heng Phua (OIST)

📅 1 July 9AM CEST
🔗 tinyurl.com/4mjaverj

Spread the word!
@protistwtmostest.bsky.social @ehehenberger.bsky.social @chandnibhickta.bsky.social&Norico Yamada

Florent Waltz @florentwaltz.bsky.social · May 23

Stunning representation!

Florent Waltz @florentwaltz.bsky.social · May 23

Looks cool!
Maybe I should have crashed the course, while i was around.

Florent Waltz @florentwaltz.bsky.social · May 19

Re-redeading this one 📖. Great book for evolution and bioenergetics aficionados. The view is a bit distracting though ⛵

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Reposted by Florent Waltz

Schuller Jan @schullerjm.bsky.social · May 12

Happy to present the lab latest work, today from the green-side. The ultimate PSII assembly intermediate that directly precedes incorporation of the Mn4O5Ca cluster and formation of the OEC. Psb32 binds to PsbV, challenging the assumption the extrinsic subunits all associate spontaneously in-vivo.

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Reposted by Florent Waltz

Ben Engel @cellarchlab.com · May 7

“The Website” is here! It can be intimidating getting into analysis of #CryoET data, and software is evolving all the time👩‍💻🚀. @phaips.vd.st & @florentwaltz.bsky.social put our lab’s workflows into an online guide. We hope this helps lower the bar to joining #TeamTomo. Feedback much appreciated! 🧪🧶🧬🔬

Philippe Van der Stappen @phaips.vd.st · May 6

Hey #TeamTomo,
Ever been in need of a tutorial about the fundamentals of cryo-electron tomography? From preprocessing raw frames to high-res subtomogram averaging?
That's why @florentwaltz.bsky.social and I made this website!

tomoguide.github.io

Follow the thread 1 /🧵
#CryoET #CryoEM 🔬🧪

Welcome to TomoGuide

A step-by-step Cryo-ET guide

tomoguide.github.io

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Florent Waltz @florentwaltz.bsky.social · May 7

Ribosomes for everyone

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Florent Waltz @florentwaltz.bsky.social · May 7

Thanks Sven !

Florent Waltz @florentwaltz.bsky.social · May 7

The never ending journey of fixing tomography ...

a boy is riding on the back of a white dog with the words " it 's a never ending story " on the bottom

ALT: a boy is riding on the back of a white dog with the words " it 's a never ending story " on the bottom

media.tenor.com

Florent Waltz @florentwaltz.bsky.social · May 7

Work mode