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Reposted by Philippe Van der Stappen

David Kuster @rnadavid.bsky.social · 4d

Translation landscape of stress granules | Science Advances

www.science.org/doi/10.1126/...

Translation landscape of stress granules

Cryo–electron tomography visualizes stress granules in situ, revealing their spatial interplay with translation machinery.

www.science.org

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Reposted by Philippe Van der Stappen

Richard Sever @richardsever.bsky.social · 7d

Another record month for bioRxiv - and further evidence the pandemic spike+dip was just that and growth continues. Thanks to all involved and that includes 🫵

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Biozentrum, University of Basel @biozentrum.unibas.ch · 9d

Assistant/Associate Professor in Structural Biology, Biophysics or Biological Imaging

www.biozentrum.unibas.ch/open-positio...

#biozentrum #University #Basel #Professor #Structural #Biology #Biophysics #Biological #Imaging

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Jamie Blaza @jnb-lab.bsky.social · 22d

CryoET is a particularly brutal area for combining a spectacular public success with hidden heroic failure!

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Torsten Schwede @torstenschwede.bsky.social · Sep 4

Authors concluded that this study “demonstrates that following current climate policies will not only overshoot the 1.5-°C limit of the Paris Agreement by a wide margin but also may prohibit returning to it thereafter.” Wishful thinking is not a realistic strategy for future generations.

⬇️ ⬇️ ⬇️

Nature @nature.com · Sep 4

Nature research paper: A prudent planetary limit for geologic carbon storage

go.nature.com/4p6MvOQ

A prudent planetary limit for geologic carbon storage - Nature

A risk-based, spatially explicit analysis of carbon storage in sedimentary basins establishes a prudent planetary limit of around 1,460 Gt of geological carbon storage, which requires making explicit decisions on priorities for storage use.

go.nature.com

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Philippe Van der Stappen @phaips.vd.st · Aug 28

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Biozentrum, University of Basel @biozentrum.unibas.ch · Aug 26

🧪 The University of Basel is setting up a new endowed professorship in #ClimateBiophysics at the @biozentrum.unibas.ch, funded by the Georg H. Endress Foundation. This new professorship strengthens climate research @unibas.ch. www.biozentrum.unibas.ch/news/detail/...

New endowed professorship strengthens climate research at the University of Basel

The University of Basel is setting up a new endowed professorship at the Biozentrum to make fundamental discoveries at the interface between biophysics and climate-relevant environmental biology. This...

www.biozentrum.unibas.ch

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cryoEM papers @cryoempapers.bsky.social · Jul 17

The Luminal Ring Protein C2CD3 Acts as a Radial In-to-Out Organizer of the Distal Centriole and Appendages pubmed.ncbi.nlm.nih.gov/40667239/ #cryoem

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Philippe Van der Stappen @phaips.vd.st · Jul 10

For me it is definitely DeepDeWedge from Simon Wiedemann!
www.nature.com/articles/s41...

A deep learning method for simultaneous denoising and missing wedge reconstruction in cryogenic electron tomography - Nature Communications

The authors propose DeepDeWedge, a deep learning method to improve the visual quality of 3D images obtained with cryogenic electron tomography. DeepDeWedge effectively removes noise and artefacts due ...

www.nature.com

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Will Wan @williamnwan.bsky.social · Jul 8

Happy to say that my Current Opinion in Structural Biology article came out today. I hope it helps to guide to you in using cryo-ET to make new biological discoveries!

www.sciencedirect.com/science/arti...

A practical look at cryo-electron tomography image processing: Key considerations for new biological discoveries

Cryo-electron tomography (cryo-ET) enables 3D visualization of complex biological environments without the need for purification, thereby preserving t…

www.sciencedirect.com

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Paul & Virginie - Centriole Lab @centriolelab.bsky.social · Jun 19

🚨 New preprint!
Using U-ExM + in situ cryo-ET, we show how C2CD3 builds an in-to-out radial architecture connecting the distal centriole lumen to its appendages. Great collab with @cellarchlab.com @chgenoud.bsky.social @stearnslab.bsky.social 🙌. #TeamTomo #UExM
www.biorxiv.org/content/10.1...

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Neil deGrasse Tyson @neildegrassetyson.com · Jun 17

Every machine in a Hospital that diagnoses your body without cutting you open is based on a principle of Physics, discovered by a Physicist who had no interest in Medicine.

If you think the world doesn’t need Basic Science, or that somehow Science has failed you, think again.

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BWJones @bwjones.bsky.social · Jun 8

Almost all Nobel Prizes are awarded for work that is exploratory, or absolutely basic science with no obvious commercial or medical benefit.

You cannot predict where advancements come from, so you have to invest in science and scientists.

Targeted (corporate) science investment will never do this.

Ted Pavlic (he/him/his) @tedpavlic.bsky.social · Jun 8

Reminder: Nobel-prize winning PCR (1983), used in basically all genetic tech today, was only possible because of extremophile bacterium discovered in 1964 in Yellowstone funded by a small ~$80k NSF grant with no obvious application at the time. #science 🧪
www.richmondscientific.com/how-a-discov...

How a discovery in Yellowstone National Park led to the development of PCR - Richmond Scientific

A discovery in Yellowstone National Park led to the development of PCR, the gold-standard COVID-19 tests used to fight the global pandemic.

www.richmondscientific.com

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Alex Schier @schierlab.bsky.social · Jun 7

"I invite any Trump administration official who thinks our academic standards have declined to sit for an exam in my class. If you can explain the quantum principles underlying the structure of the Periodic Table (like my 18-year-old freshmen can), then you can lecture me on academic standards".

adamezracohen.bsky.social @adamezracohen.bsky.social · May 28

I wrote about the government's attacks on Harvard. Hope this reaches a few persuadable minds.
prosyn.org/PhWi74r?h=Ky...

Defunding Harvard Hurts America | by Adam Ezra Cohen - Project Syndicate

Adam Ezra Cohen explains the real-world consequences of canceling federal research grants in the name of fighting antisemitism.

prosyn.org

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Manon Demulder @manondemulder.bsky.social · Jun 4

We’re building a collaborative space for early-career researchers working at the intersection of dinoflagellate taxonomy& molecular biology.
🔗 Learn more: sites.google.com/view/dinosph... 💬 Got questions or input? Please reach out and let us know.
Hope to see you there!

DinoSphere

Welcome

sites.google.com

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Manon Demulder @manondemulder.bsky.social · Jun 4

We’re kicking off the DinoSphere Online Seminar Series! Join us for our first session with Karel Mockaer (Heidelberg) & Yong Heng Phua (OIST)

📅 1 July 9AM CEST
🔗 tinyurl.com/4mjaverj

Spread the word!
@protistwtmostest.bsky.social @ehehenberger.bsky.social @chandnibhickta.bsky.social&Norico Yamada

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Fay-Wei Li @fernway.bsky.social · May 30

Shameless self-promotion continues...🙃 You might find this #fern book in your local bookstores! mailchi.mp/btiscience/f...

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Philippe Van der Stappen @phaips.vd.st · May 9

Thanks Marten, glad to hear that!

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Florent Waltz @florentwaltz.bsky.social · May 6

You want to start tomography? Solve structures inside cells? Reach Nyquist 😳 ? @phaips.vd.st and I have a website for you! tomoguide.github.io
You'll find a tutorial on how to reconstruct tomograms, pick particles and do subtomogram averaging, using different software!
Hope it will be useful !

3.8 angstrom resolution ribosome from 33 tomograms

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Philippe Van der Stappen @phaips.vd.st · May 6

Last but definitely not least: thanks to all the software developers!
@sjorsscheres.bsky.social @martenchaillet.bsky.social @Shawn Zheng @Scipion developers
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Philippe Van der Stappen @phaips.vd.st · May 6

A big thank you especially to @florentwaltz.bsky.social, the amazing logos by @sofie-dot-rec.bsky.social, all things computational with the great @lifeonthewedge.bsky.social, and all @cellarchlab.com members!
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Philippe Van der Stappen @phaips.vd.st · May 6

The field is evolving at a rapid speed, both hardware and software become better by the day. That is why your feedback regarding any issues, problem, recommendations, or comments is invaluable! Let us know directly on github.com/TomoGuide/To...
We hope this will be of great value.
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GitHub - TomoGuide/TomoGuide.github.io

Contribute to TomoGuide/TomoGuide.github.io development by creating an account on GitHub.

github.com

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Philippe Van der Stappen @phaips.vd.st · May 6

Using the amazing #pytom-match-pick we guide you through particle picking. From the template matching results we show you how to perform STA in #RELION5 pushing Ribosomes to their absolute limit (Nyquist)!
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Philippe Van der Stappen @phaips.vd.st · May 6

We decided to summarize our (the @cellarchlab.com group) most common workflows! The Tutorial guides you through tomogram pre- and postprocessing using either #RELION5, #Scipion, or #AreTomo3. With the Chlamy dataset (www.ebi.ac.uk/empiar/EMPIA...) as a possible resource for all those steps!
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Philippe Van der Stappen @phaips.vd.st · May 6

Hey #TeamTomo,
Ever been in need of a tutorial about the fundamentals of cryo-electron tomography? From preprocessing raw frames to high-res subtomogram averaging?
That's why @florentwaltz.bsky.social and I made this website!

tomoguide.github.io

Follow the thread 1 /🧵
#CryoET #CryoEM 🔬🧪

Welcome to TomoGuide

A step-by-step Cryo-ET guide

tomoguide.github.io

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