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Lux Alptraum @luxalptraum.com · 8h

TFW you paid $1400 to see Beckett’s most famous work without knowing anything about it

One Star Review of Waiting for Godot on Broadway
I recently attended Waiting for Godot on Broadway and spent over $1,400 for two Row C seats (103 and 104). I'm a longtime admirer of Broadway productions and even hold a season pass for Shea's Performing Arts Theatre, so I came in with genuine enthusiasm and high expectations. Unfortunately, this show was unlike anything ! have ever experienced —and not in a good way.
What I encountered was not the artistry, music, or emotional storytelling I usually associate with Broadway, but instead what felt like an endless cycle of nonsensical conversation between characters who seemed trapped in their own madness. I tried-truly tried-to find meaning, symbolism, or even a thread of emotional resonance. I stayed through the first half hoping the second would offer clarity. But by intermission, it was clear: this was a waste of both time and money.
Keanu Reeves is an actor I respect greatly, but I cannot fathom why he would agree to participate in such a disjointed, inaccessible production. His talent was lost in a performance that defied reason rather than provoked insight.
To anyone considering attending: unless you are drawn to highly abstract, nearly incomprehensible theater, I strongly caution you against this show. For the average, educated, thoughtful theatergoer, it is far more frustrating than fulfilling. In my opinion, this was the single most disappointing Broadway experience I've ever had - an unfortunate waste of money and, more importantly, of time.

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David W. Sanders! @davidwsanders.bsky.social · 9h

Humbled to announce that we received a New Innovator award. I thank the NIH’s civil servants for their hard work during a stressful funding cycle. I thank the leadership (and chair, Marc Diamond) at UTSW for betting on my lab’s high risk, high reward research. www.utsouthwestern.edu/newsroom/art...

UT Southwestern researcher receives NIH Director’s New Innovator Award

David Sanders, Ph.D., Assistant Professor in the Center for Alzheimer’s and Neurodegenerative Diseases and Molecular Biology at UT Southwestern Medical Center, has been awarded $2.4 million over five ...

www.utsouthwestern.edu

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Jerelle Joseph @jerelleaj.bsky.social · 1d

Is there a way to directly connect microstructural dynamics of condensates to their mechanical response?

In his new pre-print, Pablo presents a “condensate Deborah number” that does just that!

www.biorxiv.org/content/10.1...

Biomolecular condensate viscoelasticity is dictated by the interplay between single-molecule shape memory and mesh reconfigurability

Biomolecular condensates are membraneless organelles that compartmentalize biological functions in living cells. Formed by the phase separation of biomolecules, condensates possess a wide range of mec...

www.biorxiv.org

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Ryan Flynn @raflynn5.bsky.social · 1d

We’re excited to report work led by postdoc Jennifer Porat in the lab, finding that DNA accumulates on the surface of living cells and that the secreted extracellular protein DNASE1L3 can modulate its levels on B and T cells. With a new twist for ATAC-seq as well www.biorxiv.org/content/10.1...

DNASE1L3 surveils mitochondrial DNA on the surface of distinct mammalian cells

The extracellular space is a critical environment for discriminating self versus non-self nucleic acids and initiating the appropriate immune responses through signaling cascades to relay information ...

www.biorxiv.org

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bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 4d

Structural insights into mitotic-centrosome assembly https://www.biorxiv.org/content/10.1101/2025.10.03.680336v1

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Isaac Wong @isaacsiuwong.bsky.social · 4d

Our new preprint reveals that 🪰's Cnn and 🪱's SPD-5 both form condensates in vitro, but assemble via divergent mechanisms in vivo. We show how phosphorylation unlocks Cnn’s autoinhibited scaffold and identify conserved features in 🚶‍♂️'s CDK5RAP2.

bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 4d

Structural insights into mitotic-centrosome assembly https://www.biorxiv.org/content/10.1101/2025.10.03.680336v1

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David Kuster @rnadavid.bsky.social · 4d

Translation landscape of stress granules | Science Advances

www.science.org/doi/10.1126/...

Translation landscape of stress granules

Cryo–electron tomography visualizes stress granules in situ, revealing their spatial interplay with translation machinery.

www.science.org

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Camille Moore @camille-moore.bsky.social · 6d

Today I am so pleased to present our work on how chromatin remodelers affect mesoscale chromatin organization.
www.science.org/doi/10.1126/...

ATP-dependent remodeling of chromatin condensates reveals distinct mesoscale outcomes

Adenosine triphosphate (ATP)–dependent chromatin remodeling enzymes mobilize nucleosomes, but how such mobilization affects chromatin condensation is unclear. We investigate effects of two major remod...

www.science.org

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Jerelle Joseph @jerelleaj.bsky.social · 15d

Out now in #SoftMatter, our work on linking single molecule features, microstructure, and macroscopic properties of condensates! Led by Daniel Tan, a former undergrad student who is now pursuing a PhD in Computational biophysics, Dilimulati Aierken and Pablo Garcia!

pubs.rsc.org/en/content/a...

pubs.rsc.org

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brangwynnelab.bsky.social @brangwynnelab.bsky.social · 18d

A tremendous honor! Thrilled & humbled to receive 2025 Keio Medical Science Prize for launching LLPS #phaseseparation field (= #softmatter + #cellbio) w collaborators esp @HymanLab. & Congrats to Akiko Iwasaki @virusesimmunity.bsky.social. www.princeton.edu/news/2025/09...
#KeioMedicalSciencePrize

Bioengineer Clifford Brangwynne wins Keio Medical Science Prize

Japan’s Keio University awards the prize annually to honor contributions in medicine and life sciences. Brangwynne is being recognized for groundbreaking work that has opened up a new field of cell bi...

www.princeton.edu

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Frog and Toad Bot @frogandtoadbot.bsky.social · 17d

Frog drank the tea, and then he said, “Tell me a story while I am resting.”

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RCSB Protein Data Bank @rcsbpdb.bsky.social · 19d

September 21 is #WorldAlzheimersDay
Alzheimer's disease and prion diseases are linked to unnatural aggregation of proteins into amyloid fibrils.

PDB101: Molecule of the Month: Amyloids

Alzheimer's disease and prion diseases are linked to unnatural aggregation of proteins into amyloid fibrils.

pdb101.rcsb.org

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Jack Bateman @jbateman01.bsky.social · 19d

Kinetic organization of the genome revealed by ultraresolution multiscale live imaging www.science.org/doi/10.1126/...

Kinetic organization of the genome revealed by ultraresolution multiscale live imaging

Genome function requires regulated genome motion. However, tools to directly observe this motion in vivo have been limited in coverage and resolution. Here we introduce an approach to tile mammalian c...

www.science.org

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Amy Strom @dnamystrom.bsky.social · 26d

Chuffed to be recognized with an Early Career Award for work on the chromatin-nucleated phase separation of BRD4. ✨ Give it a read!

www.molbiolcell.org/doi/full/10....

Shout-out @drjorine.bsky.social @brangwynnelab.bsky.social

And huge thank you @ascbiology.bsky.social

Interplay of condensation and chromatin binding underlies BRD4 targeting | Molecular Biology of the Cell

Nuclear compartments form via biomolecular phase separation, mediated through multivalent properties of biomolecules concentrated within condensates. Certain compartments are associated with specific ...

www.molbiolcell.org

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GBM (Gesellschaft für Biochemie und Molekularbiologie) @gbmev.bsky.social · 20d

Congratulations to the Fritz Lipmann Lecturer Michael Rosen (Dallas) by the GBM president Harald Kolmar.

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Barack Obama @barackobama.bsky.social · 20d

After years of complaining about cancel culture, the current administration has taken it to a new and dangerous level by routinely threatening regulatory action against media companies unless they muzzle or fire reporters and commentators it doesn’t like.

Let’s be clear about what happened to Jimmy Kimmel

Trump’s most brazen attack on free speech yet.

www.yahoo.com

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Guillermina Ramirez-SanJuan @guille-rochelle.bsky.social · 20d

In another exciting development our new preprint is online:
www.biorxiv.org/cgi/content/...

This is the work of my brilliant graduate student Katerina Kourkoulou in collaboration with Maggie Liu and Arnold Mathijssen. Here is a video of the subject of our study:

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Sarah Cohen @cohenlaboratory.bsky.social · 21d

Wonderful to see our paper on the #organelle signatures of #neurons and #astrocytes out in final form - congratulations, Shannon Rhoads and team!🎉 t.co/BPxKlbU6Ou

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Lars Hubatsch @larshubatsch.bsky.social · 22d

Paper alert!🧪
We derive a theory that underpins interface resistance with a physical foundation and look at how it changes droplet growth and recovery kinetics! Awesome collab with @bosste.bsky.social Tyler Harmon @hymanlab.bsky.social @m-pol.bsky.social and Frank Jülicher @mpipks.bsky.social 1/4

Transport kinetics across interfaces between coexisting liquid phases

elifesciences.org

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David Kuster @rnadavid.bsky.social · 23d

That's probably at the heart of why the world shifts towards populism & ultimately facism..

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Jerelle Joseph @jerelleaj.bsky.social · 23d

Now out in #ProteinScience! Work led by the talented 🥳🥳@ananyac2000.bsky.social

onlinelibrary.wiley.com/doi/10.1002/...

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Diez Lab @ TU Dresden @stefandiezlab.bsky.social · 24d

What a pleasure to collaborate with Laura #Schaedel and her team at @uni-saarland.de to study #microtubule damage and repair under mechanical load.

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Anaïs Bailles @anaisbailles.bsky.social · 26d

Thanks a lot to @elisecutts.bsky.social for nicely highlighting and putting in context our article! It was very interesting to discuss together, notably about the analogies between the emergence of order in Hydra and other physical phenomena.

Elise Cutts @elisecutts.bsky.social · 27d

Hydra are ~basically~ immortal.

Shred 50 of the lil guys to bits and pack their cells in a blob, and that blob will grow into a new Hydra... albeit with a few extra heads!

This week's post is a Q&A @anaisbailles.bsky.social @mpi-cbg.de about the physics of how Hydra coax order from chaos.🧪⚛️

Hydra are a cosmos in a cuvette

Anaïs Bailles on astrophysics and immortal animals

www.reviewertoo.com

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Vienna BioCenter Scientific Training @vbcscitraining.bsky.social · 27d

Our Autumn PhD call is OPEN!
20+ fully funded positions across diverse life science disciplines. Explore projects in Cell & Chromosome biology + more 👉 www.vbcphd.at

Apply by 10 Oct 2025

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siddhartha jena @epijenatics.bsky.social · 27d

Excited to share my postdoc work, out on bioRxiv today! Histones package DNA into nucleosomes to form the building blocks of chromatin, but how modular and programmable is this system? 1/9

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