jerelleaj.bsky.social
Jerelle Joseph
@jerelleaj.bsky.social
480 followers 130 following 58 posts
Assistant Professor, Princeton University | biomolecular condensates + computer simulations | https://josephgroup.princeton.edu (she/her)
josephgroup.princeton.edu
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jerelleaj.bsky.social
Jerelle Joseph @jerelleaj.bsky.social · Jul 3
Huge congratulations to @alinaemelianova.bsky.social Pablo and Daniel on their paper on small-molecule partitioning into condensates now published in JACS Au and selected as ACS Editor’s Choice!!! pubs.acs.org/doi/full/10....
Prediction of Small-Molecule Partitioning into Biomolecular Condensates from Simulation
Predicting small-molecule partitioning into biomolecular condensates is the key to developing drugs that selectively target aberrant condensates. However, the molecular mechanisms underlying small-mol...
pubs.acs.org
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jerelleaj.bsky.social
Jerelle Joseph @jerelleaj.bsky.social · 17h
Is there a way to directly connect microstructural dynamics of condensates to their mechanical response?

In his new pre-print, Pablo presents a “condensate Deborah number” that does just that!

www.biorxiv.org/content/10.1...
Biomolecular condensate viscoelasticity is dictated by the interplay between single-molecule shape memory and mesh reconfigurability
Biomolecular condensates are membraneless organelles that compartmentalize biological functions in living cells. Formed by the phase separation of biomolecules, condensates possess a wide range of mec...
www.biorxiv.org
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jerelleaj.bsky.social
Jerelle Joseph @jerelleaj.bsky.social · 19h
Wow 😩
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Jerelle Joseph @jerelleaj.bsky.social · 8d
Yasssssssss!!!!!! Congratulations Alex!!! 💃🏽💃🏽💃🏽💃🏽💃🏽💃🏽💃🏽💃🏽💃🏽
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jerelleaj.bsky.social
Jerelle Joseph @jerelleaj.bsky.social · 8d
Out now in #ACSMacroLett: we demonstrate how molecular charge asymmetry can control the size of condensates! Work done in collaboration with @zwickergroup.bsky.social!!

Theory led by Chengjie Luo and simulations by @nathanieldhess.bsky.social!!

pubs.acs.org/doi/10.1021/...
Theory of Condensate Size Control by Molecular Charge Asymmetry
Biomolecular condensates are complex droplets comprising diverse molecules that interact by various mechanisms. Condensation is often driven by short-range attraction, but net charges can also mediate...
pubs.acs.org
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jerelleaj.bsky.social
Jerelle Joseph @jerelleaj.bsky.social · 15d
Out now in #SoftMatter, our work on linking single molecule features, microstructure, and macroscopic properties of condensates! Led by Daniel Tan, a former undergrad student who is now pursuing a PhD in Computational biophysics, Dilimulati Aierken and Pablo Garcia!

pubs.rsc.org/en/content/a...
pubs.rsc.org
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jerelleaj.bsky.social
Jerelle Joseph @jerelleaj.bsky.social · 23d
@ananyac2000.bsky.social (not sure why your tag got messed up, my bad)! 🥳🥳
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jerelleaj.bsky.social
Jerelle Joseph @jerelleaj.bsky.social · 23d
Now out in #ProteinScience! Work led by the talented 🥳🥳@ananyac2000.bsky.social

onlinelibrary.wiley.com/doi/10.1002/...
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jerelleaj.bsky.social
Jerelle Joseph @jerelleaj.bsky.social · Sep 3
Wow!
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Jerelle Joseph @jerelleaj.bsky.social · Sep 3
Nice work!!!
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jerelleaj.bsky.social
Jerelle Joseph @jerelleaj.bsky.social · Sep 3
Who else gets nervous for the first lecture of the semester? It doesn’t matter how many times you’ve taught the course?!!! 😩#fallsemester
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jerelleaj.bsky.social
Jerelle Joseph @jerelleaj.bsky.social · Jul 28
Our new approach, MAPPS, opens up new opportunities for screening small-molecule-condensate interactions on computers! Read the article here: pubs.acs.org/doi/full/10.10… 6/6
https://pubs.acs.org/doi/full/10.10…
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jerelleaj.bsky.social
Jerelle Joseph @jerelleaj.bsky.social · Jul 28
Leveraging these findings, as well as our Mpipi model for proteins, we developed a framework for probing small molecule partitioning into condensates — which is much faster that all atom simulations and allows us to model biologically relevant systems 5/
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Jerelle Joseph @jerelleaj.bsky.social · Jul 28
Our work suggests that small molecule selectivity of condensates can be engineered 4/
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Jerelle Joseph @jerelleaj.bsky.social · Jul 28
We also find that condensates enriched in hydrophobic residues exhibit stronger selectivity for small molecules. However those rich in polar residues can be selective for higher log P compounds that also have high dipole moments! 3/
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jerelleaj.bsky.social
Jerelle Joseph @jerelleaj.bsky.social · Jul 28
By simulating ~65 atomistic system’s this work probes the partitioning landscape of four model condensates (varying in their hydrophobic residue content). We find that BOTH characteristics of condensates and small molecules dictate partitioning 2/
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Jerelle Joseph @jerelleaj.bsky.social · Jul 28
On the cover of JACS Au! @alinaemelianova.bsky.social’s work with Pablo and Daniel on using atomistic and residue-resolution coarse-grained simulation to probe interactions between small molecules and biomolecular condensates!! Cover designed by D. Aierken w/ Alina! 1/
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Jerelle Joseph @jerelleaj.bsky.social · Jul 14
I second that!!! ♥️
weber-lab.bsky.social
WeberLab@McGill @weber-lab.bsky.social · Jul 11
So grateful to my co-coordinators, @zwickergroup.bsky.social, @jerelleaj.bsky.social, and Frank Jülicher, to all of the participants for sharing their knowledge and contributing to such open and stimulating discussions, and to everyone @kitp-ucsb.bsky.social for making our stay so comfortable. 🙏🙏🙏
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jerelleaj.bsky.social
Jerelle Joseph @jerelleaj.bsky.social · Jul 3
Huge congratulations to @alinaemelianova.bsky.social Pablo and Daniel on their paper on small-molecule partitioning into condensates now published in JACS Au and selected as ACS Editor’s Choice!!! pubs.acs.org/doi/full/10....
Prediction of Small-Molecule Partitioning into Biomolecular Condensates from Simulation
Predicting small-molecule partitioning into biomolecular condensates is the key to developing drugs that selectively target aberrant condensates. However, the molecular mechanisms underlying small-mol...
pubs.acs.org
1 6
Reposted by Jerelle Joseph
schmitbiophysics.bsky.social
Jeremy Schmit @schmitbiophysics.bsky.social · Jun 28
Can't say enough about the Condensates program at @kitp-ucsb.bsky.social. Invigorating discussions, fantastic facilities, and a beautiful location (a place I consider "home"). Thanks to @weber-lab.bsky.social, @jerelleaj.bsky.social, @zwickergroup.bsky.social, and Frank Julicher for organizing!
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jerelleaj.bsky.social
Jerelle Joseph @jerelleaj.bsky.social · Jun 29
Thanks Jeremy! It was wonderful having you join us. You always bring such insight and fresh perspectives! Hope you had a safe trip back
jerelleaj.bsky.social
Jerelle Joseph @jerelleaj.bsky.social · Jun 23
Few more days left to nominate a rising star in bioengineering! Self-nominations are welcomed!
jerelleaj.bsky.social
Jerelle Joseph @jerelleaj.bsky.social · Apr 18
📣 Calling all Rising Stars in Biological Engineering. Nominate someone or self nominate: forms.gle/EszC1AvRFpfN...
forms.gle
jerelleaj.bsky.social
Jerelle Joseph @jerelleaj.bsky.social · Jun 16
“Biological Physics of Biomolecular Condensates: Bridging Theory and Experiment”

The conference associated with our #KITP program on condensates runs for the next three days. Looking forward to meeting everyone and the discussions!

www.kitp.ucsb.edu/activities/b...
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jerelleaj.bsky.social
Jerelle Joseph @jerelleaj.bsky.social · Jun 14
There’s nothing quite like #KITP! So grateful that we got the opportunity to put this on! The fun continues…🥰
weber-lab.bsky.social
WeberLab@McGill @weber-lab.bsky.social · Jun 13
@jerelleaj.bsky.social, master painter 👩🏽‍🎨 of the blackboard 👩🏽‍🏫, in action! 🤩 She is amazing at capturing the essence of our complex, meandering (and sometimes contentious) discussions @kitp-ucsb.bsky.social
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Jerelle Joseph @jerelleaj.bsky.social · May 29
I’m beyond proud of them! And so thankful for the graduate students and postdocs in the group who served as their day-to-day mentors! Looking forward to all they accomplish in the next chapter of their careers! ♥️♥️
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jerelleaj.bsky.social
Jerelle Joseph @jerelleaj.bsky.social · May 29
This was a big week for the group! Our four seniors graduated and made us very proud. Ethan graduates as a Sachs Scholar, Ian secured several minors, Daniel won the MacCracken Senior Thesis Award from SEAS, and Caroline earned the highest awards in both CBE and Engineering!
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