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Amy Strom @dnamystrom.bsky.social · 20d

One point for McKnight but a new point for Brangwynne
www.ms-fund.keio.ac.jp/en/prize/

Keio Medical Science Prize - Keio University Medical Science Fund

Keio University Medical Science Fund

www.ms-fund.keio.ac.jp

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Amy Strom @dnamystrom.bsky.social · 24d

Just two scientists building our empires with style 💅🏼🙌🏼

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Amy Strom @dnamystrom.bsky.social · 26d

And check out the other winners here 🎉
www.ascb.org/society-news...

ASCB and MBoC Announce 2025 Paper of the Year Award Winners - ASCB

ASCB and its research journal, Molecular Biology of the Cell (MBoC), are proud to recognize the outstanding scientific achievements of early career researchers through the 2025 Paper of the Year Award...

www.ascb.org

Amy Strom @dnamystrom.bsky.social · 26d

Chuffed to be recognized with an Early Career Award for work on the chromatin-nucleated phase separation of BRD4. ✨ Give it a read!

www.molbiolcell.org/doi/full/10....

Shout-out @drjorine.bsky.social @brangwynnelab.bsky.social

And huge thank you @ascbiology.bsky.social

Interplay of condensation and chromatin binding underlies BRD4 targeting | Molecular Biology of the Cell

Nuclear compartments form via biomolecular phase separation, mediated through multivalent properties of biomolecules concentrated within condensates. Certain compartments are associated with specific ...

www.molbiolcell.org

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Amy Strom @dnamystrom.bsky.social · 28d

Thanks Jase! It's a whirlwind so far but I'm psyched to get started. Let's catch up!

Amy Strom @dnamystrom.bsky.social · 28d

It's so great!

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Amy Strom @dnamystrom.bsky.social · 28d

First, organize and label. Then, science.

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Amy Strom @dnamystrom.bsky.social · 28d

Getting Strom Lab set up!

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Amy Strom @dnamystrom.bsky.social · Aug 5

First day at my new job!
I'm a Lab Head, Principal Scientist in Discovery Oncology at Genentech.
I'll be searching for new targets to develop cancer treatments.

2nd photo is my newest friend on campus, decoy-ote.
@genentech.bsky.social

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Amy Strom @dnamystrom.bsky.social · Jul 13

The latest in my favorite love triangle:
Chromatin <-(💜)-> Condensates <-(💚)-> Mechanics

brangwynnelab.bsky.social @brangwynnelab.bsky.social · Jul 12

Congrats to Jing @jesszhiyuezhao.bsky.social‬
& @dnamystrom.bsky.social‬ on cool manuscript!!! Reveals how cell nucleus is a heterogeneous material, w chromatin organization controlling formation & phase behavior of nuclear condensates. #CellBiology #Chromatin #PhaseSeparation rdcu.be/evWxR

Chromatin heterogeneity modulates nuclear condensate dynamics and phase behavior

Nature Communications - Chromatin heterogeneity in the cell nucleus modulates the size, mobility, and formation of biomolecular condensates; decreasing chromatin heterogeneity correlates with...

rdcu.be

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Amy Strom @dnamystrom.bsky.social · Jul 10

Cancelling grants that were already competitively won and awarded is the waste and abuse.

www.nytimes.com/2025/07/10/u...

The Surprising Scientists Hit by Trump’s D.E.I. Cuts

www.nytimes.com

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Amy Strom @dnamystrom.bsky.social · Jul 7

Huge thanks to my family, mentors, and funders for making this path possible — and to Genentech for the leap of faith. Can’t wait to get started next month!

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Amy Strom @dnamystrom.bsky.social · Jul 7

I'm thrilled to announce my next career step-- I’m joining Genentech as a Principal Scientist & Lab Head in Discovery Oncology!
I’ll be hunting new ways to target cancers using my background in disordered nuclear proteins.

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Amy Strom @dnamystrom.bsky.social · Jun 21

Yes drew this sketch, love an excuse to spend a few mins in Illustrator :)

Re bulk chromatin it's hard to tell in vivo since we can't see H3K9me. But, in vitro work suggests yes. Lucy Brennan combined HP1 with Methylated and unmod nucleosomes--only Me in HP1 drops!
www.biorxiv.org/content/10.1...

www.biorxiv.org

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Amy Strom @dnamystrom.bsky.social · Jun 18

The HP1 and BRD4 chimeric constructs help us answer this-- if it were solely the denser placement of affinity polymer blocks, we'd expect the HP1-BRD4 construct (HP1's chromodomain + BRD4's IDR) to also engulf chromatin, but we find the opposite-- it can localize to HC but reduces chrom. density!

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Amy Strom @dnamystrom.bsky.social · Jun 18

Thanks for your great questions!
Yes, exactly, we find that wetting condensates bundle fibers and stiffen the network, contributing to mechanical frustration alongside fiber flexibility and density.
Interestingly, this is re-entrant, with a sweet spot of wetting vol frac (see Ext Data Fig 4f-i)

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Amy Strom @dnamystrom.bsky.social · Jun 17

hah thanks David!

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