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adamezracohen.bsky.social @adamezracohen.bsky.social · Sep 5

My favorite effect is that each channel "sees" its own effect on the membrane voltage, so the statistics of spontaneous gating events become totally different. There are long-lived single-channel memory effects, mediated by membrane voltage.

adamezracohen.bsky.social @adamezracohen.bsky.social · Sep 5

Now that it's realistic to think about imaging voltage in small structures, we need a theory to go along with the data. This preprint is a first attempt at this.

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adamezracohen.bsky.social @adamezracohen.bsky.social · Sep 5

In small enclosed structures (like vesicles), the flickering of individual ion channels can have substantial effects on membrane voltage and internal ion concentrations. Mean-field conductance-based models break down. We studied what happens:
www.biorxiv.org/content/10.1...

Electrophysiology in small compartments

Voltage-gated ion channels are found in many membrane-enclosed structures, including synaptic vesicles, endosomes, mitochondria, chloroplasts, viruses and bacteria. In small compartments, assumptions ...

www.biorxiv.org

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Reposted

Parichy Lab | Dave Parichy @dparichy.bsky.social · Aug 26

Nemo needs gap junctions, too. New preprint with Marleen Klann, Vincent Laudet, et al. showing anemonefish Snowflake mutant due to E42K substitution in Connexin Gja5b. Found exact same E42K in zebrafish gja5b (= leopard) by ENU, to the nucleotide! Details, inferences: www.biorxiv.org/content/10.1...

gap junction mutant phenotypes in clownfish and zebrafish

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Reposted

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · Aug 23

Voltage Imaging of CA1 Pyramidal Cells and SST+ Interneurons Reveals Stability and Plasticity Mechanisms of Spatial Firing https://www.biorxiv.org/content/10.1101/2025.08.20.671230v1

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adamezracohen.bsky.social @adamezracohen.bsky.social · Jul 29

"The axon does not think. It only ax." George Bishop, 1965 😂

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · Jul 28

Dynamics of Excitability in Axonal Trees https://www.biorxiv.org/content/10.1101/2025.07.24.666461v1

adamezracohen.bsky.social @adamezracohen.bsky.social · Jul 22

I like this 😀.

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · Jul 22

Astrocytes connect specific brain regions through plastic gap junctional networks https://www.biorxiv.org/content/10.1101/2025.07.18.665573v1

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adamezracohen.bsky.social @adamezracohen.bsky.social · Jul 1

Jurassic parking.

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adamezracohen.bsky.social @adamezracohen.bsky.social · Jun 26

A rare appearance of my Dad on the internet!

James O'Dwyer @jpodwyer.bsky.social · Jun 26

For “Reflections on the history of modeling and theory”, @sarperotto.bsky.social and I met with Joel Cohen. We learn how he navigated math and biology, the value of embracing ignorance, and what is a population. Or really, what _isn't_ a population: www.youtube.com/watch?v=RCt9...
@smtpb.bsky.social

Reflections on Modeling and Theory in Population Biology: Joel Cohen

YouTube video by SMTPB

www.youtube.com

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adamezracohen.bsky.social @adamezracohen.bsky.social · May 29

Yes, and mine is terminated because we're trying to punish antisemites. Kafka couldn't do better if he tried.

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Sean Eddy @cryptogenomicon.bsky.social · May 28

My father worked in a tire factory in Appalachia. Friends and family in the military. Used to vote Republican. Got into college on a diversity program for the underprivileged. Ended up a Harvard professor. And now my funding is terminated because we're trying to stick it to the elites.

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adamezracohen.bsky.social @adamezracohen.bsky.social · May 28

I wrote about the government's attacks on Harvard. Hope this reaches a few persuadable minds.
prosyn.org/PhWi74r?h=Ky...

Defunding Harvard Hurts America | by Adam Ezra Cohen - Project Syndicate

Adam Ezra Cohen explains the real-world consequences of canceling federal research grants in the name of fighting antisemitism.

prosyn.org

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tsaiwenchen.bsky.social @tsaiwenchen.bsky.social · May 23

My debut on BlueSky! Here’s how we harvest the firing of neurons to see them better in the living brain! 👇

www.nature.com/articles/s41...

Grateful for the amazing dyes from @rhodamine110.bsky.social and insightful suggestions from @adamezracohen.bsky.social !

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adamezracohen.bsky.social @adamezracohen.bsky.social · May 15

Now out in JACS. pubs.acs.org/doi/full/10....
Grateful to thoughtful reviewers who found some errors in our model and encouraged us to make a better one! A renaissance in magnetobiology is coming...

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adamezracohen.bsky.social @adamezracohen.bsky.social · May 4

This guy deserves a Nobel Prize, an IgNobel Prize, and a Darwin Award (honorable mention, for effort).
www.nprillinois.org/2025-05-02/h...

He let snakes bite him some 200 times to create a better snakebite antivenom

Scientists have created a broadly effective antivenom using the blood of a Wisconsin man who has spent years exposing himself to deadly snakebites from black mambas, taipans, cobras and many others.

www.nprillinois.org

adamezracohen.bsky.social @adamezracohen.bsky.social · May 2

Led by Nate Lord, with @harrymcnamara.bsky.social, Alison Guyer, Bill Jia, Vicente Parot, Caleb Dobbs, and Alex Schier.

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adamezracohen.bsky.social @adamezracohen.bsky.social · May 2

Using light to sculpt vertebrate development! OptoNodal2 converts patterns of illumination into patterns of morphogen signaling.
journals.biologists.com/dev/article/...

Zebrafish embryos expressing the OptoNodal receptor. Patterns of illumination control the pattern of Nodal activation.

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adamezracohen.bsky.social @adamezracohen.bsky.social · Apr 23

Yeah, there's a thin ring btwn the coarse focus knob and the microscope body. On one side of the microscope this sets the upper limit to the focus, the other side sets the friction in the focus train. Increase the friction.

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Lauren Kreeger @laurenkreeger.bsky.social · Apr 18

Thrilled that our paper has been published in @elife.bsky.social
doi.org/10.7554/eLif...

We ask: how can a neuron integrate information across multiple time scales?

Twist: This neuron has extreme properties that helps it work ~300x times faster than neurons in the hippocampus

Summary 🧵to follow

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adamezracohen.bsky.social @adamezracohen.bsky.social · Apr 17

Discussing the findings in our recent paper on dendritic voltage imaging in acute brain slices:
www.nature.com/articles/s41...

Dendritic excitations govern back-propagation via a spike-rate accelerometer - Nature Communications

Neural mechanisms mediating information flow and processing in dendrites are not fully understood. Here the authors developed techniques to map bioelectrical excitations in the dendrites of neuro...

www.nature.com

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adamezracohen.bsky.social @adamezracohen.bsky.social · Apr 17

Here's a little essay on dendritic excitations -- what are they for? (hint: I don't think it's for integration, at least not in hippocampal pyramidal cells) brain.harvard.edu/hbi_news/exc...

Excitement Over Dendritic Excitations - Harvard Brain Science Initiative

brain.harvard.edu

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bioRxivpreprint @biorxivpreprint.bsky.social · Apr 8

Injury-induced electrochemical coupling triggers regenerative cell proliferation https://www.biorxiv.org/content/10.1101/2025.04.03.647033v1

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adamezracohen.bsky.social @adamezracohen.bsky.social · Apr 5

Sure. Easy to map potentiated spine density across space. If the expression density is high, the challenge is to trace from the spines along the dendrites back to the parent cell. That would require some sort of high resolution connectomics. Totally plausible, but that would be a project.

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adamezracohen.bsky.social @adamezracohen.bsky.social · Apr 5

Not yet. The problem is we don't know the identity of the presynaptic cells; and typically only a tiny fraction of synapses are potentiated. We (or somebody) should do this in a slice LTP assay.

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adamezracohen.bsky.social @adamezracohen.bsky.social · Apr 3

How about this one?
www.nature.com/articles/s41...

EPSILON: a method for pulse-chase labeling to probe synaptic AMPAR exocytosis during memory formation - Nature Neuroscience

Kim and coworkers describe a technique, EPSILON, to map AMPA receptor exocytosis, a proxy for synaptic plasticity, in mice. The authors demonstrated a correlation between AMPA receptor exocytosis and ...

www.nature.com

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