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Reposted by Ahmad Jomaa

The Daum Lab @daumlab.bsky.social · 2d

Out in Science Advances: Our #cryoEM structure of HFTV1, a virus infecting the halophile #archaea. *First full atomic structure (containing all structural proteins) of any tailed virus!* Congrats and thanks to all co-authors and our fantastic collaborators! www.science.org/doi/10.1126/...

Cryo-EM resolves the structure of the archaeal dsDNA virus HFTV1 from head to tail

This structure of an archaeal tailed virus (arTV) provides detailed insights into arTV assembly and infection mechanisms.

www.science.org

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Reposted by Ahmad Jomaa

Briggs Group @briggsgroup.bsky.social · 2d

The mechanistic basis of cargo selection during Golgi maturation. From Rebecca Taylor, @katciazynska.bsky.social, @jggkaufman.bsky.social & @grigorytagiltsev.bsky.social at @mpibiochem.bsky.social with David Owen and Sean Munro's group @cellbiol-mrclmb.bsky.social | www.science.org/doi/10.1126/...

The mechanistic basis of cargo selection during Golgi maturation

Resident proteins of the Golgi recycle in vesicles and the protein GOLPH3 enables the COPI vesicle coat to accomplish this.

www.science.org

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Reposted by Ahmad Jomaa

Susan Shao @sshaolab.bsky.social · 5d

Beautiful reconstitution of amino acid stress-dependent ISR activation by my @harvardcellbio.bsky.social colleagues presenting a unifying mechanism for GCN2 activation, which requires ribosome collisions and is enhanced by cognate uncharged tRNA in the A site! www.science.org/doi/10.1126/...

GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling

During nutrient deprivation, activation of the protein kinase GCN2 regulates cell survival and metabolic homeostasis. In addition to amino acid stress, GCN2 is activated by a variety of cellular stres...

www.science.org

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Ahmad Jomaa @jomaalab.bsky.social · 5d

Nice!

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Reposted by Ahmad Jomaa

Ben Engel @cellarchlab.com · 18d

A molecular-resolution look into the near-native architecture of the spinach chloroplast🌱. This one was a long time in the oven, but we're happy to finally share our "version of record". What long-standing debates did we settle? Check back for a short thread🧵 on Monday. #TeamTomo #PlantScience 🧪🧶🧬🔬🌾

eLife @elife.bsky.social · 18d

🌱 Using ‘compelling’ methods, including #CryoET, researchers mapped spinach thylakoid membranes at single-molecule precision, revealing how photosynthetic complexes are organised and settling long-standing debates on chloroplast architecture.
buff.ly/j3TSIkn

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Reposted by Ahmad Jomaa

Sazanov Lab @sazanovlab.bsky.social · 20d

How the twin-arginine translocase (Tat) system manages to transport folded proteins across membranes without any leaks? To answer this fundamental question we solved the first structure of TatB3C3 complex with bound cargo. Please check out new preprint!
t.co/962Kj9pt6F

https://www.biorxiv.org/content/10.1101/2025.09.16.676506v1

t.co

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Ahmad Jomaa @jomaalab.bsky.social · 22d

Awesome, congrats Ed!

Reposted by Ahmad Jomaa

Ed Twomey @cryoet.bsky.social · 22d

🚨🧠🔬 A major breakthrough in molecular neuroscience:

I am excited to share a new story from our lab, published in accelerated format today by @nature.com:

"Delta-type glutamate receptors are ligand-gated ion channels"

Read more here (free article link): rdcu.be/eGIKz

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Reposted by Ahmad Jomaa

Edwin Antony @professorantony.bsky.social · 28d

We were one of the lucky ones to receive our NCI award. We have an open postdoctoral fellow or research tech position in the group. If you (or anyone you know) has strong expertise in structural biology or cell biology (genomic instability mechanisms) please reach out. www.antonylab.org

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Reposted by Ahmad Jomaa

The EMBO Journal @embojournal.org · Sep 3

Structural studies by Ahmad Jomaa and colleagues @jomaalab.bsky.social show how NAC on translating #ribosomes couples protein synthesis to N-myristoylation of nascent polypeptides by NMT2
www.embopress.org/doi/full/10....

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Reposted by Ahmad Jomaa

Tanmay Bharat @tbharat-lab.bsky.social · Aug 31

Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging

Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social

www.biorxiv.org/cgi/content/...
@mrclmb.bsky.social @wellcometrust.bsky.social

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Reposted by Ahmad Jomaa

Oli Clarke @olibclarke.bsky.social · Aug 30

Happy to share a new preprint from the Clarke & Vallese (@fravallese.bsky.social) labs reporting #cryoem structures of two RBC stomatin complexes – with AQP1 & UT-B - continuing the SPFH theme from our recent vault preprint! This was a fun one and has been cooking for a while - read on for more! ⬇️

Upper - cryo-EM reconstruction of stomatin AQP1 complex. Lower - reconstruction of stomatin-UT-B complex.

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Reposted by Ahmad Jomaa

Bronwyn Lucas @bronwynalucas.bsky.social · Aug 30

First pre-print from the Lucas Lab led by Matthew Giammar and @joshdcryoem.bsky.social online today! We develop a new, extensible Python implementation of 2DTM and apply it to build pixel size optimization, constrained search and characterize molecular motions in situ www.biorxiv.org/content/10.1...

Leopard-EM: An extensible 2DTM package to accelerate in situ structural biology

The ability to generate high-resolution views of cells with cryogenic electron microscopy (cryo-EM) can reveal the molecular mechanisms of biological processes in their native cellular context. The re...

www.biorxiv.org

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Reposted by Ahmad Jomaa

Dan Grabarczyk @dangrabarczyk.bsky.social · Aug 28

Glad to share the final version of our story about the UBR4 complex, an E4 ligase protein quality control hub @science.org. Now with more cryo-EM structures and a deeper dive into substrate recognition, especially escaped mitochondrial proteins @clausenlab.bsky.social www.science.org/doi/10.1126/...

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Ahmad Jomaa @jomaalab.bsky.social · Aug 29

thank you!

Reposted by Ahmad Jomaa

Dan Grabarczyk @dangrabarczyk.bsky.social · Aug 27

Happy to share our work on the structure and function of the unusual E3 ligase ZNFX1 @cp-cell.bsky.social. It uses a nucleic acid-activated transthiolation mechanism, ubiquitinating and clustering RNA to protect cells in an immune response. @clausenlab.bsky.social
www.cell.com/cell/fulltex...

A split-site E3 ligase mechanism enables ZNFX1 to ubiquitinate and cluster single-stranded RNA into ubiquitin-coated nucleoprotein particles

Grabarczyk et al. show the structure and mechanism of a non-canonical ubiquitin ligase, which is activated through nucleic-acid-induced oligomerization and is critical for cell survival during immune ...

www.cell.com

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Reposted by Ahmad Jomaa

jortegamcgill.bsky.social @jortegamcgill.bsky.social · Aug 27

Our new review paper in stalled neuronal ribosomes with Wayne Sossin @mcgill.ca is out today:
portlandpress-com.proxy3.library.mcgill.ca/biochemsoctr...

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Ahmad Jomaa @jomaalab.bsky.social · Aug 27

thanks, Charles!

Ahmad Jomaa @jomaalab.bsky.social · Aug 27

Thanks, Ling, for all your support!

Ahmad Jomaa @jomaalab.bsky.social · Aug 26

Want to know how lipidation of some nascent chains takes place by NMT2-- Check our latest work on how NAC couples Protein Synthesis with Nascent Polypeptide Myristoylation on the Ribosome out today @embojournal.org‬: www.embopress.org/doi/full/10....

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Ahmad Jomaa @jomaalab.bsky.social · Aug 21

Congrats Niladri!

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Reposted by Ahmad Jomaa

Heather Feaga @heatherfeaga.bsky.social · Aug 19

Latest from the lab! Analysis of everyone’s favorite regulatory mechanism in bacteria — the RF2 programmed frameshift! Likely present in the ancestor of bacteria, use of this mechanism is influenced by stop codon usage! Big congrats to @cassidyprints.bsky.social
journals.asm.org/doi/10.1128/...

Conservation and evolution of the programmed ribosomal frameshift in prfB across the bacterial domain | mBio

Translation termination is catalyzed by one of two release factors in bacteria, RF1 or RF2. It has been known for decades that RF2 levels in Escherichia coli are regulated by a programmed ribosomal frameshift within the prfB gene that encodes RF2. We ...

journals.asm.org

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Ahmad Jomaa @jomaalab.bsky.social · Aug 18

Congrats Mimi and team!

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Reposted by Ahmad Jomaa

Chi-Min Ho @cmholab.bsky.social · Aug 18

Our #CryoET story on how a top antimalarial drug candidate perturbs the native malarial translation machinery is out @natsmb.nature.com🥳 rdcu.be/eBbrH

A massive team effort led by @leonieanton.bsky.social Meseret Haile & Wenjing Cheng in collaboration with Jerzy Dziekan & the Alan Cowman! #TeamTomo

Integrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug

Nature Structural & Molecular Biology - Integrated structural biology approach leveraging in situ cryo-electron tomography reveals molecular details of the native malarial translation...

rdcu.be

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Reposted by Ahmad Jomaa

Structural Biology @actacrystd.iucr.org · Aug 18

How can you find consistent biological 3D structures in heavily contaminated electron microscopy data sets without using any prior knowledge? #CryoEM #SingleParticle #Reconstruction doi.org/10.1107/S205...

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