Structural Biology
@actacrystd.iucr.org
2.8K followers 180 following 230 posts
Acta Crystallographica Section D: Structural Biology is a leading structural biology journal published by the IUCr. journals.iucr.org/d
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actacrystd.iucr.org
Acta Crystallographica Section D - Structural Biology welcomes the submission of articles covering all aspects of structural biology, with a particular emphasis on the structures of biological macromolecules or the methods used to determine them.
➡️ journals.iucr.org/d/
actacrystd.iucr.org
A principled framework is provided for identifying the number of structurally meaningful classes in cryo-EM data sets #CryoEM #3DClassification #StructuralHeterogeneity doi.org/10.1107/S205...
actacrystd.iucr.org
A comprehensive validation process for helical symmetry parameters in the EMDB examines their consistency by combining high-throughput computational evaluation with manual verification #CryoEM #Validation #HelicalSymmetry doi.org/10.1107/S205...
Reposted by Structural Biology
actacrystd.iucr.org
October issue is now available! journals.iucr.org/d/issues/202...

The cover highlights the article on categorizing prediction modes within low-pLDDT regions of AlphaFold2 structures from the Richardson lab @duke-university.bsky.social : doi.org/10.1107/S205...

Image credit: Chistopher Williams
Reposted by Structural Biology
iucr2026.bsky.social
We’re thrilled to announce that abstract submissions for IUCr 2026 are officially OPEN 🎉

🗓 Deadline: February 15, 2026
📍 Location: Calgary, Canada

🔗 Submit your abstract today: www.iucr2026.org/

#IUCr2026 #CallForAbstracts #Crystallography #StructuralScience #science #IUCr
actacrystd.iucr.org
October issue is now available! journals.iucr.org/d/issues/202...

The cover highlights the article on categorizing prediction modes within low-pLDDT regions of AlphaFold2 structures from the Richardson lab @duke-university.bsky.social : doi.org/10.1107/S205...

Image credit: Chistopher Williams
Reposted by Structural Biology
lulu-catapano.bsky.social
🚨 Registration is open for the CCP4 Study Weekend 2026:
“Ligands in Focus: Decoding Ligand Binding in Modern Structural Biology” 🎉
📅 7–9 January 2026

I’m honoured to be a scientific organiser with Tobias Krojer and Stephanie Wankowicz.

👉 Programme & registration: studyweekend.ccp4.ac.uk
Reposted by Structural Biology
glycojones.bsky.social
I'm incredibly proud to present this @actacrystf.iucr.org interview with Alex Mendez and Cydni Bolling on their first paper ever! The interview was co-led by Dr Graham Chakafana from Hampton University in the USA, who supervised the authors' undergraduate research.
www.youtube.com/watch?v=5rjI...
Structure of Plasmodium vivax N-myristoyltransferase with the NMT inhibitor IMP-1088
YouTube video by International Union of Crystallography
www.youtube.com
Reposted by Structural Biology
lacarlson.bsky.social
I've also purified ArnA by mistake (who hasn't?). Did mass spec before plunging it though, so never got this nice structure :)
cryoempapers.bsky.social
Off-target structural insights: ArnA and AcrB in bacterial membrane-protein cryo-EM analysis pubmed.ncbi.nlm.nih.gov/40927951/ #cryoem
actacrystd.iucr.org
S. Narasinga Rao and Manuel Soriano Garcia remember Rengachary Parthasarathy (1939-2025) doi.org/10.1107/S205...
actacrystd.iucr.org
40- and 71-substitution variants of hydroxynitrile lyase demonstrate the essential role of distant, indirectly acting residues to catalysis in α/β-hydrolase enzymes @UMNews #EngineeredProteins #HydroxynitrileLyases #HydrolaseFold doi.org/10.1107/S205...
actacrystd.iucr.org
The role of the hinge-loop composition in domain swapping in the c-Src SH3 domain has been studied by interchanging residues in the RT and n-Src loops between two SH3 domains #SH3Domains #DDomainSwapping #HingeLoop doi.org/10.1107/S205...
actacrystd.iucr.org
By integrating cutting-edge technologies and workflows, XFBLD-Platform addresses key challenges in fragment-based lead discovery, such as throughput, accuracy and data management #FragmentBasedLeadDiscovery #ProteinCrystallography #FragmentScreening doi.org/10.1107/S205...
actacrystd.iucr.org
The three-dimensional structure of the β2-microglobulin-BBM.1 antibody complex lays the groundwork for rational antibody design #Beta2Microglobulin #Antibody #SingleChainVariableFragment doi.org/10.1107/S205...
Reposted by Structural Biology
actacrystd.iucr.org
The September issue is here! tinyurl.com/bdeby9au

The cover highlights XFBLD-Platform, a crystallographic fragment-screening platform at Shanghai Synchrotron Radiation Facility. Find out more at tinyurl.com/36rzxazr
actacrystd.iucr.org
The September issue is here! tinyurl.com/bdeby9au

The cover highlights XFBLD-Platform, a crystallographic fragment-screening platform at Shanghai Synchrotron Radiation Facility. Find out more at tinyurl.com/36rzxazr
actacrystd.iucr.org
Jeroen Mesters remembers Rolf Hilgenfeld (1954-2025) doi.org/10.1107/S205...
actacrystd.iucr.org
John Helliwell reviews Time-Resolved Methods in Structural Biology (Methods in Enzymology Volume 709) doi.org/10.1107/S205...
actacrystd.iucr.org
In 216 ligand-bound structures of human FABP isoforms, many at better than 1.2 Å resolution, an estimated 15% of the ligands had a different chemical composition to that expected #StructureBasedDrugDesign #FattyAcidBindingProteins #LigandBinding doi.org/10.1107/S205...
Reposted by Structural Biology
rcsbpdb.bsky.social
Paper Published: 3DEM Structure-Map Validation Recommendations
Learn how wwPDB is addressing the challenge of validating 3DEM structures against primary map data
Paper Published: 3DEM Structure-Map Validation Recommendations
Learn how wwPDB is addressing the challenge of validating 3DEM structures against primary map data
www.rcsb.org