Sazanov Lab
@sazanovlab.bsky.social
820 followers 690 following 7 posts
Professor, Institute of Science and Technology Austria Visiting Professor, Imperial College London Structure/function of molecular machines and membrane proteins cryoEM Bioenergetics Fellow of Royal Society and EMBO
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sazanovlab.bsky.social
Congratulations, Yifan!
Reposted by Sazanov Lab
stephenturner.us
Apple is entering the protein folding arena.
SimpleFold: Folding Proteins is Simpler than You Think arxiv.org/abs/2509.18480 🧬🖥️🧪 github.com/apple/ml-sim...
sazanovlab.bsky.social
How the twin-arginine translocase (Tat) system manages to transport folded proteins across membranes without any leaks? To answer this fundamental question we solved the first structure of TatB3C3 complex with bound cargo. Please check out new preprint!
t.co/962Kj9pt6F
https://www.biorxiv.org/content/10.1101/2025.09.16.676506v1
t.co
sazanovlab.bsky.social
Interesting shapes and sizes of respiratory complexes
sazanovlab.bsky.social
Happy to share new preprint from our collaboration with Peter Nixon group from Imperial College. New insights into Photosystem II assembly/disassembly.

t.co/Qac81hZ9kp
https://www.biorxiv.org/content/10.1101/2025.07.17.665390v1
t.co
Reposted by Sazanov Lab
davidfinlaytcd.bsky.social
Authors use an elegant transgenic model to demonstrate that acute oral administration of metformin targets mitochondrial complex I to lower blood glucose.

A crucial contribution to the debate about the mechanisms of action of #metformin.

#metabolism #glucose

doi.org/10.1126/scia...
Metformin targets mitochondrial complex I to lower blood glucose levels
Acute oral metformin administration lowers blood glucose levels by targeting mitochondrial complex I.
doi.org
sazanovlab.bsky.social
Árbol del Tule, Montezuma cypress near Oaxaca in Mexico is amazing. It is the biggest tree in the world by trunk width (14 m diameter). How just a few green needles maintain this tree over 2000 years is a mystery to me.
Reposted by Sazanov Lab
paulschanda.bsky.social
Interested in a doing a PhD at Institute of Science and Technology Austria (ISTA)?
Exciting research in phys, chem, structural biology, math, neuro, earth sciences, computer sciences and more...

Sign up here for the virtual student open day Nov 20, 2024.
phd.pages.ista.ac.at/student-open...
Virtual Student Open Day 2024
Each year, the Institute of Science and Technology Austria (ISTA) opens its doors to give prospective PhD and internship candidates an insight into what it is like to study and do research at the inst...
phd.pages.ista.ac.at
sazanovlab.bsky.social
Hi, I heard there is cryo-EM starter pack here - how do I join? Many thanks!