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Reposted by Chi-Min Ho

Meg Younger @megyounger.bsky.social · 20h

It was so fun to work on this with @gkocker.bsky.social and @clienkaemper.bsky.social! It is out @pnas.org
If you love olfaction and love math, this one is for you!
🦟👃🧮

When noncanonical olfaction is optimal | PNAS www.pnas.org/doi/10.1073/...

When noncanonical olfaction is optimal | PNAS

The early olfactory system is canonically described by a “one-receptor-to-one-neuron” model: each olfactory sensory neuron (OSN) expresses a single...

www.pnas.org

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Chi-Min Ho @cmholab.bsky.social · 8d

Congrats, Halil and Team! 🥳

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Reposted by Chi-Min Ho

Aydin Lab @aydinlab.bsky.social · 8d

Excited to share that our paper on mitochondrial cardiolipin dynamics is published in @natcomms.nature.com today! We provide molecular explanations for unique aspects of mitochondrial morphology and the mechanisms underlying cardiolipin-related Barth Syndrome.
www.nature.com/articles/s41...

Cardiolipin dynamics promote membrane remodeling by mitochondrial OPA1 - Nature Communications

This study reveals how cardiolipin governs mitochondrial morphology by modulating the activity of human OPA1 and how its replacement by monolyso-cardiolipin, as observed in Barth syndrome, impacts mitochondrial membrane-shaping mechanisms.

www.nature.com

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Reposted by Chi-Min Ho

NY-CURES @nycures.bsky.social · 14d

Behind every scientist is an army of workers who keep the biomedical research ecosystem running. Hear from these workers and how they contribute at www.nycures.org/ and SIGN UP to have your voice heard!

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Reposted by Chi-Min Ho

Misha Kudryashev @mishakudryashev.bsky.social · 16d

We have a preprint of a book chapter for you: Structural Analysis of Membrane Proteins in Cell-Derived Microvesicles.

We describe how to image membrane proteins in mid-sized vesicles using cryo-electron tomography

zenodo.org/records/1717...

Structural Analysis of Membrane Proteins in Cell-Derived Microvesicles

zenodo.org

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Reposted by Chi-Min Ho

Kexin Zhang @kekexinz.bsky.social · 21d

🚀 Check out our new preprint on extending the scope of single-particle cryo-EM with 2D template matching!
Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching is now available on bioRxiv!
www.biorxiv.org/content/10.1...

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Reposted by Chi-Min Ho

Oli Clarke @olibclarke.bsky.social · 26d

This one is a bit of a departure from the usual and definitely a work in progress!

We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.

Read on for details... 1/x

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Reposted by Chi-Min Ho

NY-CURES @nycures.bsky.social · Sep 4

🚀 NY-CURES Launch — Championing State-Wide Investment in Science! 🚀

Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities.

Sign up. Stay informed. Join the movement: www.nycures.org/

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Reposted by Chi-Min Ho

SBGrid Consortium @sbgrid.bsky.social · Sep 8

Stopping Ribosomes in Action!: a publication highlight from @keandreyam.bsky.social featuring the lab of @cmholab.bsky.social of @columbiauniversity.bsky.social & colleagues.

Read more here: buff.ly/jWYKq7r

#SBGrid #CryoET

Stopping Ribosomes in Action!

SBGrid member Chi-Min Ho uses cryo-electron tomography to map malaria’s ribosomes at work.

buff.ly

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Reposted by Chi-Min Ho

Ahmad Jomaa @jomaalab.bsky.social · Aug 26

Want to know how lipidation of some nascent chains takes place by NMT2-- Check our latest work on how NAC couples Protein Synthesis with Nascent Polypeptide Myristoylation on the Ribosome out today @embojournal.org‬: www.embopress.org/doi/full/10....

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Chi-Min Ho @cmholab.bsky.social · Aug 19

Thanks Judy! Hope to see you again at 3DEM GRC next year :)

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Chi-Min Ho @cmholab.bsky.social · Aug 19

Thank you Freddy!! Miss seeing you at BoP, I got used to hanging out every year! Hoping to attend BioMalPar next spring, so hopefully we get a chance to catch up then :)

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Reposted by Chi-Min Ho

Wai-Hong Tham @thamlab.bsky.social · Aug 8

Cryo-EM of fertilisation complex Pfs230-Pfs48/45 from malaria parasites! 💕

FREE ACCESS reprint link found here: findaresearcher.wehi.edu.au/tham

📱click on 🌎 and last link
💻 last link on the left hand side

#malaria #transmission #cryoEM #ScienceResearch

www.science.org/doi/10.1126/...

Cryo-EM structure of endogenous Plasmodium falciparum Pfs230 and Pfs48/45 fertilization complex

Malaria parasite fertilization occurs in the midgut of a female Anopheles mosquito. Blocking fertilization within the mosquito can prevent malaria transmission. Plasmodium falciparum Pfs230 and Pfs48/...

www.science.org

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Chi-Min Ho @cmholab.bsky.social · Aug 19

Thanks Neel!! 😊

Chi-Min Ho @cmholab.bsky.social · Aug 19

Thanks Ahmad!! ❄️🔬

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Chi-Min Ho @cmholab.bsky.social · Aug 19

Thank you Reika!! ❄️🔬🦠

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Reposted by Chi-Min Ho

Nature Structural & Molecular Biology @natsmb.nature.com · Aug 18

New online: Integrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug

Integrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug

Nature Structural & Molecular Biology, Published online: 18 August 2025; doi:10.1038/s41594-025-01632-3Integrated structural biology approach leveraging in situ cryo-electron tomography reveals molecular details of the native malarial translation elongation cycle and its perturbation by cabamiquine, a potent antimalarial drug candidate.

go.nature.com

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Chi-Min Ho @cmholab.bsky.social · Aug 18

Our #CryoET story on how a top antimalarial drug candidate perturbs the native malarial translation machinery is out @natsmb.nature.com🥳 rdcu.be/eBbrH

A massive team effort led by @leonieanton.bsky.social Meseret Haile & Wenjing Cheng in collaboration with Jerzy Dziekan & the Alan Cowman! #TeamTomo

Integrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug

Nature Structural & Molecular Biology - Integrated structural biology approach leveraging in situ cryo-electron tomography reveals molecular details of the native malarial translation...

rdcu.be

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Reposted by Chi-Min Ho

Ian L Morgan @ianlmorgan.bsky.social · Jul 27

Right now, the continuation of many restored NIH grants relies on the SCOTUS shadow docket. SCOTUS is not immune to pressure.
Also, if you are represented by one of the 14 R senators that called for the restoration of NIH grants, please write them a thank you. Good behavior should be rewarded.

National Institutes of Health v. American Public Health Association

When political ideologies interfere with science, everyone loses.

open.substack.com

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Reposted by Chi-Min Ho

Florian Jug @florianjug.bsky.social · Jul 14

Submit your method to our denoising challenge!!! 👍

AI4Life @ai4life.bsky.social · Jun 27

If unsupervised approaches are your thing, also check out the unsupervised denoising challenge and submit your solutions (the challenge is from last year, but we are still taking entries from everyone who is interested).

👉 ai4life-mdc24.grand-challenge.org

AI4Life Microscopy Denoising Challenge - Grand Challenge

Wellcome to AI4Life-MDC24! In this challenge, we want to focus on an unsupervised denoising of microscopy images. By participating, researchers can contribute to a critical area of scientific research...

ai4life-mdc24.grand-challenge.org

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Reposted by Chi-Min Ho

Kelly Nguyen @kellythd-nguyen.bsky.social · Jul 10

Proud to share our work where we resolved a longstanding question regarding the existence of a human telomerase dimer and provided insights into its function. Led by 3 amazing lab members in collaboration with @yiliangding.bsky.social and @rdaslab.bsky.social.
www.science.org/doi/10.1126/...

Cryo-EM structure of human telomerase dimer reveals H/ACA RNP-mediated dimerization

Telomerase ribonucleoprotein (RNP) synthesizes telomeric repeats at chromosome ends using a telomerase reverse transcriptase (TERT) and a telomerase RNA (hTR in humans). Previous structural work showe...

www.science.org

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Reposted by Chi-Min Ho

Thomas Arnesen @natmachinery.bsky.social · Jul 9

DEGRONOPEDIA - a web server for identifying and predicting protein degradation signals across eukaryotic proteomes. Detailed guide by Natalia Szulc @lumirare.com and Wojciech Pokrzywa @wpokrzywa.bsky.social in Methods in Enzymology. @ispt-proteinterm.bsky.social www.sciencedirect.com/science/arti...

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Reposted by Chi-Min Ho

Juha Huiskonen @juhahuiskonen.bsky.social · Jul 8

In our latest preprint on bioRxiv, we present the in situ structure of
the human gap junction at 14 Å resolution using cryo-ET.

The structure provides a blueprint for investigating how connexin
regulation shapes intercellular communication in health and disease.

CryoET tomogram with the gap junction (green), ribosomes (cyan) and microtubules (pink)

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Reposted by Chi-Min Ho

Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · Jul 5

An Evaluation of Biomolecular Energetics Learned by AlphaFold
by Lyu, Herschlag et al
doi.org/10.1101/2025...

Interesting comparison of AF2/3 structures with the PDB (AF2 appears better)

Reminder: The PDB itself is probably biased relative to solution conformational ensembles and energetics

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Reposted by Chi-Min Ho

Nogales Lab @nogaleslab.bsky.social · Jul 7

Our work, co-led by @alfredo0712.bsky.social and @nlue8.bsky.social is out in @natsmb.nature.com Shout out to coauthors P.Grob, B. Kaeser, J.Fang, and S. Kassube for their contributions and thanks to the reviewers for the suggestions that led to the final work.
www.nature.com/articles/s41...

Structural insights into transcriptional regulation by the helicase RECQL5 - Nature Structural & Molecular Biology

Florez Ariza and Lue et al. use cryo-electron microscopy to investigate how the RECQL5 helicase regulates transcription. Their structural findings suggest that RECQL5 can modulate RNA polymerase II’s ...

www.nature.com

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