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Edwin Antony

@professorantony.bsky.social

2.1K followers 2.7K following 190 posts

Professor of Biochemistry at St. Louis University School of Medicine. Passionate about mechanistic & structural enzymology, electron transfer & nucleic acid binding enzymes. Fascinated by Cryo-EM, kinetics, single molecules and student training. Golf Nut!

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Edwin Antony @professorantony.bsky.social · 3h

Spread the word if you can.
We have an unused stopped flow accessory from Applied Photophysics. We traded in our Chirascan CD instrument so we have no use for this anymore. Reach out if you are interested and can find a home for this setup. Will ofcourse only work with a Chirascan!

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Reposted by Edwin Antony

midwestenzyme.bsky.social @midwestenzyme.bsky.social · 2d

MECC 2025 was a success at UW-Milwaukee! 153 attendees. 76 poster presenters. Talks by 4 faculty, 1 post-doc, 4 grad students, and 1 keynote.

Check out our poster prize winners on the website: mecc2025.midwestenzyme.org/photographs

See you next year in Chicago at Loyola University for MECC 2026!

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Edwin Antony @professorantony.bsky.social · 8d

@midwestenzyme.bsky.social MECC 2025 was a very cool meeting this year. 160 attendees, 80 posters, and great science all around. Thanks to our sponsors @slu-biochemistry.bsky.social @uwmilwaukee.bsky.social Refeyn @ei-science.bsky.social Abbott Inc, Hampton Research, CoAla BioSci, NEB

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Edwin Antony @professorantony.bsky.social · 14d

That would be amazing to have! Thanks

Edwin Antony @professorantony.bsky.social · 14d

ORDERED.......Thanks for the tip!

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Edwin Antony @professorantony.bsky.social · 14d

Yes, yes, yes .......... I want, I need, I drool! Ordering copies for the group tomorrow...

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Reposted by Edwin Antony

Sven T. Stripp @stripplab.bsky.social · 15d

Folks with Christmas around the corner can I suggest a meaningful present real quick? 🎄

https://www.amazon.de/Iron-Sulfur-Clusters-Biochemistry-Silke-Leimk%C3%BChler/dp/3527352554

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Edwin Antony @professorantony.bsky.social · 26d

...and here is the show and tell video for those of you who have a minute to spare

Edwin Antony @professorantony.bsky.social · 27d

Since this is a native structure, it showcases differential occupancy of ADP and 2-oxoglutarate (2OG) thereby priming the complex for immediate remodeling in response to metabolic demands.

Edwin Antony @professorantony.bsky.social · 27d

The structure reveals how nitrogenase is inhibited by the NifI complex. Three units of the NifDK tetramer (MoFe protein of nitrogenase) are bundled together by six NifI1a-NifI1b-Nif2 heterotrimers as a 888 kDa supercomplex made of 30 subunits.

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Edwin Antony @professorantony.bsky.social · 27d

Methanogens are dare-devils that operate near the thermodynamic limits of life, conserving significantly less energy during methane production than aerobic diazotrophs. Thus, efficient regulation of nitrogenase is vital for survival under fluctuating nitrogen conditions.

Edwin Antony @professorantony.bsky.social · 27d

Thanks to funding from the Department of Energy and The Doisy Research Fund @slu-biochemistry.bsky.social

Edwin Antony @professorantony.bsky.social · 27d

Credit for the structural work goes to @rajnandani.bsky.social @slu-biochemistry.bsky.social Heroic effort from Tom Deere in Dan Lessner's group @uarkpress.bsky.social to isolate the native nitrogenase complex from the methanogen. The structure also shows a novel mode of nitrogenase regulation.

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Edwin Antony @professorantony.bsky.social · 27d

STRUCTURE OF A NITROGENASE-PII SUPERCOMPLEX
New work from the oxidoreductase half of the group.
www.biorxiv.org/content/10.1...

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Edwin Antony @professorantony.bsky.social · 27d

We were one of the lucky ones to receive our NCI award. We have an open postdoctoral fellow or research tech position in the group. If you (or anyone you know) has strong expertise in structural biology or cell biology (genomic instability mechanisms) please reach out. www.antonylab.org

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Edwin Antony @professorantony.bsky.social · 28d

I read it this morning. Wonderful study! Another ssDNA binding protein that is amazing in significance!

Reposted by Edwin Antony

Kurianlab @kurianlab.bsky.social · Aug 30

Also, check the accompanying article:

Principles of cotranslational mitochondrial protein import: Cell www.cell.com/cell/fulltex...

Principles of cotranslational mitochondrial protein import

Selective ribosome profiling reveals that nearly 20% of mitochondrial proteins in human cells are imported during translation on cytosolic ribosomes. Cotranslational import requires an N-terminal pres...

www.cell.com

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Reposted by Edwin Antony

Duxin lab @duxinlab.bsky.social · Aug 22

It is not always safe to repair DNA Damage. Sometimes, cells "just bypass it".

During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication.

Read our review and find out why and how: doi.org/10.1016/j.ti...

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Reposted by Edwin Antony

John Ngo @johntngo.bsky.social · Aug 20

My lab at BU is looking to hire a post-doc with experience in biophysics, protein engineering, and chemical (or synthetic) biology. The anticipated start date is Jan 2026. Please send a resume, cover letter, and names/emails for 3 references. We are looking to interview people during Sept/Oct 2025.

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Edwin Antony @professorantony.bsky.social · Aug 20

I see about 14 new R01 applications funded since Aug 10th by the NCI …. and half are MYF!

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Reposted by Edwin Antony

Fusion Conferences @fusionconf.bsky.social · Aug 19

Please help promote the meeting by reposting: @loizoulab.bsky.social @hopfnerlab.bsky.social @lapassmore.bsky.social @raychaudhurilab.bsky.social @hw1o9.bsky.social @westlabcrick.bsky.social @gwuite.bsky.social @dijiang319.bsky.social

Edwin Antony @professorantony.bsky.social · Aug 18

One more week for abstract deadlines for MECC-2025.
Looking forward to seeing many of you in Milwaukee!
mecc2025.midwestenzyme.org

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Reposted by Edwin Antony

Basil Greber @bjgreber.bsky.social · Aug 15

Just published: Our paper on high-throughput analysis of cyclin docking interactions, led by the group of Norman Davey @icr.ac.uk and with some small-complex-plus-peptide #cryoEM by @natalia-mg.bsky.social from my lab. Congratulations, everyone!
www.nature.com/articles/s41...

High-throughput investigation of cyclin docking interactions reveals the complexity of motif binding determinants - Nature Communications

Many protein–protein interactions depend on Short Linear Motifs (SLiMs). In this study, the authors use large-scale binding assays, deep mutational scanning, and structural analysis to map SLiMs recog...

www.nature.com

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Reposted by Edwin Antony

Stacey Ogden 🦔 @labogden.bsky.social · Aug 12

Are you an undergrad thinking about grad school? Check out the St. Jude @stjuderesearch.bsky.social Symposium for Predoctoral Research! 🧪

*Reposts appreciated! 🤓

QR code for information on the 2025 St. Jude Symposium for undergraduate research.

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Reposted by Edwin Antony

Carter Lab @carter-lab.bsky.social · Aug 5

Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before.
www.biorxiv.org/content/10.1...

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