Lightnews — Scholar-powered news

Reposted by Basil Greber

Doudna Lab @doudna-lab.bsky.social · 8h

Congratulations to my colleagues Omar Yaghi and John Clarke — the two latest UC Berkeley Nobel Laureates! Omar’s development of metal-organic frameworks changed the way we capture carbon, store energy, and harvest water from desert air. shorturl.at/GpBsu 1/2

UC Berkeley’s Omar Yaghi shares 2025 Nobel Prize in Chemistry - Berkeley News

Yaghi created a field called reticular chemistry, which involves stitching together molecular building blocks to form porous structures — metal-organic frameworks (MOFs) — with myriad applications.

shorturl.at

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Briggs Group @briggsgroup.bsky.social · 2d

The mechanistic basis of cargo selection during Golgi maturation. From Rebecca Taylor, @katciazynska.bsky.social, @jggkaufman.bsky.social & @grigorytagiltsev.bsky.social at @mpibiochem.bsky.social with David Owen and Sean Munro's group @cellbiol-mrclmb.bsky.social | www.science.org/doi/10.1126/...

The mechanistic basis of cargo selection during Golgi maturation

Resident proteins of the Golgi recycle in vesicles and the protein GOLPH3 enables the COPI vesicle coat to accomplish this.

www.science.org

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Mrs. Betty Bowers @mrsbettybowers.bsky.social · 1d

Thanks, New Yorker

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Michael E. Mann @michaelemann.bsky.social · 2d

“The Party told you to reject the evidence of your eyes and ears. It was their final, most essential command.”

― George Orwell, 1984

Aaron Rupar @atrupar.com · 2d

Mike Johnson: "Let me look right into the camera and tell you very clearly: Republicans are the ones concerned about healthcare. Republicans are the party working around the clock everyday to fix healthcare. This is not talking points for us: we've done it."

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Karolinska Institutet @ki.se · 2d

The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi for their groundbreaking discoveries concerning peripheral immune tolerance that prevents the immune system from harming the body 🧪 www.nobelprize.org/prizes/medic...

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Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 2d

#nobelprize @nobelprize.bsky.social hasn't posted anything yet, so to follow the results live ⬇️

www.youtube.com/live/vUut_3Y...

Announcement of the 2025 Nobel Prize in Physiology or Medicine

YouTube video by Nobel Prize

www.youtube.com

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Harmit Singh Malik @harmitmalik.bsky.social · 3d

I am leaving Rochester NY after attending the retirement fest of four giants in the field of evolutionary biology including my PhD advisor. This visit gave me a chance to revisit old haunts and reflect on my own somewhat unlikely origin story. 1/n

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Ruth Ann Crystal @drruth.bsky.social · 4d

The HPV vaccine is doing what had been promised.
17 years after it became available, HPV infections decreased significantly in vaccinated people and unvaccinated people because of herd immunity. buff.ly/WvjQ1BS

h/t @boghuma.bsky.social

#medsky #pedsky 🛟🧪

Light blue background. Young woman with dark hair makes a sign of strength with her arm and she has a vaccine bandaid on her upper arm. It says "The HPV Vaccine Works!"

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Karolin Luger @nucleosomepolice.bsky.social · 4d

that time of the year... writing letters for 8 UG's applying to grad school, each of them to ~15 programs. And while I passionately support every one of them, thats A LOT of letters, a lot of web sites to keep track of, a lot of my time. Why dont Grad programs use interfolio? One and done???

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The Ass is the father of the legs @internethippo.bsky.social · 5d

"We're going to create superintelligence" How about making outlook search work first. How about that

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Camille Moore @camille-moore.bsky.social · 6d

Today I am so pleased to present our work on how chromatin remodelers affect mesoscale chromatin organization.
www.science.org/doi/10.1126/...

ATP-dependent remodeling of chromatin condensates reveals distinct mesoscale outcomes

Adenosine triphosphate (ATP)–dependent chromatin remodeling enzymes mobilize nucleosomes, but how such mobilization affects chromatin condensation is unclear. We investigate effects of two major remod...

www.science.org

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Michael E. Mann @michaelemann.bsky.social · 7d

Such a loss...
abcnews.go.com/Internationa...

Jane Goodall, famed primatologist and conservationist, dies at 91

Jane Goodall, the most prolific primatologist of a generation, has died. She was 91 years old.

abcnews.go.com

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Alicia Michael @aliciakmichael.bsky.social · 7d

We're hosting the 8th Austrian CryoEM symposium at ISTA Nov 11-12 @istaresearch.bsky.social this year - you don't want to miss! We have a fantastic lineup of invited speakers + selected talks from abstracts #cryoEM
Deadline for abstracts Oct 15
Final deadline Oct 31
cryoem-symposium.pages.ist.ac.at

8th Austrian Cryo-EM Symposium

cryoem-symposium.pages.ist.ac.at

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Alexey Amunts @amunts.bsky.social · 8d

Today, @rcsbpdb.bsky.social introduces Q-score in EM validation reports. Q-score assesses model-map fit. A new percentile slider will compare an entry’s average Q-score to the full archive and a resolution-matched subset. This would help judge whether the fit is typical for the reported resolution.

Introducing the first 3DEM Model-Map percentile slider to the wwPDB validation report

Introducing the latest wwPDB Percentile slider based on the Q-score model-map validation metric

www.rcsb.org

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Ben Engel @cellarchlab.com · 8d

EXCITING NEWS!! We're searching for a new professor colleague at the Biozentrum🇨🇭. Ideal candidates are exploring novel biological questions with structure, biophysics, or high-resolution imaging. 🧪 🧶🧬 🔬

The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩‍🔬🤓

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Lucas Farnung @lucas.farnunglab.com · 9d

New week, new tool: Find our Protein Domain Designer tool to generate publication-ready protein domain diagrams here: domaindesigner.farnunglab.com

Protein Domain Designer tool for the generation of publication-ready protein domain diagrams

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The Guardian @theguardian.com · 10d

As my daughter got sicker and sicker, our quest for answers dragged on. How did we all miss the bacteria taking over her body?

I write about nature, but when Milly got sick with a mystery illness, it never occurred to me that a long-forgotten tick bite could be the cause

www.theguardian.com

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Sjors Scheres @sjorsscheres.bsky.social · 12d

For those reviewing #cryoEM structures of #amyloids, please read: journals.iucr.org/d/issues/202...

Amyloid structure determination in RELION-3.1

Amyloid structure determination in RELION is increasingly popular, but may suffer from refinements becoming stuck in local minima. This paper describes a new method for initial model generation that m...

journals.iucr.org

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Basil Greber @bjgreber.bsky.social · 12d

Impressive results, instant feedback, immediate updates. Almost starts to feel like the heydays of #cryoEM Twitter.

Oli Clarke @olibclarke.bsky.social · 13d

Initial attempt at replicating in relion (parameters in next post). This is for Aca2-RNA, using a 100k subset of the 2D-classified particles (no prior 3D cleanup).

A 1-class ab initio in relion, then local refinement in relion (1.8deg searches+blush) gives a nominally 3.3Å map; 3.5 Å w/out blush.

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Basil Greber @bjgreber.bsky.social · 13d

My understanding too. I think other major publishers have similar policies.

Basil Greber @bjgreber.bsky.social · 13d

You are correct: Many do not. But I guess they will (have to) soon.

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Basil Greber @bjgreber.bsky.social · 15d

Synthetic shell, probably, yes. These are remarkably huge in cells, and they are packed with cargo, too.

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Basil Greber @bjgreber.bsky.social · 15d

Cool indeed. But shouldn’t that carboxysome (a real-life cellular one, I mean) be a fair bit bigger?

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Basil Greber @bjgreber.bsky.social · 15d

👀

Caitie McCafferty @computingcaitie.bsky.social · 15d

I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate www.biorxiv.org/content/10.1... #cilia #protistsonsky 🧬🧪

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Stuart Neil @tetherin.bsky.social · 15d

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