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Doudna Lab @doudna-lab.bsky.social · 6d

"Her work made it impossible to separate what we learn from our obligation to protect it. Generations of researchers have tried to follow that example." - Jennifer Doudna (2/2)

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Doudna Lab @doudna-lab.bsky.social · 6d

"Jane Goodall showed us what a life in science could look like: rigorous discovery paired with fierce advocacy for what you study. She gave the world six decades of groundbreaking research on chimpanzees and their habitats, then turned that knowledge into a global movement for conservation." (1/2)

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Innovative Genomics Institute @innovativegenomics.bsky.social · 6d

then turned that knowledge into a global movement for conservation. Her work made it impossible to separate what we learn from our obligation to protect it. Generations of researchers have tried to follow that example." 2/2

Photos of Jane Goodall in Gombe National Park, credit Simon Fraser University

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Innovative Genomics Institute @innovativegenomics.bsky.social · 6d

From IGI Founder Jennifer Doudna: "Jane Goodall showed us what a life in science could look like: rigorous discovery paired with fierce advocacy for what you study. She gave the world six decades of groundbreaking research on chimpanzees and their habitats... 1/2

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Doudna Lab @doudna-lab.bsky.social · 6d

Published alongside complementary work from our friends
@benmorehouse.bsky.social & @aaronwhiteley.bsky.social, led by @aesully98.bsky.social

www.nature.com/articles/s41...

The Panoptes system uses decoy cyclic nucleotides to defend against phage - Nature

The Panoptes antiphage system defends bacteria by detecting phage-encoded counter-defences that sequester cyclic nucleotide signals, triggering membrane disruption and highlighting a broader strategy of sensing immune evasion through second-messenger surveillance.

www.nature.com

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Doudna Lab @doudna-lab.bsky.social · 6d

New paper online at @nature.com from co-leads @erinedoherty.bsky.social + @benadler.bsky.social !

Erin Doherty @erinedoherty.bsky.social · 6d

Now online at @nature.com we show how the Panoptes defense system protects against viruses that attempt immune evasion - and expands our understanding of the role of oligonucleotides in immunity.

Check out this work co-led with @benadler.bsky.social here:

www.nature.com/articles/s41...

A miniature CRISPR–Cas10 enzyme confers immunity by inhibitory signalling - Nature

Panoptes, an anti-phage defence system against virus-mediated immune suppression, is revealed.

www.nature.com

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Ben Morehouse @benmorehouse.bsky.social · 6d

Our story describing the Panoptes bacterial immune defense system is now finally peer-reviewed and published today! www.nature.com/articles/s41...

The Panoptes system uses decoy cyclic nucleotides to defend against phage - Nature

The Panoptes antiphage system defends bacteria by detecting phage-encoded counter-defences that sequester cyclic nucleotide signals, triggering membrane disruption and highlighting a broader strategy of sensing immune evasion through second-messenger surveillance.

www.nature.com

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Waggoner Lab @labwaggoner.bsky.social · 6d

Bacteria use a decoy defense molecule to set a trap for viruses @doudna-lab.bsky.social @ucberkeleyofficial.bsky.social @ucirvine.bsky.social @aaronwhiteley.bsky.social @colorado.edu @aesully98.bsky.social
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...

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Ben Adler @benadler.bsky.social · 6d

Today in @nature.com , we highlight how a cousin of CRISPR-Cas10, mCpol, establishes an evolutionary trap in anti-phage immune systems.

Check out @erinedoherty.bsky.social and my work from @doudna-lab.bsky.social lab here:
www.nature.com/articles/s41...

A miniature CRISPR–Cas10 enzyme confers immunity by inhibitory signalling - Nature

Panoptes, an anti-phage defence system against virus-mediated immune suppression, is revealed.

www.nature.com

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Reposted by Doudna Lab

Innovative Genomics Institute @innovativegenomics.bsky.social · 6d

Out today in @nature.com, a new paper from @doudna-lab.bsky.social lab, co-first authors @erinedoherty.bsky.social + @benadler.bsky.social and collaborators at @ucsandiego.bsky.social unveils a powerful new defense strategy in the arms war between viruses + microbes. Read here: ow.ly/mPQI50X5g68

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Doudna Lab @doudna-lab.bsky.social · 7d

Congrats to Doudna lab postdoc @erinedoherty.bsky.social! 🎊

berkeleyMCB @berkeleymcb.bsky.social · 7d

Congrats to our 2025 MCB Outstanding Postdoc Award recipients who are being honored for their excellence in research, leadership, and service! 👏🎉Erin Doherty @erinedoherty.bsky.social, Kevin Eislmayr, Naohiro Kuwayama, & Joseph Lobel
mcb.berkeley.edu/news-and-eve...

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Doudna Lab @doudna-lab.bsky.social · Aug 22

New pre-print from Doudna lab members @erinedoherty.bsky.social & @jnoms.bsky.social ✨

Here we explore how recurrent adaptation of a single anti-defense protein fold enables evasion of distinct immune systems.

Erin Doherty @erinedoherty.bsky.social · Aug 22

Excited to share our new preprint co-led by @jnoms.bsky.social!

Here we reveal an exceptional diversity of viral 2H phosphodiesterases (PDEs) that enable immune evasion by selectively degrading oligonucleotide-based messengers. This 2H PDE fold has evolved striking substrate breath & specificity.

Divergent viral phosphodiesterases for immune signaling evasion

Cyclic dinucleotides (CDNs) and other short oligonucleotides play fundamental roles in immune system activation in organisms ranging from bacteria to humans. In response, viruses use phosphodiesterase...

www.biorxiv.org

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Innovative Genomics Institute @innovativegenomics.bsky.social · Aug 21

@jenniferdoudna.bsky.social @doudna-lab.bsky.social
talks about the history and future of #CRISPR with Cleo Abram! Check out the interview: www.youtube.com/watch?v=0OXa...

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Innovative Genomics Institute @innovativegenomics.bsky.social · Jul 31

In a recent paper, IGI's @jenniferdoudna.bsky.social @doudna-lab.bsky.social and Jill Banfield @banfieldlab.bsky.social collaborate with UCLA's @jacobsenucla.bsky.social to create a new, tiny #CRISPR tool for quicker, easier plant genome editing! Read more in this Q&A with Steve: ow.ly/6Szs50VGElf

Tiny CRISPR Tool Opens the Door to Faster, Simpler Plant Genome Editing

Tiny CRISPR Tool Opens the Door to Faster, Simpler Plant Genome Editing - Innovative Genomics Institute (IGI)

ow.ly

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Doudna Lab @doudna-lab.bsky.social · Jul 29

‼️ New pre-print from co-leads @owentuck.bsky.social and Jason Hu! Check out this fascinating example of how coevolution enables defense system innovation.

Owen Tuck @owentuck.bsky.social · Jul 29

Excited to finally share this work!
We noticed a pair of genes - a nuclease and a protease - shuffles between antiviral systems. We show how proteolysis activates the nuclease, triggering defense in known and unknown immune contexts.
tinyurl.com/2uwwy4ty

Recurrent acquisition of nuclease-protease pairs in antiviral immunity

Antiviral immune systems diversify by integrating new genes into existing pathways, creating new mechanisms of viral resistance. We identified genes encoding a predicted nuclease paired with a trypsin...

tinyurl.com

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Eric Topol @erictopol.bsky.social · Jul 8

A new Pediatric Center for CRISPR Cures builds on the recent saved life of Baby KJ, who expeditiously had bespoke in vivo base genome editing
@jenniferdoudna.bsky.social @doudna-lab.bsky.social
@innovativegenomics.bsky.social
@chanzuckerberg.bsky.social
erictopol.substack.com/p/new-center...

Our conversation photo and photo of Baby KKJ

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Innovative Genomics Institute @innovativegenomics.bsky.social · Jun 24

“What we’ve done here is uncover the secret sauce that makes typical #Cas9 — the original Nobel molecule — so efficient and precise." – Co-first author Honglue Shi of the @doudna-lab.bsky.social on his recent paper in Molecular Cell

Read here: innovativegenomics.org/uncovering-c...

Kevin Wasko (left) and Honglue Shi in front of their gel imager, confirming that the SpRY Cas9 variant struggles to effectively open DNA

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Innovative Genomics Institute @innovativegenomics.bsky.social · Jun 12

Thanks to the BBC's The Inquiry program for great conversations with IGI's @jenniferdoudna.bsky.social @doudna-lab.bsky.social and @urnov.bsky.social about Baby KJ, #CRISPR on-demand, and the future of personalized medicine!

Listen here: www.bbc.com/audio/play/w...

Photo credit: TODAY

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Doudna Lab @doudna-lab.bsky.social · Jun 12

Registration is open for the 2025 Computational Structural Virology Symposium, featuring Doudna lab postdoc @jnoms.bsky.social!

Jason Nomburg @jnoms.bsky.social · Jun 12

Hello everyone! I am pleased to share information on the first ever Computational Structural Virology Symposium, conducted August 4th on zoom and highlighting work in this emerging field. You can register for this event here: forms.gle/CNiqskMwQEuV.... Please re-post!

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Jason Nomburg @jnoms.bsky.social · Jun 12

Hello everyone! I am pleased to share information on the first ever Computational Structural Virology Symposium, conducted August 4th on zoom and highlighting work in this emerging field. You can register for this event here: forms.gle/CNiqskMwQEuV.... Please re-post!

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Kaustuva Das @kaustuvadas.bsky.social · May 29

US supercomputer named after Nobel laureate Jennifer Doudna @jenniferdoudna.bsky.social @innovativegenomics.bsky.social to power AI and scientific research
apnews.com/article/nvid...

US supercomputer named after Nobel laureate Jennifer Doudna to power AI and scientific research

A new supercomputer named after a winner of the Nobel Prize in chemistry will help power artificial intelligence technology and scientific discoveries from a perch in the hills above the University of...

apnews.com

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Doudna Lab @doudna-lab.bsky.social · May 28

Congratulations to Matt on this incredible accomplishment! 🎉This K08 will allow him to continue developing CRISPR based therapies for children with inherited immune diseases.

Matthew Kan @matthewkan.bsky.social · May 27

Elated to share that I was awarded a K08 clinician-scientist research career development award from the National Institutes of Allergy and Infectious Diseases!

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Matthew Kan @matthewkan.bsky.social · May 27

Elated to share that I was awarded a K08 clinician-scientist research career development award from the National Institutes of Allergy and Infectious Diseases!

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Doudna Lab @doudna-lab.bsky.social · May 27

Congrats to Doduna lab postdoc @erinedoherty.bsky.social for being selected as a Leading Edge Fellow! @leadingedgeprogram.bsky.social

Leading Edge Fellows Program @leadingedgeprogram.bsky.social · May 27

We are thrilled to announce the 2025 Leading Edge Fellows! 40 outstanding postdoctoral fellows doing pioneering research in a wide range of biological and biomedical disciplines.

Learn more about these exceptional scientists:

www.leadingedgesymposium.org/fellows

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Jane Coffin Childs Fund for Medical Research @jcchildsfund.bsky.social · Apr 24

Congrats to Dr. Honglue Shi @honglue.bsky.social on his latest research! The importance of weak, yet specific, interactions 👀

@doudna-lab.bsky.social @cellpress.bsky.social

Doudna Lab @doudna-lab.bsky.social · Apr 23

Now online at Molecular Cell! What makes SpyCas9 such an efficient editor? Read more at: www.cell.com/molecular-ce...

Congrats @honglue.bsky.social, Noor Al-Sayyad, and @kevinwasko.bsky.social!

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