Lightnews — Scholar-powered news

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Raquel Fueyo @fueyoraquel.bsky.social · 6d

Today in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK.
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD

A human-specific regulatory mechanism revealed in a pre-implantation model

Nature - Genetic manipulation of blastoids reveals the role of recently emerged transposable elements and genes in human development.

rdcu.be

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Sweta Agrawal @hokuba.bsky.social · 6d

The Agrawal lab is moving! This January we will be setting up shop at #UBC in Vancouver, in the department of #Zoology! We are actively recruiting at all levels, especially masters and PhD students. These position are #funded! Please send anyone interested my way!

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Dr. Liz Haynes 🐟🔬 @drlizhaynes.bsky.social · 12d

Here's a movie from the 3D neuroimaging paper - this is the telencephalon of a 19 month old tg(kdrl:mCherry, mpeg1:eGFP) fish. We use imaris to strip the top layer (the skin and skull) off the projection so we can see just the tissue beneath the skull. This was taken with a Bruker 2P+ multiphoton.

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Dr. Liz Haynes 🐟🔬 @drlizhaynes.bsky.social · 12d

Want to image the adult zebrafish brain? Here's a nifty design that I made with the help of a talented master's student, Corey Steinhauser.

Supporting files here!
morgridge.org/research/lab...

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Andrea Jones, PhD @dr-andrea-jones.bsky.social · 12d

My pre-print from the Shikanov Lab is live! We detail oocyte and somatic transcriptome, and whole follicle proteome signatures driving folliculogenesis in vitro towards improved ART. www.biorxiv.org/content/10.1...

Transcriptomic and proteomic dynamics of ovarian follicle group culture resemble in vivo folliculogenesis

The prohibitively low yield of fertilizable oocytes obtained from cultured ovarian follicles limits clinical translation of in vitro follicle maturation for fertility preservation. This is in part due...

www.biorxiv.org

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eartha mae @endoeartha.bsky.social · 13d

Very excited and proud to share my postdoctoral research with @neurrriot.bsky.social looking at the context-specific encoding of social behavior 💃🕺 in hormone-sensitive, large-scale brain networks in mice!

www.biorxiv.org/content/10.1...

#neuroskyence #compneurosky 🧪
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Laura Seeholzer @lauraseeholzer.bsky.social · 23d

Feeling grateful for everyone who supported me during my PhD and post-doc training: my incredible mentors David Julius and Vanessa Ruta, my wonderful lab mates, and the amazing communities @leadingedgeprogram.bsky.social @ucsfhealth.bsky.social @rockefelleruniv.bsky.social and HHWF

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Laura Seeholzer @lauraseeholzer.bsky.social · 23d

I'm excited to share that I've started my lab @stanford.edu in the Neurobiology Department! neurobiology.stanford.edu/who-we-are/f...

#stanford #newPI #neuroscience

Faculty

neurobiology.stanford.edu

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Christina Fitzsimmons @fitzsimmonscm.bsky.social · Aug 25

Excited to announce the opening of the @fitzsimmonslab.bsky.social at @michiganstateu.bsky.social dept. of biochemistry & molecular biology! (1/3)

A photo of a newly renovated science lab with metal cabinets and tile floors. Select pieces of equipment such as test tube racks and chairs are visible.

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UC Davis @ucdavis.bsky.social · Aug 22

@accorsi-alice.bsky.social studies how freshwater apple snails regrow their eyes—with the goal of helping to restore vision in people with eye injuries. Her team developed methods for editing the snail’s genome, allowing them to explore the genetic and molecular mechanisms behind eye regeneration.

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Meike van der Heijden @meikeesther.bsky.social · Aug 22

I’m honored to serve on @dystoniafoundation.bsky.social ‘s medial and scientific advisory board for the next four years.

news.vt.edu/articles/202...

Meike van der Heijden appointed to Dystonia Foundation’s medical and scientific advisory council

Council members are international leaders in dystonia care and research. They review research grants for funding and attend workshops to discuss the most pressing research directions.

news.vt.edu

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Erin Doherty @erinedoherty.bsky.social · Aug 22

Excited to share our new preprint co-led by @jnoms.bsky.social!

Here we reveal an exceptional diversity of viral 2H phosphodiesterases (PDEs) that enable immune evasion by selectively degrading oligonucleotide-based messengers. This 2H PDE fold has evolved striking substrate breath & specificity.

Divergent viral phosphodiesterases for immune signaling evasion

Cyclic dinucleotides (CDNs) and other short oligonucleotides play fundamental roles in immune system activation in organisms ranging from bacteria to humans. In response, viruses use phosphodiesterase...

www.biorxiv.org

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Sumru Bayin @sumrubayin.bsky.social · Aug 22

Excited to share our recent viewpoint with @storerlab.bsky.social led by Kirsten Sadler, on epigenetic mechanisms of regenerative resilience.

Ageing versus developmental silencing: Answers from the epigenome - Sadler - The FEBS Journal - febs.onlinelibrary.wiley.com/doi/10.1111/...

FEBS Press

It is easier for young animals to regenerate damaged or missing tissues. In this Viewpoint, we propose that this is, in part, attributed to epigenetic changes, with chromatin becoming more closed and....

febs.onlinelibrary.wiley.com

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Caroline Bartman @cbartman.bsky.social · Aug 15

Happy to get to contribute to this perspective in JEM!

Journal of Experimental Medicine @jem.org · Aug 15

#WomenInSTEM becoming independent: People should feel free to be themselves and do great science. We asked ten women researchers about their science and the process of setting up a lab as an independent researcher: rupress.org/jem/article/...

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Stowers Institute @stowersinstitute.bsky.social · Jul 28

This #MicroscopyMonday is a developing Apple Snail embryo. On the left is the shell, the middle the body & the foot at the bottom. On the right the head with the eye (green circle) & the tentacle bud. (@planaria1.bsky.social lab) #ResearchSky #SciSky

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Stowers Institute @stowersinstitute.bsky.social · Aug 6

🐌👀What do apple snails have to do with human vision?

Stowers scientists took a chance on a tiny creature, with big results. Learn how @planaria1.bsky.social & then postdoc @accorsi-alice.bsky.social brought apple snails to the Institute. ⬇️ #ResearchSky #SciSky

Learn more: youtu.be/U-yQ7z1e6nA

How Apple Snail research began at the Stowers Institute: unlocking the secrets of eye regeneration

YouTube video by Stowers Institute for Medical Research

youtu.be

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Matt Barber @biobarber.bsky.social · Aug 1

This week we said farewell to the amazing @caitlinkowa.bsky.social as she moves to start her new lab at Dartmouth. So grateful for all her leadership and mentoring the last few years.

If you’re interested in all things skin microbes (especially fungi) check out her lab! I can’t recommend enough.

HOME

Visit the post for more.

caitlinkowalski.com

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bishara marzook @ghostpathogen.bsky.social · Jul 24

Our paper has finally graduated from pre-print to peer-reviewed, pretty much unscathed, and is out now! www.cell.com/cell/fulltex...

The essential host genome for Cryptosporidium survival exposes metabolic dependencies that can be leveraged for treatment

An arrayed microscopy-based CRISPR screen revealed host genes affecting multiple infection phenotypes of the intracellular parasite Cryptosporidium. Hits in the host cholesterol biosynthesis pathway a...

www.cell.com

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Ines Sturmlechner @inessturmlechner.bsky.social · Jul 14

I’m excited to share our new T cell aging study published in Nature Communications @natcomms.nature.com !

We show that T cells do not age uniformly but undergo distinct aging trajectories even if they were primed simultaneously early in life.

www.nature.com/articles/s41...

👇👇

Antigen specificity shapes distinct aging trajectories of memory CD8⁺ T cells - Nature Communications

Homeostasis of memory T cells is modulated by each antigen encounter, thereby creating a heterogeneous population preventing precise tracking. Here, the authors use barcode-assisted tracing of Epstein...

www.nature.com

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Sweta Agrawal @hokuba.bsky.social · Jul 7

Which llms are best for coding help? what strategies help students actually learn how to write and eval code? I'll continue asking probing q's and emphasize checking work, but rn feel like i cant trust any of their plots...2/2

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Sweta Agrawal @hokuba.bsky.social · Jul 7

This summer I'm noticing students embracing vibe coding for data analysis to worrying effect. #Neuroskyence #🧪 1/2

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Caroline Bartman @cbartman.bsky.social · Jul 7

Super excited to share my final postdoc paper from Rabinowitz lab- on how whole-body and tissue metabolism changes in viral infection!
pubmed.ncbi.nlm.nih.gov/40581045/

pubmed.ncbi.nlm.nih.gov

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DLRamamurthy @dlramamurthy.bsky.social · Jul 3

My postdoc work on attention in the mouse whisker system is out now in @natcomms.nature.com! We show that mice flexibly allocate attention to recently rewarded touch stimuli on a trial-by-trial basis, with corresponding modulation of the S1 neural code (1/6).

Dan Feldman @danfeldman.bsky.social · Jul 1

New paper from Deepa Ramamurthy in my lab, just out. Mice flexibly shift attention between different whiskers based on the recent history of whisker stimuli and rewards, during a tactile detection task. We saw a strong neural correlate of this attentional capture in S1 cortex.

rdcu.be/euij3

Reward history guides focal attention in whisker somatosensory cortex

Nature Communications - Mice flexibly shift attention between specific whiskers on a rapid timescale based on recent stimulus reward history in a detection task. Attention is correlated with a...

rdcu.be

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Hannah Ledvina Ph.D. @hannahledvina.bsky.social · Jul 2

Words cannot describe how excited I am to share the findings from the second half of my postdoc in @aaronwhiteley.bsky.social's lab where we discover that bacteria use functional amyloids to defend themselves from predatory bacteria. rdcu.be/euu5Y. See thread for details on this epic adventure 1/.

Functional amyloid proteins confer defence against predatory bacteria

Nature - Escherichia coli uses curli fibres, oligomers of the functional amyloid CsgA, as a barrier to protect against the predatory bacteria Bdellovibrio bacteriovorus and Myxococcus xanthus in a...

rdcu.be

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Anna Vlasits @annaintegrated.bsky.social · Jul 2

Exciting news:
⭐I'm thrilled to receive a grant from the Brain Research Foundation! tinyurl.com/2p9ku4sd

⭐"Atypical retinal ganglion cell function in a mouse model of Fragile X syndrome" was published! tinyurl.com/htk3ekce

⭐my review on retinal receptive fields was published! tinyurl.com/48b9xbs2

a picture of a woman with the words this is exciting below her

ALT: a picture of a woman with the words this is exciting below her

media.tenor.com

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