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Ines Sturmlechner

@inessturmlechner.bsky.social

130 followers 230 following 10 posts

Post-doc, K99 awardee, studying the aging immune system at Mayo Clinic, Leading Edge fellow, former AFAR/Glenn Foundation fellow | PhD, cellular senescence at University Groningen and Mayo Clinic | MSc, tRNA maturation at IMBA Vienna

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Ines Sturmlechner @inessturmlechner.bsky.social · Jul 14

I’m excited to share our new T cell aging study published in Nature Communications @natcomms.nature.com !

We show that T cells do not age uniformly but undergo distinct aging trajectories even if they were primed simultaneously early in life.

www.nature.com/articles/s41...

👇👇

Antigen specificity shapes distinct aging trajectories of memory CD8⁺ T cells - Nature Communications

Homeostasis of memory T cells is modulated by each antigen encounter, thereby creating a heterogeneous population preventing precise tracking. Here, the authors use barcode-assisted tracing of Epstein...

www.nature.com

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Reposted by Ines Sturmlechner

Waggoner Lab @labwaggoner.bsky.social · 2d

Get your Zoster vaccine! @naturemedicine.bsky.social
A consistent relationship of VZV reactivation with dementia in 100M US adults after controlling for nearly 400 measured characteristics, with zoster vaccines reducing risk of dementia in dose-dependent manner
www.nature.com/articles/s41...

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Reposted by Ines Sturmlechner

Salk Institute @salkinstitute.bsky.social · 2d

Applications are now open for the Salk SURF — a fully funded, 10-week program that gives undergraduate students access to world-class facilities, mentorship from leading scientists, and a supportive community of peers.

📅 Deadline: December 7, 2025

Apply today: www.salk.edu/about/our-communi...

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Reposted by Ines Sturmlechner

American Aging Association @americanaging.bsky.social · 20d

Research Spotlight: Dr. @inessturmlechner.bsky.social, PhD – Mayo Clinic

Her new Nature Communications study reveals how antigen specificity shapes aging paths of memory CD8⁺ T cells, explaining immune decline & infection risk in older adults.

👉 Read: www.nature.com/articles/s41...

#AgingResearch

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Ines Sturmlechner @inessturmlechner.bsky.social · Aug 15

Congrats! Very interesting topic!

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Reposted by Ines Sturmlechner

ulrichtechnau.bsky.social @ulrichtechnau.bsky.social · Jul 26

Great opportunity! The Uni Vienna has launched a call (APART) for 4-funding for outstanding postdocs from a US institution. The host lab has to nominate by 1 August a candidate for further selection. Anyone interested in our work please contact me by email with CV/motivation letter. Hurry up!

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Reposted by Ines Sturmlechner

Max Kozlov @maxkozlov.bsky.social · Jul 14

This story was made possible thanks to NIH staff who reached out. I'm always looking for more sources, message me on Signal (mkozlov.01).

If you hit a paywall, making a free account will open the full story.

Exclusive: NIH to dismiss dozens of grant reviewers to align with Trump priorities

The move would undo years of work, leaving advisory councils understaffed, and without the full expertise needed for reviews.

www.nature.com

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Ines Sturmlechner @inessturmlechner.bsky.social · Jul 14

Huge thank you 🙏 to my awesome co-first author Abhinav Jain @abhinav1993.bsky.social, all co-authors, the Robert & Arlene Kogod Center on Aging, AFAR @afar.org, and the San Diego NSC @nathanshockcenters.org for all their support! 🙏

Ines Sturmlechner @inessturmlechner.bsky.social · Jul 14

➡️ intriguing contribution of TCR avidity in this process – low TCR avidity may select for cells prone to acquire innate/NK features, while high TCR avidity associates with stem-like features and may be lost with aging

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Ines Sturmlechner @inessturmlechner.bsky.social · Jul 14

➡️ many aging changes are happening and common to many, but not all, EBV-specific T cell populations is a loss of stem-like traits and a gain of lymphocyte innateness = CD8+ T cells become more like NK cells as they age

➡️ no evidence of age-related exhaustion or cellular senescence

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Ines Sturmlechner @inessturmlechner.bsky.social · Jul 14

➡️ human memory CD8+ T cells specific to different Epstein-Barr virus proteins acquire diverse phenotypes already in young adults

➡️ depending on the antigen specificity, these memory CD8+ T cells follow divergent phenotypic and transcriptional aging trajectories, in older adults

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Ines Sturmlechner @inessturmlechner.bsky.social · Jul 14

Antigen specificity shapes distinct aging trajectories of memory CD8⁺ T cells - Nature Communications

www.nature.com

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Reposted by Ines Sturmlechner

Bérénice A. Benayoun, PhD @bbparis1984.bsky.social · Jul 11

✨✨ #GLAM2025 ✨✨ is back 9/5/2025 to showcase #geroscience trainee research! Registration and poster submission are open (and #FlashTalk selection for #undergrads!).
Event website: gero.usc.edu/laara/event/...
Thanks to @activemotifusa.bsky.social, #Hevolution and #VWR for their support!

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Reposted by Ines Sturmlechner

Nature @nature.com · Jun 30

Inflammation, thought to be a driver of age-related disease, does not worsen with age in some Indigenous communities

https://go.nature.com/45NHWSr

Ageing is linked to inflammation — but only in the industrialized world

Inflammation, thought to be a driver of age-related disease, does not worsen with age in some Indigenous communities.

go.nature.com

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Reposted by Ines Sturmlechner

Bérénice A. Benayoun, PhD @bbparis1984.bsky.social · Jun 18

🚨 Preprint alert 🚨 , spearheaded by the talented Mr. #RyanLu, a graduate student: "Murine peritoneal macrophages undergo female-specific remodeling with aging", a functional genomics study of sex-dimorphism ♀️♂️ in #immune #aging 🖥️🧬🧪. #GeroSky #ImmunoSky 🧵, 1/13
www.biorxiv.org/content/10.1...

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Reposted by Ines Sturmlechner

Waggoner Lab @labwaggoner.bsky.social · Jun 7

Preprint: Antigen-specific Th17 T cells offset the age-related decline in durable T cell immunity
www.biorxiv.org/content/10.1...
@inessturmlechner.bsky.social

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Ines Sturmlechner @inessturmlechner.bsky.social · May 27

Thank you, Matt!!

Ines Sturmlechner @inessturmlechner.bsky.social · May 27

I’m so excited and honored to be part of this incredible community!

Leading Edge Fellows Program @leadingedgeprogram.bsky.social · May 27

We are thrilled to announce the 2025 Leading Edge Fellows! 40 outstanding postdoctoral fellows doing pioneering research in a wide range of biological and biomedical disciplines.

Learn more about these exceptional scientists:

www.leadingedgesymposium.org/fellows

Reposted by Ines Sturmlechner

Nathan Shock Centers Coordinating Center @nathanshockcenters.org · May 14

Call for Applications! The 32nd Annual NIA Training Course provides intense exposure to current concepts in experimental aging research for a cohort of 15-20 research scientists. Applications are due July 1, 2025. Learn more here: bit.ly/44y6RIY

Reposted by Ines Sturmlechner

Dan Tyrrell @danis1337.bsky.social · Apr 25

Super excited to announce our new paper (and tool) spearheaded by
@hasansiam.xyz
! CAFE (cell analyzer for flow experiments) is a user-friendly web app to analyze flow cytometry data. No coding required! Check out the paper academic.oup.com/bioinformati... 🔬💻

Fig. 2. Profiling of Human PBMCs Reveals Distinct Immune Subpopulations and
Marker Expression Patterns. (a) UMAP plots showing selected marker expression intensities across all cells in the UMAP space to highlight lineage-specific marker distribution.
(b) Dot plot of all marker expression across all identified PBMC cell types. Dendrogram
highlighted distinct marker-based groupings. (c) UMAP visualization showing 16
distinct clusters with annotated cell types including Naive CD4 and CD8 T cells, central
memory CD4 and CD8 T cells (Tcm), effector memory CD8 T cells (Tem), terminally
differentiated effector memory CD8 T cells (Temra), mucosal-associated invariant (MAIT)
T cells, classical monocytes (cMO), intermediate monocytes (iMO), B cells, NK cells,
gamma delta (γδ) T cells (Tgd), conventional dendritic cell (cDC) and plasmacytoid dendritic
cell (pDC).

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Ines Sturmlechner @inessturmlechner.bsky.social · Apr 25

This sounds very cool and useful!!
Congrats!

Ines Sturmlechner @inessturmlechner.bsky.social · Mar 23

Congrats!!

Reposted by Ines Sturmlechner

BrunetLab @brunetlab.bsky.social · Mar 22

Interested in aging?

Super excited about this upcoming Keystone meeting!! 🧪🌲🌲
Aging: Immune Function and Organ Health -- Banff, Canada in 2026!!! ✨✨

Joint meeting with the Keystone Innate Immunity meeting!

#aging #immunity @keystonesymposia.bsky.social

www.keystonesymposia.org/conferences/...

Aging: Immune Function and Organ Health | Keystone Symposia

Join us at the Keystone Symposia on Aging: Immune Function and Organ Health, March 2026, in Banff, with field leaders!

www.keystonesymposia.org

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Reposted by Ines Sturmlechner

Laura Haynes👩‍🔬⚾️🐾💙 @drlaurahaynes.bsky.social · Jan 18

Just found this account celebrating the achievements of women👇🏽

WomanToday @womantoday.bsky.social · Jan 18

1/ Frances Elizabeth Allen (1932–2020) was an American computer scientist and pioneer in the field of optimizing compilers. #WomenInSTEM

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Reposted by Ines Sturmlechner

Research Centers Collaborative Network (RCCN) @rccn-aging.org · Jan 10

Applications are now open for the NIA Butler-Williams Scholars Program which provides unique opportunities for new/junior investigators to gain insight about #AgingResearch. Learn more and apply here: bit.ly/4h9NQiX

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Reposted by Ines Sturmlechner

Bérénice A. Benayoun, PhD @bbparis1984.bsky.social · Jan 8

Biological sex is a key modifier of #aging phenotypes, including #Brain 🧠 aging.
See this piece out today in #Neuron, spearheaded by @denadubal.bsky.social, co-authored by #YousinSuh, @ctmurphy1.bsky.social and myself on the topic:
www.sciencedirect.com/science/arti...
#GeroSky #SexDifferences

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