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BrunetLab

@brunetlab.bsky.social

3.8K followers 3.6K following 210 posts

Aging lab @Stanford. Our interests include mechanisms of aging, brain aging and rejuvenation, neural stem cell aging, genetics of lifespan and suspended animation in killifish

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BrunetLab @brunetlab.bsky.social · Dec 18

Thrilled to see this paper out!! 🧪

Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!

Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!

rdcu.be/d33uQ 🧵

Spatial transcriptomic clocks reveal cell proximity effects in brain ageing

Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...

rdcu.be

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Deborah Kronenberg-Versteeg @debkrov.bsky.social · 6d

✨ It's happening again! 🚀 Registration for Stem Cells in Neuroscience 2026 has officially opened! 🧠 Don't miss your chance to attend this exciting event with great keynote speakers, thought-provoking workshops and ample networking opportunities 👉🏼 www.stemcelltuebingen.com #neuroscience #stemcells

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Coleen Murphy @ctmurphy1.bsky.social · 14d

It should be great!

EMBO @embo.org · 15d

Learn all things C. elegans #research at the EMBO | The Company of Biologists Workshop "C. elegans Biology: IV LAWM" in Merida, Mexico, 24–28 February 2026.

Registration by 16 January 2026
Abstract submission by 17 October 2025

meetings.embo.org/event/26-worm
#EMBOWorms2026 #EMBOevents 🧪

C. elegans Biology: IV LAWM

This EMBO Workshop on C. elegans Biology is t he IV Latin American Worm Meeting. It will convene in Mérida, Mexico. The overall mission of this meeting is to create an inclusive environment that pro…

meetings.embo.org

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BrunetLab @brunetlab.bsky.social · 14d

Interesting in aging, immune function, and organ health?

Join us for a super exciting joint Keystone Symposia in Banff, Canada in March 2026!!

@ericverdin.bsky.social

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American Society for Cell Biology @ascbiology.bsky.social · 19d

🎉 Congratulations to Needhi Bhalla, UC Santa Cruz (www.bhallalab.com
), named a 2025 #ASCB Fellow! This honor celebrates her outstanding contributions to cell biology, leadership, & service. Fellows will be recognized at #CellBio2025 in Philadelphia this December. #CellBiology

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Jesse Engreitz @jengreitz.bsky.social · 19d

New preprint from our lab!

What can we learn about the properties of gene regulatory elements by CRISPR’ing a random set of accessible sites in human cells?

Find out here: www.biorxiv.org/content/10.1...

👇

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bioRxiv - An unbiased survey of distal element-gene regulatory interactions with direct-capture targeted Perturb-seq

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BrunetLab @brunetlab.bsky.social · 21d

Exciting meeting in beautiful Ascona, Switzerland!!

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David Vilchez @thevilchezlab.bsky.social · Sep 3

🚨 New from our lab: Here we explored how aging contributes to harmful protein aggregation in diseases like Huntington’s & ALS.
The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch
🧵
www.nature.com/articles/s43...

The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivation - Nature Aging

Aging is a risk factor for neurodegenerative diseases associated with protein aggregation. Here the authors identify age-related hyperactivation of EPS8/RAC signaling in C. elegans as a driver of path...

www.nature.com

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Marlen Knobloch @knoblochlab.bsky.social · Aug 26

Save the date and apply! We are organising another edition of the Monte Verità meeting “Neurogenesis from development to adulthood in health and disease”, March 30th to April 2nd 2026. Fantastic line up of speakers and beautiful setting! More details can be found here: neuro-unige.ch/news/csf-mee...

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Martin Kampmann @kampmann.bsky.social · Aug 22

Excited that the paper presenting our mouse brain in vivo CRISPR screening platform is out today in @natneuro.nature.com!

Great team effort, led by Biswa Ramani and @ivlrose.bsky.social in the Kampmann lab.

www.nature.com/articles/s41...

CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes - Nature Neuroscience

The authors developed an adeno-associated virus-based high-throughput in vivo CRISPR screening platform for endogenous mouse brain cell types. Using this platform, they define genes and pathways essen...

www.nature.com

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Marla Feller @mfeller.bsky.social · Aug 20

Come join our new Department of Neuroscience @ucberkeleyofficial.bsky.social as an Assistant Professor! aprecruit.berkeley.edu/JPF05041

Assistant Professor - Molecular, Cellular, and Developmental Neuroscience - Department of Neuroscience

University of California, Berkeley is hiring. Apply now!

aprecruit.berkeley.edu

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Eileen Furlong @eileen-furlong.bsky.social · Jul 30

To all post-docs: The Genome Biology dept ‪@embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Group Leader - Genome Biology Unit

Are you ready to lead groundbreaking research in Genome Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group addressing exciting and original biological...

embl.wd103.myworkdayjobs.com

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Anne West @ennatsew.bsky.social · Jul 27

The Anne West lab at Duke is hiring a postdoc to work on nuclear cell biology in neurogenesis. Please help me spread the word! Applications to [email protected].

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eLife @elife.bsky.social · Jul 21

🧬June's most-read Genetics paper independently validates previous research showing that #CElegans can inherit learned pathogen avoidance: buff.ly/IFNoPF3

Have a paper people should see? See what our Editors look for: buff.ly/WiP1juL

electron microscopy image of a C elegans on a yellow background

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randolab.bsky.social @randolab.bsky.social · Jun 30

Happy to share our review at Cell Stem Cell as part of their Hallmarks series. As always, a pleasure to work with friends and colleagues Anne Brunet (@brunetlab.bsky.social) and Peggy Goodell(@goodell-lab.bsky.social).

Hallmarks of stem cell aging: Cell Stem Cell www.cell.com/cell-stem-ce...

Hallmarks of stem cell aging

Aging disrupts core functions of somatic stem cells throughout the body, leading to impaired tissue maintenance and repair. We identify five key features of aged stem cells, highlighting how their dys...

www.cell.com

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BrunetLab @brunetlab.bsky.social · Jun 25

Excited to share our review on Hallmark of Stem Cell Aging! With Tom Rando and Peggy Goodell @goodell-lab.bsky.social!!

www.sciencedirect.com/science/arti...

Hallmarks of stem cell aging

As organisms age, somatic stem cells progressively lose their ability to sustain tissue homeostasis and support regeneration. Although stem cells are …

www.sciencedirect.com

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Seth Blackshaw @sethblackshaw.bsky.social · Jun 19

New collaborative study out with Mark Wu’s group identifies a thalamic reuniens-zona incerta circuit as both responsive to induced sleep deprivation and essential for mediating recovery sleep. Further perspective on this work follows./1
www.science.org/doi/epdf/10....

Sleep need–dependent plasticity of a thalamic circuit promotes homeostatic recovery sleep

Prolonged wakefulness leads to persistent, deep recovery sleep (RS). However, the neuronal circuits that mediate this process remain elusive. From a circuit screen in mice, we identified a group of th...

www.science.org

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Ardem Patapoutian @ardemp.bskyverified.social · Jun 19

I spoke with Jade Hindmon, host of @kpbssandiego.bsky.social Midday Edition, about the consequences of the current administration’s cuts to science funding. Please share to help spread the word and raise awareness.
www.kpbs.org/podcasts/kpb...

Nobel laureate on how Trump's cuts are hurting science

Neuroscientist, biologist and 2021 Nobel Prize winner Ardem Patapoutian joined Midday Edition to talk about how the Trump administration's effort to cut back on science spending is impacting researche...

www.kpbs.org

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Amy Walker @akw-lab.bsky.social · May 6

1/n Fellow C elegans enthusiasts!

For those of you using WormCat for RNA seq pathway analysis, we are working on the 3.0 version. Comments on annotations/website welcome. Either PM here or let's talk at the Worm meeting in Davis. #Worm25 #celegans

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Coleen Murphy @ctmurphy1.bsky.social · Jun 17

Highlighting this new paper NOT by my lab, but by Andres Vidal-Gadea's lab: doi.org/10.7554/eLif...
#Celegans - more to say on this later 🧪

Independent Validation of Transgenerational Inheritance of Learned Pathogen Avoidance in Caenorhabditis elegans

doi.org

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euanashley @euanashley.bsky.social · Jun 14

Atul Butte died yesterday.
The world lost a giant.
A big bear of a man.
With a huge smile.
With love for everyone.
With energy that could power a room.
I loved everything about Atul.
I loved how he was always happy.
I loved how excited he was about science and helping people.

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Lamming Lab @lamminglab.bsky.social · May 30

Sad to learn we lost Keith Blackwell, an unsung hero of the aging field. Keith showed rapamycin extends C. elegans lifespan, that mTORC2 has diet-dependent effects on aging, and linked together skn1 TOR splicing and aging.
www.legacy.com/us/obituarie...

THOMAS BLACKWELL Obituary (1957 - 2025-05-09) - Boston, MA - Boston Globe

View THOMAS KEITH BLACKWELL's obituary, send flowers and sign the guestbook.

www.legacy.com

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Antebi Lab @antebilab.bsky.social · Apr 28

Preprint alert @biorxivpreprint! We are excited to share our latest study led by @kkawamura13.bsky.social @annadiederich01.bsky.social in collaboration with & C. Demetriades Lab & @muellerrom.bsky.social Lab
www.biorxiv.org/content/10.1...

Resilience and restoration from fasting-refeeding mediated by a nutrient-regulated linker histone

Intermittent fasting and fasting-refeeding regimens can slow biological aging across taxa[1][1]. Shifts between fed and fasted states activate ancient nutrient-sensing pathways which alter cellular an...

www.biorxiv.org

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Coleen Murphy @ctmurphy1.bsky.social · Jun 5

I'm giving a talk tomorrow morning about my book ("How We Age"). But the slides already feel out of date because 1) there are so many new stories in the field, and 2) science as we know it is being destroyed, so the pipeline from ideas to drugs will dry up soon. Sigh

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Coleen Murphy @ctmurphy1.bsky.social · Jun 4

A few days late, but I’m happy to post our recent publication on body-to-brain signaling regulation of memory in Nature Aging:

Nature Aging @nataging.nature.com · Jun 2

Online now!✨RESEARCH: Zhou, Novak et al show that the hypodermis regulates memory in C. elegans via insulin/IGF-1 and Notch signaling; activating this pathway rescues CREB-dependent memory in aged worms @ctmurphy1.bsky.social www.nature.com/articles/s43... rdcu.be/eo3Pd

Body-to-brain insulin and Notch signaling regulates memory through neuronal CREB activity - Nature Aging

Zhou, Novak and colleagues identify that the Caenorhabditis elegans hypodermis, a peripheral liver-like metabolic tissue, regulates memory via insulin/IGF-1 and Notch signaling, and show that activati...

www.nature.com

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Stefano Cacciatore @tkcaccia.bsky.social · Jun 2

KODAMA goes spatial.
doi.org/10.1101/2025...
#spatialtranscriptomics #visium #visiumhd #seurat #giotto

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