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Lamming Lab @lamminglab.bsky.social · 5d

Perhaps the most important paper of the decade with respect to how cells sense amino acid insufficiency, finally laying to rest the idea that GCN2 is activated by uncharged tRNAs!

Susan Shao @sshaolab.bsky.social · 5d

Beautiful reconstitution of amino acid stress-dependent ISR activation by my @harvardcellbio.bsky.social colleagues presenting a unifying mechanism for GCN2 activation, which requires ribosome collisions and is enhanced by cognate uncharged tRNA in the A site! www.science.org/doi/10.1126/...

GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling

During nutrient deprivation, activation of the protein kinase GCN2 regulates cell survival and metabolic homeostasis. In addition to amino acid stress, GCN2 is activated by a variety of cellular stres...

www.science.org

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Lamming Lab @lamminglab.bsky.social · 26d

Thanks to all our collaborators and colleagues who helped make this possible, including @drcaragreen.bsky.social @mikemacarthur.bsky.social Cholsoon Jang @judisimcox.bsky.social Kristen Malecki and many more!

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Lamming Lab @lamminglab.bsky.social · 26d

Diet analysis by Michael MacArthur shows that humans who score highly on the Healthy Eating Index (HEI) score have a lower relative isoleucine intake.

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Lamming Lab @lamminglab.bsky.social · 26d

Importantly, by looking across different genetic backgrounds Michaela was able to identify a core set of molecular pathways engaged by IleR, providing new insights into the molecular mechanisms by which it functions.

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Lamming Lab @lamminglab.bsky.social · 26d

Michaela showed that isoleucine restriction (IleR) prevents metabolic syndrome in mice fed a Western diet, with beneficial effects on metabolic health across strains and in both sexes. Conversely, excess dietary Ile has strain-specific effects on fat mass and insulin resistance.

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Lamming Lab @lamminglab.bsky.social · 26d

We have a thesis defense to celebrate today, but first - we need to celebrate the publication of former student Dr. Michaela Trautman's opus, "Dietary isoleucine content modulates the metabolic and molecular response to a Western diet in mice" now in Mol Metab! www.sciencedirect.com/science/arti...

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Lamming Lab @lamminglab.bsky.social · Sep 5

Thanks to all our colleagues and collaborators including @drcaragreen.bsky.social, Michelle Sonsalla, Chung-Yang Yeh, @baileyknopf.bsky.social, Teresa Liu, Shoshana Yakar @sadagurski.bsky.social and many more who made this work possible!

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Lamming Lab @lamminglab.bsky.social · Sep 5

Here is the link to the paper, demonstrating that valine restriction has robust effects on healthspan in both sexes and a sex-specific benefit for lifespan in males. www.biorxiv.org/content/10.1...

www.biorxiv.org

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Lamming Lab @lamminglab.bsky.social · Sep 5

Our most recent work by graduate student @mariahcalubag
- demonstrating the sex-specific extension of lifespan by valine restriction was presented last week at #ARDD2025 and is now available on bioRxiv! Thanks to Daniela Bakula, @scheibyeknudsenlab.bsky.social, and Alex Zhavoronkov for the invite!

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Lamming Lab @lamminglab.bsky.social · Aug 4

Our results suggest that not only how much we eat - but also when - may influence the development and progression of Alzheimer’s disease.

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Lamming Lab @lamminglab.bsky.social · Aug 4

Reji asked if the benefits of CR for Alzheimer's disease also depend on fasting - and found that YES, a prolonged fast between meals is necessary for the benefits of CR, including reduced Alzheimer’s pathology, improved neuroprotective signaling, and improved cognition.

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Lamming Lab @lamminglab.bsky.social · Aug 4

Here we build on previous work by @heidipak.bsky.social who showed that fasting between meals was required for the benefits of a calorie restricted (CR) diet on metabolic health, frailty, and lifespan. www.nature.com/articles/s42...

Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice - Nature Metabolism

Pak et al. show that prolonged fasting is required for the effects of calorie restriction on insulin sensitivity, fuel utilization and ageing in mice.

www.nature.com

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Lamming Lab @lamminglab.bsky.social · Aug 4

"Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer's disease" from first author Dr. Reji Babygirija and with our collabs including @wiscosurgicalmetab.bsky.social is now available online! www.nature.com/articles/s41...

Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer’s disease - Nature Communications

Caloric restriction improves Alzheimer’s Disease outcomes in mice, but this diet not only reduces calories, but imposes a prolonged fast between meals. Here, the authors show this fast is essential to...

www.nature.com

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