Lightnews — Scholar-powered news

Karolinska Institutet @ki.se · 13h

KI researchers comment on this year’s #NobelPrize in Physiology or Medicine. The prize rewards discoveries that reveal how our immune system is kept in check, paving the way for possible new therapies for cancer and autoimmune diseases like type 1 diabetes and MS 🧪 news.ki.se/nobel-prize-...

Nobel Prize rewards key to future MS and cancer treatment

The year’s Nobel Prize in Physiology or Medicine rewards discoveries that reveal how our immune system is kept in check – in other words, how the body protects itself from attack by its own immune cel...

news.ki.se

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Karolinska Institutet @ki.se · 2d

Link to publication: doi.org/10.1073/pnas...

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

doi.org

Karolinska Institutet @ki.se · 2d

A study published in @pnas.org by Marie Wahren-Herlenius and colleagues at KI and @liu.se reveals that a gene associated with several rheumatic diseases affects how cells move, providing new insights into disease mechanisms and potential future therapies 🧪 #rheumatology news.ki.se/gene-linked-...

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Karolinska Institutet @ki.se · 2d

The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi for their groundbreaking discoveries concerning peripheral immune tolerance that prevents the immune system from harming the body 🧪 www.nobelprize.org/prizes/medic...

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Karolinska Institutet @ki.se · 8d

In a new study published in @natcomms.nature.com, researchers have investigated how the physical structure of fat tissue helps ovarian cancer cells invade the body, offering potential new treatment strategies 🧪

rdcu.be/eIJna

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Karolinska Institutet @ki.se · 12d

A study in @ofidjournal.bsky.social demonstrates the feasibility of detecting Mycobacterium tuberculosis DNA in respiratory aerosols using the TB Hotspot detectOR (THOR) in primary care. This method could help identify infectious TB cases. #Tuberculosis 🧪
academic.oup.com/ofid/advance...

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Karolinska Institutet @ki.se · 12d

Link to publication: doi.org/10.1038/s414...

An injury-associated lobular microniche is associated with the classical tumor cell phenotype in pancreatic cancer - Nature Communications

Peritumoural pancreatitis and lobular injury are commonly seen in pancreatic cancer. Here, the authors reveal interactions between invading tumour cells and inflammation-related lobular cells, linked to switching from a basal to classical tumor cell phenotype.

doi.org

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Karolinska Institutet @ki.se · 12d

Tumour cells grow not only in the connective tissue-rich environment typical of #PancreaticCancer, but also in damaged parts of the pancreas. This may play a role in how tumours in the pancreas develop and respond to treatment. New study published in @natcomms.nature.com 🧪 news.ki.se/tumour-cells...

Tumour cells exploit damaged tissue in the pancreas

Pancreatic cancer is one of the most aggressive cancer types. A new study from Karolinska Institutet, in collaboration with the Department of Pathology at Karolinska University Hospital, shows that tu...

news.ki.se

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Karolinska Institutet @ki.se · 14d

A new study published in @thelancet.bsky.social discusses the efficacy and controversies of anti-β amyloid monoclonal antibodies in treating #AlzheimersDisease. The findings highlight the potential and challenges of these treatments
🧪
www.thelancet.com/journals/lan...

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Karolinska Institutet @ki.se · 15d

A study in @jamanetworkopen.com shows that women with premenstrual disorders (PMDs), particularly PMDD, have significantly lower quality of life compared to those without PMDs. This highlights the need for better healthcare and social support for affected women. 🧪
jamanetwork.com/journals/jam...

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Karolinska Institutet @ki.se · 22d

Link to publication: doi.org/10.1172/JCI1...

JCI - TIE2 activation by antibody-clustered endogenous angiopoietin-2 prevents capillary loss and fibrosis in experimental kidney disease

doi.org

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Karolinska Institutet @ki.se · 22d

Researchers at KI, @uu.se and Northwestern University have identified a new way to protect the kidney’s blood vessels and reduce tissue damage in chronic #kidneydisease. The findings are published in @jclinical-invest.bsky.social. #Nephrology 🧪 news.ki.se/new-antibody...

New antibody may slow kidney damage

Researchers at Karolinska Institutet, Uppsala University and Northwestern University have identified a new way to protect the kidney’s blood vessels and reduce tissue damage in chronic kidney disease....

news.ki.se

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Reposted by Karolinska Institutet

Knut and Alice Wallenberg Foundation @kawresearch.bsky.social · 29d

Wallenberg Scholar Rickard Sandberg @ki.se aims to deepen our understanding of how the brain’s synapses develop by mapping gene activity in neurons. To achieve this, he is developing new methods of exploring the uncharted field of splicing #research @rickardsandberg.bsky.social
tinyurl.com/mtpde34z

Understanding the brain | Knut and Alice Wallenberg Foundation

Wallenberg Scholar Rickard Sandberg aims to deepen our understanding of how the brain’s synapses develop by mapping gene activity in neurons. To achieve this, he is developing new methods of exploring...

tinyurl.com

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Karolinska Institutet @ki.se · Sep 8

By 2021, 15% of young women in Stockholm identified as bisexual – a group facing greater mental health and social challenges than their heterosexual and homosexual peers. New KI study published in @amjpublichealth.bsky.social. #Sexuality #LGBTQ 🧪 ajph.aphapublications.org/doi/epdf/10....

Temporal Trends in Sexual Identity and Sociodemographic Disparities in Stockholm, Sweden, 2010–2021

ajph.aphapublications.org

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Reposted by Karolinska Institutet

Knut and Alice Wallenberg Foundation @kawresearch.bsky.social · Sep 1

The Iberian ribbed newt has the ability to heal its own heart after an injury. The secret might lie in a specific protein also found in humans. Elif Eroglu @ki.se studies salamanders to discover new ways of regenerating our heart cells after a #heartattack.
#research #medicine tinyurl.com/mssmcmc2

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Karolinska Institutet @ki.se · Sep 1

A study from KI & @helsinki.fi published in @cp-cellrepmed.bsky.social shows that low interferon type I activity in ovarian cancer cells predicts poor response to platinum-based chemotherapy. Stimulating this pathway may improve outcomes for chemo-refractory #OvarianCancer 🧪 doi.org/10.1016/j.xc...

Redirecting

doi.org

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Karolinska Institutet @ki.se · Aug 26

A study shows that cancer screening not only reduces the risk of dying from cancer – it also does not increase the risk of dying from other diseases. The results counter previous criticism of benefits and safety of screening.
Published in ‪@jamainternalmed.com‬ 🧪
jamanetwork.com/journals/jam...

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Karolinska Institutet @ki.se · Aug 21

Frequent dried blood spot sampling in mice reveals transient proteomic changes that enable early prediction and prevention of #Type1Diabetes. The study is published in Diabetologia by researchers at KI, @kthuniversity.bsky.social and @scilifelab.se. #Proteomics #Diabetes 🧪 doi.org/10.1007/s001...

Frequent longitudinal blood microsampling and proteome monitoring identify disease markers and enable timely intervention in a mouse model of type 1 diabetes - Diabetologia

Aims/hypothesis Type 1 diabetes manifests after irreversible beta cell damage, highlighting the crucial need for markers of the presymptomatic phase to enable early and effective interventions. Curren...

doi.org

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Karolinska Institutet @ki.se · Aug 18

Final call: Applications close September 2! KI is recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential. All positions: ki.se/en/about-ki/...

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Karolinska Institutet @ki.se · Aug 18

A new study in ‪@natbiomedeng.nature.com‬ introduces GenomePAM, a method for direct PAM characterization in mammalian cells. This technique leverages genomic repetitive sequences and does not require protein purification or synthetic oligos. #GenomeEditing #CRISPR 🧪
www.nature.com/articles/s41...

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Reposted by Karolinska Institutet

Knut and Alice Wallenberg Foundation @kawresearch.bsky.social · Aug 13

Wallenberg Scholar @gocastelobranco.bsky.social @ki.se is seeking to discover what happens in the brain during the progression of #multiplesclerosis (MS). His findings may lead to new ways of diagnosing and treating the disease earlier than is currently possible #research tinyurl.com/3kb22kkh

New methods to map the progression of MS | Knut and Alice Wallenberg Foundation

Wallenberg Scholar Gonçalo Castelo-Branco is seeking to discover what happens in the brain during the progression of multiple sclerosis (MS). His findings may lead to new ways of diagnosing and treati...

tinyurl.com

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Karolinska Institutet @ki.se · Aug 12

A new study in reveals three distinct genetic subtypes of follicular lymphoma, aiding in better diagnosis and personalized treatment. This could significantly improve patient outcomes. Published in ‪@cp-cellrepmed.bsky.social‬ 🧪
#Lymphoma #Genetics
www.cell.com/cell-reports...

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Karolinska Institutet @ki.se · Aug 6

A new study published in Modern Pathology reveals that the growth pattern of breast cancer tumors after neoadjuvant treatment can indicate the risk of recurrence. This insight is crucial for assessing patient prognosis 🧪
#BreastCancer #Oncology
www.modernpathology.org/article/S089...

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Karolinska Institutet @ki.se · Jul 10

Link to publication ⬇️
www.science.org/doi/10.1126/...

Down-regulation of human-specific lncRNA TMEM9B-AS1 in skeletal muscle of people with type 2 diabetes affects ribosomal biogenesis

TMEM9B-AS1, down-regulated in type 2 diabetes, regulates ribosomal biogenesis in muscle by promoting IGF2BP1-MYC mRNA interaction.

www.science.org

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Karolinska Institutet @ki.se · Jul 10

Researchers have discovered a previously unknown molecule that may explain why people with type 2 diabetes often suffer from muscle weakness and muscle loss – a condition that has a major impact on quality of life. Research by @annakrook.bsky.social et al 🧪

news.ki.se/newly-discov...

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