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Reposted by Carter Lab

Simon Bullock @simonbullock11.bsky.social · Aug 5

Our latest work, in collaboration with the terrific @kashishsingh.bsky.social in the Carter lab @mrclmb.bsky.social is out. So proud of this study and everyone involved...

bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · Aug 2

Cryo-EM structures of Egl-BicD-RNA complexes reveal how diverse mRNAs are selected for subcellular localization https://www.biorxiv.org/content/10.1101/2025.08.02.668268v1

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Carter Lab @carter-lab.bsky.social · Aug 5

Here is the correct link: www.biorxiv.org/content/10.1...

Cryo-EM structures of Egl-BicD-RNA complexes reveal how diverse mRNAs are selected for subcellular localization

Localization of mRNAs is a widespread mechanism for controlling where proteins operate in cells and underpins many fundamental processes, from embryonic patterning to synaptic plasticity. This spatial...

www.biorxiv.org

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Carter Lab @carter-lab.bsky.social · Aug 5

Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before.
www.biorxiv.org/content/10.1...

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Carter Lab @carter-lab.bsky.social · Jul 11

Check out this exciting new study from the @rgassmann.bsky.social lab that we are thrilled to be part of — revealing that CDR2 is a dynein adaptor that regulates ER sheet organization!!

Journal of Cell Biology @jcb.org · Jul 10

Teixeira et al. @i3suporto.bsky.social identify the onconeural antigen CDR2 as an ER-localized adaptor for the microtubule-based motor cytoplasmic dynein-1 & show that CDR2 contributes to ER organization thru. its interaction w/ the integral ER membrane protein kinectin. rupress.org/jcb/article/...

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Carter Lab @carter-lab.bsky.social · Feb 28

In Today's #journalclub, we had a look at how TinA can make the kinesin-14 KlpA to switch to minus-end processivity on microtubules in vitro:

www.biorxiv.org/content/10.1...

TinA enables kinesin-14/KlpA to exhibit processive minus-end-directed motility

Kinesin-14 motors contribute to spindle assembly by localizing to spindle poles and anchoring the minus ends of spindle microtubules. Unlike other kinesin-14 motors, KlpA uniquely exhibits plus-end-di...

www.biorxiv.org

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Carter Lab @carter-lab.bsky.social · Feb 21

Today in #journalclub, we looked at this fantastic new method from the @doudna-lab.bsky.social in Nature Biotechnology! They show how CRISPR–Csm enables single-molecule live-cell imaging of endogenous RNAs. Super cool!
www.nature.com/articles/s41...

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Carter Lab @carter-lab.bsky.social · Feb 7

A new study reveals how alternative splicing fine-tunes dynein cargo specificity! ZYG-12/Hook uses different isoforms to recruit dynein to either early endosomes or the nuclear envelope, showcasing a clever mechanism for organelle-specific transport. #journalclub
www.molbiolcell.org/doi/abs/10.1...

Molecular Biology of the Cell (MBoC)

www.molbiolcell.org

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Carter Lab @carter-lab.bsky.social · Feb 7

Today in #journalclub, we looked at the new study from Nguyen et al. showing how Cryo-EM captures early steps in dynein activation by LIS1. They identified a novel ‘Pre-Chi’ intermediate, shedding light on how LIS1 relieves dynein autoinhibition!
www.biorxiv.org/content/10.1...

Cryo-EM captures early intermediate steps in dynein activation by LIS1

Cytoplasmic dynein-1 (dynein) is an essential molecular motor in eukaryotic cells. Dynein primarily exists in an autoinhibited “Phi” state and requires conformational changes to assemble with its cofa...

www.biorxiv.org

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Reposted by Carter Lab

Ennio @amicoennio.bsky.social · Nov 15

First #JournalClub on the blue side: an exciting story about dynein at the kinetochore and its role in biorientation!

www.nature.com/articles/s41...

Kinetochore dynein is sufficient to biorient chromosomes and remodel the outer kinetochore - Nature Communications

Mitotic chromosomes recruit multiple microtubule-directed activities to ensure their faithful segregation. Using an approach where only one major activity is present, the authors reveal sufficiency of...

www.nature.com

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Carter Lab @carter-lab.bsky.social · Nov 14

As my lab's first post on Bluesky. If you are a UK Structural Biologist please come to our one day meeting on Friday 6th December
Lots of talk slots to be selected from abstracts.
Deadline for abstracts is TOMORROW: Friday 15th Nov.
bit.ly/4fDEqfZ

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Reposted by Carter Lab

Harry Low’s Lab @lowlab.bsky.social · Nov 6

❗️Exciting science alert!! Come join us at the BCA Winter Meeting at the MRC Laboratory of Molecular Biology, Cambridge, 6th December. Short talks available - a great opportunity for early career researchers to present.. bit.ly/4fDEqfZ

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Carter Lab @carter-lab.bsky.social · Nov 14

Thanks!

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Carter Lab @carter-lab.bsky.social · Nov 13

Could you add me too? Would like to start our regular Journal Club posts here on Friday.

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Reposted by Carter Lab

Dominik Hrebik @dhrebik.bsky.social · Nov 12

Our new preprint from Briggs lab is out! We solved the in-virus #cryoEM structure of the HIV matrix protein by SPA. The structure led us to a discovery resolving a long mystery in HIV biology – a peptide SP2 triggers the maturation of the HIV matrix domain. A 🧵 1/x
Paper: tinyurl.com/c7szhtfa

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Reposted by Carter Lab

Rémi Fronzes @fronzeslab.bsky.social · Nov 13

Nice to see @pilhoferlab.bsky.social here !!

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