amicoennio.bsky.social
Ennio
@amicoennio.bsky.social
110 followers 230 following 4 posts
A biochemist. Molecular motors, especially dynein
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Reposted by Ennio
vcmentowski.bsky.social
Verena Cmentowski @vcmentowski.bsky.social · 23d
Excited to share our new paper! 🎉
The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona
www.science.org/doi/10.1126/...
Very thankful to @andrea-musacchio.bsky.social for his mentorship and support over the years.
The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona
The kinetochore fibrous corona docks on CENP-E and a second elusive receptor identified as the checkpoint protein BUB1.
www.science.org
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Reposted by Ennio
andrea-musacchio.bsky.social
Andrea Musacchio @andrea-musacchio.bsky.social · 23d
The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona | Science Advances www.science.org/doi/10.1126/...

Congratulations @vcmentowski.bsky.social for solving a remarkably challenging molecular puzzle
The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona
The kinetochore fibrous corona docks on CENP-E and a second elusive receptor identified as the checkpoint protein BUB1.
www.science.org
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amicoennio.bsky.social
Ennio @amicoennio.bsky.social · Mar 17
The power of collaboration (and of in vitro reconstitution)!
jcb.org
Journal of Cell Biology @jcb.org · Mar 17
Schweighofer, Mulay, @andrea-musacchio.bsky.social et al. reconstitute direct interactions between FAcilitates Chromatin Transcription and the 16-subunit constitutive centromere–associated network core of the chromatin-proximal #kinetochore rupress.org/jcb/article/...
#mitosis
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Reposted by Ennio
jcb.org
Journal of Cell Biology @jcb.org · Feb 11
New: Colombo et al. @surreylab.bsky.social show that NuMA is a mitotic dynein adaptor that binds and caps microtubule minus ends, explaining how dynein, NuMA, dynactin, and Lis1 focus microtubule minus ends at mitotic spindle poles https://buff.ly/41aj9F9
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amicoennio.bsky.social
Ennio @amicoennio.bsky.social · Dec 8
Excited to share the first published paper of my postdoc - a collaboration with Yildiz and Dumont groups led by Merve Aslan, on the fascinating dynein adaptor NuMA. Lots of super cool insights on how NuMA can activate dynein during mitosis. Thanks to @carter-lab.bsky.social for the support!
www.biorxiv.org
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Reposted by Ennio
chrisvanhoorn.bsky.social
chrisvanhoorn.bsky.social @chrisvanhoorn.bsky.social · Dec 8
Our #CryoET paper on ciliary rootlet ultrastructure from mouse retina is now out in @elife.bsky.social! Have a peek with this video or dive deeper at bit.ly/3ZJzhgc. Big thanks to @carter-lab.bsky.social and #teamtomo.

#CryoET #CryoEM #Cilia #Rootlet #Centriole #Research #Science
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amicoennio.bsky.social
Ennio @amicoennio.bsky.social · Nov 27
Brilliant and supportive mentor, great location, exciting project - what's not to love? Plus a unique opportunity to really learn from the best at figuremaking!
abidalilab.bsky.social
Ferdos Abid Ali @abidalilab.bsky.social · Nov 27
If you’re interested in how molecular motors coordinate to power intracellular trafficking events (e.g. endocytosis), I’ve got a PhD position available to study this at vibrant Bristol uni. In this project, we will capture highly dynamic events by #cryoEM, single molecule imaging & cell biology. 🔬❄️🧪
This scheme shows the cargo adaptor FHF in the middle with arrows pointing to distinct microtubule and actin-based motors (dynein-dynactin, KIFC1, KIF1C and myosins V, IX and X as well as Tropomyosin 1). It also shows a link to Rab5 marked early endosomes. The hypothesis is that FHF coordinates multi motor binding at the early stages of endocytosis. The PhD project would address the hierarchy of motor binding and how these motors coordinate to allow the newly formed vesicle to transition from the actin to MT cytoskeletal network.
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amicoennio.bsky.social
Ennio @amicoennio.bsky.social · Nov 15
First #JournalClub on the blue side: an exciting story about dynein at the kinetochore and its role in biorientation!

www.nature.com/articles/s41...
Kinetochore dynein is sufficient to biorient chromosomes and remodel the outer kinetochore - Nature Communications
Mitotic chromosomes recruit multiple microtubule-directed activities to ensure their faithful segregation. Using an approach where only one major activity is present, the authors reveal sufficiency of...
www.nature.com
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