Lightnews — Scholar-powered news

Reposted by Ferdos Abid Ali

(GIRISH)MALI LAB @dyneinassembly.bsky.social · 29d

The annual Dunn School DPhil studentship competition for 2026 is open for applications.

We have a project aimed at understanding the molecular mechanisms of ciliary dynein transport. See details below and please pass on to anyone who might be interested.

www.path.ox.ac.uk/project/mech...

Mechanistic studies on axonemal dynein transport to motile cilia - Dunn School

Over 30 groups work at the Dunn School to uncover the molecular and cellular mechanisms underlying disease. Discover which research groups are accepting students for our next round of applications.

www.path.ox.ac.uk

9 13

Reposted by Ferdos Abid Ali

Carter Lab @carter-lab.bsky.social · Aug 5

Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before.
www.biorxiv.org/content/10.1...

4 45 140

Reposted by Ferdos Abid Ali

Suyang Zhang @suyangzhang.bsky.social · Jul 10

Excited to share our latest work! We found transcription factor SPT6 and phosphorylated Pol II CTD help recruit U1 snRNP to elongating Pol II, allowing efficient co-transcriptional splicing.

Glad to be featured in the Editors’ Highlights!

www.nature.com/articles/s41...

#splicing #cryoEM

1 21 69

Reposted by Ferdos Abid Ali

Kat Toropova @kattoropova.bsky.social · Apr 30

Postdoc position in my lab: investigating how the microtubule motor protein dynein-2 works in cilia.

Here's dynein-2 at work translocating microtubules - how is this activity regulated? How does dynein-2 malfunction in disease?

Find out more and apply:
my.corehr.com/pls/uoxrecru...

2 34 65

Ferdos Abid Ali @abidalilab.bsky.social · Apr 28

Thank you so much Xin for your kind words and also for beautifully shining the light on FHF in your own work!

1 1

Ferdos Abid Ali @abidalilab.bsky.social · Apr 28

Thanks Max!

1 1

Ferdos Abid Ali @abidalilab.bsky.social · Apr 24

Great to see our story on dynein & kinesin co-dependence published www.nature.com/articles/s41..., and absolutely chuffed that it's made the front cover (thanks NSMB!). A brilliant News & Views too by Steven Markus www.nature.com/articles/s41.... Collab between @carter-lab.bsky.social & Straube lab🔬

1 8 26

Ferdos Abid Ali @abidalilab.bsky.social · Dec 8

Huge congrats both - so good to see this out in final form @chrisvanhoorn after all the meticulous and clever ways you approached this beast of an organelle. Stunning 🤩

chrisvanhoorn.bsky.social @chrisvanhoorn.bsky.social · Dec 8

Our #CryoET paper on ciliary rootlet ultrastructure from mouse retina is now out in @elife.bsky.social! Have a peek with this video or dive deeper at bit.ly/3ZJzhgc. Big thanks to @carter-lab.bsky.social and #teamtomo.

#CryoET #CryoEM #Cilia #Rootlet #Centriole #Research #Science

5

Reposted by Ferdos Abid Ali

Izzy Jayasinghe @ijayas.bsky.social · Dec 1

Reading the paper in Cell about how to close the scissor plots in gender representation at senior academic positions, I feel just a touch of pessimism. Having reached a level of seniority (middle management) I didn’t think I ever would, I read these great ideas wanting more, much more /1.

Closing the scissor-shaped curve: Strategies to promote gender equality in academia

Gender inequality in STEM fields remains pervasive and undermines the ability for talented individuals to excel. Despite advances, women still encounter obstacles in pursuing academic careers and reac...

www.cell.com

12 130 310

Reposted by Ferdos Abid Ali

Jessica Cross @jessicacross.bsky.social · Nov 28

Please share this PhD opportunity in my new lab in Bristol, using protein design/ engineering to understand and build molecular motors to control intracellular transport. Working with @markdodding.bsky.social and Prof Dek Woolfson.
www.findaphd.com/phds/project...
www.swbio.ac.uk/biomolecular...

3 39 59

Reposted by Ferdos Abid Ali

adam grieve @adamgrieve.bsky.social · Nov 15

Can I ask you to share a PhD advert at Bristol Uni please? Rhomboid proteases play a role in neurons that is essential for life- but it is not characterised. Got a student interested in cell biology, electrophysiology and neurobiology? Send them our way! tinyurl.com/56f24f7c

1 80 72

Ferdos Abid Ali @abidalilab.bsky.social · Nov 27

A huge achievement - congrats to all! 🥳

Alessandro Costa @costalaboratory.bsky.social · Nov 27

Our article "MCM double hexamer loading visualized with human proteins" published in Nature today! ❄️🔬🧬🎉🥳

Great collaboration with John Diffley's lab. Congratulations to Florian Weissmann, Julia Greiwe and all other authors!

rdcu.be/d1F7m

3

Ferdos Abid Ali @abidalilab.bsky.social · Nov 27

Thanks Adam for this and for being so welcoming 😊

Ferdos Abid Ali @abidalilab.bsky.social · Nov 27

Thanks a lot Ennio!! Grateful for the support 😊

Ferdos Abid Ali @abidalilab.bsky.social · Nov 27

Grazie mille Paolo! :-)

Ferdos Abid Ali @abidalilab.bsky.social · Nov 27

Thanks so much Alex, appreciate it! 😊

1

Ferdos Abid Ali @abidalilab.bsky.social · Nov 27

Ah, so kind, thanks a lot Girish - and likewise!

2

Ferdos Abid Ali @abidalilab.bsky.social · Nov 27

⌛ Deadline is Midnight (23:59pm GMT), Wednesday 11 December 2024. Also, underrepresented groups are particularly encouraged to apply #BlackinSTEM. Lab website coming soon for more details & future opportunities. Reposts highly appreciated!

This graphic summarises what the South West Biosciences Doctoral Training Partnership offers prospective PhD students: training, 4 years funding, placement opportunities, structured first year training, interdisciplinary projects, collaborations with industry, fieldwork opportunities, a supportive cohort environment. Also has a link to the swbio website (www.swbio.ac.uk) and application deadline details. The graphic depicts life sciences cartoons ranging from DNA to animals, plants, and a range of cell types (all in lime green on a dark green background).

1

Ferdos Abid Ali @abidalilab.bsky.social · Nov 27

The position is either funded by a UoB scholarship or SWBio DTP - to be considered for both pools of funding apply separately for each of these. Secondary sup. is the brilliant @markdodding.bsky.social. 📧 E-mail [email protected] for informal enquiries & 📝apply here tinyurl.com/yvzeb2kw.

Funded PhD- Coordination Between Actin and Microtubule Motors During Endocytosis at University of Bristol on FindAPhD.com

PhD Project - Funded PhD- Coordination Between Actin and Microtubule Motors During Endocytosis at University of Bristol, listed on FindAPhD.com

tinyurl.com

1 3 4

Ferdos Abid Ali @abidalilab.bsky.social · Nov 27

If you’re interested in how molecular motors coordinate to power intracellular trafficking events (e.g. endocytosis), I’ve got a PhD position available to study this at vibrant Bristol uni. In this project, we will capture highly dynamic events by #cryoEM, single molecule imaging & cell biology. 🔬❄️🧪

This scheme shows the cargo adaptor FHF in the middle with arrows pointing to distinct microtubule and actin-based motors (dynein-dynactin, KIFC1, KIF1C and myosins V, IX and X as well as Tropomyosin 1). It also shows a link to Rab5 marked early endosomes. The hypothesis is that FHF coordinates multi motor binding at the early stages of endocytosis. The PhD project would address the hierarchy of motor binding and how these motors coordinate to allow the newly formed vesicle to transition from the actin to MT cytoskeletal network.

1 30 53

Reposted by Ferdos Abid Ali

samlacey.bsky.social @samlacey.bsky.social · Nov 18

Our review of Intraflagellar transport is out now! We cover lots of the recent advances in our understanding of IFT, and where we think there are still some gaps.
www.nature.com/articles/s41...

The intraflagellar transport cycle - Nature Reviews Molecular Cell Biology

Intraflagellar transport (IFT) ensures delivery of selected proteins into cilia. The IFT protein complexes IFT-A and IFT-B polymerize at the base of the cilium to form an anterograde train that facili...

www.nature.com

2 28 87

Reposted by Ferdos Abid Ali

Marc van der Kamp @marcvanderkamp.bsky.social · Nov 18

International Day of LGBQTIA+ People in STEM is TODAY! 🏳️‍🌈

And for those in Bristol (@bristoluni.bsky.social), check out the LGBTQ+ STEM mini-conference on Wednesday in C42 (BMS building), 1-5pm.
Register via: forms.office.com/e/LxuMpa6nQF

0th of November 2024, we will be celebrating LGBTQ+ in STEM day in style, with a mini-conference to showcase the research, roles and experience of our LGBTQ+ staff and students. The event will be taking place in C42 in the Biomedical Sciences Building from 1-5pm.

The event will feature a plenary talk from Sarah Cosgriff on Asexuality in STEM, before talks from staff and students in STEM departments in the university, sharing perspectives on their research, roles or study area alongside personal insights, stories or experience of being LGBTQ+ in the field of STEM.

1 13 26

Reposted by Ferdos Abid Ali

Stephen Royle @steveroyle.bsky.social · Nov 12

BSCB Women in #CellBiology prize 🧪
Deadline extended (15th Nov)
The deal: UK-based scientist, running lab for < 7 years with 1+ senior author publication.
Do you know someone who should be nominated? Maybe it's you?
Details (a bit out of date): bscb.org/competitions...

Women in Cell Biology Early Career Award Medal | British Society for Cell Biology

bscb.org

52 46

Reposted by Ferdos Abid Ali

Harry Low’s Lab @lowlab.bsky.social · Nov 6

❗️Exciting science alert!! Come join us at the BCA Winter Meeting at the MRC Laboratory of Molecular Biology, Cambridge, 6th December. Short talks available - a great opportunity for early career researchers to present.. bit.ly/4fDEqfZ

4 8

Reposted by Ferdos Abid Ali

MRC-LMB Cell Biology Division @cellbiol-mrclmb.bsky.social · Nov 12

This year’s UK Membrane Trafficking Meeting is on Dec 16th at King’s College London (Guy’s Campus, London Bridge).
Registration closes 9th December. Sign up is here.
estore.kcl.ac.uk/conferences-...
Thanks go to @J_Cell_Sci for sponsoring student/postdoc prizes!

UK Membrane Trafficking Meeting 2024 | King's College London eStore

Registration for the 2024 UK Membrane Trafficking Meeting, held at KCL.  Registration per person, to include sandwich lunch and coffee breaks and even

estore.kcl.ac.uk

12 17