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The Daum Lab @daumlab.bsky.social · 2d

Out in Science Advances: Our #cryoEM structure of HFTV1, a virus infecting the halophile #archaea. *First full atomic structure (containing all structural proteins) of any tailed virus!* Congrats and thanks to all co-authors and our fantastic collaborators! www.science.org/doi/10.1126/...

Cryo-EM resolves the structure of the archaeal dsDNA virus HFTV1 from head to tail

This structure of an archaeal tailed virus (arTV) provides detailed insights into arTV assembly and infection mechanisms.

www.science.org

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(GIRISH)MALI LAB @dyneinassembly.bsky.social · 7d

Thank you lab neighbour :)

(GIRISH)MALI LAB @dyneinassembly.bsky.social · 8d

Thank you Karina!

(GIRISH)MALI LAB @dyneinassembly.bsky.social · 8d

Thanks Mike @mike-wieczorek.bsky.social

(GIRISH)MALI LAB @dyneinassembly.bsky.social · 8d

Thank you!

(GIRISH)MALI LAB @dyneinassembly.bsky.social · 8d

Thanks Leo!

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(GIRISH)MALI LAB @dyneinassembly.bsky.social · 8d

Thanks Jack! hope all well with your postdoc. Congrats on winning best thesis prize to you too!

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(GIRISH)MALI LAB @dyneinassembly.bsky.social · 8d

Thank you Fay :) long overdue a catch up!

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(GIRISH)MALI LAB @dyneinassembly.bsky.social · 8d

Merci Philippe! I will see you in a few weeks to celebrate in person.

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(GIRISH)MALI LAB @dyneinassembly.bsky.social · 8d

A very talented PhD student @matthew-batisio.bsky.social (sadly not in my lab!). Feel free to get in touch with him for scientific animation projects.

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(GIRISH)MALI LAB @dyneinassembly.bsky.social · 8d

This animation was made by the talented @matthew-batisio.bsky.social

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(GIRISH)MALI LAB @dyneinassembly.bsky.social · 8d

Happy to share the inaugural paper from the lab. We describe a molecular mechanism for the activation of outer dynein arm motors that power the vital motion of cilia.

Open access link below:
www.nature.com/articles/s41...

Here's a cool animated summary

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(GIRISH)MALI LAB @dyneinassembly.bsky.social · 19d

Lovely tribute to David's legacy.

Richard Sever @richardsever.bsky.social · 22d

Lovely to see David Stephens highlighted in 100 years of cell biologists at J. Cell Sci., alongside Linda Amos, Peter Medawar, Juan Bonifacino, and others
journals.biologists.com/jcs/article/...

‘First Persons’ through the decades – 100 years of notable scientists in Journal of Cell Science

Summary: JCS highlights the lives and careers of 10 notable scientists from around the world who published first author papers in our journal over the last 100 years.

journals.biologists.com

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The Dunn School, Oxford @dunnschool.bsky.social · Sep 8

Our PhD studentship programme is officially open; pass it on

If you are looking for a fully-funded PhD in the mechanisms underlying human disease, here are the details...

Great science and a great environment!

www.path.ox.ac.uk/news-article...

Applications now open for our PhD studentship programme - Dunn School

Applications are now open to apply for our four year, fully-funded PhD programme in Molecular Cell Biology in Health and Disease.

www.path.ox.ac.uk

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Matthew Freeman @mjafreeman.bsky.social · 28d

Another exciting opportunity @dunnschool.bsky.social !

Come and be a colleague to a great group of scientists working on the fundamental mechanisms underlying disease, and how to transform health

Please help us find great applicants

The Dunn School, Oxford @dunnschool.bsky.social · 28d

We're hiring (again)!

We are looking for an associate professor in cell and molecular biology, with a particular focus on immunology (defined broadly)

If you have a great record and exciting plans, consider joining our thriving and welcoming department

www.path.ox.ac.uk/vacancy/asso...

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UK Cilia and Centrosome Network @ukcilianetwork.bsky.social · 22d

We've had a very active summer of Cilia and Centrosome science!

We had our Annual Network meeting in London this year organised by Prof. Hannah Mitchison and Dr. Dagan Jenkins. Meeting highlights are now available to read on the network website.

www.cilianetwork.org.uk/events/annua...

Annual Meeting 2025 - Highlights: UK Cilia and Centrosome Network

UK Cilia and Centrosome Network

www.cilianetwork.org.uk

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Michael Way @drmichaelway.bsky.social · 22d

And now for something completely different @tianyang22.bsky.social & #YanCao uncover of how SPIN90 dimers activate Arp2/3 to nucleate bidirectional linear actin filaments. Great collaboration with @romet-jegou-lab.bsky.social & @carolynmoores1.bsky.social #Cryo-EM #Arp2/3 rdcu.be/eGoH4

Arp2/3-mediated bidirectional actin assembly by SPIN90 dimers

Nature Structural & Molecular Biology - Liu et al. show that SPIN90 dimerizes and binds two Arp2/3 complexes to nucleate two bidirectional actin filaments and the dimerization domain is...

rdcu.be

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(GIRISH)MALI LAB @dyneinassembly.bsky.social · 22d

Exciting new study from new-PI Mohinder Pal on the role of CCDC103 and it's links to PCD as the most recent dynein assembly factor (DNAAF19). Congratulations to the entire team.

@Mohinder Pal (currently not on Bluesky)
@mike-wieczorek.bsky.social
@laurencepearl.bsky.social

UK Cilia and Centrosome Network @ukcilianetwork.bsky.social · 22d

New pre-print on the role of CCDC103/DNAAF19 in dynein assembly highlighting it's link to PCD.

www.biorxiv.org/content/10.1...

CCDC103-mediated assembly of the R2C complex links RUVBL1-RUVBL2 to Primary Ciliary Dyskinesia

Primary ciliary dyskinesia (PCD) is a genetic disorder caused by defective cilia motility, powered by axonemal dynein motors. Assembly of these motors is facilitated by the molecular chaperone HSP90, ...

www.biorxiv.org

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Lotte B. Pedersen @lottepedersen.bsky.social · 28d

KIF13B controls ciliary protein content by promoting endocytic retrieval and suppressing release of large extracellular vesicles from cilia: Current Biology www.cell.com/current-biol...

KIF13B controls ciliary protein content by promoting endocytic retrieval and suppressing release of large extracellular vesicles from cilia

Rezi et al. show that kinesin-3 KIF13B regulates ciliary protein content by promoting endocytic retrieval and small extracellular vesicle (EV) release of ciliary proteins while suppressing their relea...

www.cell.com

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(GIRISH)MALI LAB @dyneinassembly.bsky.social · 29d

The annual Dunn School DPhil studentship competition for 2026 is open for applications.

We have a project aimed at understanding the molecular mechanisms of ciliary dynein transport. See details below and please pass on to anyone who might be interested.

www.path.ox.ac.uk/project/mech...

Mechanistic studies on axonemal dynein transport to motile cilia - Dunn School

Over 30 groups work at the Dunn School to uncover the molecular and cellular mechanisms underlying disease. Discover which research groups are accepting students for our next round of applications.

www.path.ox.ac.uk

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Kat Toropova @kattoropova.bsky.social · 29d

The Dunn School PhD programme is live! 🎉

Two projects in our labs:
1) How the motor protein giant dynein-2 works
2) How signalling-essential membrane proteins get into cilia

Cryo-EM/ET, single mol & live-cell fluor microscopy, CRISPR-based genetic tools & more!

www.path.ox.ac.uk/study-with-u...

How to Apply - Dunn School

Here you can find more information on how to apply for our PhD programme, including deadlines and application requirements.

www.path.ox.ac.uk

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(GIRISH)MALI LAB @dyneinassembly.bsky.social · 29d

The annual Dunn School DPhil studentship competition for 2026 is open for applications.

We have a project aimed at understanding the molecular mechanisms of ciliary dynein transport. See details below and please pass on to anyone who might be interested.

www.path.ox.ac.uk/project/mech...

Mechanistic studies on axonemal dynein transport to motile cilia - Dunn School

Over 30 groups work at the Dunn School to uncover the molecular and cellular mechanisms underlying disease. Discover which research groups are accepting students for our next round of applications.

www.path.ox.ac.uk

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Jasmeen Oberoi @jasmeenoberoi.bsky.social · 29d

🧬🧪 A research technician position - Protein Biochemistry (6 months) is available in my lab @gdsc-sussex.bsky.social investigating structure and function of fusion kinase complexes in Leukaemia.

📅 Deadline: 29th September 2025.

🙏 Please share with anyone who might be interested.

Research Technician – Protein Biochemistry at University of Sussex

Explore an exciting academic career as a Research Technician – Protein Biochemistry. Don't miss out on other academic jobs. Click to apply and explore more opportunities.

www.jobs.ac.uk

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Matthew Freeman @mjafreeman.bsky.social · Sep 1

Are you a postdoc interested in the mechanisms of disease?

Do you have a great record and an exciting vision?

Come and start your own lab @dunnschool.bsky.social by applying for sponsorship for early career fellowships.

Deadline 30th September...pass it on!

www.path.ox.ac.uk/work-with-us...

Group Leader Career Development Fellowships - Dunn School

Are you an early career researcher interested in the cell or molecular mechanisms underlying disease? Do you have an outstanding record and an innovative research plan?

www.path.ox.ac.uk

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(GIRISH)MALI LAB @dyneinassembly.bsky.social · Aug 27

Wow, amazing news! Many congratulations Roger :)

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