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Reposted by UK Cilia and Centrosome Network

Ali Shaib @alishaib.bsky.social · 8d

#GEF25 Concluding Plenary Lecture with the wonderful Virginie Hamel.

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Reposted by UK Cilia and Centrosome Network

(GIRISH)MALI LAB @dyneinassembly.bsky.social · 8d

Happy to share the inaugural paper from the lab. We describe a molecular mechanism for the activation of outer dynein arm motors that power the vital motion of cilia.

Open access link below:
www.nature.com/articles/s41...

Here's a cool animated summary

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UK Cilia and Centrosome Network @ukcilianetwork.bsky.social · 8d

Exciting new work on the activation mechanism of the dynein motors that power motile ciliary beating!

(GIRISH)MALI LAB @dyneinassembly.bsky.social · 8d

Happy to share the inaugural paper from the lab. We describe a molecular mechanism for the activation of outer dynein arm motors that power the vital motion of cilia.

Open access link below:
www.nature.com/articles/s41...

Here's a cool animated summary

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Reposted by UK Cilia and Centrosome Network

Philippe Bastin's Lab @bastinlab.bsky.social · 20d

Thank you @jcb.org Cynthia and Yameng for this commentary on our IFT paper!

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Reposted by UK Cilia and Centrosome Network

NanoTag Biotechnologies @nanotag.bsky.social · 21d

#ExM turned 10 this year - just like #NanoTag! 🎉
Join us & the super-resolution community in Göttingen for the ExM Forum! 🔬Hear from our founder Felipe Opazo @opazo.bsky.social and CSO Steffen Frey on how NanoTag’s sdAb solutions empower nanoscopy & #multiplex imaging.

See you in Göttingen!
#GEF25

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UK Cilia and Centrosome Network @ukcilianetwork.bsky.social · 22d

We've had a very active summer of Cilia and Centrosome science!

We had our Annual Network meeting in London this year organised by Prof. Hannah Mitchison and Dr. Dagan Jenkins. Meeting highlights are now available to read on the network website.

www.cilianetwork.org.uk/events/annua...

Annual Meeting 2025 - Highlights: UK Cilia and Centrosome Network

UK Cilia and Centrosome Network

www.cilianetwork.org.uk

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Reposted by UK Cilia and Centrosome Network

Paul & Virginie - Centriole Lab @centriolelab.bsky.social · 23d

Be our new colleague! 🎉
The Dept of Molecular and Cellular Biology at the University of Geneva is hiring an Assistant Professor or Associate Professor.

👉 More details here: lnkd.in/e8Z9eAm4
👉 Our department: mocel.unige.ch

Please feel free to share this opportunity with your network.

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UK Cilia and Centrosome Network @ukcilianetwork.bsky.social · 22d

New pre-print on the role of CCDC103/DNAAF19 in dynein assembly highlighting it's link to PCD.

www.biorxiv.org/content/10.1...

CCDC103-mediated assembly of the R2C complex links RUVBL1-RUVBL2 to Primary Ciliary Dyskinesia

Primary ciliary dyskinesia (PCD) is a genetic disorder caused by defective cilia motility, powered by axonemal dynein motors. Assembly of these motors is facilitated by the molecular chaperone HSP90, ...

www.biorxiv.org

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Reposted by UK Cilia and Centrosome Network

Kirsty Wan @micromotility.bsky.social · Aug 6

We have a postdoc opening for a protistologist with biophysics inclinations to join our @hfspo.bsky.social project! (focus will be on characterising the morphology, ultrastructure and behaviour of excavates) #protistsonsky

Apply by Sept 17th (RTs appreciated!)
jobs.exeter.ac.uk/hrpr_webrecr...

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Reposted by UK Cilia and Centrosome Network

Lotte B. Pedersen @lottepedersen.bsky.social · 28d

KIF13B controls ciliary protein content by promoting endocytic retrieval and suppressing release of large extracellular vesicles from cilia: Current Biology www.cell.com/current-biol...

KIF13B controls ciliary protein content by promoting endocytic retrieval and suppressing release of large extracellular vesicles from cilia

Rezi et al. show that kinesin-3 KIF13B regulates ciliary protein content by promoting endocytic retrieval and small extracellular vesicle (EV) release of ciliary proteins while suppressing their relea...

www.cell.com

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Reposted by UK Cilia and Centrosome Network

Kat Toropova @kattoropova.bsky.social · 29d

The Dunn School PhD programme is live! 🎉

Two projects in our labs:
1) How the motor protein giant dynein-2 works
2) How signalling-essential membrane proteins get into cilia

Cryo-EM/ET, single mol & live-cell fluor microscopy, CRISPR-based genetic tools & more!

www.path.ox.ac.uk/study-with-u...

How to Apply - Dunn School

Here you can find more information on how to apply for our PhD programme, including deadlines and application requirements.

www.path.ox.ac.uk

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Reposted by UK Cilia and Centrosome Network

(GIRISH)MALI LAB @dyneinassembly.bsky.social · 29d

The annual Dunn School DPhil studentship competition for 2026 is open for applications.

We have a project aimed at understanding the molecular mechanisms of ciliary dynein transport. See details below and please pass on to anyone who might be interested.

www.path.ox.ac.uk/project/mech...

Mechanistic studies on axonemal dynein transport to motile cilia - Dunn School

Over 30 groups work at the Dunn School to uncover the molecular and cellular mechanisms underlying disease. Discover which research groups are accepting students for our next round of applications.

www.path.ox.ac.uk

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Reposted by UK Cilia and Centrosome Network

Mill_lab @cilialab.bsky.social · Aug 20

PCD Foundation On The Move 2025 kicks off in Minneapolis. President Michele Manion welcomes an audience of 200! Exciting times ahead for #PrimaryCiliaryDyskinesia- registries, clinical trials and more! #OTM2025

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Reposted by UK Cilia and Centrosome Network

Mill_lab @cilialab.bsky.social · Aug 20

Incredibly powerful patient panel to counter narrative that PCD is mild- importance of advocacy for care for their own health in a system where PCD is under appreciated. Burden of airway clearance & toll of school, family & work. Trade-offs choice of nebs, commitments & health trade-offs. #OTM2025

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Reposted by UK Cilia and Centrosome Network

Sven Lange @sven-m-lange.bsky.social · Aug 20

Excited to see this work published online at @cp-cell.bsky.social today!

www.cell.com/cell/fulltex...

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Reposted by UK Cilia and Centrosome Network

FOR5547 Primary cilia dynamics @for5547.bsky.social · Aug 21

Great teamwork by the @wachtenlab.bsky.social @masslab.bsky.social and the May-Simera lab in our #FOR5547! Congratulations to the whole team!

WachtenLab @wachtenlab.bsky.social · Aug 21

🚨 New in The EMBO Journal!
Loss of BBS8 disrupts ciliary Hedgehog signaling, switching adipocyte precursors into fibrogenic cells—remodeling adipose tissue before obesity begins.
🔬 #BBS #cilia @for5547.bsky.social @sfb1454.bsky.social @batenergy.bsky.social
📄 www.embopress.org/doi/full/10....

BBS8-dependent ciliary Hedgehog signaling governs cell fate in the white adipose tissue | The EMBO Journal

imageimageDisruption of ciliogenesis in Bardet-Biedl syndrome (BBS) leads to obesity and disrupted adipogenesis. This study reveals that ciliary dysfunction in a mouse model of BBS induces a a cell fa...

www.embopress.org

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Reposted by UK Cilia and Centrosome Network

Journal of Cell Biology @jcb.org · Aug 13

With a combination of FIB-SEM, super-resolution & expansion #microscopy, Araujo Alves, Bastin et al @bastinlab.bsky.social @pasteur.fr reveal how IFT trains are progressively restricted to a limited number of #microtubule doublets in the flagellum of T. brucei. rupress.org/jcb/article/...

#Cilia

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Reposted by UK Cilia and Centrosome Network

Barbara Tanos @tanosbarbara.bsky.social · Aug 18

Thrilled for the publication of our latest paper on the role of SAS-6 in invasion.
This was a pre-pandemic and post-pandemic effort that would not have been possible without our students and the support of so many colleagues and friends!

@zech-lab.bsky.social @cengem.bsky.social #cilia #centrioles

Life Science Alliance @lsajournal.org · Aug 18

SAS-6 promotes invasion through YAP pathway activation @cengem.bsky.social @tanosbarbara.bsky.social
www.life-science-alliance.org/content/8/10...

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UK Cilia and Centrosome Network @ukcilianetwork.bsky.social · Aug 13

This has always been a fantastic community driven meeting. It is also a rare forum for scientists, patients and clinicians to come together to come up with solutions to solve the biggest challenges facing the cilia community and fill knowledge gaps. All cilia enthusiasts - mark your calendars!

EuroCilia2027 @eurocilia.bsky.social · Aug 11

Have you saved the date for #Cilia2027?
It is going to be in March 2027 at this lake near #Milan. 👇

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Reposted by UK Cilia and Centrosome Network

Mill_lab @cilialab.bsky.social · Aug 12

⏰ One week countdown- 19/08/2025 15:00 BST we kick off our 52nd BSCB GenSoc UK Cilia and Centrosome Network e-symposium with 6 stellar talks from the field's rising stars 🌠 on the latest breaking science 🧪!!

FOMO? Join the fun: www.eventbrite.co.uk/e/bscb-genso...

Mill_lab @cilialab.bsky.social · Jul 29

We have something for everyone- CSF flow & #neurodegeneration, ciliary trafficking of PKD2 complexes, cilia & #actin dynamics, #DNADamageResponse & multiciliation, cilia & pituitary development & transcriptional control of ciliogenesis... Great breaking science & rising talent to be showcased...🧪

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UK Cilia and Centrosome Network @ukcilianetwork.bsky.social · Aug 1

Congratulations to Girish and his team (Karim, Muyang and Siham) #cilia #motors

The Dunn School, Oxford @dunnschool.bsky.social · Jul 31

Many congratulations to Girish R Mali (@dyneinassembly.bsky.social) and team, awarded the 2025 Ian & Barbara Gibbons Award for their work on the regulation of axonemal dynein motors that power ciliary beating!

The award recognises groundbreaking advances in the Dynein field every four years.

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Reposted by UK Cilia and Centrosome Network

Kirsty Wan @micromotility.bsky.social · Jul 14

Excited to share that we have received significant funding from the @wellcometrust.bsky.social for a new interdisciplinary consortium project on #cilia coordination and function across scales and organisms! 🎉🥂@lsiexeter.bsky.social

news.exeter.ac.uk/living-syste...

Multi-million project to ‘crack the code’ of cilia – tiny structures with big impact on human health

An international team of researchers, led by the University of Exeter, have been awarded a Wellcome Discovery Award grant of almost £5 million to investigate one of the body’s most fascinating microsc...

news.exeter.ac.uk

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Mill_lab @cilialab.bsky.social · Jul 29

Peak #SummerFun- our amazing line-up for our 52nd @bscb-official.bsky.social @gensocuk.bsky.social @ukcilianetwork.bsky.social e-symposium 19/08/2025 15:00-17:45 is now live! Join us for all things #cilia & #centrosomes- free & open to all. Register for here- www.eventbrite.co.uk/e/1220921258...

BSCB GenSoc UK Cilia and Centrosome Network e-Symposia Series

www.eventbrite.co.uk

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(GIRISH)MALI LAB @dyneinassembly.bsky.social · Jul 29

Super cool new story from our lab neighbours. Congratulations to the whole team! #cilia #molecularmotors

Kat Toropova @kattoropova.bsky.social · Jul 29

Thrilled to see our study on how kinesin-2 motors are switched on and off published in @natsmb.nature.com ⚛️

➡️ www.nature.com/articles/s41...

Congrats to all authors from me and Anthony 🎉 @dunnschool.bsky.social Check out this animation made by talented PhD student @matthew-batisio.bsky.social 😆

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FOR5547 Primary cilia dynamics @for5547.bsky.social · Jun 19

Congratulations to our PIs @masslab.bsky.social and @wachtenlab.bsky.social - great story in @nature.com Children born to obese mothers are at higher risk of metabolic disease—even with a healthy diet.

Mass Lab @masslab.bsky.social · Jun 18

We are SO EXCITED to share our story @nature.com:
🧵1/
Maternal obesity reprograms fetal liver macrophages, triggering adult fatty liver disease in the offspring.
This study uncovers how Kupffer cells act as intergenerational messengers in metabolic disease.
👉 Read here: rdcu.be/erD3b

Kupffer cell programming by maternal obesity triggers fatty liver disease

Nature - In a mouse model, maternal obesity during pregnancy can lead to fatty liver disease in the offspring, driven by aberrant developmental programming of Kuppfer cells.

rdcu.be

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