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lsajournal.org
Life Science Alliance
@lsajournal.org
260 followers 13 following 260 posts
#OpenAccess community-driven journal for peer-reviewed research in all areas of the life sciences. By EMBO Press (@embopress.org), Rockefeller University Press (@rupress.org), and Cold Spring Harbor Laboratory Press (@cshlpress.bsky.social).
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lsajournal.org
Life Science Alliance @lsajournal.org · 1h
A variant of Lnk/SH2B3 adaptor has been reported as a risk for several autoimmune diseases, including type 1 diabetes.
www.life-science-alliance.org/content/8/12...
lsajournal.org
Life Science Alliance @lsajournal.org · 7h
Flavonoids, plant compounds with antioxidant properties, regulate the internal biological clock in Arabidopsis plants by modulating cellular levels of reactive oxygen species. @winkellab.bsky.social
www.life-science-alliance.org/content/8/12...
lsajournal.org
Life Science Alliance @lsajournal.org · 2d
KANSL3 controls hepatocyte differentiation and metabolism via histone acetylation. Loss of this epigenetic regulator leads to hyperplasia and liver fibrosis. #Epigenetics #Metabolism #Hepatology #NSLComplex @mwiese.bsky.social www.life-science-alliance.org/content/8/12...
lsajournal.org
Life Science Alliance @lsajournal.org · 5d
This study examines how the combined deletion of ADAMTS10 and ADAMTS17 proteases affects bone growth and skin development, suggesting roles in ECM regulation and postnatal survival. www.life-science-alliance.org/content/8/12...
lsajournal.org
Life Science Alliance @lsajournal.org · 5d
The authors found that Lnk prevents the abnormal activation of DCs by GM-CSF, followed by autocrine IL-27/IL-27R loops, and protects individuals from developing autoimmune diabetes. www.life-science-alliance.org/content/8/12...
lsajournal.org
Life Science Alliance @lsajournal.org · 6d
Explore how RNA-sequencing data can reveal splicing events' role in predicting nonsense-mediated mRNA decay during sepsis. This could offer new diagnostic and therapeutic insights. www.life-science-alliance.org/content/8/12...
lsajournal.org
Life Science Alliance @lsajournal.org · 6d
Take a look at this recently published paper in LSA:
Daytime SHP2 inhibitor dosing, when immune cell numbers are elevated, shrinks neurofibromas
@cincychildrenscbdi.bsky.social @cincyresearch.bsky.social
www.life-science-alliance.org/content/8/12...
lsajournal.org
Life Science Alliance @lsajournal.org · 7d
Here comes our October issue, including:
-Manchette architecture revealed by cryo-EM
-Cell-free epigenome profiling in asymptomatic COVID-19 patients
-How to fine-tune RING E3 ubiquitin ligase activity
-HINT1 serves as a sensor of cell density, and more!
www.life-science-alliance.org/content/8/10
lsajournal.org
Life Science Alliance @lsajournal.org · 7d
New research shows that flavonoids aid in timekeeping in plants by controlling oxidative stress. This adds to our understanding of the plant clock, with potential for improving agriculture.
@winkellab.bsky.social
www.life-science-alliance.org/content/8/12...
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lsajournal.org
Life Science Alliance @lsajournal.org · 7d
Have you already seen this research article at LSA:
Longer internal exons tend to have more tandem repeats and more frequently experience insertions and deletions
www.life-science-alliance.org/content/8/12...
lsajournal.org
Life Science Alliance @lsajournal.org · 13d
A computational analysis of alternative splicing and nonsense-mediated decay using critically ill patients' RNA-sequencing data can elucidate sepsis transcriptomics and potentially associated protein targets.
www.life-science-alliance.org/content/8/12...
lsajournal.org
Life Science Alliance @lsajournal.org · 13d
SHP2 inhibition may be a general strategy to target benign tumors in which T cells and myeloid cells are pro-tumorigenic. @cincychildrenscbdi.bsky.social @cincyresearch.bsky.social www.life-science-alliance.org/content/8/12...
lsajournal.org
Life Science Alliance @lsajournal.org · 14d
The authors found that insertions and deletions occur more frequently in longer internal exons and mostly encode structure-less regions, and that half of them are attributable to alterations in tandem repeats.
www.life-science-alliance.org/content/8/12...
lsajournal.org
Life Science Alliance @lsajournal.org · 14d
Have you already read this Research Article recently published in LSA?
CTPS2 regulates CTP synthetase activity by interacting with CTPS1 @institutimagine.bsky.social www.life-science-alliance.org/content/8/11...
lsajournal.org
Life Science Alliance @lsajournal.org · 20d
Artificial intelligence can unlock new gene functions, but prediction models are limited by current knowledge. Integrating mass fingerprinting with machine learning improves these predictions. www.life-science-alliance.org/content/8/11...
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lsajournal.org
Life Science Alliance @lsajournal.org · 20d
This study shows that overexpression of the acetyltransferases ATase1 and ATase2 in the mouse alters the quality of the secretory pathway, causing a progeria-like phenotype. @waismancenter.bsky.social
www.life-science-alliance.org/content/8/12...
lsajournal.org
Life Science Alliance @lsajournal.org · 21d
Human CTP synthetase 1 and 2 form complexes, co-localizing in filament-cytoophidia structures. Their interaction modifies enzymatic activity independently of cytoophidia, revealing a new regulation mechanism. @institutimagine.bsky.social
www.life-science-alliance.org/content/8/11...
lsajournal.org
Life Science Alliance @lsajournal.org · 23d
Human skeletal muscles play a more direct role in the pathogenesis of enterovirus D68 through productive infection, which leads to structural destruction, functional loss, and hampered regeneration.
@bmlaksono.bsky.social @debbyvanriel.bsky.social
www.life-science-alliance.org/content/8/11...
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lsajournal.org
Life Science Alliance @lsajournal.org · 23d
ES cells implement specialized survival strategies in response to different AA limitations, highlighting their ability to reprogram cellular biochemistry under nutrient stress. www.life-science-alliance.org/content/8/11...
lsajournal.org
Life Science Alliance @lsajournal.org · 27d
Artificial intelligence offers a solution to unlock the potential of new gene functions. However, prediction models are limited by available knowledge. By combining mass fingerprinting with machine learning, prediction can be improved. www.life-science-alliance.org/content/8/11...
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lsajournal.org
Life Science Alliance @lsajournal.org · 27d
@Waismancenter.bsky.social
In a new study, the Puglielli laboratory at UW-Madison shows that overexpression of the acetyltransferases ATase1 and ATase2 in the mouse alters the quality of the secretory pathway, causing a progeria-like phenotype.
www.life-science-alliance.org/content/8/12...
lsajournal.org
Life Science Alliance @lsajournal.org · 28d
This study reveals that TIL products expanded from pediatric neuroblastoma tumors exhibit anti-cancer capabilities, with γδ T cells as the primary active agents. #CancerResearch #Immunotherapy www.life-science-alliance.org/content/8/11...
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lsajournal.org
Life Science Alliance @lsajournal.org · 28d
Have you seen this recently published paper in LSA?
Amino acid-dependent TSC2 dephosphorylation by lysosome-PP2A regulates mTORC1 signaling transduction www.life-science-alliance.org/content/8/11...
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lsajournal.org
Life Science Alliance @lsajournal.org · Sep 8
Enterovirus D68 replicates efficiently in 2D and 3D hiPSC-derived skeletal muscle models & the infection leads to tissue damage, a reduction in contractile force & hampered muscle regeneration. @bmlaksono.bsky.social @debbyvanriel.bsky.social www.life-science-alliance.org/content/8/11...
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lsajournal.org
Life Science Alliance @lsajournal.org · Sep 8
Diverse cell death versus survival responses to differential amino acid starvation in non-transformed cells www.life-science-alliance.org/content/8/11...