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Reposted by Kat Toropova

Samara Reck-Peterson @samreckpeterson.bsky.social · 9d

We are hiring an Assistant Professor of Biochemistry and Biophysics at Weill Cornell Medicine. Come join our collaborative research environment with state-of-the-art facilities in NYC! Application review starts Oct 22.
biochem.weill.cornell.edu/join-our-fac...

Join our Faculty | Department of Biochemistry & Biophysics

Call for applications:We invite applications for a tenure-track Assistant Professor position in the newly established Department of Biochemistry and Biophysics. We are conducting an open search for ou...

biochem.weill.cornell.edu

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Kat Toropova @kattoropova.bsky.social · 8d

Huge congrats Girish and team 😍

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Reposted by Kat Toropova

(GIRISH)MALI LAB @dyneinassembly.bsky.social · 9d

Happy to share the inaugural paper from the lab. We describe a molecular mechanism for the activation of outer dynein arm motors that power the vital motion of cilia.

Open access link below:
www.nature.com/articles/s41...

Here's a cool animated summary

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Reposted by Kat Toropova

The Dunn School, Oxford @dunnschool.bsky.social · 25d

We had a fantastic time today showcasing our amazing history and cutting-edge research at #OxfordOpenDoors! Visitors learnt about 100 years of medical research, the development of penicillin and our ongoing work on microbiology and AMR. Thanks to all the volunteers!

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Lotte B. Pedersen @lottepedersen.bsky.social · 28d

KIF13B controls ciliary protein content by promoting endocytic retrieval and suppressing release of large extracellular vesicles from cilia: Current Biology www.cell.com/current-biol...

KIF13B controls ciliary protein content by promoting endocytic retrieval and suppressing release of large extracellular vesicles from cilia

Rezi et al. show that kinesin-3 KIF13B regulates ciliary protein content by promoting endocytic retrieval and small extracellular vesicle (EV) release of ciliary proteins while suppressing their relea...

www.cell.com

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Reposted by Kat Toropova

(GIRISH)MALI LAB @dyneinassembly.bsky.social · 29d

The annual Dunn School DPhil studentship competition for 2026 is open for applications.

We have a project aimed at understanding the molecular mechanisms of ciliary dynein transport. See details below and please pass on to anyone who might be interested.

www.path.ox.ac.uk/project/mech...

Mechanistic studies on axonemal dynein transport to motile cilia - Dunn School

Over 30 groups work at the Dunn School to uncover the molecular and cellular mechanisms underlying disease. Discover which research groups are accepting students for our next round of applications.

www.path.ox.ac.uk

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Reposted by Kat Toropova

Inés @ines-ddo.bsky.social · 25d

Great time showcasing the amazing science we do at the @dunnschool.bsky.social at #OxfordOpenDoors today!

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Bronwyn Lucas @bronwynalucas.bsky.social · Aug 30

First pre-print from the Lucas Lab led by Matthew Giammar and @joshdcryoem.bsky.social online today! We develop a new, extensible Python implementation of 2DTM and apply it to build pixel size optimization, constrained search and characterize molecular motions in situ www.biorxiv.org/content/10.1...

Leopard-EM: An extensible 2DTM package to accelerate in situ structural biology

The ability to generate high-resolution views of cells with cryogenic electron microscopy (cryo-EM) can reveal the molecular mechanisms of biological processes in their native cellular context. The re...

www.biorxiv.org

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Reposted by Kat Toropova

Matthew Freeman @mjafreeman.bsky.social · 28d

Another exciting opportunity @dunnschool.bsky.social !

Come and be a colleague to a great group of scientists working on the fundamental mechanisms underlying disease, and how to transform health

Please help us find great applicants

The Dunn School, Oxford @dunnschool.bsky.social · 28d

We're hiring (again)!

We are looking for an associate professor in cell and molecular biology, with a particular focus on immunology (defined broadly)

If you have a great record and exciting plans, consider joining our thriving and welcoming department

www.path.ox.ac.uk/vacancy/asso...

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Kat Toropova @kattoropova.bsky.social · Sep 8

The Dunn School PhD programme is live! 🎉

Two projects in our labs:
1) How the motor protein giant dynein-2 works
2) How signalling-essential membrane proteins get into cilia

Cryo-EM/ET, single mol & live-cell fluor microscopy, CRISPR-based genetic tools & more!

www.path.ox.ac.uk/study-with-u...

How to Apply - Dunn School

Here you can find more information on how to apply for our PhD programme, including deadlines and application requirements.

www.path.ox.ac.uk

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Reposted by Kat Toropova

The Dunn School, Oxford @dunnschool.bsky.social · Sep 8

Our PhD studentship programme is officially open; pass it on

If you are looking for a fully-funded PhD in the mechanisms underlying human disease, here are the details...

Great science and a great environment!

www.path.ox.ac.uk/news-article...

Applications now open for our PhD studentship programme - Dunn School

Applications are now open to apply for our four year, fully-funded PhD programme in Molecular Cell Biology in Health and Disease.

www.path.ox.ac.uk

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Reposted by Kat Toropova

Matthew Freeman @mjafreeman.bsky.social · Sep 1

Are you a postdoc interested in the mechanisms of disease?

Do you have a great record and an exciting vision?

Come and start your own lab @dunnschool.bsky.social by applying for sponsorship for early career fellowships.

Deadline 30th September...pass it on!

www.path.ox.ac.uk/work-with-us...

Group Leader Career Development Fellowships - Dunn School

Are you an early career researcher interested in the cell or molecular mechanisms underlying disease? Do you have an outstanding record and an innovative research plan?

www.path.ox.ac.uk

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Kat Toropova @kattoropova.bsky.social · Aug 12

Very cool!!

Carter Lab @carter-lab.bsky.social · Aug 5

Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before.
www.biorxiv.org/content/10.1...

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Sjors Scheres @sjorsscheres.bsky.social · Aug 5

Fantastic work by the group of @matteoall.bsky.social : a SUN5:Nesprin3 complex at the head:tail junction of sperm cells. 🤯 #teamtomo

www.biorxiv.org/content/10.1...

In-cell structure of a LINC complex reveals the molecular basis for membrane remodelling and head-to-tail coupling in sperm cells

In eukaryotic cells, LINC complexes physically bridge the two nuclear membranes to cytoskeletal filaments, transmitting mechanical forces to the nucleus. Due to their dynamic and membrane-embedded nat...

www.biorxiv.org

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Reposted by Kat Toropova

Liz Miller @lizmillercu.bsky.social · Aug 4

Go check out the latest preprint from Giulia Zanetti's lab. @dr-downes.bsky.social used cryo-tomography to directly visualize COPI and COPII coated vesicles in situ at unprecedented resolution in human cells. Amazingly beautiful, rigorous, insightful work.
www.biorxiv.org/content/10.1...

Multi-scale Molecular Imaging of Human Cells reveals COPI and COPII Vesicles at ER Exit Sites

Trafficking from the endoplasmic reticulum to the Golgi apparatus comprises the first steps toward the correct localization of 30% of eukaryotic proteins. Coat protein complexes COPII and COPI are inv...

www.biorxiv.org

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Reposted by Kat Toropova

Nature Chemical Biology @natchembio.nature.com · Aug 1

Cryo-EM and biochemical reconstitution analysis reveal that Nde1 enhances Lis1 binding to autoinhibited dynein, promoting formation of a Phi-like-Lis1 intermediate during dynein activation

www.nature.com/articles/s41...

Nde1 promotes Lis1 binding to full-length autoinhibited human dynein 1 - Nature Chemical Biology

Cryo-electron microscopy and biochemical reconstitution analysis reveals that Nde1 enhances Lis1 binding to autoinhibited dynein, promoting formation of a Phi-like–Lis1 intermediate during dynein acti...

www.nature.com

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Kat Toropova @kattoropova.bsky.social · Aug 3

Congratulations team! 🎉🎉

The Dunn School, Oxford @dunnschool.bsky.social · Jul 31

Many congratulations to Girish R Mali (@dyneinassembly.bsky.social) and team, awarded the 2025 Ian & Barbara Gibbons Award for their work on the regulation of axonemal dynein motors that power ciliary beating!

The award recognises groundbreaking advances in the Dynein field every four years.

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Kat Toropova @kattoropova.bsky.social · Jul 31

This is a brilliant opportunity. I was sponsored through this scheme, and the support was (and remains) phenomenal. Please share.

The Dunn School, Oxford @dunnschool.bsky.social · Jul 30

📣 Applications now open 📣

We are seeking outstanding ECRs looking for a stimulating and supportive environment in which to establish their research group as externally-funded fellows, in any area or cell or molecular biology underlying disease!

Please share!

www.path.ox.ac.uk/work-with-us...

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Kat Toropova @kattoropova.bsky.social · Jul 29

Thrilled to see our study on how kinesin-2 motors are switched on and off published in @natsmb.nature.com ⚛️

➡️ www.nature.com/articles/s41...

Congrats to all authors from me and Anthony 🎉 @dunnschool.bsky.social Check out this animation made by talented PhD student @matthew-batisio.bsky.social 😆

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Reposted by Kat Toropova

Paul & Virginie - Centriole Lab @centriolelab.bsky.social · Apr 23

New lab preprint! Unveiling the Molecular Architecture of T Cells and Immune Synapses with Cryo-Expansion Microscopy (Cryo-ExM). A fantastic collaboration with Dr. Benita Wolf. Congratulations to all authors, especially Florent Lemaitre, for leading this amazing work! www.biorxiv.org/content/10.1...

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Reposted by Kat Toropova

Ben Engel @cellarchlab.com · Jun 19

Very impressive cryo-lift out of high-pressure-frozen mouse brain sections by @michaelgrange.bsky.social & co. 🐭🧠❄️🔬

Making it look too easy!! Now all my @biozentrum.unibas.ch colleagues will to want to do #cryoET of their tissue samples, haha 🤷‍♂️

There's no stopping #TeamTomo 🧪🧶🧬

Michael Grange @michaelgrange.bsky.social · Jun 17

Proud to share our latest paper. doi.org/10.1016/j.cr...

Through the dedication of @glynnca.bsky.social and @cryingem.bsky.social we report a thorough method to image molecular organisation within hippocampus tissue.

Structural biology in tissue is well and truly here!

@rosfrankinst.bsky.social

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Reposted by Kat Toropova

Josh Dickerson @joshdcryoem.bsky.social · Jun 28

Check out our recent review discussing the merits of tilt series vs single micrographs for in situ cryo-EM! www.sciencedirect.com/science/arti...

To tilt or not to tilt? Strategies for in situ cryo-EM data collection

Recent breakthroughs in single-particle cryogenic electron microscopy (cryo-EM) and protein structure prediction have transformed our ability to resol…

www.sciencedirect.com

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Reposted by Kat Toropova

Stan Yatskevich @stanislauy.bsky.social · Jul 15

Happy to share our latest work on the structure and assembly of holocentric kinetochores! Huge thanks to Ines for a very fruitful collaboration, Claudio for all the support, and congratulations to Christine and all co-authors!

www.biorxiv.org/content/10.1...

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Matthew Clark @matthew-batisio.bsky.social · Jul 17

IFT trains are really cool - and what better way to communicate their structure than baking a cake?

Created for my 1st year PhD project with Anthony Roberts and @kattoropova.bsky.social

IFT-A 🟡 IFT-B 🟢 Dynein-2 🔵

Matthew Clark holding a tray with a layered rectangular cake, showing the periodic repeating structure of IFT-A and IFT-B. Gingerbread cookies cut in the shape of dynein-2 ride on top.

A close up photo of the cake on a table, showing the periodic repeating structure of IFT-A and IFT-B. Gingerbread cookies cut in the shape of dynein-2 ride on top.

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Kat Toropova @kattoropova.bsky.social · Jun 13

This is wonderful, congratulations!!