Liz Miller
@lizmillercu.bsky.social
1.8K followers 2.2K following 23 posts
Cell Biologist at MRC-LMB and University of Dundee, formerly at Columbia University. Interested in membrane traffic, protein quality control. Opinions my own. She/her.
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lizmillercu.bsky.social
Hope it gets back online! Such a great tool.
lizmillercu.bsky.social
Lovely work! Yeast polytopic proteins have fewer ribosomes than soluble proteins doi.org/10.1016/j.cu... likely reducing ribosome collisions. I wonder if you separate polytopics from single-pass MPs you see differences in codon use. We wondered about initiation but maybe codon use is also important.
Redirecting
doi.org
Reposted by Liz Miller
simonbullock11.bsky.social
Our latest work, in collaboration with the terrific @kashishsingh.bsky.social in the Carter lab @mrclmb.bsky.social is out. So proud of this study and everyone involved...
biorxiv-cellbio.bsky.social
Cryo-EM structures of Egl-BicD-RNA complexes reveal how diverse mRNAs are selected for subcellular localization https://www.biorxiv.org/content/10.1101/2025.08.02.668268v1
Reposted by Liz Miller
kaksonen.bsky.social
Hello microscopy and imaging experts and enthusiasts!
We are looking for a staff scientist to join us here in Geneva to work on microscopy and image analysis projects! See the link for the job announcement (in French and in English).

Please apply and/or repost!

jobs.unige.ch/www/wd_porta...
Reposted by Liz Miller
alexisbarr.bsky.social
We're recruiting junior team leaders @mrc-lms.bsky.social This time we're looking for those working in human metabolic disease.

It's a great place to start your lab. Fantastic colleagues, exciting science, world class facilities. Join us!

lms.mrc.ac.uk/work/vacanci...
Programme Leader Track - MRC Laboratory of Medical Sciences
We are recruiting Programme Leader Track positions focusing on 1) Metabolic Physiology using murine and/or human in vivo models and 2) Immunometabolism.
lms.mrc.ac.uk
lizmillercu.bsky.social
Thanks to Josh and all the students and post-docs for a great visit. Such a wonderful community doing great science!
Reposted by Liz Miller
sten.linnarsson.org
A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)
ki.se
Applications are now open! We are recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential.
🔗 All positions: ki.se/en/about-ki/...
Reposted by Liz Miller
xlichem.bsky.social
🚨Interdisciplinary perspectives needed🚨
Have you worked across disciplines in research? We want to hear from you!
Take part in the Healthier Science through Collaboration (HxC) survey. Help shape better, more inclusive research environments.
app.onlinesurveys.jisc.ac.uk/s/edinburgh/...
Please RT.
HxC Survey on Interdisciplinary Work
Online surveys is a powerful, easy to use tool for creating online surveys. Run by Jisc, online surveys is used by over 300 different organisations in the UK...
app.onlinesurveys.jisc.ac.uk
lizmillercu.bsky.social
I think it's a clamp. Provides structural rigidity but via protein-protein interfaces so it might be dynamic/malleable. Four complexes (so far - not privilege to Alex's info): Sec31 (the OG and only essential function in yeast), Sec16 (function unknown), NPC, GATOR.
Reposted by Liz Miller
jcb.org
Justin Krish Williams, Randy Schekman et al. @ucberkeleyofficial.bsky.social show that human cells shed extracellular vesicles in order to repair their membranes. rupress.org/jcb/article/...

#EVs #Exosomes
Reposted by Liz Miller
jcb.org
Our Immune Cell Biology collection emphasizes cellular dynamics, immune regulation, and disease mechanisms. Explore research on the mechanisms of dendritic cell regulation, T cell migration, neutrophil spreading and macrophage motility in tumor invasion, & more: rupress.org/jcb/collecti...
#AAI2025
Reposted by Liz Miller
katjaroeper.bsky.social
Latest paper from the lab @cellbiol-mrclmb.bsky.social, Anna's PhD work hot off the press @plosbiology.org ! Using single cell genomics to understand tube morphogenesis, and why it's as important to switch things off as it is to switch them on!
Reposted by Liz Miller
lmachesky.bsky.social
Congrats to Ian Ganley of Dundee University on winning the #BSCB Hooke Medal 🥇for his outstanding work on mitophagy 🎉🎉🌟
Reposted by Liz Miller
bscb-official.bsky.social
Only one week to go until #biologists100 conference!

Check out this pre-conference guide from @biologists.bsky.social @the-node.bsky.social @focalplane.bsky.social @prelights.bsky.social
focalplane.bsky.social
Attending #biologists100 in Liverpool?

We’ve put together a pre-conference recording together with @the-node.bsky.social and @prelights.bsky.social.
And @jens-cells.bsky.social has published a general conference guide on the Node to help you prep!
focalplane.biologists.com/2025/03/17/b...
Biologists @ 100 video guide - FocalPlane
Biologists @ 100 video guide - News
focalplane.biologists.com
Reposted by Liz Miller
carter-lab.bsky.social
As my lab's first post on Bluesky. If you are a UK Structural Biologist please come to our one day meeting on Friday 6th December
Lots of talk slots to be selected from abstracts.
Deadline for abstracts is TOMORROW: Friday 15th Nov.
bit.ly/4fDEqfZ
lizmillercu.bsky.social
One last shout-out to @jcellbiol.bsky.social who handled an efficient, constructive and very fair peer review process. I know I'm biased because I'm an academic editor there, but this is now my go-to journal for our very best work.
lizmillercu.bsky.social
Finally, bioinformatic analysis by @xlichem.bsky.social systematically examined SURF4 export signals across the secretome, finding that cytokines/chemokines and proteases are most likely to access the "fast-track".
lizmillercu.bsky.social
...usually co-translational. Stalled translation products STILL bound SURF4 when folding could not have happened. We think this is a fast-track out of the ER for certain classes of proteins that have strong SURF4-binding motifs immediately downstream of their signal peptides.
lizmillercu.bsky.social
Third surprise: SURF4 can bind some clients co-translationally. This is not how we thought export receptors should work - we assumed that they would only bind fully folded cargoes, once they were competent for export. But the ER export signal is revealed after signal peptide cleavage, which is ...
lizmillercu.bsky.social
Second surprise: SURF4-SEC24A interaction uses two sites on SEC24A, the B-site and the D-site, but SURF4 only occupies the D-site. The B-site interaction is likely driven by a putative co-receptor, TMED10, which also interacts with the lumenal client.
lizmillercu.bsky.social
First surprise: SURF4 interacts with both SEC24A and SEC24C, with the different interactions responsible for export of different lumenal cargoes.