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Reposted by Xiaohan Li

Hao Yin @haoyin.bsky.social · 2d

Best practices & tools in R & Python for statistical processing and visualization of #Lipidomics & #Metabolomics data

Data imputation/normalization
Batch correction
Data visualization
Statistical models

Instrumental handbook, adoptable for other omics

#NatComms 2025
www.nature.com/articles/s41...

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Reposted by Xiaohan Li

idpgrc.bsky.social @idpgrc.bsky.social · 6d

🚨🚨The GRC on Intrinsically Disordered Proteins #IDPs is back!! 🍝🧵🏔️Join us for cutting-edge IDP science, great discussions, and mountain views 🌄🍝
📅 June 21-26, 2026 | Les Diablerets, Switzerland
👉 Details & registration: grc.org/intrinsicall...

2026 Intrinsically Disordered Proteins Conference GRC

The 2026 Gordon Research Conference on Intrinsically Disordered Proteins will be held in Les Diablerets, Vaud (fr) Switzerland. Apply today to reserve your spot.

grc.org

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Reposted by Xiaohan Li

Sarah Shammas @sarahshammas.bsky.social · 7d

Why are transcription factors disordered? Come join us in Oxford as a postdoc and we'll find out together!

Help publish 3 mature projects, AND develop cool new single molecule fluorescence binding assays!

biophysics
transcription
protein:DNA interactions

my.corehr.com/pls/uoxrecru...

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Xiaohan Li @xlichem.bsky.social · 6d

Amazing! A lot of congrats Alex!

Reposted by Xiaohan Li

Giulio Tesei @giuliotesei.bsky.social · 7d

I'm hiring for a PhD position at Malmö University, Sweden!

The project will focus on molecular modelling of proteins, lipids, and biomolecular condensates at cell membranes.

More details and application form: tinyurl.com/4zm92365

Please feel free to share!

@vetenskapsradet.bsky.social | @mau.se

Snapshot of a condensate near a lipid membrane with Swedish Research Council and Malmö University logos.

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Reposted by Xiaohan Li

James Manton @jamesdmanton.bsky.social · 23d

The final version of our multispectral microscopy manuscript is now online at Nature Photonics: www.nature.com/articles/s41...

The main additions are some further comparisons to yet more unmixing algorithms, in which we find that our algorithm is still the most accurate.

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Xiaohan Li @xlichem.bsky.social · 23d

Is it just my feeling that the Bluesky community has suddenly grown dynamic and “real” (i.e, much less boring political statements to dilute interesting people and stuff on my timeline) in the past 3 months… oh Yay!

i.in

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Xiaohan Li @xlichem.bsky.social · 23d

I wish 7-11 can come to the UK as well. So tired of “meal deals” when you don’t have time to cook… I mean, it is indeed a deal, but not really a meal…

Alex Merz 🇺🇸🇨🇦🇺🇦 @merz.bsky.social · 23d

If you are of a certain age, you might remember the "I'll have what she's having" scene in "When Harry Met Sally."

The New York Times @nytimes.com · 24d

The Japanese parent company of 7-Eleven is betting billions of dollars that it can expand its business in the U.S. by making its convenience stores more like the food meccas they are in Japan. www.nytimes.com/2025/09/09/b...

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Reposted by Xiaohan Li

Sofya Garushyants @garushyants.bsky.social · 23d

hey bluesky 👋 visa hurdles mean I’m looking for opportunities outside the US. I’m a computational biologist (bacterial + phage genomics, postdoc in Koonin’s group @ NIH). I am interested in teaming up on funding apps. reach out if this resonates!

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Reposted by Xiaohan Li

Robert Francis @birdhistory.bsky.social · 27d

This isn't how birding is supposed to work!

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Jason Stajich @hyphaltip.bsky.social · Aug 6

New #preprint from talented graduate student for a workflow we have been using for a while into a formal usage www.biorxiv.org/content/10.1...

Phyling: phylogenetic inference from annotated genomes

Phyling is a fast, scalable, and user-friendly tool supporting phylogenomic reconstruction of species phylogenies directly from protein-encoded genomic data. It identifies orthologous genes by searchi...

www.biorxiv.org

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Reposted by Xiaohan Li

Derivery Lab - MRC LMB @deriverylab.bsky.social · Jun 23

🚨 JOB ALERT 🚨
We're hiring a Research Assistant – no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired 🧫🔬
Apply now 👉 www.nature.com/naturecareer...

#STEMCareers #ResearchJobs

A picture of 3 rows of people on steps at the MRC LMB. From left to right - top row: Akaash, Vic, Lara - Middle row: Kerrie, Manu, Paddy - bottom row: Meg and Julie

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Xiaohan Li @xlichem.bsky.social · Jun 9

🚨Interdisciplinary perspectives needed🚨
Have you worked across disciplines in research? We want to hear from you!
Take part in the Healthier Science through Collaboration (HxC) survey. Help shape better, more inclusive research environments.
app.onlinesurveys.jisc.ac.uk/s/edinburgh/...
Please RT.

HxC Survey on Interdisciplinary Work

Online surveys is a powerful, easy to use tool for creating online surveys. Run by Jisc, online surveys is used by over 300 different organisations in the UK...

app.onlinesurveys.jisc.ac.uk

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Reposted by Xiaohan Li

Richard Sever @richardsever.bsky.social · Jun 4

"a fascinating case study on the limits of AI in biology and the harms of current publishing incentives" rachel.fast.ai/posts/2025-0...

Rachel Thomas, PhD - Deep learning gets the glory, deep fact checking gets ignored

an AI researcher going back to school for immunology

rachel.fast.ai

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Xiaohan Li @xlichem.bsky.social · May 30

Join us for the first Scottish Cell Biology Meeting in Dundee! 🔥

Free registration and lots of opportunities for oral, poster presentations, and networking opportunities! #SCBM2025

Abstract submission until June 6th, general registration until July. All cell biologists are welcome!

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Reposted by Xiaohan Li

MRC Laboratory of Molecular Biology @mrclmb.bsky.social · May 29

How did life on Earth begin? 🌍🧬
New #LMBResearch from Phil Holliger’s group, including James Attwater (now @uclchemistry.bsky.social‬‬ @uclnews.bsky.social) shows how pH-freeze-thaw cycles enables RNA self-replication, overcoming a key evolutionary hurdle.‬
Read more: www.ucl.ac.uk/news/2025/ma...

Chemists recreate how RNA might have reproduced for first time

Chemists at UCL and the MRC Laboratory of Molecular Biology have demonstrated how RNA (ribonucleic acid) might have replicated itself on early Earth – a key process in the origin of life.

www.ucl.ac.uk

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Xiaohan Li @xlichem.bsky.social · May 23

Really great to see this out!

Alex Holehouse @alexholehouse.bsky.social · May 23

Now published! Big congrats to first author @gginell.bsky.social

We are actively working improving/updating various aspects of FINCHES; don't hesitate to reach out if you run into issues, have questions.
www.science.org/doi/10.1126/...

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Reposted by Xiaohan Li

Diego del Alamo @delalamo.xyz · Apr 27

"De novo prediction of protein structural dynamics"

I'll be presenting an overview of the field tomorrow at a workshop. Link to a PDF copy of the presentation: delalamo.xyz/assets/post_...

delalamo.xyz

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Reposted by Xiaohan Li

Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · Apr 17

AlphaFold is amazing but gives you static structures 🧊

In a fantastic teamwork, @mcagiada.bsky.social and @emilthomasen.bsky.social developed AF2χ to generate conformational ensembles representing side-chain dynamics using AF2 💃

Code: github.com/KULL-Centre/...
Colab: github.com/matteo-cagia...

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Reposted by Xiaohan Li

Brett Collins @brettcollins.bsky.social · Apr 16

Pleased to see Kevin's paper on the Retromer complex interaction with yeast Vps5 and Vps17 proteins now online!

Cell Biology J-Club @cellclub.bsky.social · Apr 15

Molecular basis for the assembly of the Vps5-Vps17 SNX-BAR proteins with Retromer
www.nature.com/articles/s41...

Molecular basis for the assembly of the Vps5-Vps17 SNX-BAR proteins with Retromer - Nature Communications

Retromer complex cooperates with Vps5 and Vps17 in yeast to traffic transmembrane proteins. Here, the authors present structural and functional studies that reveal the mechanism of Retromer and Vps5 i...

www.nature.com

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Reposted by Xiaohan Li

MRC-LMB Cell Biology Division @cellbiol-mrclmb.bsky.social · Apr 7

A great tribute to David Stevens, a terrific cell biologist and missed by so many of his friends and colleagues. As they say 'one of the good guys'. journals.biologists.com/jcs/article/...

Remembering David Stephens (1971–2024)

In the autumn of 2024, David Stephens, a prominent member of the UK cell biology community and a brilliant scientist, leader and mentor, passed away. With his pragmatism and natural authority, combine...

journals.biologists.com

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Reposted by Xiaohan Li

MU-Peter Shimon 🀄️ @mu-peter.bsky.social · Mar 31

Long-term studies provide unique insights into evolution 🧪
www.nature.com/articles/s41...

Showcasing groundbreaking discoveries of long-term evolutionary studies underscoring their crucial role in advancing our understanding of the complex nature of evolution across multiple systems and timescales.

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Reposted by Xiaohan Li

Katie Downes @dr-downes.bsky.social · Mar 25

I am thrilled to announce my and @giuliazanetti.bsky.social's latest review "Mechanisms of COPII coat assembly and cargo recognition in the secretory pathway" in @natrevmcb.bsky.social with @springernature.com.

Check it out here!
rdcu.be/eeY1J

#COPII #CryoEM #TeamTomo #MembraneTrafficking #ERES

Mechanisms of COPII coat assembly and cargo recognition in the secretory pathway

Nature Reviews Molecular Cell Biology - Coat protein complex II (COPII) subunits assemble to form membrane transport carriers at ER exit sites, thereby concentrating secretory cargoes and...

rdcu.be

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Reposted by Xiaohan Li

Colin Jackson @cjjackson.bsky.social · Mar 26

biorxiv.org/content/10.1... Here’s a paper that was many years in the making. The idea that the climate can affect the thermodynamic mechanism of binding due to the temperature dependence of the entropy term is interesting- we see gradual shift in binding mode along evo trajectory…

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