Viewing protein evolution through the lens of complex systems theory may offer new insights into the principles driving biological adaptation. In this Comment we explore how characteristics such as se...

This is the official web page for the James Fraser Lab at UCSF.

Telomerase ribonucleoprotein (RNP) synthesizes telomeric repeats at chromosome ends using a telomerase reverse transcriptase (TERT) and a telomerase RNA (hTR in humans). Previous structural work showe...

Please note: authors do not need to have already posted their research as a preprint for an initial evaluation by eLife. During submission authors can indicate if they have already posted a preprint, and if not, can ask us to deposit the work as a preprint to bioRxiv or medRxiv, as appropriate.

Pyruvate is the end-product of glycolysis and a central metabolite involved in many biochemical pathways. However, a lack of high-performance (i.e., Δ F / F > 10) single fluorescent protein (FP)-base...

University of California, San Francisco is hiring. Apply now!

Details about the current priorities for UCSF Advocates.

Machine learning (ML) has revolutionized protein biology, solving long-standing problems in protein folding, scaffold generation and function design tasks. A range of architectures have shown success ...

Modern science wouldn’t exist without the online research repository known as arXiv. Three decades in, its creator still can’t let it go.

Epistasis, in which the effect of a mutation depends on the genetic background it is introduced into, drives protein evolution and design by shaping the fitness landscape. Quantifying how constrained ...