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Analysis of native Ist1 dynamics reveals multiple pools of ESCRT-III on endosomes

Cell Biology J-Club @cellclub.bsky.social · 23h

Analysis of native Ist1 dynamics reveals multiple pools of ESCRT-III on endosomes url: rupress.org/jcb/article-...

This study defines the native dynamics of the ESCRT-III component Ist1 in mammalian cells, highlighting the existence of multiple, unique pools at endosome

rupress.org

CHIP, VCP, and Nucleolar Gatekeepers Remodel the Nucleolus into a Stress-Responsive Proteostasis Hub

Cell Biology J-Club @cellclub.bsky.social · 2d

CHIP, VCP, and Nucleolar Gatekeepers Remodel the Nucleolus into a Stress-Responsive Proteostasis Hub www.biorxiv.org/content/10.1...

The nucleolus, classically dedicated to ribosome biogenesis, also acts as a stress-responsive proteostasis hub. During heat shock, misfolded proteins accumulate in its granular component (GC), but whe...

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates

Cell Biology J-Club @cellclub.bsky.social · 2d

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates www.biorxiv.org/content/10.1...

The endoplasmic reticulum (ER)'s continuous morphology is tightly controlled by ER-shaping proteins, whose genetic or expression defects drive a spectrum of neurodegenerative disorders from Hereditary...

MBOAT7 and CDS2 coordinate lipid droplet dynamics and cholesterol metabolism in liver

Cell Biology J-Club @cellclub.bsky.social · 3d

MBOAT7 and CDS2 coordinate lipid droplet dynamics and cholesterol metabolism in liver www.biorxiv.org/content/10.1...

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a highly prevalent disorder worldwide characterized by the accumulation of hepatic lipid droplets (LDs). However, the mechanisms by ...

Structural polymorphism of α-synuclein fibrils alters the pathway of Hsc70-mediated disaggregation | The EMBO Journal

Cell Biology J-Club @cellclub.bsky.social · 3d

Structural polymorphism of α-synuclein fibrils alters the pathway of Hsc70-mediated disaggregation | The EMBO Journal www.embopress.org/doi/full/10....

imageimageIn synucleinopathies such as Parkinson’s disease, the intrinsically disordered protein α-synuclein aggregates into amyloid fibrils. This study explores the effect of structural polymorphism ...

www.nobelprize.org/prizes/medic...

Cell Biology J-Club @cellclub.bsky.social · 3d

Nobel Prize in Physiology or Medicine 2025

The Nobel Prize in Physiology or Medicine 2025 was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

www.nobelprize.org

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Cell Biology J-Club @cellclub.bsky.social · 3d

The Lysosome Surface is an Unappreciated Hub for Vasopressin V2 Receptor Signaling www.biorxiv.org/content/10.1...

The Lysosome Surface is an Unappreciated Hub for Vasopressin V2 Receptor Signaling

G protein-coupled receptors (GPCRs) have traditionally been understood to signal through heterotrimeric G proteins exclusively from the cell surface followed by β-arrestin (βarr)-mediated desensitizat...

Tubulin Acetylation Deficiency Promotes Axonemal Turnover and Increases Cytoplasmic Microtubules

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Cell Biology J-Club @cellclub.bsky.social · 4d

Tubulin Acetylation Deficiency Promotes Axonemal Turnover and Increases Cytoplasmic Microtubules www.biorxiv.org/content/10.1...

Tubulin post translational modifications regulate microtubule dynamics; among these, α tubulin acetylation has been linked to microtubule stability. We generated a Chlamydomonas mutant lacking the ace...

Phosphatidylserine and RhoB connect phosphatidylinositol 4-phosphate and phosphatidic acid metabolism at the plasma membrane

Cell Biology J-Club @cellclub.bsky.social · 5d

Phosphatidylserine and RhoB connect phosphatidylinositol 4-phosphate and phosphatidic acid metabolism at the plasma membrane www.biorxiv.org/content/10.1...

Cells tightly control the homeostatic levels and subcellular localizations of membrane phospholipids through the regulation of the activities of numerous lipid-metabolizing enzymes and lipid transfer ...

Mapping cryptic phosphorylation sites in the human proteome | The EMBO Journal

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Cell Biology J-Club @cellclub.bsky.social · 5d

Mapping cryptic phosphorylation sites in the human proteome | The EMBO Journal www.embopress.org/doi/full/10....

imageimageThe study reports a class of phosphorylation sites, named cryptic phosphosites, buried within protein cores. Their transient exposure during folding suggests a novel regulatory mechanism lin...

The origin of septin ring size control in budding yeast | The EMBO Journal

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Cell Biology J-Club @cellclub.bsky.social · 5d

The origin of septin ring size control in budding yeast | The EMBO Journal www.embopress.org/doi/full/10....

imageimageCdc42-driven polarization and subsequent septin ring formation in S. cerevisiae is a prominent example for formation of a subcellular structure that scales with cell size. This study integra...

Target cell adhesion limits macrophage phagocytosis and promotes trogocytosis

Cell Biology J-Club @cellclub.bsky.social · 5d

Target cell adhesion limits macrophage phagocytosis and promotes trogocytosis url: rupress.org/jcb/article-...

Macrophages are presumed to attack antibody-opsonized cancer cells by phagocytosis. Rollins et al. found that macrophages attack adherent cells using trogo

rupress.org

Proximity-specific ribosome profiling reveals the logic of localized mitochondrial translation

Cell Biology J-Club @cellclub.bsky.social · 6d

Proximity-specific ribosome profiling reveals the logic of localized mitochondrial translation: Cell www.cell.com/cell/fulltex...

Development of LOV-domain-controlled ligase for translation localization (LOCL-TL), an optogenetic approach for monitoring translation with codon resolution at any defined subcellular location under p...

www.cell.com

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Cell Biology J-Club @cellclub.bsky.social · 7d

Uncovering cargo clients and accessory factors of AP-1 and AP-4 through vesicle proteomics | PNAS www.pnas.org/doi/10.1073/...

Uncovering cargo clients and accessory factors of AP-1 and AP-4 through vesicle proteomics | PNAS

The trans-Golgi network (TGN) is a crucial sorting station in the secretory pathway, where adaptor protein (AP) complexes ensure selective cargo pa...

www.pnas.org

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Cell Biology J-Club @cellclub.bsky.social · 7d

In @elife: Tracking maternal proteins uncovers a central role for the residual body in organelle recycling during Toxoplasma gondii replication doi.org/10.7554/eLif...

doi.org

Identification of a RAB32-LRMDA-Commander membrane trafficking complex reveals the molecular mechanism of human oculocutaneous albinism type 7 - Nature Communications

Cell Biology J-Club @cellclub.bsky.social · 7d

Identification of a RAB32-LRMDA-Commander membrane trafficking complex reveals the molecular mechanism of human oculocutaneous albinism type 7
www.nature.com/articles/s41...

Membrane trafficking is essential for organelle biogenesis. Here, the authors discover an alternative assembly of the Commander trafficking complex and show its role in melanosome biogenesis and in a subtype of albinism.

www.nature.com

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Cell Biology J-Club @cellclub.bsky.social · 8d

www.pnas.org/doi/10.1073/... Mitochondrial ROS triggers mitophagy through activating the DNA damage response signaling pathway | PNAS

Mitochondrial ROS triggers mitophagy through activating the DNA damage response signaling pathway | PNAS

The homeostatic link between the production of mitochondrial ROS (mtROS) and mitophagy plays a significant role in how cells respond to various phy...

www.pnas.org

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Cell Biology J-Club @cellclub.bsky.social · 8d

Synthetic chaperone based on Hsp90-Tau interaction inhibits Tau aggregation and rescues physiological Tau-Microtubule interaction
www.nature.com/articles/s41...

Synthetic chaperone based on Hsp90-Tau interaction inhibits Tau aggregation and rescues physiological Tau-Microtubule interaction - Nature Communications

Tau aggregation, a hallmark of Alzheimer’s disease, disrupts neuron structure. Aging weakens chaperone defenses like Hsp90. This study designs β-Hsp90, a small peptide mimicking Hsp90, to prevent Tau aggregation, offering promise for new amyloid disease drugs.

www.nature.com

HSP90 differentially stabilizes plant ABCB-type auxin transporters on the plasma membrane - Nature Communications

Cell Biology J-Club @cellclub.bsky.social · 9d

HSP90 differentially stabilizes plant ABCB-type auxin transporters on the plasma membrane
www.nature.com/articles/s41...

Tsering et al. show that in pants, HSP90 acts as a positive regulator of auxin transport by providing steady-state levels of ABCB transport capacity in an action that isorchestrated by its co-chaperone FKBP42/TWISTED DWARF1.

www.nature.com

LLP1 is a pyrophosphatase involved in homeostasis/quality control of dolichol-linked oligosaccharide

Cell Biology J-Club @cellclub.bsky.social · 10d

LLP1 is a pyrophosphatase involved in homeostasis/quality control of dolichol-linked oligosaccharide url: rupress.org/jcb/article-...

Dolichol-linked oligosaccharide (DLO) is the precursor for asparagine-linked protein glycosylation. We identified a DLO-pyrophosphatase (Llp1), which is in

rupress.org

Cell Biology J-Club @cellclub.bsky.social · 10d

In @elife: Lipid packing contributes to the confinement of caveolae to the plasma membrane doi.org/10.7554/eLif...

Lipid packing contributes to the confinement of caveolae to the plasma membrane

doi.org

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Cell Biology J-Club @cellclub.bsky.social · 10d

In @elife: The Rab7-Epg5 and Rab39-ema modules cooperatively position autophagosomes for efficient lysosomal fusions doi.org/10.7554/eLif...

The Rab7-Epg5 and Rab39-ema modules cooperatively position autophagosomes for efficient lysosomal fusions

doi.org

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Cell Biology J-Club @cellclub.bsky.social · 10d

Atlas of Lysosomal Aging Reveals a Molecular Clock of Storage Disorder-Associated Metabolites www.biorxiv.org/content/10.1...

Atlas of Lysosomal Aging Reveals a Molecular Clock of Storage Disorder-Associated Metabolites

Lysosomal dysfunction is a well-recognized feature of aging, yet its systematic molecular investigation remains limited. Here, we employ a suite of tools for rapid lysosomal isolation to construct a m...