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Sarah Shammas @sarahshammas.bsky.social · 6d

Fantastic Alex!!! Congratulations. It's so well deserved. And what a beautiful tribute in your thread.

Sarah Shammas @sarahshammas.bsky.social · 7d

Please share with anyone you think may be interested

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Sarah Shammas @sarahshammas.bsky.social · 7d

Why are transcription factors disordered? Come join us in Oxford as a postdoc and we'll find out together!

Help publish 3 mature projects, AND develop cool new single molecule fluorescence binding assays!

biophysics
transcription
protein:DNA interactions

my.corehr.com/pls/uoxrecru...

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Sarah Shammas @sarahshammas.bsky.social · Sep 8

In the spirit of scientific progress if you have any thoughts after reading our manuscript I am happy to hear from you. Please email me on [email protected].

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Sarah Shammas @sarahshammas.bsky.social · Sep 8

Over 10% of human transcription factors are oligomeric. Stoichiometry might be dialled to modulate transcription. We show CREB searches in DNA mixtures as a dimer, and suggest this might be common amongst other members of the bZIP family which fold on binding DNA.

www.biorxiv.org/content/10.1...

All but one bZIP monomer, Jun, has significantly higher affinity for other monomers than its own DNA target, favouring the dimer pathway for target search at equilibrium.

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Sarah Shammas @sarahshammas.bsky.social · Jun 3

I'm excited to be invited alongside the fabulous Sonia Longhi to present at IDPseminars this Thursday. I will talk about some of our work with disordered DNA binding domains.

IDPSeminars @idpseminars.bsky.social · Jun 3

IDPSeminars is back with another seminar this week from @sarahshammas.bsky.social and @sonia-longhi.bsky.social!

Come hear about transcriptional regulation and viral pathogenesis!

Thursday June 5th!
PST 10 am EST 1 pm CET 7 pm!

Info: idpseminars.com
Signup form: forms.gle/3yCHeYvuuqLh...

Sarah Shammas (University of Oxford):Opportunities in DNA binding provided by protein disorder

Sonia Longhi (AFMB Marseille): Intrinsic disorder, phase transitions and fibril formation by the Henipavirus V and W proteins: a new hallmark of viral pathogenesis?

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Reposted by Sarah Shammas

Andrew Bowman @bowchro.bsky.social · Feb 7

Just one stop. www.nature.com/articles/s41...

Engineering a genomically recoded organism with one stop codon - Nature

Ochre, a strain of Escherichia coli engineered to have a single stop codon, enables reassignment of four codons for non-degenerate functions, such as incorporation of non-standard amino acids into pro...

www.nature.com

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Reposted by Sarah Shammas

IDPSeminars @idpseminars.bsky.social · Feb 7

Announcing the Biophysics Week IDP Trainee Symposium on March 27 at 12pm CT hosted by @idpseminars.bsky.social & The BPS IDP Subgroup! Join via Zoom for talks by talented grad students & postdocs. Abstract submissions are open! See flyer for more details! #BiophysicsWeek @biophysicalsoc.bsky.social

Information flyer for IDPSeminars/Biophysics week event - all details at https://idpseminars.com/

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Reposted by Sarah Shammas

Romain Koszul @rkoszul.bsky.social · Feb 7

Our latest work: how can compartmentalization emerge in a eukaryotic genome lacking canonical heterochromatin?
By investigating bacterial genomes put in yeast, we show that the presence or absence of transcription is sufficient!
#chromatin #3Dgenome #generegulation
www.science.org/doi/10.1126/...
👇

Sequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus

In eukaryotes, DNA-associated protein complexes coevolve with genomic sequences to orchestrate chromatin folding. We investigate the relationship between DNA sequence and the spontaneous loading and a...

www.science.org

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Reposted by Sarah Shammas

Tom Ellis @proftomellis.bsky.social · Feb 6

What happens to bacterial genomes when they're cloned into yeast? Do they transcribe, do they get silenced, do they get packaged away from the rest of the DNA? This cool study congrats to the Koszul lab team at Pasteur for this great work.
www.science.org/doi/10.1126/...

Sequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus

In eukaryotes, DNA-associated protein complexes coevolve with genomic sequences to orchestrate chromatin folding. We investigate the relationship between DNA sequence and the spontaneous loading and a...

www.science.org

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Reposted by Sarah Shammas

Magnus Kjærgaard @proteinmagnus.bsky.social · Jan 14

PhD opportunities (yes, plural!)

We will launch a center of excellence “Plat-PATH” with @bjornppedersen.bsky.social this summer. We have an opening for some PhD students to work on plant hormone transporter mechanism.

- Details and application link: tinyurl.com/44hf9zkd
Please repost 💚

Structural and biophysical analysis of plant hormone transmembrane transport

tinyurl.com

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Reposted by Sarah Shammas

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · Dec 5

Attn. Intrinsically Disordered Proteins Subgroup members:
We are excited to host our IDP subgroup dinner on Feb 15 after the IDP symposium at a Mexican restaurant in Los Angeles: Sol Agave L.A. LIVE.
www.solagave.com/los-angeles

You can purchase a dinner ticket:
www.biophysics.org/store/produc...

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Sarah Shammas @sarahshammas.bsky.social · Dec 6

Opportunity for postdocs in IDP related biophysics research! The deadline is coming up quite soon.

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · Dec 5

The deadline for the 2025 Intrinsically Disordered Protein (IDP) Subgroup Postdoctoral Awards is approaching (December 15, 2024). The award includes an oral presentation at the IDP symposium & an honorarium. Postdocs working in the IDP field are welcome to apply:
www.biophysics.org/awards-fundi...

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Sarah Shammas @sarahshammas.bsky.social · Nov 28

A paper to cite!

estella newcombe @estellaan.bsky.social · Nov 27

We did this crazy project where we tried to see if proteins could interact with their mirror image ligand. Seems impossible when proteins need to form 3D structures to interact. But what about if the interaction remains disordered???

www.nature.com/articles/s41...

Stereochemistry in the disorder–order continuum of protein interactions - Nature

Studies on protein–protein interactions using proteins containing d- or l-amino acids show that stereoselectivity of binding varies with the degree of disorder within the complex.

www.nature.com

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Sarah Shammas @sarahshammas.bsky.social · Nov 28

I've been waiting to see this come out. Congratulations! I look forward to sharing this paper with my undergraduates too :-)

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Reposted by Sarah Shammas

Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · Nov 25

If you are a PhD student and like protein disorder (or want to learn more), Birthe Kragelund @bbkrage.bsky.social and Kristian Strømgaard are organizing a PhD course on How IDPs work 🧶🧬🧪 Note the cost if you are not at a Danish university.

Details: phdcourses.ku.dk/DetailKursus...

Flyer for the course Keeping up with the interactome - How IDPs work including a list of speakers:
Professor Tanja Mittag, St Jude Children’s Hospital, Memphis, US
Professor Kresten Lindorff-Larsen, BIO, SCIENCE, UCPH
Professor Ylva Ivarsson, Uppsala University, Sweden
Dr. Michael Wehr, Systasy Bioscience, Munich, Germany
Professor Zsuzsanna Dostztányi, Eötvös Loránd University, Hungary
Professor Kristian Strømgaard, HEALTH, UCPH
Professor Stefano Gianni, Sprienza University of Rome, Italy
Professor Per Jemth, Uppsala University, Sweden
Dr. Franziska Schöppe, Novo Nordisk A/S, Denmark
Professor Benjamin Schuler, University of Zurich, Switzerland
Professor Alfonse De Simone, University of Naples, Italy
Dr. Malene Ringkjøbing Jensen, CNRS, Grenoble, France
Alleyn Plowright, Chief Scientific Officer, Pangea Bio, London UK
Professor Birthe B. Kragelund, BIO, SCIENCE, UCPH

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Reposted by Sarah Shammas

amelie-iska @amelie-iska.bsky.social · Nov 20

www.biorxiv.org/content/10.1...

Improved protein binder design using ꞵ-pairing targeted RFdiffusion

Despite recent advances in the computational design of protein binders, designing proteins that bind with high affinity to polar protein targets remains an outstanding problem. Here we show that RFdif...

www.biorxiv.org

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Reposted by Sarah Shammas

Altmetric @altmetric.com · Nov 18

We strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how:

docs.bsky.app/docs/advance...

#AcademicSky #HigherEd #Altmetrics

Action Intent Links | Bluesky

Authors, websites, and apps can use action intent links to implement "Share on Bluesky" buttons, or similar in-app actions. Logged-in users will be directed to the corresponding action view in the Blu...

docs.bsky.app

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Reposted by Sarah Shammas

Eileen Furlong @eileen-furlong.bsky.social · Nov 18

My first post on Blue Sky - moving over !

For all post-docs out there - fantastic opportunity @EMBL. Independent group leader position: Core funding, state-of-the-art core facilities, access to fantastic Ph.D. students, and of course amazing colleagues. Please apply www.embl.org/jobs/positio...

EMBL Jobs

We offer a wide range of challenging scientific and non-scientific positions at all of our European locations and encourage applications from international candidates at all career levels.

www.embl.org

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Reposted by Sarah Shammas

Rohit V. Pappu @rohitpappu68.bsky.social · Nov 15

New collaborative work in collaboration with the labs of Robert Best & Tanja Mittag driven by Ben Schuler.
Identifying Sequence Effects on Chain Dimensions of Disordered Proteins by Integrating Experiments and Simulations.
pubs.acs.org/doi/10.1021/...

Identifying Sequence Effects on Chain Dimensions of Disordered Proteins by Integrating Experiments and Simulations

It has become increasingly evident that the conformational distributions of intrinsically disordered proteins or regions are strongly dependent on their amino acid compositions and sequence. To facili...

pubs.acs.org

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Reposted by Sarah Shammas

Alex Holehouse @alexholehouse.bsky.social · Nov 10

BONUS! If IDPs are your jam, check out an ever-expanding starter pack!
go.bsky.app/J23B51L

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Reposted by Sarah Shammas

Black In Biophysics @blackinbiophys.bsky.social · Nov 14

Register for the upcoming JUST-B Seminar on Nov. 19th at 11am PST / 2pm EST to learn about the science of two amazing PhD students❗️❗️❗️

Register here: biophysics.org/store/products…

@blackinx.bsky.social

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Reposted by Sarah Shammas

Denis Wirtz @deniswirtz.bsky.social · Nov 16

Download our database of 313 different postdoctoral fellowships.

For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship).

Download our database here: research.jhu.edu/rdt/funding-...

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Sarah Shammas @sarahshammas.bsky.social · Nov 14

Looking forward to reading this today