Lightnews — Scholar-powered news

Samrat Mukhopadhyay

@samratmukhopadhyay.bsky.social

530 followers 220 following 100 posts

Professor & JC Bose Fellow at IISER Mohali, India Studying Intrinsically Disordered Proteins, Condensates, Amyloids, Single-Molecule Biophysics Editor @BiophysJ.bsky.social Attended IISc Bangalore & @Scripps.edu Lab Website: https://www.MukhopadhyayLab.org

www.MukhopadhyayLab.org

Posts Media Videos Starter Packs

Pinned

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · Nov 13

My first Bluesky post to share our latest (and 4th) Nature Communications paper. We employed homoFRET (recorded by depolarization of fluorescence anisotropy) to study condensate properties. Congrats to Ashish, Anuja, Snehasis, Lisha, Dhruba & members of Indranil's lab!
www.nature.com/articles/s41...

Intermolecular energy migration via homoFRET captures the modulation in the material property of phase-separated biomolecular condensates - Nature Communications

The properties of biomolecular condensates can be regulated by multiple factors, including intermolecular dynamics. Here, the authors use fluorescence anisotropy-based homoFRET imaging to monitor the ...

www.nature.com

2 18

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 26d

What a terrific recognition of our research field!
Dirk Görlich (Max Planck Institute Göttingen) and Steven McKnight (UT Southwestern) received the Lasker Award for their work on low-complexity domains and their phase separation.
Read the perspective in PNAS:
www.pnas.org/doi/epdf/10....

1 4

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · Aug 31

Last week, I started teaching the freshman biology class (BIO 101), which I'm very excited about. I'm sharing one of my introductory slides on the three pillars of modern biology - evolution, genetics and molecular nature of genetic material. Looking forward to teaching the first-year biology class!

1 3

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · Aug 20

Happy to share our community note published in Nature Communications @natcomms.nature.com. In this 14-page article (34 authors from 9 countries), we discuss current practices in phase separation. We hope it will be useful to the biomolecular condensate community.
www.nature.com/articles/s41...

6 21

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · Aug 17

Breathtaking view of the Shivalik range of the Himalayas from the balcony of our apartment on the 7th floor at IISER Mohali: at 5:30 pm and 7 pm.

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · Aug 1

Happy to share a sneak peek of our foray into plant proteins: A fluorescence image of phase-separated condensates of an intrinsically disordered protein from Arabidopsis (prepared & imaged by my PhD students Snehasis Sarkar & Muskan Koundal). I'll share more details later.
Happy Fluorescence Friday!

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · Jul 7

Thank you so much, CBS Montpellier! I had an exciting visit and stimulating discussions with the colleagues at CBS!

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · Jul 4

Yesterday, I had a great visit/seminar/discussion at the University of Lorraine, Metz, then arrived in Paris in the evening & had a breathtaking view of Paris from Eiffel Tower. Now at Paris CDG airport & will fly to Delhi. Had a wonderful time in France. Au revoir Paris/France/my friends in France!

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · Jul 2

Had an amazing 2-day stay in Montpellier & gave 2 seminars at IBMM, Université de Montpellier & CBS (Centre de Biologie Structurale), CNRS. Thanks to my amazing hosts, Joseph Chamieh (IBMM) & Emmanuel Margeat (CBS). I just arrived in Paris and on my way to Metz to visit the Université de Lorraine.

1 4

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · Jun 30

Goodbye, Marseille! Had an exciting scientific visit & enjoyed breathtaking views of the Mediterranean Sea! Now on the train to Montpellier to visit/speak at the Institut des Biomolécules Max Mousseron (IBMM) CNRS, Université de Montpellier in the next 4 hours. See you all at IBMM, CNRS Montpellier!

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · Jun 28

Yesterday, I taught biological phase separation at CNRS Marseille (photo credit: my former student, Harshita). Had an amazing lunch with students/postdocs of my host, Sonia Longhi. Had a wonderful dinner with Harshita near Marseille Port. Looking forward to visiting Nice & Cannes during the weekend.

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · Jun 27

Had busy last two days - gave a seminar at CNRS Marseille (photo credit: Harshita) & had discussions with scientists. Had a quick visit to Prado Beach & an amazing dinner at my host's (Sonia Longhi) beautiful house near Cassis (overlooking the Mediterranean Sea). Today, I'll teach phase separation.

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · Jun 22

Flying to Paris tomorrow. Looking forward to visiting and speaking at CNRS (Centre National de la Recherche Scientifique), Aix-Marseille Université, Institut des Biomolécules Max Mousseron, Centre de Biologie Structurale, CNRS/Université de Montpellier, and Université de Lorraine, Metz.

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · Jun 21

Congratulations to Lisha Arora @aroralisha20.bsky.social (15th PhD of my lab) and Rakshana, Ayush & Keshav (BS-MS) for receiving their degrees during commencement at IISER Mohali. We had a wonderful send-off dinner at The Lalit Chandigarh (where we also celebrated our latest Science Advances paper).

1 3

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · Jun 11

I'm so delighted to see my former PhD student, Priyanka Dogra, being featured by St. Jude Research @stjuderesearch.bsky.social. Priyanka's postdoctoral work at St. Jude aims to fight cancer at the cellular level by investigating nucleolar phase separation.

www.stjude.org/research/pro...

Reposted by Samrat Mukhopadhyay

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · Jun 7

Happy to share our latest paper published in Science Advances @aaas.org. Congratulations to my incredible students, Sandeep @sandeeprai.bsky.social, Roopali @roopsiek.bsky.social (co-first author), Anusha @anushasarbahi.bsky.social & Ashish @ashishjoshi.bsky.social.

www.science.org/doi/10.1126/...

Chaperone-mediated heterotypic phase separation regulates liquid-to-solid phase transitions of tau into amyloid fibrils

A chaperone tasked with protein quality control tunes the phase behavior of tau and prevents its pathological phase transitions.

www.science.org

2 7 17

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · Jun 7

Thank you!!

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · Jun 7

Thank you

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · Jun 7

Chaperone-mediated heterotypic phase separation regulates liquid-to-solid phase transitions of tau into amyloid fibrils

A chaperone tasked with protein quality control tunes the phase behavior of tau and prevents its pathological phase transitions.

www.science.org

2 7 17

Reposted by Samrat Mukhopadhyay

Rohit V. Pappu @rohitpappu68.bsky.social · May 28

With @tanjamittag.bsky.social we asked if A1-LCD condensates are protective or crucibles for amyloid fibril formation. Their interfaces enable fibril nucleation but their interiors suppress fibril formation. Insights were transferrable to stress granules in cells.
doi.org/10.1016/j.mo...

Redirecting

doi.org

1 4 19

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · May 23

📢Stay tuned for our latest paper that will be published on June 6.
We submitted the manuscript in July 2024.
We had a 3-country, 4-time zone epic revision meeting in Oct 2024 (see the screenshot).
This paper was accepted on May 1.
I submitted proof corrections last week from Academia Sinica, Taiwan.

A marathon revision meeting in October 2024 during my invitational professorship last year at Tohoku University in Japan.

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · May 21

I had a lovely one-week stay at Academia Sinica, Taipei. I gave a seminar, taught phase separation/single-molecule FRET & gave a plenary lecture at Taiwan Biophysics conference. I enjoyed speaking/teaching/discussing science with very talented scientists here. Thanks to my incredible host Ruby Chen.

1 3

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · Apr 26

Thank you so much!

Reposted by Samrat Mukhopadhyay

Carolyn Bertozzi @carolynbertozzi.bskyverified.social · Apr 25

Check it out - amazing new work by @raflynn5.bsky.social and Kostas Tzelepis labs, discovery of a cell surface RNA/glycoRNA binding protein that is also a cancer antigen, new target for antibody therapy!

www.nature.com/articles/s41...

Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein - Nature Biotechnology

An RNA-binding protein on leukemia cells provides an effective target in mouse models.

www.nature.com

1 34 120

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · Apr 25

The 15th PhD from my lab:
Today, Lisha Arora defended her PhD thesis. Congratulations to Dr. Arora! @aroralisha20.bsky.social
Thanks to Samir Maji (Indian Institute of Technology Bombay) for serving as the external examiner, and the doctoral committee members, Sanchita Sengupta and Raj Kumar Roy.

1 1 5

Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · Apr 20

My former PhD student, Ashish Joshi, visited our lab last week. He just reached San Diego to join Keren Lasker's lab at The Scripps Research Institute @scripps.edu
It's amazing; now 3 of my former PhD students, including Debapriya Das & Anamika Avni, are postdocs at Scripps, my postdoc alma mater.

1 6