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Matthew Clark

@matthew-batisio.bsky.social

1.2K followers 750 following 15 posts

Cellular Structural Biology Wellcome DPhil Student at The University of Oxford. Currently working in Peijun Zhang’s lab at The Oxford Division of Structural Biology. Passionate about biomedical animation and science communication: Batisio.co.uk

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Matthew Clark @matthew-batisio.bsky.social · Nov 25

I am excited to share this animation of the budding yeast inner kinetochore. Created for David Barford's lab @mrclmb.bsky.social

This DNA-binding protein complex acts as an anchor for the spindles that pull chromosomes apart during mitosis.
www.science.org/doi/10.1126/...

#blender #animation #b3d

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Reposted by Matthew Clark

(GIRISH)MALI LAB @dyneinassembly.bsky.social · 9d

Happy to share the inaugural paper from the lab. We describe a molecular mechanism for the activation of outer dynein arm motors that power the vital motion of cilia.

Open access link below:
www.nature.com/articles/s41...

Here's a cool animated summary

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Reposted by Matthew Clark

Nature Structural & Molecular Biology @natsmb.nature.com · 9d

New online: Molecular basis for the activation of outer dynein arms in cilia

Molecular basis for the activation of outer dynein arms in cilia

Nature Structural & Molecular Biology, Published online: 29 September 2025; doi:10.1038/s41594-025-01680-9Issa et al. show that the ciliary small guanosine triphosphatase Arl3 displaces the inhibitory regulator Shulin/DNAAF9 from the outer dynein arm, leading to motor activation.

go.nature.com

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Reposted by Matthew Clark

Lori Passmore @lapassmore.bsky.social · 11d

We have an open post-doc position in my group to study mRNA cleavage and polyadenylation using biochemical reconstitution and cryoEM.

Please get in touch if you are interested in joining this amazing team! 🔬🧬🤩
#RNA #cryoEM

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Reposted by Matthew Clark

Matthias Wilmanns @matthiaswilmanns.bsky.social · Sep 3

We are excited to share our latest work, where we unravel the structural and functional secrets of the once-mysterious protein Pex8 revealing how it controls the peroxisomal cargo import receptor Pex5.

Read more here: www.biorxiv.org/content/10.1101/2025.08.30.673231v1

Ensemble model of the full length Pex5 receptor (different blue color) in complex with Pex8 (green colors).

Key Findings:

Pex8 binds to a novel site on the mostly unfolded N-terminal region of the Pex5 receptor. This interaction is essential for peroxisomal protein import.

Computational modelling reveals the formation of an assembly with the trimeric peroxisomal E3-ubiquitin ligase.

We propose that this action positions the Pex5 receptor for its recycling, a step essential for the entire protein import process.

Why this matters:

Peroxisomes rely entirely on the import of folded proteins to function. Impaired peroxisome function is linked to severe disorders, and recent data show their crucial roles in carcinogenesis and the immune response. Our work elevates Pex8 from an enigma to a central player in this critical biological process.

Read the full story and see the structures here: https://www.biorxiv.org/content/10.1101/2025.08.30.673231v1

#CellBiology #StructuralBiology #Peroxisome #ProteinImport #bioRxiv #Biochemistry

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Alexey Amunts @amunts.bsky.social · Aug 29

Stunning cryo-ET from Peijun Zhang lab: Direct visualization of HIV-1 nuclear import!
Hundreds of viral cores captured entering the nucleus. The NPC dilates to let the capsid through. A masterclass in correlative microscopy that makes it quantitative. A leap for structural virology! @emboreports.org

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Reposted by Matthew Clark

Martin Pacesa @martinpacesa.bsky.social · Aug 27

Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators.

www.nature.com/articles/s41...

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Reposted by Matthew Clark

Gautam Dey @gautamdey.bsky.social · Aug 7

Want to acquire #ExM images like this and help us understand the true extent of cytoskeletal diversity across the tree of life? This position might be for you!

embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

With @dudinlab.bsky.social
@embl.org @biology-unige.bsky.social @moorefound.bsky.social

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Reposted by Matthew Clark

Clockwork @watchclockwork.com · Aug 5

🕒 NEW VIDEO 🕒

How can a cell know the time? Let's explore the beautiful 24-hour cycle produced by #KaiC proteins in the cyanobacteria S. Elongatus. Rendered in #blender3d with @bradyajohnston.bsky.social's brilliant Molecular Nodes add-on. #biology

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Matthew Clark @matthew-batisio.bsky.social · Aug 6

Awesome video! I love how you represented the slow C1 domain hydrolysis.

Reposted by Matthew Clark

A. Reza Mehdipour @rezamehdipour.bsky.social · Aug 5

We are excited to announce the first in-cell structure of a LINC complex within a native nuclear envelope at subnanometer resolution!! #In-cell cryo-ET + #atomistic MD simulations! @tomdendooven.bsky.social et al!!
www.biorxiv.org/content/10.1...

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Reposted by Matthew Clark

Carter Lab @carter-lab.bsky.social · Aug 5

Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before.
www.biorxiv.org/content/10.1...

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Reposted by Matthew Clark

Jordan Raff @jordanraff.bsky.social · Jul 31

The Dunn School is a really great environment for taking up a Career Development Fellowship, and we are looking for candidates! Please spread the word.

The Dunn School, Oxford @dunnschool.bsky.social · Jul 30

📣 Applications now open 📣

We are seeking outstanding ECRs looking for a stimulating and supportive environment in which to establish their research group as externally-funded fellows, in any area or cell or molecular biology underlying disease!

Please share!

www.path.ox.ac.uk/work-with-us...

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Reposted by Matthew Clark

Katie Downes @dr-downes.bsky.social · Jul 30

Very excited to announce that my first, first author paper, is now on BioRxiv! In this paper we unambiguously show #COPII coated vesicles in unperturbed human cells for the very first time!!

Make my day and check it out!
www.biorxiv.org/content/10.1...

#Cryo-ET #TeamTomo #Cryo-CLEM ❄️🔬❄️🔬❄️🔬❄️🔬

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Reposted by Matthew Clark

Kat Toropova @kattoropova.bsky.social · Jul 29

Thrilled to see our study on how kinesin-2 motors are switched on and off published in @natsmb.nature.com ⚛️

➡️ www.nature.com/articles/s41...

Congrats to all authors from me and Anthony 🎉 @dunnschool.bsky.social Check out this animation made by talented PhD student @matthew-batisio.bsky.social 😆

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Reposted by Matthew Clark

Alessandro Costa @costalaboratory.bsky.social · Jul 21

Less than two weeks left to apply!

Postdoc positions in my lab to study

1. initiation of DNA replication.

2. chromatin replication/epigenetic inheritance.

Great for biochemists, biophysicists & structural biologists.

Deadline 3 August 2025.

crick.wd3.myworkdayjobs.com/External/job...

Postdoctoral Fellow - Costa Lab

Salary for this Role: From £45,500 with benefits, subject to skills and experience. Job Title: Postdoctoral Fellow - Costa Lab Reports to: Alessandro Costa Closing Date: 03/Aug/2025 23.59 GMT Job Desc...

crick.wd3.myworkdayjobs.com

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Matthew Clark @matthew-batisio.bsky.social · Jul 18

Awesome work, and a beautiful graphical abstract!

Reposted by Matthew Clark

Matt Higgins @parasitematt.bsky.social · Jul 18

Delighted to share the final version of Richard Zhou's study on how the CD163 scavenger receptor cleans up after toxic haemoglobin spills out from our blood cells. An amazing grabber mechanism!
rdcu.be/ewPA2

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Reposted by Matthew Clark

Danny Gold @dannybhgold.bsky.social · Jul 15

🎉 Excited to share my first paper as 2nd author! From the Barr & Gruneberg labs, this work explores the structure of the Chromosome Passenger Complex (CPC) and suggests a ‘pivot–tether’ model for how it binds H3pT3-phosphorylated nucleosomes
@oxfordbiochemistry.bsky.social @dunnschool.bsky.social

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Matthew Clark @matthew-batisio.bsky.social · Jul 17

IFT trains are really cool - and what better way to communicate their structure than baking a cake?

Created for my 1st year PhD project with Anthony Roberts and @kattoropova.bsky.social

IFT-A 🟡 IFT-B 🟢 Dynein-2 🔵

Matthew Clark holding a tray with a layered rectangular cake, showing the periodic repeating structure of IFT-A and IFT-B. Gingerbread cookies cut in the shape of dynein-2 ride on top.

A close up photo of the cake on a table, showing the periodic repeating structure of IFT-A and IFT-B. Gingerbread cookies cut in the shape of dynein-2 ride on top.

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Reposted by Matthew Clark

Stan Yatskevich @stanislauy.bsky.social · Jul 15

Happy to share our latest work on the structure and assembly of holocentric kinetochores! Huge thanks to Ines for a very fruitful collaboration, Claudio for all the support, and congratulations to Christine and all co-authors!

www.biorxiv.org/content/10.1...

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CCeMMP Outreach @ccemmp-outreach.bsky.social · Jul 15

Big news! 📢CCeMMP is holding the 2nd 'Bench to Art' Exhibition to showcase the artistic flair of structural biology. Share your creations to be displayed in a virtual gallery during National Science Week & for a chance to win cash prizes 💰! More info: ccemmp.org/events/arc-c...

#CryoEM
#Membranes

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🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · Jul 10

NEW pub: The role of metabolism in shaping #enzyme structures over 400 million years. Now out in @nature.com

Super grateful to have played a small role in this project - congrats to lead/corr authors Oliver, Benjamin, and Markus!

www.nature.com/articles/s41...

#alphafold #evolution #genomics

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Kelly Nguyen @kellythd-nguyen.bsky.social · Jul 10

Proud to share our work where we resolved a longstanding question regarding the existence of a human telomerase dimer and provided insights into its function. Led by 3 amazing lab members in collaboration with @yiliangding.bsky.social and @rdaslab.bsky.social.
www.science.org/doi/10.1126/...

Cryo-EM structure of human telomerase dimer reveals H/ACA RNP-mediated dimerization

Telomerase ribonucleoprotein (RNP) synthesizes telomeric repeats at chromosome ends using a telomerase reverse transcriptase (TERT) and a telomerase RNA (hTR in humans). Previous structural work showe...

www.science.org

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Reposted by Matthew Clark

Suyang Zhang @suyangzhang.bsky.social · Jul 10

Excited to share our latest work! We found transcription factor SPT6 and phosphorylated Pol II CTD help recruit U1 snRNP to elongating Pol II, allowing efficient co-transcriptional splicing.

Glad to be featured in the Editors’ Highlights!

www.nature.com/articles/s41...

#splicing #cryoEM

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Reposted by Matthew Clark

Susan Schlimpert @s-lab.bsky.social · Jul 10

New Independent Fellowship position in Microbiology to launch your lab in our department @johninnescentre.bsky.social (UK). We are conducting a broad search in the area of plant-associated microbial interactions. Message me if you have any questions.

Apply here: www.jic.ac.uk/vacancies/in...

Independent Fellowship in Plant-Associated Microbial Interactions | John Innes Centre

An exciting opportunity for an Independent Fellowship in Plant-Associated Microbial Interactions has arisen at the John Innes Centre. To read the full job description for this role…

www.jic.ac.uk

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