Please RT 🙏 If you’re an early career researcher working in the fields of structural or synthetic biology wishing to start your lab then come join us at Imperial. We’re looking to support outstanding individuals for external Career Development Awards/Fellowships.

www.imperial.ac.uk/media/imperi...

Dear all, we are looking for a research assistant in protein biochemistry / cell biology to support our work on nuclear reshaping in human cells. Here the link to the call, please spread: mrc.tal.net/vx/mobile-0/...

Excited to share our latest work! We found transcription factor SPT6 and phosphorylated Pol II CTD help recruit U1 snRNP to elongating Pol II, allowing efficient co-transcriptional splicing.

Glad to be featured in the Editors’ Highlights!

www.nature.com/articles/s41...

#splicing #cryoEM

See also this nice piece of article created by the LMB news team on our work

www2.mrc-lmb.cam.ac.uk/how-recql5-a...

Special thanks to Dimitris Typas for his efficient and thoughtful handling of our manuscript and the reviewers constructive feedbacks to help us improve the manuscript.

A transcription balance required for genome stability 🧬⚖️

Our work on RNA Pol II transcription speed control by the DNA helicase RECQL5 and the transcription-coupled DNA repair complex is now on @natsmb.nature.com

#CryoEM #transcription #genomestability

www.nature.com/articles/s41...

“If you’re really curious about science, then you should do it.”

We recently caught up with David Barford, Group Leader in the LMB’s Structural Studies Division, to learn more about his career, what inspires him and his group’s research into kinetochore complexes.

youtu.be/qaudt961iMU

Thank you, Claudio!!

Thank you, Rob!

Excited to share our new preprint on co-transcriptional splicing! U1 snRNP is recruited to RNA polymerase II through multiple interaction sites, with elongation factor SPT6 binding directly to the U1 snRNP protein.

www.biorxiv.org/content/10.1...

#cryoEM #transcription #splicing

🚨 PostDoc opportunity at the MRC-LMB 🚨Join our team to explore transcription-coupled splicing using cryoEM and biochemistry! 🔬🧬
Please spread the news 🙏🏼
Apply here: mrc.tal.net/vx/mobile-0/...
#Postdoc #CryoEM #MolecularBiology

We are looking for a senior administrator to take care of the Structural Studies Division at @mrclmb.bsky.social. Come and work for the benefit of human health in a fantastic environment. Happy to chat!

www.jobs.ac.uk/job/DLY086/s...

Thank you, Eugene!

Thank you, Jan!

Thank you, Rob!

See also the beautiful work from the @nogaleslab.bsky.social on RECQL5 www.biorxiv.org/content/10.1...

Great work by my fantastic first PhD student Helen Zhang as a collaboration started with @anatv.bsky.social , with support from our lab manager Yuliya Gordiyenko and the amazing mass spec facility @mrclmb.bsky.social Tomos Morgan and @catfranco.bsky.social

Ever wondered how Pol II speed is controlled during productive elongation?
Our study reveals that the helicase RECQL5 triggers transcription braking, while the transcription-coupled DNA repair complex restores the elongation rate. #cryoEM #transcription

www.biorxiv.org/content/10.1...