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Harry Low’s Lab

@lowlab.bsky.social

3K followers 730 following 62 posts

Bacterial pathogenesis. Antibiotic discovery. Membrane remodelling. Structural biology #cryoEM @Imperial College, London thelowlab.org

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Harry Low’s Lab @lowlab.bsky.social · Nov 11

Now out in NSMB for those who missed our biorxiv back in 2023.. bacterial ESCRT-III-like #Vipp1 forms dynamic spiral filaments on membrane! Spirals are springs that drive 3D ring formation in the spiral centre! 😵‍💫 wonderful collaboration with Adai Colom’s lab and @rouxlab.bsky.social

rdcu.be/dZSPQ

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Cascales Lab @cascaleslab.bsky.social · 11h

Open position to work on Type IX secretion (#T9SS) in our lab, in collaboration withe the group of Eric Reynolds at the Dental School of the University of Melbourne. Please spread the word, and forward to anyone potentially interested ! Apply here:
emploi.cnrs.fr/Offres/Docto...

Portail Emploi CNRS - Offre d'emploi - Thèse en Microbiologie-Biochimie (H/F)

emploi.cnrs.fr

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Tung Le @tunglejic.bsky.social · 6d

Independent research fellowships leading to tenured positions at the John Innes Centre.

Repost = nice. Thank you very much!!!

John Innes Centre @johninnescentre.bsky.social · 6d

Shortlisted candidates will be invited to give a seminar at the Fellows Conference, which will be held on 10 March 2026.

Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.

Find out more: www.jic.ac.uk/training-car...

Independent Research Fellowships Leading to Tenured Faculty Positions | John Innes Centre

The John Innes Centre (JIC), is a world leading centre of excellence in plant and microbial sciences based on the Norwich Research Park, UK. We are inviting applications from outstanding researchers…

www.jic.ac.uk

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Andy Edwards @bugsinblood.bsky.social · 10d

Now published! www.nature.com/articles/s41...

Very nice collaboration with Hoogenboom ( @ucl.ac.uk ) and Bonev ( @uniofnottingham.bsky.social ) labs.

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Lori Passmore @lapassmore.bsky.social · 12d

We have an open post-doc position in my group to study mRNA cleavage and polyadenylation using biochemical reconstitution and cryoEM.

Please get in touch if you are interested in joining this amazing team! 🔬🧬🤩
#RNA #cryoEM

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Sjors Scheres @sjorsscheres.bsky.social · 16d

Do you #PhD with us!

MRC Laboratory of Molecular Biology @mrclmb.bsky.social · 17d

Calling all prospective PhD students! Why not consider the LMB for your PhD?
Applications are now open!
www2.mrc-lmb.cam.ac.uk/students/int...
General deadline: 2nd DEC
US Gates Scholarship deadline: 15th OCT

Join the LMB's PhD programme!
Applications now open for October 2026
Deadline 2nd December 2025

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Reposted by Harry Low’s Lab

Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · Oct 2

😵

Computing the Human Interactome (200 million predicted protein structures) by the Baker lab #alphafold 🧶🧬

www.biorxiv.org/content/10.1...

the db : prodata.swmed.edu/humanPPI/

Computing the Human Interactome

Protein-protein interactions (PPI) are essential for biological function. Recent advances in coevolutionary analysis and Deep Learning (DL) based protein structure prediction have enabled comprehensiv...

www.biorxiv.org

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Harry Low’s Lab @lowlab.bsky.social · 14d

Stunning!

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Harry Low’s Lab @lowlab.bsky.social · 25d

No it’s great.. sorry if I wasn’t clear! Love that we’re getting even close. Wonderful paper!

Harry Low’s Lab @lowlab.bsky.social · 26d

‘We expect that this approach may be useful for cryo-EM analysis of other small particles near or below the theoretical size limit.’ 🤯

Oli Clarke @olibclarke.bsky.social · 26d

This one is a bit of a departure from the usual and definitely a work in progress!

We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.

Read on for details... 1/x

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Willem van Schaik @wvschaik.bsky.social · Sep 6

Reminder that we are recruiting an Assistant Professor Bacterial Genomics @imibirmingham.bsky.social.

www.jobs.ac.uk/job/DOO184/a...

Deadline 24 Sept.

Assistant Professor (Research and Education) in Bacterial Genomics at University of Birmingham

Looking for a new job opportunity in academia? Check out this job opening for a Assistant Professor (Research and Education) in Bacterial Genomics on jobs.ac.uk!

www.jobs.ac.uk

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Harry Low’s Lab @lowlab.bsky.social · Sep 2

Cool new pilus architecture..

Emmanuele Severi @emmseveri.bsky.social · Sep 2

www.nature.com/articles/s41...

#microsky

A family of tubular pili from harmful algal bloom forming cyanobacterium Microcystis aeruginosa - Nature Communications

Ricca et al discover a new family of tubular pili in Microcystis aeruginosa, a harmful algal bloom-forming cyanobacterium. These pili are crucial for buoyancy by forming cell micro-colonies, which inc...

www.nature.com

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The Gold Lab @the-gold-lab.bsky.social · Aug 28

We are recruiting 2 postdocs to work on bacterial motility using a combination of cryoEM, FLM and MD. An exciting collaboration with Kirsty Wan @micromotility.bsky.social Wolfram Moebius @wolframmoebius.bsky.social and Daniel Kattnig. Please see links in the thread below!

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Joe Wanford @jwanford.bsky.social · Aug 26

🚨 Job alert 🚨

I’m recruiting two postdoctoral research associates to join my lab at KCL to study how #Klebsiella pneumoniae regulates virulence factor expression during infection! #klebclub

Mol Micro: tinyurl.com/mtrwtx5e

Infection: tinyurl.com/2s3u8ca2

Deadline: 21st September.

Postdoctoral Research Associate in Molecular Microbiology

www.kcl.ac.uk

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Biozentrum, University of Basel @biozentrum.unibas.ch · Aug 26

🧪 The University of Basel is setting up a new endowed professorship in #ClimateBiophysics at the @biozentrum.unibas.ch, funded by the Georg H. Endress Foundation. This new professorship strengthens climate research @unibas.ch. www.biozentrum.unibas.ch/news/detail/...

New endowed professorship strengthens climate research at the University of Basel

The University of Basel is setting up a new endowed professorship at the Biozentrum to make fundamental discoveries at the interface between biophysics and climate-relevant environmental biology. This...

www.biozentrum.unibas.ch

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Andy Edwards @bugsinblood.bsky.social · Aug 23

New preprint from the lab, in collaboration with Ed Tate, Nate Traaseth and many others!

www.biorxiv.org/content/10.1...

Small molecule inhibitors of the NorA multidrug efflux pump potentiate antibiotic activity by binding the outward-open conformation

Antibiotic resistance is among the greatest threats of the modern era. Multidrug efflux pumps expel antibiotics from bacterial cells and present a particular challenge by conferring resistance to a br...

www.biorxiv.org

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Ben Engel @cellarchlab.com · Nov 23

We're looking for an awesome computational #postdoc to join our group @PioneerCampus. You'll explore native cells with #cryoET, get long-term funding (5+ years), and live in Munich! For more info, see our new Cell Architecture Lab website:...

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Harry Low’s Lab @lowlab.bsky.social · Aug 20

Check this out 👇

Sonja-Verena Albers @archaellum.bsky.social · Aug 20

🚨 Imagine a bacterium that refuses to follow the textbook:
It grows as tangled filaments, divides unevenly, reshapes its own membranes… and even builds grappling hooks.
Meet Litorilinea aerophila — and here’s why it blew our minds.

Reposted by Harry Low’s Lab

Debnath Ghosal @debnathghosal.bsky.social · Aug 20

Our collaborative work on the T9SS is just out in Nature Communications! Fantastic work led by Dhana Gorasia and Eric Hanssen. This paper reveals the structure of the T9SS outer membrane PorKN ring complex and mechanistic insights into protein secretion. www.nature.com/articles/s41...

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Sven Klumpe @svenklumpe.bsky.social · Aug 15

Extremely excited for the second version of this workshop at the MPI of Biophysics l, Frankfurt, that will happen 12-20. April 2026. Absolutely amazing lineup of speakers, I am very much looking forward to learning from everyone! Apply here: meetings.embo.org/event/26-in-...

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Cees Dekker @ceesdekker.bsky.social · Aug 13

WORK!

I currently have 5 (!) open positions for postdocs/PhD students in our CDlab for projects:

- Nanopore protein sequencing
- Archaeal CDV cell division
- Microfluidics for synthetic cells
- Nuclear Pore Complex
- Origami mimics of peroxisomes

Please apply! ceesdekkerlab.nl/come-join-us/

RT=👍

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Harry Low’s Lab @lowlab.bsky.social · Aug 11

Please RT 🙏 If you’re an early career researcher working in the fields of structural or synthetic biology wishing to start your lab then come join us at Imperial. We’re looking to support outstanding individuals for external Career Development Awards/Fellowships.

www.imperial.ac.uk/media/imperi...

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John Innes Centre @johninnescentre.bsky.social · Aug 9

VACANCY - We’re recruiting for a visionary group leader to lead fundamental research on Discovery Plant Science as part of our vibrant research community

Successful candidate will be offered a six-year tenure-track position with the opportunity to apply for tenure:

www.jic.ac.uk/vacancies/gr...

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Ellinor Alseth @ellinoralseth.bsky.social · Aug 8

Feels surreal to say but: I'm hiring! If you are or know anyone interested in looking at the evolution of phage resistance using A. baumannii and natural transformation, then this might be for you
www.jobbnorge.no/en/available...

Research position in Microbial Pharmacology and Population Biology (282139) | UiT The Arctic University of Norway

Job title: Research position in Microbial Pharmacology and Population Biology (282139), Employer: UiT The Arctic University of Norway, Deadline: Wednesday, August 27, 2025

www.jobbnorge.no

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Harry Low’s Lab @lowlab.bsky.social · Aug 7

That’s cool. By growing in liquid culture in lower oxygen levels treating like a microaerophile can antibiotic be induced? Or too simplistic?

Reposted by Harry Low’s Lab

Matt Hutchings @matthutchings.bsky.social · Aug 7

Ever wondered why some antibiotics are made by Streptomyces on agar plates but not in liquid cultures? Read this work on redox control of antibiotic biosynthesis. Led by katienoble241.bsky.social and Rebecca Devine, and in collaboration with @barriewilks.bsky.social

journals.asm.org/doi/10.1128/...

journals.asm.org

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