Sjors Scheres
@sjorsscheres.bsky.social
Joint Head of Structural Studies at @mrclmb.bsky.social. Develops & uses #cryoEM to study amyloids in neurodegeneration. #tau, #alphasynuclein, #opensoftware, #RELION. All opinions my own.
No lore for me. I thought I wanted to become a vet. In The Netherlands places to its only oversubscribed vet school were assigned in a lottery. Didn't get in and went to do chemistry instead. Had a lot of fun there and never looked back. 🤪
November 23, 2025 at 3:21 PM
No lore for me. I thought I wanted to become a vet. In The Netherlands places to its only oversubscribed vet school were assigned in a lottery. Didn't get in and went to do chemistry instead. Had a lot of fun there and never looked back. 🤪
The role of @ebi.embl.org in the deployment of AI in biology has been and will continue to be essential. They do biological data like no one else in the world.
The UK Government Department for Science, Innovation & Technology published its national AI for Science strategy.
We’re pleased that EMBL-EBI is highlighted for the strength of our data foundations and look forward to seeing how this strategy supports future discoveries.
www.gov.uk/government/p...
We’re pleased that EMBL-EBI is highlighted for the strength of our data foundations and look forward to seeing how this strategy supports future discoveries.
www.gov.uk/government/p...
November 22, 2025 at 9:36 AM
The role of @ebi.embl.org in the deployment of AI in biology has been and will continue to be essential. They do biological data like no one else in the world.
Reposted by Sjors Scheres
The LMB is deeply saddened to share that Martin Kyte, Senior Design Engineer in the Electronics Workshop, died suddenly on 3rd November 2025.
A popular and trusted member of the LMB for over 30 years, Martin will be sorely missed.
www2.mrc-lmb.cam.ac.uk/martin-kyte-...
#LMBNews
A popular and trusted member of the LMB for over 30 years, Martin will be sorely missed.
www2.mrc-lmb.cam.ac.uk/martin-kyte-...
#LMBNews
November 21, 2025 at 4:51 PM
The LMB is deeply saddened to share that Martin Kyte, Senior Design Engineer in the Electronics Workshop, died suddenly on 3rd November 2025.
A popular and trusted member of the LMB for over 30 years, Martin will be sorely missed.
www2.mrc-lmb.cam.ac.uk/martin-kyte-...
#LMBNews
A popular and trusted member of the LMB for over 30 years, Martin will be sorely missed.
www2.mrc-lmb.cam.ac.uk/martin-kyte-...
#LMBNews
Reposted by Sjors Scheres
I am delighted to share that our new manuscript is published as an online Pre-proof at the Journal of Biological Chemistry!! 🎉
www.jbc.org/article/S002...
www.jbc.org/article/S002...
Seeding biosensor cell line that reproduces the Alzheimer tau fold
The assembly of tau protein into amyloid filaments through templated seeding is believed
to underlie the propagation of pathology in neurodegenerative diseases, such as Alzheimer’s
disease (AD) and ot...
www.jbc.org
November 21, 2025 at 5:08 PM
I am delighted to share that our new manuscript is published as an online Pre-proof at the Journal of Biological Chemistry!! 🎉
www.jbc.org/article/S002...
www.jbc.org/article/S002...
Oh wow, this is 🤯 amazing: ~3-fold acceleration of running #relion on A100 GPUs for realistic single-particle refinement by the group of Guangwen Yang at @tsinghuauniversity.bsky.social
.
What a fantastic example of #OpenSoftwareAcceleratesScience, literally! 😍
dl.acm.org/doi/full/10....
.
What a fantastic example of #OpenSoftwareAcceleratesScience, literally! 😍
dl.acm.org/doi/full/10....
T2-RELION: Task Parallelism, Tensor Core Accelerated RELION for Cryo-EM 3D Reconstruction | Proceedings of the International Conference for High Performance Computing, Networking, Storage and Analysis
dl.acm.org
November 21, 2025 at 12:32 PM
Oh wow, this is 🤯 amazing: ~3-fold acceleration of running #relion on A100 GPUs for realistic single-particle refinement by the group of Guangwen Yang at @tsinghuauniversity.bsky.social
.
What a fantastic example of #OpenSoftwareAcceleratesScience, literally! 😍
dl.acm.org/doi/full/10....
.
What a fantastic example of #OpenSoftwareAcceleratesScience, literally! 😍
dl.acm.org/doi/full/10....
I wonder how extremely busy people ever get any work done.
November 20, 2025 at 7:40 PM
I wonder how extremely busy people ever get any work done.
Reposted by Sjors Scheres
Want to join the LMB as a PhD student in October 2026?
You’ve got two weeks left to apply!
Visit our website for more details: www2.mrc-lmb.cam.ac.uk/students/int...
Applications close on 2nd December 2025.
You’ve got two weeks left to apply!
Visit our website for more details: www2.mrc-lmb.cam.ac.uk/students/int...
Applications close on 2nd December 2025.
November 18, 2025 at 2:29 PM
Want to join the LMB as a PhD student in October 2026?
You’ve got two weeks left to apply!
Visit our website for more details: www2.mrc-lmb.cam.ac.uk/students/int...
Applications close on 2nd December 2025.
You’ve got two weeks left to apply!
Visit our website for more details: www2.mrc-lmb.cam.ac.uk/students/int...
Applications close on 2nd December 2025.
This study claims in vitro seeded assembly in brain homogenate is more disease-relevant than fibril extraction, without providing any evidence thereof. It also ignores ample data that in vitro seeding with aSyn may NOT template the structure of seeds. 😕
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
www.sciencedirect.com
November 17, 2025 at 8:21 AM
This study claims in vitro seeded assembly in brain homogenate is more disease-relevant than fibril extraction, without providing any evidence thereof. It also ignores ample data that in vitro seeding with aSyn may NOT template the structure of seeds. 😕
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Sjors Scheres
Excellent #postdoc opportunity available in @sjorsscheres.bsky.social’ group, working on new image processing algorithms for #cryoEM structure determination in their #RELION open-source software.
www.nature.com/naturecareer...
Apply by 25 NOV
#PostdocJobs #ScienceJobs
www.nature.com/naturecareer...
Apply by 25 NOV
#PostdocJobs #ScienceJobs
November 6, 2025 at 3:46 PM
Excellent #postdoc opportunity available in @sjorsscheres.bsky.social’ group, working on new image processing algorithms for #cryoEM structure determination in their #RELION open-source software.
www.nature.com/naturecareer...
Apply by 25 NOV
#PostdocJobs #ScienceJobs
www.nature.com/naturecareer...
Apply by 25 NOV
#PostdocJobs #ScienceJobs
Reposted by Sjors Scheres
Very happy that NWO supports this major upgrade of our national EM infrastructure. It is great that this initiative got broad support all over NL, and it will EMPower fantastic science - looking forward to that!
www.uu.nl/en/news/33-m...
www.uu.nl/en/news/33-m...
33 million euro investment for national electron microscope facility EMPower
A major new national facility for electron microscopy, called EMPower, has been awarded to a consortium of Dutch universities and medical centers. EMPower aims to pave the way for major discoveries im...
www.uu.nl
November 4, 2025 at 7:14 AM
Very happy that NWO supports this major upgrade of our national EM infrastructure. It is great that this initiative got broad support all over NL, and it will EMPower fantastic science - looking forward to that!
www.uu.nl/en/news/33-m...
www.uu.nl/en/news/33-m...
At some point, Doppio will replace relion's gui. Already you can do more in Doppio than in relion! 🤩
We are pleased to announce Doppio version 1.4! Available here www.ccpem.ac.uk/software/dow...
Downloads – CCP-EM
www.ccpem.ac.uk
November 4, 2025 at 6:14 PM
At some point, Doppio will replace relion's gui. Already you can do more in Doppio than in relion! 🤩
Reposted by Sjors Scheres
Doppio is a great tool (more of a toolbelt actually) to go all the way from micrographs to deposition!! (and the more people using it, the greater it gets)
We are pleased to announce Doppio version 1.4! Available here www.ccpem.ac.uk/software/dow...
Downloads – CCP-EM
www.ccpem.ac.uk
November 4, 2025 at 5:46 PM
Doppio is a great tool (more of a toolbelt actually) to go all the way from micrographs to deposition!! (and the more people using it, the greater it gets)
🥳🥳🥳
Thrilled, and admittedly relieved, to see this major investment in Dutch #cryoEM become reality! 🇳🇱🔬
Honoured to be a co-applicant on this national initiative and very excited for the opportunity to advance our work in cellular structural virology! 🦠
www.uu.nl/en/news/33-m...
Honoured to be a co-applicant on this national initiative and very excited for the opportunity to advance our work in cellular structural virology! 🦠
www.uu.nl/en/news/33-m...
33 million euro investment for national electron microscope facility EMPower
A major new national facility for electron microscopy, called EMPower, has been awarded to a consortium of Dutch universities and medical centers. EMPower aims to pave the way for major discoveries im...
www.uu.nl
November 3, 2025 at 5:42 PM
🥳🥳🥳
Max is a fantastic scientist!! 🤩
The Wilkinson Lab is open for science! @mskcancercenter.bsky.social
🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬
annnd: I'm hiring - come join! Especially postdocs and PhD students - please get in touch (NYC is great)
🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬
annnd: I'm hiring - come join! Especially postdocs and PhD students - please get in touch (NYC is great)
Wilkinson Lab
We discover and study reverse transcriptases
wilkinsonlab.bio
October 31, 2025 at 7:01 PM
Max is a fantastic scientist!! 🤩
We are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated.
mrc.tal.net/vx/appcentre...
mrc.tal.net/vx/appcentre...
Quick Check Needed
mrc.tal.net
October 29, 2025 at 9:17 AM
We are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated.
mrc.tal.net/vx/appcentre...
mrc.tal.net/vx/appcentre...
Our amazing Sofia did it again! She previously won the Perutz Prize for best PhD thesis at the LMB; this year she has won the Joan Steitz Prize for best postdoctoral work. She is on the job market for an independent position. Any institute would be lucky to have her. 🥳
Congratulations to the 2025 recipients of the Perutz Student Prize and the Joan Steitz Postdoc Prize: Claudia De Miguel, @lucaschwarz.bsky.social, Tom Dendooven, Sofia Lövestam, Katerina Naydenva & Tomke Stürner.
Find out why they won here: www2.mrc-lmb.cam.ac.uk/lmb-prizes-2...
#LMBNews 👏
Find out why they won here: www2.mrc-lmb.cam.ac.uk/lmb-prizes-2...
#LMBNews 👏
October 28, 2025 at 5:26 PM
Our amazing Sofia did it again! She previously won the Perutz Prize for best PhD thesis at the LMB; this year she has won the Joan Steitz Prize for best postdoctoral work. She is on the job market for an independent position. Any institute would be lucky to have her. 🥳
Reposted by Sjors Scheres
We are looking to hire a postdoc to take this and other TDP-43 assay development forward! Please re-post!
October 24, 2025 at 8:58 PM
We are looking to hire a postdoc to take this and other TDP-43 assay development forward! Please re-post!
Reposted by Sjors Scheres
We are excited to share our latest work on GLIC published in @pnas.org, where we developed a #cryoEM data processing strategy that allowed us to isolate and reconstruct multiple asymmetric states, revealing detailed insights into the channel’s activation mechanism. tinyurl.com/mwtb4rpj
Asymmetric gating of a homopentameric ion channel GLIC revealed by cryo-EM | PNAS
Pentameric ligand-gated ion channels (pLGICs) are vital neurotransmitter receptors
that are key therapeutic targets for neurological disorders. Alt...
tinyurl.com
October 24, 2025 at 5:32 AM
We are excited to share our latest work on GLIC published in @pnas.org, where we developed a #cryoEM data processing strategy that allowed us to isolate and reconstruct multiple asymmetric states, revealing detailed insights into the channel’s activation mechanism. tinyurl.com/mwtb4rpj
Reposted by Sjors Scheres
Chris Russo and Anastasiia Gusach have developed a new method to prepare #cryoEM samples that avoids protein damage during freezing
Read more: www2.mrc-lmb.cam.ac.uk/a-new-method...
#LMBResearch
Read more: www2.mrc-lmb.cam.ac.uk/a-new-method...
#LMBResearch
October 22, 2025 at 4:41 PM
Chris Russo and Anastasiia Gusach have developed a new method to prepare #cryoEM samples that avoids protein damage during freezing
Read more: www2.mrc-lmb.cam.ac.uk/a-new-method...
#LMBResearch
Read more: www2.mrc-lmb.cam.ac.uk/a-new-method...
#LMBResearch
Reposted by Sjors Scheres
What do apple trees, Nobel Prizes, cows, and world-changing innovation all have in common? Well, they're all part of a new animated journey across one of Europe’s most extraordinary places, the Cambridge Biomedical Campus.
youtu.be/2K7Txdwb_k4
youtu.be/2K7Txdwb_k4
Welcome to the Cambridge Biomedical Campus
YouTube video by Cambridge Biomedical Campus
youtu.be
October 20, 2025 at 10:58 AM
What do apple trees, Nobel Prizes, cows, and world-changing innovation all have in common? Well, they're all part of a new animated journey across one of Europe’s most extraordinary places, the Cambridge Biomedical Campus.
youtu.be/2K7Txdwb_k4
youtu.be/2K7Txdwb_k4
Reposted by Sjors Scheres
You might like our lego @johninnescentre.bsky.social
October 18, 2025 at 2:13 PM
You might like our lego @johninnescentre.bsky.social
Reposted by Sjors Scheres
I’m pleased to announce that my Lego lab will officially be moving to this building should it be funded
October 17, 2025 at 2:52 PM
I’m pleased to announce that my Lego lab will officially be moving to this building should it be funded
I just made an account and voted for this biology laboratory made of LEGO to "promote biological research and inspire more people into the world of biology". They need 10K votes. Reposting and/or voting below would be helpful. 🤗
beta.ideas.lego.com/product-idea...
beta.ideas.lego.com/product-idea...
Biological Laboratory | LEGO® Ideas
This is a two-floor realistic Biological Laboratory building. In this design, I try to tell stories about biologists, introduce biology concepts to general publ…
beta.ideas.lego.com
October 16, 2025 at 8:07 AM
I just made an account and voted for this biology laboratory made of LEGO to "promote biological research and inspire more people into the world of biology". They need 10K votes. Reposting and/or voting below would be helpful. 🤗
beta.ideas.lego.com/product-idea...
beta.ideas.lego.com/product-idea...
Reposted by Sjors Scheres
the GNE headcrab went for its latest victim today, a wild @sjorsscheres.bsky.social…
Thankfully @przemekdut.bsky.social was there to save the day!
Thankfully @przemekdut.bsky.social was there to save the day!
October 10, 2025 at 3:35 AM
the GNE headcrab went for its latest victim today, a wild @sjorsscheres.bsky.social…
Thankfully @przemekdut.bsky.social was there to save the day!
Thankfully @przemekdut.bsky.social was there to save the day!
Reposted by Sjors Scheres
John Gurdon, former Group Leader and Head of @cellbiol-mrclmb.bsky.social has died.
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews
October 8, 2025 at 8:49 AM
John Gurdon, former Group Leader and Head of @cellbiol-mrclmb.bsky.social has died.
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews