Daniel Hurdiss
@danielhurdiss.bsky.social
Assistant Professor at Utrecht University 🇳🇱
We use #cryoEM and molecular #virology techniques to study the infection mechanisms of +ssRNA viruses.
https://www.uu.nl/medewerkers/DLHurdiss
Views are my own.
We use #cryoEM and molecular #virology techniques to study the infection mechanisms of +ssRNA viruses.
https://www.uu.nl/medewerkers/DLHurdiss
Views are my own.
Pinned
Daniel Hurdiss
@danielhurdiss.bsky.social
· Jun 18
Latest preprint from the lab, many years in the making!
By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase.
This could have big implications for our understanding of viral replication & assembly (🧵)
www.biorxiv.org/content/10.1...
By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase.
This could have big implications for our understanding of viral replication & assembly (🧵)
www.biorxiv.org/content/10.1...
Reposted by Daniel Hurdiss
Beautiful work from @efodor.bsky.social and Jonathan Grimes' labs - the first full structure of the influenza A virus NEP protein, and a clear indication that its role in viral replication is more nuanced that first thought
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Regulatory hotspot on the influenza A virus polymerase revealed through the structure of the NEP-polymerase complex
Structural studies reveal how influenza virus switches between making new RNA genomes and exporting them from the host nucleus.
www.science.org
January 24, 2026 at 1:42 PM
Beautiful work from @efodor.bsky.social and Jonathan Grimes' labs - the first full structure of the influenza A virus NEP protein, and a clear indication that its role in viral replication is more nuanced that first thought
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Daniel Hurdiss
Reposted by Daniel Hurdiss
Visualization of EGFR Assembly and Activation Induced by a Protein Nanocage Using Cryo-Electron Tomography pubmed.ncbi.nlm.nih.gov/41564420/ #cryoem
January 23, 2026 at 5:38 AM
Visualization of EGFR Assembly and Activation Induced by a Protein Nanocage Using Cryo-Electron Tomography pubmed.ncbi.nlm.nih.gov/41564420/ #cryoem
Reposted by Daniel Hurdiss
Loss of α2,3-linked sialoside in the receptor-binding site of a H5N1 influenza hemagglutinin identified in a human patient www.biorxiv.org/content/10.64898/2026.01.19.700419v1 #cryoem
January 23, 2026 at 8:10 AM
Loss of α2,3-linked sialoside in the receptor-binding site of a H5N1 influenza hemagglutinin identified in a human patient www.biorxiv.org/content/10.64898/2026.01.19.700419v1 #cryoem
Reposted by Daniel Hurdiss
Conserved assembly architecture of the essential herpesvirus packaging accessory factor www.biorxiv.org/content/10.64898/2026.01.22.701024v1 #cryoem
January 23, 2026 at 10:05 AM
Conserved assembly architecture of the essential herpesvirus packaging accessory factor www.biorxiv.org/content/10.64898/2026.01.22.701024v1 #cryoem
Reposted by Daniel Hurdiss
Excited to share our latest work on dissecting the mechanism of processive telomeric DNA synthesis by telomerase. Led by amazing PhD student Sebastian Balch in collaboration with lab members,@automnenine.bsky.social @rachael-kretsch.bsky.social,@rdaslab.bsky.social.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Structures of nucleotide-bound human telomerase at several steps of its telomeric DNA repeat addition cycle - Nature Communications
To maintain genome stability, the specialised reverse transcriptase telomerase processively adds telomeric DNA repeats to chromosome ends. Here the authors reported structures of human telomerase at t...
www.nature.com
January 23, 2026 at 6:57 AM
Excited to share our latest work on dissecting the mechanism of processive telomeric DNA synthesis by telomerase. Led by amazing PhD student Sebastian Balch in collaboration with lab members,@automnenine.bsky.social @rachael-kretsch.bsky.social,@rdaslab.bsky.social.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Daniel Hurdiss
Structural characterization of the HDV virion and its ribonucleoprotein pubmed.ncbi.nlm.nih.gov/41564123/ #cryoem
January 22, 2026 at 6:54 PM
Structural characterization of the HDV virion and its ribonucleoprotein pubmed.ncbi.nlm.nih.gov/41564123/ #cryoem
Reposted by Daniel Hurdiss
Establishing the molecular basis for MDA5 mutation-linked autoimmunity www.biorxiv.org/content/10.64898/2026.01.20.700587v1 #cryoem
January 21, 2026 at 8:10 AM
Establishing the molecular basis for MDA5 mutation-linked autoimmunity www.biorxiv.org/content/10.64898/2026.01.20.700587v1 #cryoem
Reposted by Daniel Hurdiss
Fully genetically encoded low-molecular-weight protein tags with defined shapes for direct molecular identification by cryo-electron tomography www.biorxiv.org/content/10.64898/2026.01.16.700029v1 #cryoem
January 21, 2026 at 9:42 AM
Fully genetically encoded low-molecular-weight protein tags with defined shapes for direct molecular identification by cryo-electron tomography www.biorxiv.org/content/10.64898/2026.01.16.700029v1 #cryoem
Reposted by Daniel Hurdiss
Interested in high containment work on viruses?
We have an opening at the Pirbright Institute, working on high consequence viruses of livestock and humans in the core CL3 team.
isw.changeworknow.co.uk/pirbright/vm...
We have an opening at the Pirbright Institute, working on high consequence viruses of livestock and humans in the core CL3 team.
isw.changeworknow.co.uk/pirbright/vm...
CL3- Research Assistant
The Pirbright Institute
The Pirbright Institute delivers world-leading research to understand, predict, detect and respond to viral disease outbreaks. We study viruses of livestock that are endemic a...
isw.changeworknow.co.uk
January 20, 2026 at 2:12 PM
Interested in high containment work on viruses?
We have an opening at the Pirbright Institute, working on high consequence viruses of livestock and humans in the core CL3 team.
isw.changeworknow.co.uk/pirbright/vm...
We have an opening at the Pirbright Institute, working on high consequence viruses of livestock and humans in the core CL3 team.
isw.changeworknow.co.uk/pirbright/vm...
Reposted by Daniel Hurdiss
Still more new NSP1 mutations in the BA.3.2 uploaded from the Netherlands today. We've never seen anything like this kind of rapid evolution in NSP1 (whose primary role is to shut down host-protein translation and degrade host mRNA).
I've labeled all BA.3.2-specific NSP1 muts here. 1/3
I've labeled all BA.3.2-specific NSP1 muts here. 1/3
January 20, 2026 at 2:09 PM
Still more new NSP1 mutations in the BA.3.2 uploaded from the Netherlands today. We've never seen anything like this kind of rapid evolution in NSP1 (whose primary role is to shut down host-protein translation and degrade host mRNA).
I've labeled all BA.3.2-specific NSP1 muts here. 1/3
I've labeled all BA.3.2-specific NSP1 muts here. 1/3
Reposted by Daniel Hurdiss
Dengue virus shaped the evolution of SARS-CoV-2 www.nature.com/articles/d44...
Dengue virus shaped the evolution of SARS-CoV-2
Two viruses can co-evolve in dengue-endemic regions
www.nature.com
January 20, 2026 at 2:31 PM
Dengue virus shaped the evolution of SARS-CoV-2 www.nature.com/articles/d44...
Reposted by Daniel Hurdiss
We are looking for a postdoc to work on mechanisms of #RNA decay in cancer using #cryoEM with #nanobodies and #minibinders! Please RT
January 18, 2026 at 2:30 PM
We are looking for a postdoc to work on mechanisms of #RNA decay in cancer using #cryoEM with #nanobodies and #minibinders! Please RT
Reposted by Daniel Hurdiss
Strategic variations in sarbecovirus and merbecovirus Nsp1 linker regions for translation inhibition pubmed.ncbi.nlm.nih.gov/41538319/ #cryoem
January 16, 2026 at 5:22 PM
Strategic variations in sarbecovirus and merbecovirus Nsp1 linker regions for translation inhibition pubmed.ncbi.nlm.nih.gov/41538319/ #cryoem
Reposted by Daniel Hurdiss
Reconstructing a Missing Link of HIV-1 Assembly: HIV-1 Envelope-Matrix Interactions in a Native Viral Context www.biorxiv.org/content/10.64898/2026.01.15.699503v1 #cryoem
January 17, 2026 at 8:10 AM
Reconstructing a Missing Link of HIV-1 Assembly: HIV-1 Envelope-Matrix Interactions in a Native Viral Context www.biorxiv.org/content/10.64898/2026.01.15.699503v1 #cryoem
Reposted by Daniel Hurdiss
The structure of a thermostable phage's portal vertex and neck complex illuminates the headful maturation mechanism pubmed.ncbi.nlm.nih.gov/41544933/ #cryoem
January 17, 2026 at 12:17 PM
The structure of a thermostable phage's portal vertex and neck complex illuminates the headful maturation mechanism pubmed.ncbi.nlm.nih.gov/41544933/ #cryoem
Reposted by Daniel Hurdiss
Structural mapping of NTCP distinguishes its dual functionality as a hepatitis B virus receptor and bile acid transporter pubmed.ncbi.nlm.nih.gov/41544142/ #cryoem
January 17, 2026 at 1:06 PM
Structural mapping of NTCP distinguishes its dual functionality as a hepatitis B virus receptor and bile acid transporter pubmed.ncbi.nlm.nih.gov/41544142/ #cryoem
Back from the Physics of Viruses and Protein Cages GRC in the beautiful Tuscan hills. Great to see the latest developments in the field and to catch up with familiar faces.
Thanks to the organisers for the invitation to present, and to everyone I spoke with for the excellent discussions.
Thanks to the organisers for the invitation to present, and to everyone I spoke with for the excellent discussions.
January 17, 2026 at 7:21 AM
Back from the Physics of Viruses and Protein Cages GRC in the beautiful Tuscan hills. Great to see the latest developments in the field and to catch up with familiar faces.
Thanks to the organisers for the invitation to present, and to everyone I spoke with for the excellent discussions.
Thanks to the organisers for the invitation to present, and to everyone I spoke with for the excellent discussions.
Reposted by Daniel Hurdiss
Cryo-EM structures of antibodies elicited by germline-targeting HIV MPER epitope scaffolds pubmed.ncbi.nlm.nih.gov/41528847/ #cryoem
January 14, 2026 at 9:58 PM
Cryo-EM structures of antibodies elicited by germline-targeting HIV MPER epitope scaffolds pubmed.ncbi.nlm.nih.gov/41528847/ #cryoem
Reposted by Daniel Hurdiss
Antigenic landscape of rabies and related lyssaviruses revealed by cryo-EM www.biorxiv.org/content/10.64898/2026.01.14.699513v1 #cryoem
January 15, 2026 at 8:10 AM
Antigenic landscape of rabies and related lyssaviruses revealed by cryo-EM www.biorxiv.org/content/10.64898/2026.01.14.699513v1 #cryoem
Reposted by Daniel Hurdiss
Moderna COVID vaccine 53% effective against adult hospitalization in 2024-25 season, data suggest www.cidrap.umn.edu/covid-19/mod...
Moderna COVID vaccine 53% effective against adult hospitalization in 2024-25 season, data suggest
www.cidrap.umn.edu
January 13, 2026 at 12:02 AM
Moderna COVID vaccine 53% effective against adult hospitalization in 2024-25 season, data suggest www.cidrap.umn.edu/covid-19/mod...
Reposted by Daniel Hurdiss
Filamentous virions act as non-infectious interfering particles to modulate papillomavirus infection journals.asm.org/doi/10.1128/...
Filamentous virions act as non-infectious interfering particles to modulate papillomavirus infection | Journal of Virology
Papillomaviruses contribute to numerous cancer incidents and significant mortality
despite available vaccinations. Hence, high-risk α HPVs have been the focus of most
research in the past. However, th...
journals.asm.org
January 13, 2026 at 8:18 PM
Filamentous virions act as non-infectious interfering particles to modulate papillomavirus infection journals.asm.org/doi/10.1128/...
Reposted by Daniel Hurdiss
Community-Scale Molecular Surveillance for Human Viruses - www.annualreviews.org/content/jour...
Community-Scale Molecular Surveillance for Human Viruses
Environmental surveillance, including wastewater and air sampling, has emerged as a powerful complement to traditional clinical surveillance for monitoring viral circulation. Advances in sampling and ...
www.annualreviews.org
January 13, 2026 at 8:24 PM
Community-Scale Molecular Surveillance for Human Viruses - www.annualreviews.org/content/jour...
Reposted by Daniel Hurdiss
Our new preprint on #SARSCoV2 nsp14 #exonuclease function in replication fidelity and fitness. ExoN- viruses are attenuated in vitro and in vivo but w/o #interferon signaling replication is largely restored! Suggests nsp14 plays a role in innate antagonism in vivo www.biorxiv.org/content/10.6...
Loss of nsp14-exonuclease activity impairs the replication, proofreading, fitness and pathogenesis of SARS-CoV-2
Coronaviruses (CoVs) replicate their RNA genomes with increased fidelity than other RNA viruses, a mechanism mediated by the proofreading and recombination activities of the exoribonuclease domain of ...
www.biorxiv.org
January 14, 2026 at 5:23 PM
Our new preprint on #SARSCoV2 nsp14 #exonuclease function in replication fidelity and fitness. ExoN- viruses are attenuated in vitro and in vivo but w/o #interferon signaling replication is largely restored! Suggests nsp14 plays a role in innate antagonism in vivo www.biorxiv.org/content/10.6...