Daniel Hurdiss
@danielhurdiss.bsky.social
Assistant Professor at Utrecht University 🇳🇱
We use #cryoEM and molecular #virology techniques to study the infection mechanisms of +ssRNA viruses.
https://www.uu.nl/medewerkers/DLHurdiss
Views are my own.
We use #cryoEM and molecular #virology techniques to study the infection mechanisms of +ssRNA viruses.
https://www.uu.nl/medewerkers/DLHurdiss
Views are my own.
Pinned
Daniel Hurdiss
@danielhurdiss.bsky.social
· Jun 18
Latest preprint from the lab, many years in the making!
By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase.
This could have big implications for our understanding of viral replication & assembly (🧵)
www.biorxiv.org/content/10.1...
By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase.
This could have big implications for our understanding of viral replication & assembly (🧵)
www.biorxiv.org/content/10.1...
Reposted by Daniel Hurdiss
Human coronavirus HKU1 neutralization by glycan receptor mimicry pubmed.ncbi.nlm.nih.gov/41278654/ #cryoem
November 26, 2025 at 5:17 AM
Human coronavirus HKU1 neutralization by glycan receptor mimicry pubmed.ncbi.nlm.nih.gov/41278654/ #cryoem
Reposted by Daniel Hurdiss
Congrats to @chgjohnston.bsky.social , Andreani, Radicella et al.!
Elegant PNAS paper on the ComEC/ComFA/ComFC complex in bacterial transformation. AF3 predictions validated by clever mutagenesis. We tried for years to solve this by cryo-EM/crystallography - never succeeded.
Elegant PNAS paper on the ComEC/ComFA/ComFC complex in bacterial transformation. AF3 predictions validated by clever mutagenesis. We tried for years to solve this by cryo-EM/crystallography - never succeeded.
A tripartite protein complex promotes DNA transport during natural transformation in Firmicutes | PNAS
Natural genetic transformation is a conserved mechanism of bacterial horizontal gene
transfer, which is directed entirely by the recipient cell and...
www.pnas.org
November 25, 2025 at 9:41 PM
Congrats to @chgjohnston.bsky.social , Andreani, Radicella et al.!
Elegant PNAS paper on the ComEC/ComFA/ComFC complex in bacterial transformation. AF3 predictions validated by clever mutagenesis. We tried for years to solve this by cryo-EM/crystallography - never succeeded.
Elegant PNAS paper on the ComEC/ComFA/ComFC complex in bacterial transformation. AF3 predictions validated by clever mutagenesis. We tried for years to solve this by cryo-EM/crystallography - never succeeded.
It’s been a while since I put together the Structural Virology starter pack, and I’m sure some new folks have joined Bluesky since then. There’s still plenty of space to fill, so if you’d like to be added to the list just let me know.
#virology #cryoEM
go.bsky.app/Qxv95BL
#virology #cryoEM
go.bsky.app/Qxv95BL
November 25, 2025 at 9:46 AM
It’s been a while since I put together the Structural Virology starter pack, and I’m sure some new folks have joined Bluesky since then. There’s still plenty of space to fill, so if you’d like to be added to the list just let me know.
#virology #cryoEM
go.bsky.app/Qxv95BL
#virology #cryoEM
go.bsky.app/Qxv95BL
Reposted by Daniel Hurdiss
Take a look through the Instruct-ERIC Facility starter pack!
Find the technology and expertise in structural biology that you need, and receive funded access to any of these facilities through Instruct - bsky.app/starter-pack...
Find the technology and expertise in structural biology that you need, and receive funded access to any of these facilities through Instruct - bsky.app/starter-pack...
November 24, 2025 at 9:27 AM
Take a look through the Instruct-ERIC Facility starter pack!
Find the technology and expertise in structural biology that you need, and receive funded access to any of these facilities through Instruct - bsky.app/starter-pack...
Find the technology and expertise in structural biology that you need, and receive funded access to any of these facilities through Instruct - bsky.app/starter-pack...
Reposted by Daniel Hurdiss
Proteins are dynamic structures, but structural biology often shows them as static snapshots. Inspired by long-exposure photography and generative art, I built ProteinCHAOS, an artistic tool inspired by molecular dynamics to capture protein flexibility over time, much like long-exposure images.
November 23, 2025 at 11:18 PM
Proteins are dynamic structures, but structural biology often shows them as static snapshots. Inspired by long-exposure photography and generative art, I built ProteinCHAOS, an artistic tool inspired by molecular dynamics to capture protein flexibility over time, much like long-exposure images.
Reposted by Daniel Hurdiss
An exciting PhD opportunity is available in my lab! More info about our group and research can be found here: bdaum2.wixsite.com/daumlab
Application deadline: 8th Jan 2026.
Apply here: www.exeter.ac.uk/study/pg-res...
If you are interested, get in touch!
#ArchaeaSky #CryoEM #TeamTomo
Application deadline: 8th Jan 2026.
Apply here: www.exeter.ac.uk/study/pg-res...
If you are interested, get in touch!
#ArchaeaSky #CryoEM #TeamTomo
November 24, 2025 at 3:09 PM
An exciting PhD opportunity is available in my lab! More info about our group and research can be found here: bdaum2.wixsite.com/daumlab
Application deadline: 8th Jan 2026.
Apply here: www.exeter.ac.uk/study/pg-res...
If you are interested, get in touch!
#ArchaeaSky #CryoEM #TeamTomo
Application deadline: 8th Jan 2026.
Apply here: www.exeter.ac.uk/study/pg-res...
If you are interested, get in touch!
#ArchaeaSky #CryoEM #TeamTomo
Reposted by Daniel Hurdiss
Very happy to share our work on lipopolysaccharide assembly by the Lpt complex, published today in @natcomms.nature.com
Fantastic collaboration with @raffaeleieva.bsky.social l and t @pstansfeld.bsky.social
Congrats to all authors, especially Haoxiang, Axel & Violette
🔗 doi.org/10.1038/s414...
Fantastic collaboration with @raffaeleieva.bsky.social l and t @pstansfeld.bsky.social
Congrats to all authors, especially Haoxiang, Axel & Violette
🔗 doi.org/10.1038/s414...
Structural basis of lipopolysaccharide assembly by the outer membrane translocon holo-complex - Nature Communications
The asymmetric distribution of lipopolysaccharide (LPS) on the surface of the bacterial outer membrane is essential and crucial for antibiotic resistance. Here, authors characterize the LPS translocon...
doi.org
November 24, 2025 at 3:22 PM
Very happy to share our work on lipopolysaccharide assembly by the Lpt complex, published today in @natcomms.nature.com
Fantastic collaboration with @raffaeleieva.bsky.social l and t @pstansfeld.bsky.social
Congrats to all authors, especially Haoxiang, Axel & Violette
🔗 doi.org/10.1038/s414...
Fantastic collaboration with @raffaeleieva.bsky.social l and t @pstansfeld.bsky.social
Congrats to all authors, especially Haoxiang, Axel & Violette
🔗 doi.org/10.1038/s414...
Reposted by Daniel Hurdiss
🌟 WeINSPIREBio is hosting its first event!
On Dec 4, we’re running a webinar:
Structures of Success: Career Journeys of Women in Structural Biology
If you work in SB, drug discovery, or just like hearing career stories from brilliant people, join us! And please share 🙏🏼
lnkd.in/ewjD5WPt
#cryoEM
On Dec 4, we’re running a webinar:
Structures of Success: Career Journeys of Women in Structural Biology
If you work in SB, drug discovery, or just like hearing career stories from brilliant people, join us! And please share 🙏🏼
lnkd.in/ewjD5WPt
#cryoEM
November 24, 2025 at 3:17 PM
🌟 WeINSPIREBio is hosting its first event!
On Dec 4, we’re running a webinar:
Structures of Success: Career Journeys of Women in Structural Biology
If you work in SB, drug discovery, or just like hearing career stories from brilliant people, join us! And please share 🙏🏼
lnkd.in/ewjD5WPt
#cryoEM
On Dec 4, we’re running a webinar:
Structures of Success: Career Journeys of Women in Structural Biology
If you work in SB, drug discovery, or just like hearing career stories from brilliant people, join us! And please share 🙏🏼
lnkd.in/ewjD5WPt
#cryoEM
Reposted by Daniel Hurdiss
Happy to see our latest work online. Here we present a new method for microsecond time-resolved cryo-EM based on jet vitrification! Details in the 🧵 below... we hope you enjoy reading! (Hint, there's some fun videos...) #cryoEM #structuralbiology
Microsecond Time-Resolved Cryo-EM Based on Jet Vitrification https://www.biorxiv.org/content/10.1101/2025.11.21.689681v1
November 22, 2025 at 11:26 AM
Happy to see our latest work online. Here we present a new method for microsecond time-resolved cryo-EM based on jet vitrification! Details in the 🧵 below... we hope you enjoy reading! (Hint, there's some fun videos...) #cryoEM #structuralbiology
Reposted by Daniel Hurdiss
On the first day of Christmas, a virus gave to me...
November 17, 2025 at 5:31 PM
On the first day of Christmas, a virus gave to me...
Reposted by Daniel Hurdiss
New Title Alert: Icecream- a self-supervised framework for cryo-ET reconstruction that integrates equivariance principles from modern imaging theory into a deep-learning architecture.
Learn more here: buff.ly/bdepEUm
#SBGrid #SBGridSoftware #StructuralBiology
Learn more here: buff.ly/bdepEUm
#SBGrid #SBGridSoftware #StructuralBiology
GitHub - swing-research/icecream: 🍦Icecream: a self-supervised framework for cryo-ET reconstruction
🍦Icecream: a self-supervised framework for cryo-ET reconstruction - swing-research/icecream
buff.ly
November 19, 2025 at 5:03 PM
New Title Alert: Icecream- a self-supervised framework for cryo-ET reconstruction that integrates equivariance principles from modern imaging theory into a deep-learning architecture.
Learn more here: buff.ly/bdepEUm
#SBGrid #SBGridSoftware #StructuralBiology
Learn more here: buff.ly/bdepEUm
#SBGrid #SBGridSoftware #StructuralBiology
Reposted by Daniel Hurdiss
Tired of knowing what you are looking for in your tomograms?
Why not try bluesky-less Frosina's new self-supervised algorithm for semantic segmentation and particle picking for #teamtomo (includes a new denoiser without the need for odd/even tomos)
Code is on GitHub if you want to try it out
Why not try bluesky-less Frosina's new self-supervised algorithm for semantic segmentation and particle picking for #teamtomo (includes a new denoiser without the need for odd/even tomos)
Code is on GitHub if you want to try it out
November 19, 2025 at 2:04 PM
Tired of knowing what you are looking for in your tomograms?
Why not try bluesky-less Frosina's new self-supervised algorithm for semantic segmentation and particle picking for #teamtomo (includes a new denoiser without the need for odd/even tomos)
Code is on GitHub if you want to try it out
Why not try bluesky-less Frosina's new self-supervised algorithm for semantic segmentation and particle picking for #teamtomo (includes a new denoiser without the need for odd/even tomos)
Code is on GitHub if you want to try it out
Reposted by Daniel Hurdiss
Are you looking for female speakers in CryoEM for seminars and conferences? Are you a woman in CryoEM and not yet on the ‚woman in CryoEM‘ list? Find your speakers and add/update name and affiliation! docs.google.com/spreadsheets...
November 18, 2025 at 10:18 AM
Are you looking for female speakers in CryoEM for seminars and conferences? Are you a woman in CryoEM and not yet on the ‚woman in CryoEM‘ list? Find your speakers and add/update name and affiliation! docs.google.com/spreadsheets...
Reposted by Daniel Hurdiss
Congratulations to #postdoc HuaxinYu in the Liu Lab @yaleschoolofmed.bsky.social for insightful findings @science.org #cryoEM #cryoET #Lambdaphage Structural basis of bacteriophage Ur-lambda infection initiation www.science.org/doi/10.1126/...
Structural basis of bacteriophage Ur-lambda infection initiation
In situ structures reveal molecular insights into infection initiation of bacteriophage Ur-lambda.
www.science.org
November 17, 2025 at 3:51 PM
Congratulations to #postdoc HuaxinYu in the Liu Lab @yaleschoolofmed.bsky.social for insightful findings @science.org #cryoEM #cryoET #Lambdaphage Structural basis of bacteriophage Ur-lambda infection initiation www.science.org/doi/10.1126/...
Reposted by Daniel Hurdiss
The outbreak in Ethiopia is #Marburg virus, the first such outbreak for this country. 9 cases so far, including some health workers. x.com/drtedros/sta...
Tedros Adhanom Ghebreyesus on X: "#Ethiopia has confirmed the outbreak that has infected at least 9 people in the south of the country is of #Marburg virus disease. I commend Ethiopia’s @FMoHealth for its rapid and transparent response to the outbreak, and the work of the Ethiopia Public Health Institute and" / X
#Ethiopia has confirmed the outbreak that has infected at least 9 people in the south of the country is of #Marburg virus disease. I commend Ethiopia’s @FMoHealth for its rapid and transparent response to the outbreak, and the work of the Ethiopia Public Health Institute and
x.com
November 14, 2025 at 4:22 PM
The outbreak in Ethiopia is #Marburg virus, the first such outbreak for this country. 9 cases so far, including some health workers. x.com/drtedros/sta...
Reposted by Daniel Hurdiss
Potent neutralization of Marburg virus by a vaccine-elicited antibody pubmed.ncbi.nlm.nih.gov/41225006/ #cryoem
November 13, 2025 at 4:23 PM
Potent neutralization of Marburg virus by a vaccine-elicited antibody pubmed.ncbi.nlm.nih.gov/41225006/ #cryoem
Reposted by Daniel Hurdiss
Human antibody targeting of coronavirus spike S2 subunit is associated with protection mediated by Fc effector functions pubmed.ncbi.nlm.nih.gov/41222229/ #cryoem
November 14, 2025 at 5:32 AM
Human antibody targeting of coronavirus spike S2 subunit is associated with protection mediated by Fc effector functions pubmed.ncbi.nlm.nih.gov/41222229/ #cryoem
Reposted by Daniel Hurdiss
Reposted by Daniel Hurdiss
Great to see a new FluView post from #CDC today after weeks without updates.
It's not yet flu season in the US, but activity is starting to pick up. www.cdc.gov/fluview/surv...
It's not yet flu season in the US, but activity is starting to pick up. www.cdc.gov/fluview/surv...
Weekly US Influenza Surveillance Report: Key Updates for Week 45, ending November 8, 2025
Seasonal influenza activity is low.
www.cdc.gov
November 14, 2025 at 9:14 PM
Great to see a new FluView post from #CDC today after weeks without updates.
It's not yet flu season in the US, but activity is starting to pick up. www.cdc.gov/fluview/surv...
It's not yet flu season in the US, but activity is starting to pick up. www.cdc.gov/fluview/surv...
Had a great time hosting @proteincapsid.bsky.social over the past few days. Thanks for the exciting lecture and for sharing your tomography expertise. Until next time!
November 14, 2025 at 3:45 PM
Had a great time hosting @proteincapsid.bsky.social over the past few days. Thanks for the exciting lecture and for sharing your tomography expertise. Until next time!
Reposted by Daniel Hurdiss
Our lab's paper describing the North American H5N1 epizootic is out now in Nature! So thrilled to have this out, and congratulations to @lambod50.bsky.social for all the fantastic work on this: www.nature.com/articles/s41...
Ecology and spread of the North American H5N1 epizootic - Nature
The panzootic of highly pathogenic H5N1 since 2021 was driven by around nine introductions into the Atlantic and Pacific flyways, followed by rapid dissemination through wild migratory birds, primaril...
www.nature.com
November 12, 2025 at 7:33 PM
Our lab's paper describing the North American H5N1 epizootic is out now in Nature! So thrilled to have this out, and congratulations to @lambod50.bsky.social for all the fantastic work on this: www.nature.com/articles/s41...
Reposted by Daniel Hurdiss
Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp
Proteome-wide in silico screening for human protein-protein interactions
Protein-protein interactions (PPIs) drive virtually all biological processes, yet most PPIs have not been identified and even more remain structurally unresolved. We developed a two-step computational...
biorxiv.org
November 12, 2025 at 9:26 PM
Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp
Reposted by Daniel Hurdiss
Special Issue: Macromolecular Assemblies is now live! Explore advances in cryoEM, cryoET, FIB milling, NMR, & AI for structure prediction. Discover cutting-edge insights into the structure & function of biological complexes. #StructuralBiology #CryoEM
spkl.io/63324AwAho
spkl.io/63324AwAho
November 10, 2025 at 1:00 PM
Special Issue: Macromolecular Assemblies is now live! Explore advances in cryoEM, cryoET, FIB milling, NMR, & AI for structure prediction. Discover cutting-edge insights into the structure & function of biological complexes. #StructuralBiology #CryoEM
spkl.io/63324AwAho
spkl.io/63324AwAho
Reposted by Daniel Hurdiss
I am excited to share our new preprint on our structural and biochemical analyses of human methionine synthase (MTR). This was the hard work of Douglas Ferreira who carried out this research as a significant part of his PhD. #CryoEM www.biorxiv.org/content/10.1...
Structural insights into cobalamin loading and reactivation of human methionine synthase
Human methionine synthase (MTR) is an essential enzyme of one carbon metabolism. Consisting of a catalytic N-half and a cobalamin binding C-half, MTR utilises this intricate organometallic cofactor in...
www.biorxiv.org
November 11, 2025 at 12:48 PM
I am excited to share our new preprint on our structural and biochemical analyses of human methionine synthase (MTR). This was the hard work of Douglas Ferreira who carried out this research as a significant part of his PhD. #CryoEM www.biorxiv.org/content/10.1...