Andy Edwards
@bugsinblood.bsky.social
Molecular bacteriologist with an interest in antibiotics, resistance and bloodstream infections.
Reposted by Andy Edwards
Great heroic work by Kevser Bilici demonstrating the import role of biotin for integration of S. aureus into the nasal microbiome.
Really happy to see the final version of this published in @isme-microbes.bsky.social. We show that production of and competition for biotin shapes S. aureus fitness in the context of nasal commensals doi.org/10.1093/isme...
Work lead by the amazing Kevser Bilici!
Work lead by the amazing Kevser Bilici!
Competitive fitness of Staphylococcus aureus against nasal commensals depends on biotin biosynthesis and acquisition
Abstract. The human nasal microbiome can serve as a reservoir for pathogens. In particular, the opportunistic pathogen Staphylococcus aureus can be a membe
doi.org
November 25, 2025 at 7:58 AM
Great heroic work by Kevser Bilici demonstrating the import role of biotin for integration of S. aureus into the nasal microbiome.
Reposted by Andy Edwards
Now properly published at @natcomms.nature.com with few additional experiments incl. demonstration of Daptomycin's ability to depolarise non-growing cells.
See the original preprint-thread for a summary of our findings.
www.nature.com/articles/s41...
#microsky
See the original preprint-thread for a summary of our findings.
www.nature.com/articles/s41...
#microsky
November 24, 2025 at 8:20 PM
Now properly published at @natcomms.nature.com with few additional experiments incl. demonstration of Daptomycin's ability to depolarise non-growing cells.
See the original preprint-thread for a summary of our findings.
www.nature.com/articles/s41...
#microsky
See the original preprint-thread for a summary of our findings.
www.nature.com/articles/s41...
#microsky
Reposted by Andy Edwards
rdcu.be/eRxNf here our new study on the characterization of the lipopolysaccharide holotranslocon, LptDE and the newly identified subunits LptM and LptY. Great collaboration with @fronzeslab.bsky.social @pstansfeld.bsky.social @JulienMarcoux @YvesQuentin
Structural basis of lipopolysaccharide assembly by the outer membrane translocon holo-complex
Nature Communications - The asymmetric distribution of lipopolysaccharide (LPS) on the surface of the bacterial outer membrane is essential and crucial for antibiotic resistance. Here, authors...
rdcu.be
November 24, 2025 at 4:08 PM
rdcu.be/eRxNf here our new study on the characterization of the lipopolysaccharide holotranslocon, LptDE and the newly identified subunits LptM and LptY. Great collaboration with @fronzeslab.bsky.social @pstansfeld.bsky.social @JulienMarcoux @YvesQuentin
Reposted by Andy Edwards
I tried an even harder example on Gemini Pro image generation and this is quite scary/amazing. I asked for a microscopy image of around 20 HeLa cells, GFP tagged 20% nuclear, 10% membrane, +1 nuclear staining, + overlap. Image below and prompt in the following post.
November 21, 2025 at 5:32 PM
I tried an even harder example on Gemini Pro image generation and this is quite scary/amazing. I asked for a microscopy image of around 20 HeLa cells, GFP tagged 20% nuclear, 10% membrane, +1 nuclear staining, + overlap. Image below and prompt in the following post.
Or not…
I may have posted this in haste...
Time to dust this off, again @avishenoy.bsky.social
November 22, 2025 at 6:56 AM
Or not…
Reposted by Andy Edwards
PhD position on bacterial (Staph aureus) transporters and host-adaptation in my group @roslininstitute.bsky.social @edinburgh-uni.bsky.social
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
EASTBIO How do transporters promote the fitness of Staphylococcus aureus in different host-species ? at University of Edinburgh on FindAPhD.com
PhD Project - EASTBIO How do transporters promote the fitness of Staphylococcus aureus in different host-species ? at University of Edinburgh, listed on FindAPhD.com
www.findaphd.com
November 21, 2025 at 8:19 AM
PhD position on bacterial (Staph aureus) transporters and host-adaptation in my group @roslininstitute.bsky.social @edinburgh-uni.bsky.social
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
I may have posted this in haste...
November 21, 2025 at 9:53 AM
I may have posted this in haste...
Time to dust this off, again @avishenoy.bsky.social
November 21, 2025 at 5:13 AM
Time to dust this off, again @avishenoy.bsky.social
Reposted by Andy Edwards
80 years after the Nobel Prize for penicillin, antimicrobial resistance is one of societies toughest challenges. GSK, the Fleming Initiative, and the @ineosoxford.bsky.social hosted leaders at the Royal Society of Medicine to advance the global response.
November 20, 2025 at 3:28 PM
80 years after the Nobel Prize for penicillin, antimicrobial resistance is one of societies toughest challenges. GSK, the Fleming Initiative, and the @ineosoxford.bsky.social hosted leaders at the Royal Society of Medicine to advance the global response.
Reposted by Andy Edwards
Why does daptomycin resistance appear so fast in Enterococcus? We finally have a clue.
DAP resistance in enterococci pops up quickly. What’s been missing is why resistance-associated membrane changes look the way they do, and why the classic path of mutations is so predictable.
DAP resistance in enterococci pops up quickly. What’s been missing is why resistance-associated membrane changes look the way they do, and why the classic path of mutations is so predictable.
A two-component system signaling hub controls enterococcal membrane remodeling in response to daptomycin https://www.biorxiv.org/content/10.1101/2025.11.16.688641v1
November 17, 2025 at 8:27 PM
Why does daptomycin resistance appear so fast in Enterococcus? We finally have a clue.
DAP resistance in enterococci pops up quickly. What’s been missing is why resistance-associated membrane changes look the way they do, and why the classic path of mutations is so predictable.
DAP resistance in enterococci pops up quickly. What’s been missing is why resistance-associated membrane changes look the way they do, and why the classic path of mutations is so predictable.
Reposted by Andy Edwards
🆕 We're part of a major new project aiming to understand exactly what makes some bacteria resistant to antibiotics.
buff.ly/dpm22l5
buff.ly/dpm22l5
Quadram joins world-class team to unlock secrets of antimicrobial resistance - Quadram Institute
The project is being led by the University of Birmingham, and funded by the Biotechnology and Biological Sciences Research Council, through its Strategic Longer and Larger (sLoLa) grants scheme.…
buff.ly
November 18, 2025 at 3:30 PM
🆕 We're part of a major new project aiming to understand exactly what makes some bacteria resistant to antibiotics.
buff.ly/dpm22l5
buff.ly/dpm22l5
Reposted by Andy Edwards
In scientific writing, it's the "why" before the "what":
"To achieve X, we did Y"
"To explore whether A repressed B, we performed C"
"To test D, we did E"
Starting with the rationale pulls the reader into your logical framework and makes the purpose of every test immediately obvious.
"To achieve X, we did Y"
"To explore whether A repressed B, we performed C"
"To test D, we did E"
Starting with the rationale pulls the reader into your logical framework and makes the purpose of every test immediately obvious.
November 18, 2025 at 2:05 PM
In scientific writing, it's the "why" before the "what":
"To achieve X, we did Y"
"To explore whether A repressed B, we performed C"
"To test D, we did E"
Starting with the rationale pulls the reader into your logical framework and makes the purpose of every test immediately obvious.
"To achieve X, we did Y"
"To explore whether A repressed B, we performed C"
"To test D, we did E"
Starting with the rationale pulls the reader into your logical framework and makes the purpose of every test immediately obvious.
Reposted by Andy Edwards
This project is with @jessicamablair.bsky.social and Sara Jabbari at UoB, @webberma.bsky.social at Quadram, @bugsinblood.bsky.social at Imperial and Dong-Hyun Kim at Nottingham - we are kicking off the project right now!
November 18, 2025 at 9:51 AM
This project is with @jessicamablair.bsky.social and Sara Jabbari at UoB, @webberma.bsky.social at Quadram, @bugsinblood.bsky.social at Imperial and Dong-Hyun Kim at Nottingham - we are kicking off the project right now!
Legit work in progress photo…
www.imperial.ac.uk/news/271753/...
www.imperial.ac.uk/news/271753/...
GSK and Fleming Initiative scientists unite to target AMR with advanced AI | Imperial News | Imperial College London
£45m in GSK funding has been allocated to new research programmes combining expertise and using cutting edge AI technology to accelerate AMR research.
www.imperial.ac.uk
November 18, 2025 at 9:57 AM
Legit work in progress photo…
www.imperial.ac.uk/news/271753/...
www.imperial.ac.uk/news/271753/...
Good day for AMR research (part1): www.ukri.org/news/powerin...
Powering team science to unlock life’s secrets
Four world-class teams awarded major BBSRC sLoLa grants to push the frontiers of discovery in microbiology, photosynthesis, gene regulation and quantum biology.
www.ukri.org
November 18, 2025 at 9:43 AM
Good day for AMR research (part1): www.ukri.org/news/powerin...
Reposted by Andy Edwards
📣Applications open for a competition-funded EastBio PhD position in my lab! I will be able to put one exceptional candidate forward and then we cross our fingers we get the funding🤞If you're interested in metabolism, virulence and antibiotic efficacy, please apply by 15th Dec!
tinyurl.com/873ycjpr
tinyurl.com/873ycjpr
EASTBIO: The Role of Purine Metabolism in Bacterial Virulence, Antibiotic Efficacy and Host-Pathogen Interactions at University of St Andrews on FindAPhD.com
PhD Project - EASTBIO: The Role of Purine Metabolism in Bacterial Virulence, Antibiotic Efficacy and Host-Pathogen Interactions at University of St Andrews, listed on FindAPhD.com
www.findaphd.com
November 17, 2025 at 10:02 AM
📣Applications open for a competition-funded EastBio PhD position in my lab! I will be able to put one exceptional candidate forward and then we cross our fingers we get the funding🤞If you're interested in metabolism, virulence and antibiotic efficacy, please apply by 15th Dec!
tinyurl.com/873ycjpr
tinyurl.com/873ycjpr
Reposted by Andy Edwards
If I were to do a PhD again, I would not hesitate to apply to Jo's group: timely and exciting science, a great team and excellent supervisor. Plus a lab with a beach view.
📣Applications open for a competition-funded EastBio PhD position in my lab! I will be able to put one exceptional candidate forward and then we cross our fingers we get the funding🤞If you're interested in metabolism, virulence and antibiotic efficacy, please apply by 15th Dec!
tinyurl.com/873ycjpr
tinyurl.com/873ycjpr
EASTBIO: The Role of Purine Metabolism in Bacterial Virulence, Antibiotic Efficacy and Host-Pathogen Interactions at University of St Andrews on FindAPhD.com
PhD Project - EASTBIO: The Role of Purine Metabolism in Bacterial Virulence, Antibiotic Efficacy and Host-Pathogen Interactions at University of St Andrews, listed on FindAPhD.com
www.findaphd.com
November 17, 2025 at 10:15 AM
If I were to do a PhD again, I would not hesitate to apply to Jo's group: timely and exciting science, a great team and excellent supervisor. Plus a lab with a beach view.
Reposted by Andy Edwards
Delighted that our review on resistance to last-resort antibiotics in Enterococci has been published in FEMS Microbiology Reviews
academic.oup.com/femsre/advan... (accepted manuscript version)
TL;DR: the Enterococci are really good at evolving resistance to antibiotics in new and creative ways.
academic.oup.com/femsre/advan... (accepted manuscript version)
TL;DR: the Enterococci are really good at evolving resistance to antibiotics in new and creative ways.
Resistance to last-resort antibiotics in enterococci
Abstract. The genus Enterococcus comprises a diverse group of species, many of which are commensal members of the gut microbiota of humans and animals. The
academic.oup.com
November 8, 2025 at 5:41 PM
Delighted that our review on resistance to last-resort antibiotics in Enterococci has been published in FEMS Microbiology Reviews
academic.oup.com/femsre/advan... (accepted manuscript version)
TL;DR: the Enterococci are really good at evolving resistance to antibiotics in new and creative ways.
academic.oup.com/femsre/advan... (accepted manuscript version)
TL;DR: the Enterococci are really good at evolving resistance to antibiotics in new and creative ways.
Reposted by Andy Edwards
Shout out to people routinely working in their 2nd or 3rd language.
Yesterday I gave a 1-hour research seminar in French. Afterwards, my brain was pretty much done for the day.
Respect to the loads of scientists who do this daily (and usually a lot more effectively than me!)
Yesterday I gave a 1-hour research seminar in French. Afterwards, my brain was pretty much done for the day.
Respect to the loads of scientists who do this daily (and usually a lot more effectively than me!)
November 7, 2025 at 10:25 PM
Shout out to people routinely working in their 2nd or 3rd language.
Yesterday I gave a 1-hour research seminar in French. Afterwards, my brain was pretty much done for the day.
Respect to the loads of scientists who do this daily (and usually a lot more effectively than me!)
Yesterday I gave a 1-hour research seminar in French. Afterwards, my brain was pretty much done for the day.
Respect to the loads of scientists who do this daily (and usually a lot more effectively than me!)
I don't understand why journals are so focussed on turnaround time - quality reviews are what matter! A poor review can cost a group months of pointless experiments.
November 7, 2025 at 8:44 AM
I don't understand why journals are so focussed on turnaround time - quality reviews are what matter! A poor review can cost a group months of pointless experiments.
Reposted by Andy Edwards
Reposted by Andy Edwards
If you are interested in researching how drug resistant bacteria evade killing by our immune system, them this PhD project is for you. Come join the our team at Newcastle, in collaboration with University of Liverpool, and lead research at the interface of microbiology, immunology and metabolomics.
MRC DiMeN Doctoral Training Partnership: Hiding in plain sight: How multi-drug resistant pathogens evade detection and killing by human neutrophils at Newcastle University on FindAPhD.com
PhD Project - MRC DiMeN Doctoral Training Partnership: Hiding in plain sight: How multi-drug resistant pathogens evade detection and killing by human neutrophils at Newcastle University, listed on Fin...
www.findaphd.com
November 2, 2025 at 8:22 PM
If you are interested in researching how drug resistant bacteria evade killing by our immune system, them this PhD project is for you. Come join the our team at Newcastle, in collaboration with University of Liverpool, and lead research at the interface of microbiology, immunology and metabolomics.
Reposted by Andy Edwards
🚨Deadline for our Senior Scientist applications is next week.
If you want to develop your academic career in London and help us tackle next-generation drug discovery for Gram-negative infections, apply!
If you want to develop your academic career in London and help us tackle next-generation drug discovery for Gram-negative infections, apply!
📢 We're searching for a PhD-level Senior Research Scientist to develop a next-generation antibacterial drug discovery strategy for Gram-negative infections.
If you're looking to combine CRISPRi and high-throughput assays, reach out to me by email or apply below.
www.linkedin.com/jobs/view/43...
If you're looking to combine CRISPRi and high-throughput assays, reach out to me by email or apply below.
www.linkedin.com/jobs/view/43...
The Francis Crick Institute hiring Senior Laboratory Research Scientist in London Area, United Kingdom | LinkedIn
Posted 2:43:22 PM. Senior Laboratory Research Scientist - Johnson LabDetails of the role:Reports to: Eachan Johnson…See this and similar jobs on LinkedIn.
www.linkedin.com
November 1, 2025 at 12:49 PM
🚨Deadline for our Senior Scientist applications is next week.
If you want to develop your academic career in London and help us tackle next-generation drug discovery for Gram-negative infections, apply!
If you want to develop your academic career in London and help us tackle next-generation drug discovery for Gram-negative infections, apply!
Reposted by Andy Edwards
Looking for an AMR-themed PhD project? Join us to investigate antibiotic tolerance in Staphylococcus aureus through a fully funded MRC DTP PhD studentship starting in September 2026.
This project is close collaboration with @kateduncan.bsky.social and @mycobacterium-ncl.bsky.social.
This project is close collaboration with @kateduncan.bsky.social and @mycobacterium-ncl.bsky.social.
MRC DiMeN Doctoral Training Partnership: Resensitisation of antibiotic-tolerant Staphylococcus aureus small colony variants at Newcastle University on FindAPhD.com
PhD Project - MRC DiMeN Doctoral Training Partnership: Resensitisation of antibiotic-tolerant Staphylococcus aureus small colony variants at Newcastle University, listed on FindAPhD.com
www.findaphd.com
November 1, 2025 at 11:11 AM
Looking for an AMR-themed PhD project? Join us to investigate antibiotic tolerance in Staphylococcus aureus through a fully funded MRC DTP PhD studentship starting in September 2026.
This project is close collaboration with @kateduncan.bsky.social and @mycobacterium-ncl.bsky.social.
This project is close collaboration with @kateduncan.bsky.social and @mycobacterium-ncl.bsky.social.