Uli Schwarz-Linek
@ulischwarzlinek.bsky.social
Structural Biologist at the University of St Andrews. Host:pathogen interactions. Gram-positive bacteria (mainly Streptococcus pyogenes) and Rift Valley fever phlebovirus. cryoEM (novice), NMR (veteran), XRC.
Pinned
I created a group A and B streptococcologists starter pack. Emphasis is on start, let's grow this community here.
go.bsky.app/JefPfn4
go.bsky.app/JefPfn4
Reposted by Uli Schwarz-Linek
Out today, we can now multiplex receptor mapping at synapses thanks to a dimeric gold nanoparticle label optimized by Hoyoung that's distinguishable from monomers!
Dimeric gold nanoparticles enable multiplexed labeling in cryoelectron tomography | PNAS www.pnas.org/doi/10.1073/...
Dimeric gold nanoparticles enable multiplexed labeling in cryoelectron tomography | PNAS www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
November 24, 2025 at 8:54 PM
Out today, we can now multiplex receptor mapping at synapses thanks to a dimeric gold nanoparticle label optimized by Hoyoung that's distinguishable from monomers!
Dimeric gold nanoparticles enable multiplexed labeling in cryoelectron tomography | PNAS www.pnas.org/doi/10.1073/...
Dimeric gold nanoparticles enable multiplexed labeling in cryoelectron tomography | PNAS www.pnas.org/doi/10.1073/...
Reposted by Uli Schwarz-Linek
Excited to share our first look at Enterococcus faecium infection biology: diabetic wounds are complex, and E. faecium persists despite early immune responses. In diabetic mice, it shows impaired clearance + sustained neutrophil recruitment, worsening healing.
Enterococcus faecium colonization and persistence in a model of diabetic wound infection https://www.biorxiv.org/content/10.1101/2025.11.20.689639v1
November 24, 2025 at 12:37 PM
Excited to share our first look at Enterococcus faecium infection biology: diabetic wounds are complex, and E. faecium persists despite early immune responses. In diabetic mice, it shows impaired clearance + sustained neutrophil recruitment, worsening healing.
Reposted by Uli Schwarz-Linek
Strep GBI 2026 registration is open. Join us for Streptococcus focused research. Keynote from Tom Parks @tom-parks.bsky.social "Streptococcus pyogenes - lessons from the host"
📌 Durham, March 30-31
🌐 strepgbi.wixsite.com/strep-gbi.
Registration/abstracts
👉 pay.durham.ac.uk/event-durham.
📌 Durham, March 30-31
🌐 strepgbi.wixsite.com/strep-gbi.
Registration/abstracts
👉 pay.durham.ac.uk/event-durham.
November 24, 2025 at 9:57 AM
Strep GBI 2026 registration is open. Join us for Streptococcus focused research. Keynote from Tom Parks @tom-parks.bsky.social "Streptococcus pyogenes - lessons from the host"
📌 Durham, March 30-31
🌐 strepgbi.wixsite.com/strep-gbi.
Registration/abstracts
👉 pay.durham.ac.uk/event-durham.
📌 Durham, March 30-31
🌐 strepgbi.wixsite.com/strep-gbi.
Registration/abstracts
👉 pay.durham.ac.uk/event-durham.
Reposted by Uli Schwarz-Linek
A recent update on Rapua, the initiate focused on accelerating Strep A vaccine development in Aotearoa New Zealand www.uniservices.co.nz/news/researc...
Research shows Auckland is an ideal place for Strep A vaccine innovation
At UniServices, we partner with the University of Auckland to transform ideas into real-world solutions that impact globally.
www.uniservices.co.nz
November 23, 2025 at 8:26 PM
A recent update on Rapua, the initiate focused on accelerating Strep A vaccine development in Aotearoa New Zealand www.uniservices.co.nz/news/researc...
Reposted by Uli Schwarz-Linek
Happy to see our latest work online. Here we present a new method for microsecond time-resolved cryo-EM based on jet vitrification! Details in the 🧵 below... we hope you enjoy reading! (Hint, there's some fun videos...) #cryoEM #structuralbiology
Microsecond Time-Resolved Cryo-EM Based on Jet Vitrification https://www.biorxiv.org/content/10.1101/2025.11.21.689681v1
November 22, 2025 at 11:26 AM
Happy to see our latest work online. Here we present a new method for microsecond time-resolved cryo-EM based on jet vitrification! Details in the 🧵 below... we hope you enjoy reading! (Hint, there's some fun videos...) #cryoEM #structuralbiology
Reposted by Uli Schwarz-Linek
PhD studentship opportunity! Join us at St Andrews to study the factors controlling plasmid transmission in the gut. Competition-funded as part of the EASTBIO DTP, co-supervised with Dr Jaclyn Pearson. Please share & pass on to anyone interested! 🦠🧫 Deadline 15th December👇
www.findaphd.com
November 18, 2025 at 11:41 AM
PhD studentship opportunity! Join us at St Andrews to study the factors controlling plasmid transmission in the gut. Competition-funded as part of the EASTBIO DTP, co-supervised with Dr Jaclyn Pearson. Please share & pass on to anyone interested! 🦠🧫 Deadline 15th December👇
Reposted by Uli Schwarz-Linek
Why does daptomycin resistance appear so fast in Enterococcus? We finally have a clue.
DAP resistance in enterococci pops up quickly. What’s been missing is why resistance-associated membrane changes look the way they do, and why the classic path of mutations is so predictable.
DAP resistance in enterococci pops up quickly. What’s been missing is why resistance-associated membrane changes look the way they do, and why the classic path of mutations is so predictable.
A two-component system signaling hub controls enterococcal membrane remodeling in response to daptomycin https://www.biorxiv.org/content/10.1101/2025.11.16.688641v1
November 17, 2025 at 8:27 PM
Why does daptomycin resistance appear so fast in Enterococcus? We finally have a clue.
DAP resistance in enterococci pops up quickly. What’s been missing is why resistance-associated membrane changes look the way they do, and why the classic path of mutations is so predictable.
DAP resistance in enterococci pops up quickly. What’s been missing is why resistance-associated membrane changes look the way they do, and why the classic path of mutations is so predictable.
Reposted by Uli Schwarz-Linek
If you'd like to celebrate the biology of viruses - or the fight against viral diseases - this winter, try out our free and updated #VirusSnowflake designs.
Please share, and if you have any photos of Virus Snowflakes in your area it would be lovely to see them!
cvr-engagement.co.uk/virus-snowfl...
Please share, and if you have any photos of Virus Snowflakes in your area it would be lovely to see them!
cvr-engagement.co.uk/virus-snowfl...
November 17, 2025 at 5:39 PM
If you'd like to celebrate the biology of viruses - or the fight against viral diseases - this winter, try out our free and updated #VirusSnowflake designs.
Please share, and if you have any photos of Virus Snowflakes in your area it would be lovely to see them!
cvr-engagement.co.uk/virus-snowfl...
Please share, and if you have any photos of Virus Snowflakes in your area it would be lovely to see them!
cvr-engagement.co.uk/virus-snowfl...
If I were to do a PhD again, I would not hesitate to apply to Jo's group: timely and exciting science, a great team and excellent supervisor. Plus a lab with a beach view.
📣Applications open for a competition-funded EastBio PhD position in my lab! I will be able to put one exceptional candidate forward and then we cross our fingers we get the funding🤞If you're interested in metabolism, virulence and antibiotic efficacy, please apply by 15th Dec!
tinyurl.com/873ycjpr
tinyurl.com/873ycjpr
EASTBIO: The Role of Purine Metabolism in Bacterial Virulence, Antibiotic Efficacy and Host-Pathogen Interactions at University of St Andrews on FindAPhD.com
PhD Project - EASTBIO: The Role of Purine Metabolism in Bacterial Virulence, Antibiotic Efficacy and Host-Pathogen Interactions at University of St Andrews, listed on FindAPhD.com
www.findaphd.com
November 17, 2025 at 10:15 AM
If I were to do a PhD again, I would not hesitate to apply to Jo's group: timely and exciting science, a great team and excellent supervisor. Plus a lab with a beach view.
Reposted by Uli Schwarz-Linek
📣New preprint alert! We report the alarming finding that stringent response mutations found in clinical isolates increase the frequency of donation of multiresistance plasmids in S. aureus 😱 Great team effort @microclaire.bsky.social @paulrjohnston.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 13, 2025 at 12:41 PM
📣New preprint alert! We report the alarming finding that stringent response mutations found in clinical isolates increase the frequency of donation of multiresistance plasmids in S. aureus 😱 Great team effort @microclaire.bsky.social @paulrjohnston.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Sign up if you’re interested in #GroupAStrep #StrepA #streptococcus infections and research. This promises to be a fabulous meeting.
Registration is open for Strep GBI 2026, bringing together ECRs and experts to highlight cutting-edge research focused on crucial aspects of Streptococcal biology.
📌 Durham
🗓️ March 30/31 2026.
🌐 strepgbi.wixsite.com/strep-gbi.
Registration and abstracts
👉 pay.durham.ac.uk/event-durham...
📌 Durham
🗓️ March 30/31 2026.
🌐 strepgbi.wixsite.com/strep-gbi.
Registration and abstracts
👉 pay.durham.ac.uk/event-durham...
November 12, 2025 at 10:08 AM
Sign up if you’re interested in #GroupAStrep #StrepA #streptococcus infections and research. This promises to be a fabulous meeting.
Reposted by Uli Schwarz-Linek
📢 Interested in #chromosomes 🧬 & #archaea thriving at the edge of life? PhD project in York,UK on how archaea pass on their genome to daughter cells.Friendly supervisors: me, @steve-quinn-lab.bsky.social & @georgerheath.bsky.social
www.findaphd.com/phds/project...
📅 January 7, 2026
Please RP🙏thx!
www.findaphd.com/phds/project...
📅 January 7, 2026
Please RP🙏thx!
November 9, 2025 at 5:20 PM
📢 Interested in #chromosomes 🧬 & #archaea thriving at the edge of life? PhD project in York,UK on how archaea pass on their genome to daughter cells.Friendly supervisors: me, @steve-quinn-lab.bsky.social & @georgerheath.bsky.social
www.findaphd.com/phds/project...
📅 January 7, 2026
Please RP🙏thx!
www.findaphd.com/phds/project...
📅 January 7, 2026
Please RP🙏thx!
Reposted by Uli Schwarz-Linek
Fantastic opportunity (available for both UK and international students) to do a PhD on the assembly of RNA viruses with @artisplicer.bsky.social - please share (and/or apply)!
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Funded PhD SWBio DTP- (STANDARD) Genome packaging as a driving force of RNA virus assembly at University of Bristol on FindAPhD.com
PhD Project - Funded PhD SWBio DTP- (STANDARD) Genome packaging as a driving force of RNA virus assembly at University of Bristol, listed on FindAPhD.com
www.findaphd.com
November 7, 2025 at 11:50 AM
Fantastic opportunity (available for both UK and international students) to do a PhD on the assembly of RNA viruses with @artisplicer.bsky.social - please share (and/or apply)!
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Reposted by Uli Schwarz-Linek
Shout out to University of Birmingham folk:
A science-themed play that I co-wrote is coming to you at the Midlands Art Centre on the 17th. A lab-night out? See you there! 🤞
linktr.ee/panaceaplay
@wvschaik.bsky.social @alanmcn1.bsky.social @drjorhodes.com @jkreft.bsky.social
A science-themed play that I co-wrote is coming to you at the Midlands Art Centre on the 17th. A lab-night out? See you there! 🤞
linktr.ee/panaceaplay
@wvschaik.bsky.social @alanmcn1.bsky.social @drjorhodes.com @jkreft.bsky.social
November 6, 2025 at 9:53 AM
Shout out to University of Birmingham folk:
A science-themed play that I co-wrote is coming to you at the Midlands Art Centre on the 17th. A lab-night out? See you there! 🤞
linktr.ee/panaceaplay
@wvschaik.bsky.social @alanmcn1.bsky.social @drjorhodes.com @jkreft.bsky.social
A science-themed play that I co-wrote is coming to you at the Midlands Art Centre on the 17th. A lab-night out? See you there! 🤞
linktr.ee/panaceaplay
@wvschaik.bsky.social @alanmcn1.bsky.social @drjorhodes.com @jkreft.bsky.social
Are you an ECR considering a #fellowship as the next step? We are holding a competitive fellowship day in January 2026. Our priority areas: host-pathogen interactions, synthetic biology, enzymology, systems biology, chemical biology. #ScienceCareers biology.st-andrews.ac.uk/news/2025/11...
Exciting Opportunity: Biomolecular Science Fellowship Day
The School of Biology at the University of St Andrews is inviting applications from outstanding visionary Research Fellow and Future Leader candidates to attend the Biomolecular Science (BMS) Fello…
biology.st-andrews.ac.uk
November 4, 2025 at 12:20 PM
Are you an ECR considering a #fellowship as the next step? We are holding a competitive fellowship day in January 2026. Our priority areas: host-pathogen interactions, synthetic biology, enzymology, systems biology, chemical biology. #ScienceCareers biology.st-andrews.ac.uk/news/2025/11...
Reposted by Uli Schwarz-Linek
🚨 Fully funded PhD studentships 🚨
We have three fully funded PhD studentships available for Oct 26 start. Funded by the MRC DiMeN programme & the BBSRC Yorkshire Biosciences DTP. Details below as they are advertised. Contact me here or via email for more details or to discuss an application
We have three fully funded PhD studentships available for Oct 26 start. Funded by the MRC DiMeN programme & the BBSRC Yorkshire Biosciences DTP. Details below as they are advertised. Contact me here or via email for more details or to discuss an application
Clostridial Cell Biology Group
We are the Clostridial Cell Biology Group at the University of Sheffield. We study all aspects of cell biology, including the architecture and biogenesis of surface structures on both vegetative cells...
sites.google.com
October 31, 2025 at 3:44 PM
🚨 Fully funded PhD studentships 🚨
We have three fully funded PhD studentships available for Oct 26 start. Funded by the MRC DiMeN programme & the BBSRC Yorkshire Biosciences DTP. Details below as they are advertised. Contact me here or via email for more details or to discuss an application
We have three fully funded PhD studentships available for Oct 26 start. Funded by the MRC DiMeN programme & the BBSRC Yorkshire Biosciences DTP. Details below as they are advertised. Contact me here or via email for more details or to discuss an application
Reposted by Uli Schwarz-Linek
Our new preprint is out 🥳🥳🥳
Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?
👇
Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?
👇
November 3, 2025 at 12:26 PM
Our new preprint is out 🥳🥳🥳
Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?
👇
Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?
👇
Reposted by Uli Schwarz-Linek
Are you looking for a postdoctoral opportunity in the field of Biocatalysis and Structural Biology in Barcelona?
The Biotransformation and Bioactive Molecules Group at the IQAC-CSIC is seeking a potential candidate to apply for a Juan de la Cierva Postdoctoral Fellowship and join our team. 🔽
The Biotransformation and Bioactive Molecules Group at the IQAC-CSIC is seeking a potential candidate to apply for a Juan de la Cierva Postdoctoral Fellowship and join our team. 🔽
www.iqac.csic.es
October 31, 2025 at 12:31 PM
Are you looking for a postdoctoral opportunity in the field of Biocatalysis and Structural Biology in Barcelona?
The Biotransformation and Bioactive Molecules Group at the IQAC-CSIC is seeking a potential candidate to apply for a Juan de la Cierva Postdoctoral Fellowship and join our team. 🔽
The Biotransformation and Bioactive Molecules Group at the IQAC-CSIC is seeking a potential candidate to apply for a Juan de la Cierva Postdoctoral Fellowship and join our team. 🔽
Reposted by Uli Schwarz-Linek
The Wallace Lab is expanding in 2026, with five new Postdoctoral Research Associate positions now open. If you're passionate about engineering biology for sustainability, we'd love to hear from you! 🧬 ♻️
Deadline: 12th November 2025, details below ⬇️
Deadline: 12th November 2025, details below ⬇️
October 29, 2025 at 12:34 PM
The Wallace Lab is expanding in 2026, with five new Postdoctoral Research Associate positions now open. If you're passionate about engineering biology for sustainability, we'd love to hear from you! 🧬 ♻️
Deadline: 12th November 2025, details below ⬇️
Deadline: 12th November 2025, details below ⬇️
Reposted by Uli Schwarz-Linek
elifesciences.org/articles/102...
I am very excited to share with you our publication building Deep3DSIM microscope using adaptive optic. It allows imaging into an intact fly brain >130 microns with high quality 3DSIM as well as remote focusing without moving the objective or specimen.
I am very excited to share with you our publication building Deep3DSIM microscope using adaptive optic. It allows imaging into an intact fly brain >130 microns with high quality 3DSIM as well as remote focusing without moving the objective or specimen.
Deep3DSIM: Super-resolution imaging of thick tissue using 3D structured illumination with adaptive optics
Deep3DSIM enables super-resolution imaging >130 µm into complex tissues of fixed and live specimens in an upright configuration, allowing sample manipulation, as well as rapid refocusing without th...
elifesciences.org
October 29, 2025 at 2:30 PM
elifesciences.org/articles/102...
I am very excited to share with you our publication building Deep3DSIM microscope using adaptive optic. It allows imaging into an intact fly brain >130 microns with high quality 3DSIM as well as remote focusing without moving the objective or specimen.
I am very excited to share with you our publication building Deep3DSIM microscope using adaptive optic. It allows imaging into an intact fly brain >130 microns with high quality 3DSIM as well as remote focusing without moving the objective or specimen.
Reposted by Uli Schwarz-Linek
If you’re interested in metals, microbes and maths 🤘 - please check out this PhD on the impact of metals on microbial communities with @thecopperdoctor.bsky.social @blindmath.bsky.social Denis Patterson and myself, you’d be based in Durham & be part of a vibrant interdisciplinary research group
We're advertising a PhD at the intersection of mathematical ecology, metallobiology, and microbiology to study the impact of metals on microbial communities with @thecopperdoctor.bsky.social @kateduncan.bsky.social and Denis Patterson. Come join us in lovely Durham!
iapetus.ac.uk/studentships...
iapetus.ac.uk/studentships...
When nutrients turn toxic: how metals shape microbial coexistence
iapetus.ac.uk
October 29, 2025 at 2:49 PM
If you’re interested in metals, microbes and maths 🤘 - please check out this PhD on the impact of metals on microbial communities with @thecopperdoctor.bsky.social @blindmath.bsky.social Denis Patterson and myself, you’d be based in Durham & be part of a vibrant interdisciplinary research group
Reposted by Uli Schwarz-Linek
Looking for a PhD? 🚀 MIBTP projects are out lots to explore!
🔬 #Bacteria • #AMR • #Interdisciplinary • FUN!
My projects explore how Gram-negative bacteria build and maintain their three-layered cell envelope, using cryo-EM, fluorescence microscopy and biochemistry.
warwick.ac.uk/fac/cross_fa...
🔬 #Bacteria • #AMR • #Interdisciplinary • FUN!
My projects explore how Gram-negative bacteria build and maintain their three-layered cell envelope, using cryo-EM, fluorescence microscopy and biochemistry.
warwick.ac.uk/fac/cross_fa...
Dr Melissa Webby
Dr Melissa Webby
warwick.ac.uk
October 23, 2025 at 5:56 PM
Looking for a PhD? 🚀 MIBTP projects are out lots to explore!
🔬 #Bacteria • #AMR • #Interdisciplinary • FUN!
My projects explore how Gram-negative bacteria build and maintain their three-layered cell envelope, using cryo-EM, fluorescence microscopy and biochemistry.
warwick.ac.uk/fac/cross_fa...
🔬 #Bacteria • #AMR • #Interdisciplinary • FUN!
My projects explore how Gram-negative bacteria build and maintain their three-layered cell envelope, using cryo-EM, fluorescence microscopy and biochemistry.
warwick.ac.uk/fac/cross_fa...
Reposted by Uli Schwarz-Linek
We hiring! Please share this post with your talented ECRs
We're looking for a postdoc interested in the formation and function of tertiary lymphoid structures - project funded by Wellcome
Based at @lmcb-ucl.bsky.social at University College London
Apply here:
www.jobs.ac.uk/job/DPD418/r...
We're looking for a postdoc interested in the formation and function of tertiary lymphoid structures - project funded by Wellcome
Based at @lmcb-ucl.bsky.social at University College London
Apply here:
www.jobs.ac.uk/job/DPD418/r...
October 21, 2025 at 3:57 PM
We hiring! Please share this post with your talented ECRs
We're looking for a postdoc interested in the formation and function of tertiary lymphoid structures - project funded by Wellcome
Based at @lmcb-ucl.bsky.social at University College London
Apply here:
www.jobs.ac.uk/job/DPD418/r...
We're looking for a postdoc interested in the formation and function of tertiary lymphoid structures - project funded by Wellcome
Based at @lmcb-ucl.bsky.social at University College London
Apply here:
www.jobs.ac.uk/job/DPD418/r...
Reposted by Uli Schwarz-Linek
Why did severe #StrepA infections in children increase after the pandemic?
Our new @jamanetworkopen paper suggests COVID restrictions delayed immunity development in young children.
tiny.cc/63vt001
Our new @jamanetworkopen paper suggests COVID restrictions delayed immunity development in young children.
tiny.cc/63vt001
Immunity to S pyogenes and Common Respiratory Viruses at Age 0 to 4 Years
This cross-sectional study examines changes in immunity to Streptococcus pyogenes and other common respiratory pathogens among young children in 10 European countries after the introduction of nonphar...
tiny.cc
October 15, 2025 at 5:50 PM
Why did severe #StrepA infections in children increase after the pandemic?
Our new @jamanetworkopen paper suggests COVID restrictions delayed immunity development in young children.
tiny.cc/63vt001
Our new @jamanetworkopen paper suggests COVID restrictions delayed immunity development in young children.
tiny.cc/63vt001
Reposted by Uli Schwarz-Linek
Out in Science Advances: Our #cryoEM structure of HFTV1, a virus infecting the halophile #archaea. *First full atomic structure (containing all structural proteins) of any tailed virus!* Congrats and thanks to all co-authors and our fantastic collaborators! www.science.org/doi/10.1126/...
Cryo-EM resolves the structure of the archaeal dsDNA virus HFTV1 from head to tail
This structure of an archaeal tailed virus (arTV) provides detailed insights into arTV assembly and infection mechanisms.
www.science.org
October 6, 2025 at 11:31 AM
Out in Science Advances: Our #cryoEM structure of HFTV1, a virus infecting the halophile #archaea. *First full atomic structure (containing all structural proteins) of any tailed virus!* Congrats and thanks to all co-authors and our fantastic collaborators! www.science.org/doi/10.1126/...