Daniela Barillà
@danielabarilla.bsky.social
Microbial geneticist interested in large and small DNA 🧬 rings in bacteria and archaea.
Living in Brontë country and based at the University of Old York.
https://barillalabyork.weebly.com/
Living in Brontë country and based at the University of Old York.
https://barillalabyork.weebly.com/
Pinned
And the story is published now!🍾
www.nature.com/articles/s41...
Open access link: rdcu.be/exnOc
Many years in the making, great collaboration with @archaellum.bsky.social & @tunglejic.bsky.social
Thanks @ukri.org BBSRC & @leverhulme.ac.uk for funding, reviewers & editor!! 🙏
#microsky #archaeasky
www.nature.com/articles/s41...
Open access link: rdcu.be/exnOc
Many years in the making, great collaboration with @archaellum.bsky.social & @tunglejic.bsky.social
Thanks @ukri.org BBSRC & @leverhulme.ac.uk for funding, reviewers & editor!! 🙏
#microsky #archaeasky
Reposted by Daniela Barillà
"... academia becomes McDonaldized — subject to the fast-food industry principles of efficiency, calculability, predictability and control — ..."
@nature.com
www.nature.com/articles/d41...
@nature.com
www.nature.com/articles/d41...
Introducing the j-metric: a true measure of what matters in academia
Science has become obsessed with publishing numbers. With this new satirical proposal, have we reached peak metric?
www.nature.com
November 26, 2025 at 7:29 AM
"... academia becomes McDonaldized — subject to the fast-food industry principles of efficiency, calculability, predictability and control — ..."
@nature.com
www.nature.com/articles/d41...
@nature.com
www.nature.com/articles/d41...
Reposted by Daniela Barillà
Biogeography and host interactions of CPR and DPANN viruses in acid mine drainage sediments | Nature Communications https://www.nature.com/articles/s41467-025-65461-0
Biogeography and host interactions of CPR and DPANN viruses in acid mine drainage sediments - Nature Communications
The ecological role of viruses for CPR bacteria and DPANN archaea remains understudied. Here, the authors apply metagenomic approaches to study the biogeographic distribution of CPR and DPANN viruses in acid mine drainage sediments and elucidate their complex interplays.
www.nature.com
November 25, 2025 at 10:26 PM
Biogeography and host interactions of CPR and DPANN viruses in acid mine drainage sediments | Nature Communications https://www.nature.com/articles/s41467-025-65461-0
Reposted by Daniela Barillà
The hinge bypass gate paper is finally out! doi.org/10.1038/s414...
We show how loop-extruding SMC complexes can maintain DNA entrapment while bypassing obstacles on DNA — including transcription machinery & potentially other SMCs.
A lucky convergence of 3 projects lead to the initial discovery!
We show how loop-extruding SMC complexes can maintain DNA entrapment while bypassing obstacles on DNA — including transcription machinery & potentially other SMCs.
A lucky convergence of 3 projects lead to the initial discovery!
The SMC Hinge is a Selective Gate for Obstacle Bypass - Nature Communications
SMC complexes are ring-shaped motors that fold DNA by extruding loops, but how they navigate large DNA obstacles is unclear. Here, Liu et al., show that SMC complexes bypass obstacles by threading obs...
doi.org
November 25, 2025 at 3:26 PM
The hinge bypass gate paper is finally out! doi.org/10.1038/s414...
We show how loop-extruding SMC complexes can maintain DNA entrapment while bypassing obstacles on DNA — including transcription machinery & potentially other SMCs.
A lucky convergence of 3 projects lead to the initial discovery!
We show how loop-extruding SMC complexes can maintain DNA entrapment while bypassing obstacles on DNA — including transcription machinery & potentially other SMCs.
A lucky convergence of 3 projects lead to the initial discovery!
Reposted by Daniela Barillà
#OpenCloning is a an Open Source alternative to SnapGene/Benchling that supports automation and integration with other software
✅ Free
🔓 Open Source
🧬 More cloning methods than SnapGene
🤖 Can be automated with python
👨🔬 Built by a researcher — for researchers!
👉 Check it out at opencloning.org
✅ Free
🔓 Open Source
🧬 More cloning methods than SnapGene
🤖 Can be automated with python
👨🔬 Built by a researcher — for researchers!
👉 Check it out at opencloning.org
November 24, 2025 at 4:57 PM
#OpenCloning is a an Open Source alternative to SnapGene/Benchling that supports automation and integration with other software
✅ Free
🔓 Open Source
🧬 More cloning methods than SnapGene
🤖 Can be automated with python
👨🔬 Built by a researcher — for researchers!
👉 Check it out at opencloning.org
✅ Free
🔓 Open Source
🧬 More cloning methods than SnapGene
🤖 Can be automated with python
👨🔬 Built by a researcher — for researchers!
👉 Check it out at opencloning.org
Reposted by Daniela Barillà
An exciting PhD opportunity is available in my lab! More info about our group and research can be found here: bdaum2.wixsite.com/daumlab
Application deadline: 8th Jan 2026.
Apply here: www.exeter.ac.uk/study/pg-res...
If you are interested, get in touch!
#ArchaeaSky #CryoEM #TeamTomo
Application deadline: 8th Jan 2026.
Apply here: www.exeter.ac.uk/study/pg-res...
If you are interested, get in touch!
#ArchaeaSky #CryoEM #TeamTomo
November 24, 2025 at 3:09 PM
An exciting PhD opportunity is available in my lab! More info about our group and research can be found here: bdaum2.wixsite.com/daumlab
Application deadline: 8th Jan 2026.
Apply here: www.exeter.ac.uk/study/pg-res...
If you are interested, get in touch!
#ArchaeaSky #CryoEM #TeamTomo
Application deadline: 8th Jan 2026.
Apply here: www.exeter.ac.uk/study/pg-res...
If you are interested, get in touch!
#ArchaeaSky #CryoEM #TeamTomo
Reposted by Daniela Barillà
Now properly published at @natcomms.nature.com with few additional experiments incl. demonstration of Daptomycin's ability to depolarise non-growing cells.
See the original preprint-thread for a summary of our findings.
www.nature.com/articles/s41...
#microsky
See the original preprint-thread for a summary of our findings.
www.nature.com/articles/s41...
#microsky
November 24, 2025 at 8:20 PM
Now properly published at @natcomms.nature.com with few additional experiments incl. demonstration of Daptomycin's ability to depolarise non-growing cells.
See the original preprint-thread for a summary of our findings.
www.nature.com/articles/s41...
#microsky
See the original preprint-thread for a summary of our findings.
www.nature.com/articles/s41...
#microsky
Reposted by Daniela Barillà
New paper out: An archaeal genetic code with all TAG codons as pyrrolysine: www.science.org/doi/10.1126/...
An archaeal genetic code with all TAG codons as pyrrolysine
Multiple genetic codes developed during the evolution of eukaryotes and bacteria, yet no alternative genetic code is known for archaea. We used proteomics to confirm our prediction that certain archae...
www.science.org
November 23, 2025 at 7:22 PM
New paper out: An archaeal genetic code with all TAG codons as pyrrolysine: www.science.org/doi/10.1126/...
Reposted by Daniela Barillà
Fish plate - Southern Italy
c. 2,350 years old
Used to serve fish, with a depression to hold a dish for perhaps a sauce.
Now in @rammuseum.bsky.social
#FindsFriday
c. 2,350 years old
Used to serve fish, with a depression to hold a dish for perhaps a sauce.
Now in @rammuseum.bsky.social
#FindsFriday
November 21, 2025 at 7:51 AM
Fish plate - Southern Italy
c. 2,350 years old
Used to serve fish, with a depression to hold a dish for perhaps a sauce.
Now in @rammuseum.bsky.social
#FindsFriday
c. 2,350 years old
Used to serve fish, with a depression to hold a dish for perhaps a sauce.
Now in @rammuseum.bsky.social
#FindsFriday
Reposted by Daniela Barillà
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Intracellular competition shapes plasmid population dynamics
From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...
www.science.org
November 20, 2025 at 9:42 PM
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Let’s wrap things up: my commentary on the Asgard hypernucleosomes.
Congratulations to all the authors of the paper 🍾!
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
Cryo-EM reveals open and closed Asgard chromatin assemblies: Molecular Cell www.cell.com/molecular-ce...
Congratulations to all the authors of the paper 🍾!
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
Cryo-EM reveals open and closed Asgard chromatin assemblies: Molecular Cell www.cell.com/molecular-ce...
Cryo-EM reveals open and closed Asgard chromatin assemblies
Ranawat et al. show the cryo-EM structures of Asgard archaeal chromatin assemblies,
revealing that the histone HHoB assembles into both compact closed and extended open
hypernucleosomes. The closed co...
www.cell.com
November 20, 2025 at 4:23 PM
Let’s wrap things up: my commentary on the Asgard hypernucleosomes.
Congratulations to all the authors of the paper 🍾!
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
Cryo-EM reveals open and closed Asgard chromatin assemblies: Molecular Cell www.cell.com/molecular-ce...
Congratulations to all the authors of the paper 🍾!
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
Cryo-EM reveals open and closed Asgard chromatin assemblies: Molecular Cell www.cell.com/molecular-ce...
Reposted by Daniela Barillà
Equipositioning of Chromosomes in the Polyploid Archaeon Haloferax volcanii by HpaAB https://www.biorxiv.org/content/10.1101/2025.11.19.689047v1
November 19, 2025 at 4:18 PM
Equipositioning of Chromosomes in the Polyploid Archaeon Haloferax volcanii by HpaAB https://www.biorxiv.org/content/10.1101/2025.11.19.689047v1
New exciting work on genome segregation in Haloferax by @premrajka.bsky.social and @bramkamplab.bsky.social group. 🧬<>🧬
Equipositioning of Chromosomes in the Polyploid Archaeon Haloferax volcanii by HpaAB https://www.biorxiv.org/content/10.1101/2025.11.19.689047v1
November 19, 2025 at 10:06 PM
New exciting work on genome segregation in Haloferax by @premrajka.bsky.social and @bramkamplab.bsky.social group. 🧬<>🧬
Reposted by Daniela Barillà
New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!
November 19, 2025 at 9:16 PM
New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!
Reposted by Daniela Barillà
✨Opportunity to join the 🦁🦠 Predatory Bacteria lab!
My lab will move to University of Bern (CH) in April 2026 based on my #ERCStG.
Therefore, we are looking for:
-a PhD student (shorturl.at/mt0LR)
-a 50% Technical Assistant/Lab manager (shorturl.at/0IIKe)
🙏Thanks for sharing.
#MicroSky
My lab will move to University of Bern (CH) in April 2026 based on my #ERCStG.
Therefore, we are looking for:
-a PhD student (shorturl.at/mt0LR)
-a 50% Technical Assistant/Lab manager (shorturl.at/0IIKe)
🙏Thanks for sharing.
#MicroSky
November 19, 2025 at 7:01 PM
✨Opportunity to join the 🦁🦠 Predatory Bacteria lab!
My lab will move to University of Bern (CH) in April 2026 based on my #ERCStG.
Therefore, we are looking for:
-a PhD student (shorturl.at/mt0LR)
-a 50% Technical Assistant/Lab manager (shorturl.at/0IIKe)
🙏Thanks for sharing.
#MicroSky
My lab will move to University of Bern (CH) in April 2026 based on my #ERCStG.
Therefore, we are looking for:
-a PhD student (shorturl.at/mt0LR)
-a 50% Technical Assistant/Lab manager (shorturl.at/0IIKe)
🙏Thanks for sharing.
#MicroSky
Reposted by Daniela Barillà
Two 4-year PhD positions available for Oct 2026 🪴 We're part of CNAP with 12 plant/microbe research groups combining excellent fundamental science with innovation.
1st - MAGIC Crops: Genomics to breed high yielding, resilient and nutritious amaranth for smallholder farmers
tinyurl.tools/fa83da49
1st - MAGIC Crops: Genomics to breed high yielding, resilient and nutritious amaranth for smallholder farmers
tinyurl.tools/fa83da49
November 19, 2025 at 8:28 AM
Two 4-year PhD positions available for Oct 2026 🪴 We're part of CNAP with 12 plant/microbe research groups combining excellent fundamental science with innovation.
1st - MAGIC Crops: Genomics to breed high yielding, resilient and nutritious amaranth for smallholder farmers
tinyurl.tools/fa83da49
1st - MAGIC Crops: Genomics to breed high yielding, resilient and nutritious amaranth for smallholder farmers
tinyurl.tools/fa83da49
Reposted by Daniela Barillà
PhD studentship opportunity! Join us at St Andrews to study the factors controlling plasmid transmission in the gut. Competition-funded as part of the EASTBIO DTP, co-supervised with Dr Jaclyn Pearson. Please share & pass on to anyone interested! 🦠🧫 Deadline 15th December👇
www.findaphd.com
November 18, 2025 at 11:41 AM
PhD studentship opportunity! Join us at St Andrews to study the factors controlling plasmid transmission in the gut. Competition-funded as part of the EASTBIO DTP, co-supervised with Dr Jaclyn Pearson. Please share & pass on to anyone interested! 🦠🧫 Deadline 15th December👇
Reposted by Daniela Barillà
Hey Labour
Remember the majority of voters who believe in treating people decently and not stealing from those who've endured months and years of hardship fleeing war and persecution to seek a place of safety?
We're still over here 👋
Remember the majority of voters who believe in treating people decently and not stealing from those who've endured months and years of hardship fleeing war and persecution to seek a place of safety?
We're still over here 👋
November 17, 2025 at 7:49 AM
Hey Labour
Remember the majority of voters who believe in treating people decently and not stealing from those who've endured months and years of hardship fleeing war and persecution to seek a place of safety?
We're still over here 👋
Remember the majority of voters who believe in treating people decently and not stealing from those who've endured months and years of hardship fleeing war and persecution to seek a place of safety?
We're still over here 👋
Reposted by Daniela Barillà
🚨 PhD Opportunity 🚨
Interested in microbiology, phages & water security?
Join me and Prof Cindy Smith to test phages as a sustainable alternative to chlorine in drinking-water biofilters.
Metagenomics, phage discovery & ecology — all in one exciting project!
Apply: www.gla.ac.uk/colleges/mvl...
Interested in microbiology, phages & water security?
Join me and Prof Cindy Smith to test phages as a sustainable alternative to chlorine in drinking-water biofilters.
Metagenomics, phage discovery & ecology — all in one exciting project!
Apply: www.gla.ac.uk/colleges/mvl...
November 15, 2025 at 3:30 PM
🚨 PhD Opportunity 🚨
Interested in microbiology, phages & water security?
Join me and Prof Cindy Smith to test phages as a sustainable alternative to chlorine in drinking-water biofilters.
Metagenomics, phage discovery & ecology — all in one exciting project!
Apply: www.gla.ac.uk/colleges/mvl...
Interested in microbiology, phages & water security?
Join me and Prof Cindy Smith to test phages as a sustainable alternative to chlorine in drinking-water biofilters.
Metagenomics, phage discovery & ecology — all in one exciting project!
Apply: www.gla.ac.uk/colleges/mvl...
Reposted by Daniela Barillà
MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
November 14, 2025 at 6:38 PM
MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
Reposted by Daniela Barillà
One of our top-rated posts on @altmetric.com this past was published in @nataging.nature.com. You can read 'Multilingualism protects against accelerated aging in cross-sectional and longitudinal analyses of 27 European countries' here: spklr.io/63325BMpTZ
Multilingualism protects against accelerated aging in cross-sectional and longitudinal analyses of 27 European countries - Nature Aging
In cross-sectional and longitudinal analyses of 86,149 participants across 27 European countries, Amoruso, Hernandez and colleagues identify multilingualism as a protective factor against accelerated aging, using biobehavioral age gaps.
spklr.io
November 14, 2025 at 8:07 PM
One of our top-rated posts on @altmetric.com this past was published in @nataging.nature.com. You can read 'Multilingualism protects against accelerated aging in cross-sectional and longitudinal analyses of 27 European countries' here: spklr.io/63325BMpTZ
Reposted by Daniela Barillà
Latest #CDlab paper on nanopore protein sequencing on @biorxivpreprint.bsky.social: www.biorxiv.org/cgi/content/...
Here, Justas Ritmejeris, @xiuqichen.bsky.social, collaborator @albadalab.bsky.social and me developed a conjugation chemistry strategy for nanopore sequencing of natural peptides!
Here, Justas Ritmejeris, @xiuqichen.bsky.social, collaborator @albadalab.bsky.social and me developed a conjugation chemistry strategy for nanopore sequencing of natural peptides!
November 13, 2025 at 7:16 PM
Latest #CDlab paper on nanopore protein sequencing on @biorxivpreprint.bsky.social: www.biorxiv.org/cgi/content/...
Here, Justas Ritmejeris, @xiuqichen.bsky.social, collaborator @albadalab.bsky.social and me developed a conjugation chemistry strategy for nanopore sequencing of natural peptides!
Here, Justas Ritmejeris, @xiuqichen.bsky.social, collaborator @albadalab.bsky.social and me developed a conjugation chemistry strategy for nanopore sequencing of natural peptides!
Reposted by Daniela Barillà
Great opportunity to join Freiburg University as a Postdoc from abroad! Happy to help !
If you know postdocs in the US whose work is restricted or becoming difficult, there are new fellowship possibilities in the south of Germany. Please, forward this information to them:
uni-freiburg.de/frias/call-f...
Our lab in Freiburg can also serve as a host — happy to discuss options.
uni-freiburg.de/frias/call-f...
Our lab in Freiburg can also serve as a host — happy to discuss options.
Call for Applications: Early Career Rescue Fellowship – Freiburg Institute for Advanced Studies
uni-freiburg.de
November 14, 2025 at 7:16 AM
Great opportunity to join Freiburg University as a Postdoc from abroad! Happy to help !
Thermophiles don’t just survive heat, they thrive in it. 🔥
They provide heat-stable enzymes, insights into early Earth, and tools for biotech.
Our new thematic issue in #FEMSMicrobiolEcol captures how diverse this field is. Explore the collection👉 buff.ly/kD8fmOL
They provide heat-stable enzymes, insights into early Earth, and tools for biotech.
Our new thematic issue in #FEMSMicrobiolEcol captures how diverse this field is. Explore the collection👉 buff.ly/kD8fmOL
November 14, 2025 at 8:20 AM
Reposted by Daniela Barillà
34 fully-funded PhD studentships in the Biosciences across UK Universities in the South West (including Bristol Biochemistry!)
Home and International students eligible
Information and applications here
www.swbio.ac.uk
Home and International students eligible
Information and applications here
www.swbio.ac.uk
SWBiosciences Doctoral Training Partnership
www.swbio.ac.uk
November 13, 2025 at 9:50 PM
34 fully-funded PhD studentships in the Biosciences across UK Universities in the South West (including Bristol Biochemistry!)
Home and International students eligible
Information and applications here
www.swbio.ac.uk
Home and International students eligible
Information and applications here
www.swbio.ac.uk
Reposted by Daniela Barillà
Any #archaea #archaeasky lab out there interested in having their Natrialba species sequenced on ONT r10 up to about 3Kx read depth for free? I'll send back annotated assembly, methylation data and raw signal files. I need at least one more species for a paper. Feel free to DM!
🧫🦠🧪
🧫🦠🧪
November 13, 2025 at 5:00 AM
Any #archaea #archaeasky lab out there interested in having their Natrialba species sequenced on ONT r10 up to about 3Kx read depth for free? I'll send back annotated assembly, methylation data and raw signal files. I need at least one more species for a paper. Feel free to DM!
🧫🦠🧪
🧫🦠🧪